KEGG   PATHWAY: asao04144
Entry
asao04144                   Pathway                                
Name
Endocytosis - Anolis sagrei ordinatus (Brown anole)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
asao04144  Endocytosis
asao04144

Other DBs
GO: 0006897
Organism
Anolis sagrei ordinatus (Brown anole) [GN:asao]
Gene
132782153  ADP-ribosylation factor 6-like [KO:K07941]
132760700  ARF6; ADP-ribosylation factor 6 [KO:K07941]
132767370  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
132781133  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
132764149  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
132763953  PIP5KL1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 [KO:K13712] [EC:2.7.1.68]
132777471  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
132769806  phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
132769807  phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
132763578  DNM1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
132767983  DNM2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
132768112  CLTA; clathrin light chain A isoform X1 [KO:K04644]
132769026  CLTB; clathrin light chain B isoform X1 [KO:K04645]
132781622  CLTCL1; clathrin heavy chain 2 isoform X1 [KO:K04646]
132763365  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
132771260  AP2A2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
132778102  AP2A1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
132770935  AP-1 complex subunit beta-1 isoform X1 [KO:K11825]
132770420  AP2M1; AP-2 complex subunit mu [KO:K11826]
132781692  AP2S1; AP-2 complex subunit sigma [KO:K11827]
132772854  AP-2 complex subunit sigma-like [KO:K11827]
132780201  EHD2; EH domain-containing protein 2 [KO:K12469]
132778483  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
132778673  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
132774781  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
132767103  ZFYVE16; zinc finger FYVE domain-containing protein 16 isoform X1 [KO:K04679]
132773922  ZFYVE9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
132762635  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
132766861  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
132762413  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
132769784  TFRC; LOW QUALITY PROTEIN: transferrin receptor protein 1 [KO:K06503]
132778525  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
132776647  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
132771014  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
132771374  fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
132769044  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
132762556  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
132782292  CBL; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
132772009  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
132771716  SH3KBP1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
132767428  SH3GL2; endophilin-A1 [KO:K11247]
132762340  SH3GL3; endophilin-A3 isoform X1 [KO:K11247]
132781028  SH3GL1; endophilin-A2 isoform X1 [KO:K11247]
132774108  SH3GLB1; endophilin-B1 isoform X1 [KO:K11248]
132763750  SH3GLB2; endophilin-B2 isoform X1 [KO:K21269]
132778548  AMPH; amphiphysin isoform X1 [KO:K12562]
132774195  BIN1; myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
132782101  EPN2; epsin-2 [KO:K12471]
132777846  EPN1; epsin-1 isoform X1 [KO:K12471]
132768659  EPN3; epsin-3 isoform X1 [KO:K12471]
132773913  EPS15; epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
132780945  EPS15L1; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
132772084  SPART; spartin isoform X1 [KO:K19366]
132762644  NEDD4; E3 ubiquitin-protein ligase NEDD4 [KO:K10591] [EC:2.3.2.26]
132766894  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
132776175  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
132768609  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
132768326  RNF41; E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
132773235  ITCH; E3 ubiquitin-protein ligase Itchy homolog [KO:K05632] [EC:2.3.2.26]
132767783  SMURF2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
132780009  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
132774961  WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
132768007  LDLR; low-density lipoprotein receptor [KO:K12473]
132761744  low density lipoprotein receptor adapter protein 1-A-like isoform X1 [KO:K12474]
132780704  LDLRAP1; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
132766944  DAB2; disabled homolog 2 isoform X1 [KO:K12475]
132778618  C-C chemokine receptor type 5-like [KO:K04180]
132778619  C-C chemokine receptor type 5-like [KO:K04180]
132779755  C-C chemokine receptor type 5-like [KO:K04180]
132761924  C-X-C chemokine receptor type 1-like [KO:K05050]
132761925  C-X-C chemokine receptor type 2-like [KO:K05050]
132775215  CXCR4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
132770640  GRK7; rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
132777522  GRK1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
132773153  GRK2; beta-adrenergic receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
132780912  GRK3; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
132771002  GRK5; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
132782396  G protein-coupled receptor kinase 5-like [KO:K08291] [EC:2.7.11.16]
132769056  GRK6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
132777453  ARRB2; beta-arrestin-2 [KO:K04439]
132770298  beta-arrestin-1 [KO:K04439]
132776285  WASL; actin nucleation-promoting factor WASL isoform X1 [KO:K23612]
132780620  actin-related protein 2-like [KO:K17260]
132780630  ACTR2; actin-related protein 2 [KO:K17260]
132764277  actin-related protein 2-B-like [KO:K17260]
132761031  actin-related protein 3-like [KO:K18584]
132779795  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
132775044  ACTR3; actin-related protein 3 [KO:K18584]
132780005  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
132780007  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
132774000  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
132781331  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
132774402  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
132763696  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
132777058  WIPF1; WAS/WASL-interacting protein family member 1 [KO:K19475]
132778260  WIPF2; WAS/WASL-interacting protein family member 2 [KO:K19475]
132778723  WIPF3; WAS/WASL-interacting protein family member 3 isoform X1 [KO:K19475]
132764571  heat shock 70 kDa protein 1B-like [KO:K03283]
132782299  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
132780170  heat shock cognate 71 kDa protein-like [KO:K03283]
132764141  heat shock 70 kDa protein-like [KO:K03283]
132774018  DNAJC6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
132775867  WASHC4; WASH complex subunit 4 [KO:K18465]
132773515  WASHC5; WASH complex subunit 5 [KO:K18464]
132771383  WASH complex subunit 2-like isoform X1 [KO:K18462]
132775793  WASHC1; WASH complex subunit 1 [KO:K18461]
132775846  WASHC3; WASH complex subunit 3 [KO:K18463]
132776266  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
132777345  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
132773448  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
132762744  F-actin-capping protein subunit alpha-2-like [KO:K10364]
132764764  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
132781527  vacuolar protein sorting-associated protein 29-like [KO:K18467]
132781663  VPS29; vacuolar protein sorting-associated protein 29 [KO:K18467]
132771185  VPS26A; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 26A [KO:K18466]
132782298  VPS26B; vacuolar protein sorting-associated protein 26B [KO:K18466]
132782927  VPS35; vacuolar protein sorting-associated protein 35 [KO:K18468]
132760848  SNX3; sorting nexin-3 isoform X1 [KO:K17918]
132762881  SNX12; sorting nexin-12 [KO:K17918]
132763257  sorting nexin-12 [KO:K17918]
132762347  USP8; ubiquitin carboxyl-terminal hydrolase 8 isoform X1 [KO:K11839] [EC:3.4.19.12]
132782614  STAMBP; STAM-binding protein [KO:K11866] [EC:3.4.19.12]
132769312  RAB7A; ras-related protein Rab-7a [KO:K07897]
132767843  ras-related protein Rab-7a-like [KO:K07897]
132768471  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
132775866  STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705]
132778892  STAM; signal transducing adapter molecule 1 [KO:K04705]
132770795  TSG101; tumor susceptibility gene 101 protein [KO:K12183]
132768189  MVB12A; multivesicular body subunit 12A [KO:K12186]
132763689  MVB12B; multivesicular body subunit 12B isoform X1 [KO:K12186]
132783213  vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
132775171  VPS28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
132776677  VPS37A; vacuolar protein sorting-associated protein 37A [KO:K12185]
132772211  VPS37C; vacuolar protein sorting-associated protein 37C [KO:K12185]
132763320  VPS37D; vacuolar protein sorting-associated protein 37D [KO:K12185]
132781337  VPS37B; vacuolar protein sorting-associated protein 37B [KO:K12185]
132778167  SNF8; vacuolar-sorting protein SNF8 [KO:K12188]
132782091  VPS36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
132778387  VPS25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
132768434  CHMP6; charged multivesicular body protein 6 isoform X1 [KO:K12195]
132773240  CHMP4B; charged multivesicular body protein 4b [KO:K12194]
132774948  CHMP4C; charged multivesicular body protein 4c [KO:K24782]
132778060  CHMP2A; charged multivesicular body protein 2a [KO:K12191]
132761771  charged multivesicular body protein 2a-like [KO:K12191]
132771944  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
132782376  CHMP7; charged multivesicular body protein 7 isoform X1 [KO:K15053]
132782970  VPS4A; vacuolar protein sorting-associated protein 4A [KO:K12196]
132774531  VPS4B; vacuolar protein sorting-associated protein 4B [KO:K12196]
132761014  VTA1; vacuolar protein sorting-associated protein VTA1 homolog isoform X1 [KO:K12199]
132783020  CHMP1A; charged multivesicular body protein 1a [KO:K12197]
132763002  CHMP1B; charged multivesicular body protein 1b [KO:K12197]
132778469  CHMP5; charged multivesicular body protein 5 [KO:K12198]
132783042  IST1; IST1 homolog isoform X1 [KO:K19476]
132778581  PDCD6IP; programmed cell death 6-interacting protein isoform X1 [KO:K12200]
132762540  SPG21; maspardin [KO:K19367]
132761104  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
132767237  SNX2; sorting nexin-2 isoform X1 [KO:K17917]
132762400  SNX1; sorting nexin-1 [KO:K17917]
132765117  SNX6; sorting nexin-6 [KO:K17920]
132774292  SNX5; sorting nexin-5 [KO:K17920]
132773197  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
132771520  HRAS; GTPase HRas [KO:K02833]
132775631  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
132777364  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
132762891  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
132767620  transforming protein RhoA-like [KO:K04513]
132769106  RHOA; transforming protein RhoA [KO:K04513]
132765326  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
132765329  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
132765334  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
132765340  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
132765342  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
132765343  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
132765344  major histocompatibility complex class I-related gene protein-like [KO:K06751]
132765814  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
132765818  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
132769747  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
132773866  riboflavin-binding protein-like [KO:K13649]
132768754  RTBDN; retbindin [KO:K13649]
132770292  folate receptor gamma-like [KO:K13649]
132776256  CAV1; caveolin-1 isoform X1 [KO:K06278]
132776255  CAV2; caveolin-2 [KO:K12958]
132766534  caveolin-2-like [KO:K12958]
132767837  caveolin-3-like [KO:K12959]
132761354  EHD3; EH domain-containing protein 3 [KO:K12476]
132779076  EH domain-containing protein 3 [KO:K12476]
132766496  EHD4; EH domain-containing protein 4 [KO:K12477]
132776100  EEA1; early endosome antigen 1 isoform X1 [KO:K12478]
132778704  RAB5A; ras-related protein Rab-5A [KO:K07887]
132768208  RAB5B; ras-related protein Rab-5B [KO:K07888]
132778216  RAB5C; ras-related protein Rab-5C [KO:K07889]
132763483  RABEP1; rab GTPase-binding effector protein 1 [KO:K12480]
132769352  RBSN; rabenosyn-5 [KO:K12481]
132761174  RAB4A; ras-related protein Rab-4A [KO:K07879]
132771198  RUFY2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
132768930  RUFY1; RUN and FYVE domain-containing protein 1 isoform X1 [KO:K12482]
132764062  EHD1; EH domain-containing protein 1 [KO:K12483]
132764165  VPS45; vacuolar protein sorting-associated protein 45 [KO:K12479]
132774793  SNX4; sorting nexin-4 [KO:K17919]
132773099  RAB22A; ras-related protein Rab-22A [KO:K07891]
132774716  RAB31; ras-related protein Rab-31 [KO:K07891]
132761722  RAB10; ras-related protein Rab-10 [KO:K07903]
132774797  ras-related protein Rab-10-like isoform X1 [KO:K07903]
132780952  RAB8A; ras-related protein Rab-8A [KO:K07901]
132777782  ras-related protein Rab-35-like [KO:K07876]
132781282  RAB35; ras-related protein Rab-35 [KO:K07876]
132762404  RAB11A; ras-related protein Rab-11A [KO:K07904]
132764007  ras-related protein Rab-11A-like [KO:K07904]
132781730  RAB11B; ras-related protein Rab-11B [KO:K07905]
132770991  RAB11FIP2; rab11 family-interacting protein 2 isoform X1 [KO:K12484]
132782361  RAB11FIP1; rab11 family-interacting protein 1 isoform X1 [KO:K12484]
132770853  ZFYVE27; protrudin isoform X1 [KO:K19368]
132767719  KIF5A; kinesin heavy chain isoform X1 [KO:K10396]
132778946  KIF5B; kinesin-1 heavy chain [KO:K10396]
132775682  KIF5C; kinesin heavy chain isoform X1 [KO:K10396]
132781778  RAB11FIP3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
132768254  RAB11FIP4; rab11 family-interacting protein 4 isoform X1 [KO:K12485]
132778954  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
132783270  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
132773136  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
132774652  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
132764871  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
132770513  PRKCI; LOW QUALITY PROTEIN: protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
132764663  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
132760721  SMAP1; stromal membrane-associated protein 1 isoform X1 [KO:K12486]
132780455  SMAP2; stromal membrane-associated protein 2 [KO:K12486]
132783387  ARF GTPase-activating protein GIT1-like [KO:K05737]
132763304  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
132780902  GIT2; ARF GTPase-activating protein GIT2 isoform X1 [KO:K12487]
132782874  ASAP2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
132773271  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1-like [KO:K12488]
132780529  ASAP3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 [KO:K12488]
132775113  ASAP1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
132764833  ACAP3; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 [KO:K12489]
132777532  ACAP1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 [KO:K12489]
132770323  ACAP2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12489]
132772331  ARAP1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 [KO:K18439]
132777197  ARAP2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 [KO:K18440]
132774281  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 [KO:K12490]
132779099  AGAP3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 [KO:K12491]
132780271  AGAP1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12491]
132767653  AGAP2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
132773046  ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
132776485  ARFGAP3; ADP-ribosylation factor GTPase-activating protein 3 isoform X1 [KO:K12493]
132768005  ARFGAP2; ADP-ribosylation factor GTPase-activating protein 2 isoform X1 [KO:K12493]
132771329  PSD; PH and SEC7 domain-containing protein 1 isoform X1 [KO:K12494]
132782359  PH and SEC7 domain-containing protein 4-like [KO:K12494]
132768076  PH and SEC7 domain-containing protein 3-like isoform X1 [KO:K12494]
132774236  PSD2; PH and SEC7 domain-containing protein 2 [KO:K12494]
132767866  IQSEC2; IQ motif and SEC7 domain-containing protein 2 isoform X1 [KO:K12495]
132769243  IQSEC1; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
132775792  IQSEC3; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
132775914  CYTH4; cytohesin-4 [KO:K18441]
132782028  CYTH3; cytohesin-3 [KO:K18441]
132777896  CYTH2; cytohesin-2 [KO:K18441]
132768458  CYTH1; cytohesin-1 isoform X1 [KO:K18441]
132773156  ARFGEF2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1 [KO:K18442]
132774898  ARFGEF1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X1 [KO:K18442]
132771324  GBF1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
132779034  ARF1; ADP-ribosylation factor 1 [KO:K07937]
132768338  ARF3; ADP-ribosylation factor 3 [KO:K07938]
132769289  ADP-ribosylation factor 4-like [KO:K07939]
132769290  ADP-ribosylation factor 4 [KO:K07939]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
asao04060  Cytokine-cytokine receptor interaction
asao04070  Phosphatidylinositol signaling system
asao04130  SNARE interactions in vesicular transport
asao04142  Lysosome
asao04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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