KEGG   PATHWAY: ccad05132
Entry
ccad05132                   Pathway                                
Name
Salmonella infection - Cervus canadensis (wapiti)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
ccad05132  Salmonella infection
ccad05132

Organism
Cervus canadensis (wapiti) [GN:ccad]
Gene
122438654  PODXL; podocalyxin isoform X1 [KO:K06817]
122451894  PTPRC; receptor-type tyrosine-protein phosphatase C isoform X1 [KO:K06478] [EC:3.1.3.48]
122445528  RAB5A; ras-related protein Rab-5A [KO:K07887]
122431844  ras-related protein Rab-5B-like [KO:K07888]
122427055  RAB5B; ras-related protein Rab-5B [KO:K07888]
122441670  RAB5C; ras-related protein Rab-5C [KO:K07889]
122425494  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
122424281  RAB7A; ras-related protein Rab-7a [KO:K07897]
122452325  RAB7B; ras-related protein Rab-7b [KO:K07898]
122453329  ras-related protein Rab-7b-like [KO:K07898]
122440198  PLEKHM1; pleckstrin homology domain-containing family M member 1 isoform X1 [KO:K23282]
122449614  VPS11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
122448360  VPS16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
122443410  VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
122423998  VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182]
122443436  VPS39; vam6/Vps39-like protein [KO:K20183]
122438560  VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
122447715  rab-interacting lysosomal protein [KO:K13883]
122454743  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 isoform X1 [KO:K10413]
122449476  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
122453707  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
122438114  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
122446590  cytoplasmic dynein 1 intermediate chain 2-like [KO:K10415]
122420742  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
122424619  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
122441626  DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 isoform X1 [KO:K10417]
122450853  DYNLL2; dynein light chain 2, cytoplasmic [KO:K10418]
122434963  dynein light chain 1, cytoplasmic-like [KO:K10418]
122422531  DYNLL1; dynein light chain 1, cytoplasmic [KO:K10418]
122454002  dynein light chain 1, cytoplasmic-like [KO:K10418]
122448822  DYNLRB1; dynein light chain roadblock-type 1 [KO:K10419]
122421610  DYNLRB2; dynein light chain roadblock-type 2 isoform X1 [KO:K10419]
122433923  DYNLT1; dynein light chain Tctex-type 1 isoform X1 [KO:K10420]
122435312  DYNLT3; dynein light chain Tctex-type 3 [KO:K10420]
122443884  dynein light chain Tctex-type 1 [KO:K10420]
122441490  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
122438931  LOW QUALITY PROTEIN: dynactin subunit 1-like [KO:K04648]
122427415  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
122431975  DCTN3; dynactin subunit 3 isoform X1 [KO:K10425]
122439692  DCTN4; dynactin subunit 4 [KO:K10426]
122429401  DCTN5; LOW QUALITY PROTEIN: dynactin subunit 5 [KO:K10427]
122432445  DCTN6; dynactin subunit 6 [KO:K10428]
122441381  ACTR1B; beta-centractin isoform X1 [KO:K16575]
122445973  ACTR1A; alpha-centractin [KO:K16575]
122443694  ACTR10; actin-related protein 10 [KO:K16576]
122448202  TUBAL3; tubulin alpha chain-like 3 isoform X1 [KO:K07374]
122422249  tubulin alpha-1B chain-like [KO:K07374]
122423885  TUBA8; tubulin alpha-8 chain [KO:K07374]
122455068  tubulin alpha-3 chain isoform X1 [KO:K07374]
122455101  tubulin alpha-3 chain [KO:K07374]
122426664  tubulin alpha-1D chain [KO:K07374]
122426544  tubulin alpha-4A chain [KO:K07374]
122427610  TUBA1B; tubulin alpha-1B chain [KO:K07374]
122427612  tubulin alpha-1A chain [KO:K07374]
122427613  tubulin alpha-1C chain isoform X1 [KO:K07374]
122427692  tubulin alpha-1B chain isoform X1 [KO:K07374]
122448735  TUBB1; tubulin beta-1 chain [KO:K07375]
122421324  tubulin beta-3 chain [KO:K07375]
122440303  TUBB4A; tubulin beta-4A chain [KO:K07375]
122442387  TUBB4B; tubulin beta-4B chain isoform X1 [KO:K07375]
122425626  TUBB6; tubulin beta-6 chain [KO:K07375]
122430098  tubulin beta-2A chain [KO:K07375]
122430099  tubulin beta-2B chain [KO:K07375]
122429521  TUBB; tubulin beta chain [KO:K07375]
122424273  FYCO1; FYVE and coiled-coil domain-containing protein 1 isoform X1 [KO:K21954]
122452021  ARL8A; ADP-ribosylation factor-like protein 8A [KO:K07955]
122424516  ARL8B; ADP-ribosylation factor-like protein 8B [KO:K07955]
122451903  PLEKHM2; pleckstrin homology domain-containing family M member 2 isoform X1 [KO:K15348]
122448050  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396] [EC:5.6.1.3]
122453877  KIF5C; kinesin heavy chain [KO:K10396] [EC:5.6.1.3]
122427596  KIF5A; kinesin heavy chain isoform X1 [KO:K10396] [EC:5.6.1.3]
122421082  KLC3; kinesin light chain 3 [KO:K10407]
122429140  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
122430785  KLC2; kinesin light chain 2 isoform X1 [KO:K10407]
122454760  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
122451917  ACBD3; Golgi resident protein GCP60 [KO:K23935]
122424963  RHOA; transforming protein RhoA [KO:K04513]
122423253  M6PR; cation-dependent mannose-6-phosphate receptor isoform X1 [KO:K10089]
122435095  RAB9A; ras-related protein Rab-9A [KO:K07899]
122435467  RAB9B; ras-related protein Rab-9B [KO:K07900]
122441718  GCC2; GRIP and coiled-coil domain-containing protein 2 [KO:K20282]
122440521  STX10; syntaxin-10 isoform X1 [KO:K23937]
122440035  PFN3; profilin-3 [KO:K05759]
122442009  PFN4; profilin-4 [KO:K05759]
122446616  PFN1; profilin-1 [KO:K05759]
122426218  profilin-1-like [KO:K05759]
122434533  profilin-2-like [KO:K05759]
122445056  PFN2; profilin-2 [KO:K05759]
122434434  FLNA; filamin-A isoform X1 [KO:K04437]
122437001  EXOC7; exocyst complex component 7 isoform X1 [KO:K07195]
122443688  EXOC5; exocyst complex component 5 isoform X1 [KO:K19984]
122438658  EXOC4; exocyst complex component 4 isoform X1 [KO:K06111]
122429077  EXOC2; exocyst complex component 2 isoform X1 [KO:K17637]
122438558  RALA; ras-related protein Ral-A [KO:K07834]
122438358  ACTG1; actin, cytoplasmic 2 [KO:K05692]
122432952  ACTB; actin, cytoplasmic 1 [KO:K05692]
122434871  S100A10; protein S100-A10 [KO:K17274]
122443538  ANXA2; annexin A2 [KO:K17092]
122430832  AHNAK; neuroblast differentiation-associated protein AHNAK isoform X1 [KO:K23934]
122419796  AHNAK2; protein AHNAK2 [KO:K23934]
122443733  RHOJ; rho-related GTP-binding protein RhoJ [KO:K07864]
122445017  ARHGEF26; rho guanine nucleotide exchange factor 26 [KO:K13744]
122449422  RHOG; rho-related GTP-binding protein RhoG [KO:K07863]
122434658  rho-related GTP-binding protein RhoG-like isoform X1 [KO:K07863]
122438380  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
122447898  ELMO2; engulfment and cell motility protein 2 [KO:K18985]
122442064  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
122423562  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
122428171  MYL5; LOW QUALITY PROTEIN: myosin light chain 5 [KO:K12753]
122438532  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
122447927  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
122437006  myosin regulatory light chain 2, smooth muscle major isoform-like isoform X1 [KO:K12755]
122433241  MYL10; myosin regulatory light chain 10 isoform X1 [KO:K12756]
122425824  myosin regulatory light polypeptide 9 isoform X1 [KO:K12757]
122425826  myosin regulatory light chain 12B [KO:K12757]
122436681  myosin regulatory light polypeptide 9-like [KO:K12757]
122454534  myosin regulatory light polypeptide 9-like [KO:K12757]
122454885  myosin regulatory light polypeptide 9-like [KO:K12757]
122454899  myosin regulatory light polypeptide 9-like [KO:K12757]
122432784  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
122421721  FHOD1; FH1/FH2 domain-containing protein 1 isoform X1 [KO:K23938]
122426807  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
122448567  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
122433321  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
122453539  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
122427436  NCKAP1L; nck-associated protein 1-like isoform X1 [KO:K05750]
122439633  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
122453733  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
122448166  ABI1; abl interactor 1 isoform X1 [KO:K23649]
122428300  LOW QUALITY PROTEIN: abl interactor 1-like [KO:K23649]
122424664  BRK1; protein BRICK1 [KO:K05752]
122447437  WASF3; wiskott-Aldrich syndrome protein family member 3 isoform X1 [KO:K06083]
122441845  ACTR2; actin-related protein 2 [KO:K17260]
122424660  actin-related protein 2-like [KO:K17260]
122438896  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
122425799  actin-related protein 3-like [KO:K18584]
122453554  ACTR3; actin-related protein 3 [KO:K18584]
122441667  LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 1A-like [KO:K05757]
122433235  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
122433094  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
122435083  actin-related protein 2/3 complex subunit 1A-like [KO:K05757]
122426187  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
122421212  actin-related protein 2/3 complex subunit 3-like [KO:K05756]
122422192  actin-related protein 2/3 complex subunit 3-like [KO:K05756]
122423677  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
122424608  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
122442158  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
122452100  ARPC5; actin-related protein 2/3 complex subunit 5 isoform X1 [KO:K05754]
122430687  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
122434452  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
122422556  MYO6; unconventional myosin-VI isoform X1 [KO:K10358]
122451688  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
122445271  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
122444906  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
122438308  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
122449449  PIK3C2A; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [KO:K00923] [EC:2.7.1.154]
122423954  PIK3C2G; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma [KO:K00923] [EC:2.7.1.154]
122451784  PIK3C2B; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X1 [KO:K00923] [EC:2.7.1.154]
122421109  CYTH2; cytohesin-2 [KO:K18441]
122437759  CYTH1; cytohesin-1 isoform X1 [KO:K18441]
122423600  CYTH4; cytohesin-4 [KO:K18441]
122432882  CYTH3; cytohesin-3 isoform X1 [KO:K18441]
122443461  ARF6; ADP-ribosylation factor 6 [KO:K07941]
122440617  ARF1; ADP-ribosylation factor 1 [KO:K07937]
122440111  ADP-ribosylation factor 2 [KO:K07937]
122448790  ADP-ribosylation factor 1 [KO:K07937]
122433886  SNX9; sorting nexin-9 isoform X1 [KO:K17923]
122452352  LOW QUALITY PROTEIN: sorting nexin-18-like [KO:K17923]
122454223  SNX18; sorting nexin-18 [KO:K17923]
122455038  SNX33; sorting nexin-33 [KO:K17923]
122438593  WASL; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
122440408  DNM2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
122421979  TLR6; toll-like receptor 6 [KO:K10169]
122451361  TLR2; toll-like receptor 2 [KO:K10159]
122431228  toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
122424834  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
122439825  CD14; monocyte differentiation antigen CD14 [KO:K04391]
122431924  TLR4; toll-like receptor 4 [KO:K10160]
122451162  LY96; lymphocyte antigen 96 [KO:K05400]
122452331  TLR5; toll-like receptor 5 isoform X1 [KO:K10168]
122425090  TLR9; toll-like receptor 9 isoform X1 [KO:K10161]
122434303  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
122427504  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
122449806  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
122422588  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
122423255  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
122433842  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
122434580  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
122434540  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
122446045  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
122432633  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
122455294  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
122422050  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
122430633  RELA; transcription factor p65 isoform X1 [KO:K04735]
122438427  NOD1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727]
122429164  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
122421313  heat shock protein HSP 90-alpha-like [KO:K04079]
122455223  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
122427662  heat shock protein HSP 90-alpha-like [KO:K04079]
122423312  HSP90B1; endoplasmin [KO:K09487]
122435267  endoplasmin-like [KO:K09487]
122451134  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
122448977  CSE1L; exportin-2 [KO:K18423]
122444631  KPNA1; importin subunit alpha-5 [KO:K23940]
122447221  KPNA3; importin subunit alpha-4 isoform X1 [KO:K23583]
122444979  KPNA4; importin subunit alpha-3 [KO:K23583]
122420398  40S ribosomal protein S3-like [KO:K02985]
122449519  RPS3; 40S ribosomal protein S3 [KO:K02985]
122434981  40S ribosomal protein S3-like [KO:K02985]
122455088  40S ribosomal protein S3-like [KO:K02985]
122430591  HRAS; GTPase HRas isoform X1 [KO:K02833]
122425059  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
122443062  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
122440231  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
122440910  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
122446062  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
122447261  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
122433033  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
122455309  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122443696  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
122429019  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
122429123  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
122429963  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
122423531  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
122423529  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
122445001  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
122428005  dual specificity mitogen-activated protein kinase kinase 4-like [KO:K04430] [EC:2.7.12.2]
122440347  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
122440572  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
122428339  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
122446321  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
122443873  FOS; proto-oncogene C-Fos [KO:K04379]
122436906  JUN; transcription factor AP-1 [KO:K04448]
122430072  TNF; tumor necrosis factor [KO:K03156]
122441784  IL1B; interleukin-1 beta [KO:K04519]
122438196  IL6; interleukin-6 [KO:K05405]
122428451  CXCL8; interleukin-8 [KO:K10030]
122428482  C-X-C motif chemokine 15-like isoform X1 [KO:K10030]
122425067  CTNNB1; catenin beta-1 [KO:K02105]
122439921  TCF7; transcription factor 7 isoform X1 [KO:K02620]
122441729  TCF7L1; transcription factor 7-like 1 isoform X1 [KO:K04490]
122445909  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
122422034  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
122451212  MYC; myc proto-oncogene protein [KO:K04377]
122440557  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
122455120  FBXO22; F-box only protein 22 [KO:K10302]
122439920  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
122450567  S-phase kinase-associated protein 1-like [KO:K03094]
122420769  S-phase kinase-associated protein 1-like [KO:K03094]
122423229  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
122442423  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
122421734  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
122449723  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
122449787  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
122429455  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
122429816  glyceraldehyde-3-phosphate dehydrogenase-like isoform X1 [KO:K00134] [EC:1.2.1.12]
122439480  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
122423367  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
122452169  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
122428616  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
122444929  TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721]
122432089  tumor necrosis factor receptor superfamily member 10A-like isoform X1 [KO:K04722]
122432087  tumor necrosis factor receptor superfamily member 10A-like isoform X1 [KO:K04722]
122431085  FADD; FAS-associated death domain protein [KO:K02373]
122426570  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
122443150  RIPK3; receptor-interacting serine/threonine-protein kinase 3 isoform X1 [KO:K08847] [EC:2.7.11.1]
122421035  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
122430151  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
122438479  cytochrome c [KO:K08738]
122440592  cytochrome c [KO:K08738]
122432475  cytochrome c-like [KO:K08738]
122434040  cytochrome c [KO:K08738]
122435448  cytochrome c [KO:K08738]
122443337  cytochrome c-like [KO:K08738]
122453615  cytochrome c [KO:K08738]
122444772  cytochrome c-like [KO:K08738]
122454513  cytochrome c-like [KO:K08738]
122436938  cytochrome c-like [KO:K08738]
122425862  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
122432443  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
122446263  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
122442028  RHOB; rho-related GTP-binding protein RhoB [KO:K07856]
122422294  RHOH; rho-related GTP-binding protein RhoH [KO:K07873]
122421012  RRAS; ras-related protein R-Ras [KO:K07829]
122420500  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122452448  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122455107  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122421006  MLKL; mixed lineage kinase domain-like protein isoform X1 [KO:K08849] [EC:2.7.11.1]
122431926  TXN; thioredoxin [KO:K03671]
122423411  TXN2; thioredoxin, mitochondrial [KO:K03671]
122426721  thioredoxin-like [KO:K03671]
122454264  baculoviral IAP repeat-containing protein 1 [KO:K12807]
122441540  NLRC4; NLR family CARD domain-containing protein 4 isoform X1 [KO:K12805]
122433435  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
122449949  CASP1; caspase-1 isoform X1 [KO:K01370] [EC:3.4.22.36]
122449941  IL18; interleukin-18 isoform X1 [KO:K05482]
122449950  caspase-13 isoform X1 [KO:K04394] [EC:3.4.22.57 3.4.22.64]
122451442  GSDMD; gasdermin-D isoform X1 [KO:K20917]
Compound
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:28875943
  Authors
Bernal-Bayard J, Ramos-Morales F
  Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
  Journal
Curr Issues Mol Biol 25:133-168 (2018)
DOI:10.21775/cimb.025.133
Reference
PMID:28848711
  Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
  Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
  Journal
Front Cell Infect Microbiol 7:348 (2017)
DOI:10.3389/fcimb.2017.00348
Reference
PMID:31402916
  Authors
Wemyss MA, Pearson JS
  Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
  Journal
Front Immunol 10:1758 (2019)
DOI:10.3389/fimmu.2019.01758
Reference
PMID:27974148
  Authors
Bierschenk D, Boucher D, Schroder K
  Title
Salmonella-induced inflammasome activation in humans.
  Journal
Mol Immunol 86:38-43 (2017)
DOI:10.1016/j.molimm.2016.11.009
Reference
PMID:29477730
  Authors
Pinaud L, Sansonetti PJ, Phalipon A
  Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
  Journal
Trends Microbiol 26:266-283 (2018)
DOI:10.1016/j.tim.2018.01.010
Reference
PMID:25749450
  Authors
LaRock DL, Chaudhary A, Miller SI
  Title
Salmonellae interactions with host processes.
  Journal
Nat Rev Microbiol 13:191-205 (2015)
DOI:10.1038/nrmicro3420
Reference
PMID:17983751
  Authors
Ramsden AE, Holden DW, Mota LJ
  Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
  Journal
Trends Microbiol 15:516-24 (2007)
DOI:10.1016/j.tim.2007.10.002
Reference
PMID:22702524
  Authors
van der Heijden J, Finlay BB
  Title
Type III effector-mediated processes in Salmonella infection.
  Journal
Future Microbiol 7:685-703 (2012)
DOI:10.2217/fmb.12.49
Reference
PMID:27222578
  Authors
Galan JE
  Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
  Journal
Proc Natl Acad Sci U S A 113:6338-44 (2016)
DOI:10.1073/pnas.1606335113
Reference
PMID:19157959
  Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
  Title
Salmonella takes control: effector-driven manipulation of the host.
  Journal
Curr Opin Microbiol 12:117-24 (2009)
DOI:10.1016/j.mib.2008.12.001
Reference
PMID:12675800
  Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
  Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
  Journal
Mol Microbiol 48:401-15 (2003)
DOI:10.1046/j.1365-2958.2003.t01-1-03456.x
Reference
PMID:17074883
  Authors
Patel JC, Galan JE
  Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
  Journal
J Cell Biol 175:453-63 (2006)
DOI:10.1083/jcb.200605144
Reference
PMID:18411289
  Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
  Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
  Journal
Infect Immun 76:2722-35 (2008)
DOI:10.1128/IAI.00152-08
Reference
PMID:10499590
  Authors
Fu Y, Galan JE
  Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
  Journal
Nature 401:293-7 (1999)
DOI:10.1038/45829
Related
pathway
ccad04010  MAPK signaling pathway
ccad04064  NF-kappa B signaling pathway
ccad04210  Apoptosis
ccad04217  Necroptosis
ccad04621  NOD-like receptor signaling pathway
KO pathway
ko05132   
LinkDB

DBGET integrated database retrieval system