Entry
Name
Ras signaling pathway - Bos indicus (zebu cattle)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Bos indicus (zebu cattle) [GN:
biu ]
Gene
109559983 EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357 ]
109570879 FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497 ]
109578611 PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359 ]
109558630 LOW QUALITY PROTEIN: platelet-derived growth factor subunit B-like [KO:K17386 ]
109555962 CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453 ]
109572992 FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454 ]
109576576 VEGFA; LOW QUALITY PROTEIN: vascular endothelial growth factor A [KO:K05448 ]
109555471 VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449 ]
109574393 NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
109572707 PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859 ] [EC:3.1.4.11 ]
109554125 LOW QUALITY PROTEIN: RAS guanyl-releasing protein 2-like [KO:K12361 ]
109578681 LAT; linker for activation of T-cells family member 1 isoform X1 [KO:K07362 ]
109570386 GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536 ]
109578415 GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537 ]
109558919 GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825 ]
109557856 GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538 ]
109565125 GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539 ]
109554309 GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540 ]
109553666 GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541 ]
109556134 GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542 ]
109561787 GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543 ]
109573005 GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544 ]
109558211 GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546 ]
109556958 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546 ]
109561546 LOW QUALITY PROTEIN: uncharacterized LOC105372280 homolog [KO:K04347 ]
109556175 GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347 ]
109578787 GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547 ]
109558062 GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548 ]
109574071 GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549 ]
109575777 RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349 ]
109561127 RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326 ]
109570679 CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183 ]
109576581 SYNGAP1; ras/Rap GTPase-activating protein SynGAP isoform X1 [KO:K17631 ]
109570518 RASAL2; ras GTPase-activating protein nGAP isoform X1 [KO:K17633 ]
109570657 RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015 ]
109562052 TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731 ]
109559805 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
109570415 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
109557823 PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
109574805 PIK3R1; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
109561418 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
109556345 phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
109560296 NFKB1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580 ]
109570785 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
109575379 RALGAPA1; ral GTPase-activating protein subunit alpha-1 isoform X1 [KO:K25768 ]
109568045 RALGAPA2; ral GTPase-activating protein subunit alpha-2 isoform X1 [KO:K25768 ]
109567445 RALGAPB; LOW QUALITY PROTEIN: ral GTPase-activating protein subunit beta [KO:K25769 ]
109565671 RALGDS; ral guanine nucleotide dissociation stimulator [KO:K08732 ]
109570528 RGL1; ral guanine nucleotide dissociation stimulator-like 1 [KO:K17635 ]
109576584 RGL2; ral guanine nucleotide dissociation stimulator-like 2 isoform X1 [KO:K17636 ]
109557298 RAPGEF5; rap guanine nucleotide exchange factor 5 isoform X1 [KO:K08019 ]
109553155 PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860 ] [EC:3.1.4.11 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Karnoub AE, Weinberg RA
Title
Ras oncogenes: split personalities.
Journal
Reference
Authors
Malumbres M, Barbacid M
Title
RAS oncogenes: the first 30 years.
Journal
Reference
Authors
Cox AD, Der CJ
Title
Ras history: The saga continues.
Journal
Reference
Authors
Cox AD, Der CJ
Title
Ras family signaling: therapeutic targeting.
Journal
Reference
Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
Title
Ras oncogenes and their downstream targets.
Journal
Reference
Authors
Schubbert S, Shannon K, Bollag G
Title
Hyperactive Ras in developmental disorders and cancer.
Journal
Reference
Authors
Poulogiannis G, Luo F, Arends MJ
Title
RAS signalling in the colorectum in health and disease.
Journal
Reference
Authors
Berndt N, Hamilton AD, Sebti SM
Title
Targeting protein prenylation for cancer therapy.
Journal
Reference
Authors
Overmeyer JH, Maltese WA
Title
Death pathways triggered by activated Ras in cancer cells.
Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:
10.2741/3814
Reference
Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
Title
Cancer targets in the Ras pathway.
Journal
Reference
Authors
Cox AD, Der CJ
Title
The dark side of Ras: regulation of apoptosis.
Journal
Reference
Authors
Braun BS, Shannon K
Title
Targeting Ras in myeloid leukemias.
Journal
Reference
Authors
Pino MS, Chung DC
Title
The chromosomal instability pathway in colon cancer.
Journal
Reference
Authors
Schrader JW, Schallhorn A, Grill B, Guo X
Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
Journal
Reference
Authors
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
Title
Regulating the regulator: post-translational modification of RAS.
Journal
Reference
Authors
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
Title
A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
Journal
Reference
Authors
Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
Title
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
Journal
Reference
Authors
Kortum RL, Rouquette-Jazdanian AK, Samelson LE
Title
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
Journal
Reference
Authors
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
Title
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
Journal
Reference
Authors
Reuther GW, Der CJ
Title
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
Journal
Reference
Authors
Fernandez-Medarde A, Santos E
Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
Journal
Reference
Authors
Iwashita S, Song SY
Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
Journal
Reference
Authors
Ory S, Morrison DK
Title
Signal transduction: implications for Ras-dependent ERK signaling.
Journal
Reference
Authors
Matheny SA, White MA
Title
Signaling threshold regulation by the Ras effector IMP.
Journal
Reference
Authors
Lemmon MA, Schlessinger J
Title
Cell signaling by receptor tyrosine kinases.
Journal
Reference
Authors
Skaper SD
Title
The neurotrophin family of neurotrophic factors: an overview.
Journal
Reference
Authors
Apken LH, Oeckinghaus A
Title
The RAL signaling network: Cancer and beyond.
Journal
Related pathway
biu04660 T cell receptor signaling pathway
biu04810 Regulation of actin cytoskeleton
KO pathway
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