KEGG   PATHWAY: ccad05417
Entry
ccad05417                   Pathway                                
Name
Lipid and atherosclerosis - Cervus canadensis (wapiti)
Description
Atherosclerosis is a chronic inflammatory disease marked by a narrowing of the arteries from lipid-rich plaques present within the walls of arterial blood vessels. It represents the root cause of the majority of cardiovascular diseases (CVDs) and their complications, including conditions such as coronary artery disease, myocardial infarction and stroke.  An elevated level of low density lipoprotein (LDL) cholesterol constitutes a major risk factor for genesis of atherosclerosis. LDL can accumulate within the blood vessel wall and undergo modification by oxidation. Oxidized LDL (oxLDL) leads to endothelial dysfunction leading to expression of adhesion molecules and recruitment of monocyte in subendothelial space. The monocytes proliferate, differentiate into macrophages, and take up the lipoproteins, forming cholesterol-engorged "foam cells." With the time, the foam cells die, leaving a 'necrotic core' of crystalline cholesterol and cell debris. Smooth muscle cells proliferate and migrate into the region, laying down a protective cap over the lesion. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), which mediates the recognition and internalization of oxLDL, is involved in all of these events critical in the pathogenesis of atherosclerosis.
Class
Human Diseases; Cardiovascular disease
Pathway map
ccad05417  Lipid and atherosclerosis
ccad05417

Organism
Cervus canadensis (wapiti) [GN:ccad]
Gene
122442022  APOB; apolipoprotein B-100 [KO:K14462]
122450302  APOA4; apolipoprotein A-IV [KO:K08760]
122450304  apolipoprotein A-I-like [KO:K08757]
122450015  APOA1; apolipoprotein A-I [KO:K08757]
122440398  LDLR; low-density lipoprotein receptor isoform X1 [KO:K12473]
122423989  OLR1; oxidized low-density lipoprotein receptor 1 isoform X1 [KO:K08763]
122420164  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
122450309  LOW QUALITY PROTEIN: interstitial collagenase-like [KO:K01388] [EC:3.4.24.7]
122449754  interstitial collagenase-like [KO:K01388] [EC:3.4.24.7]
122424963  RHOA; transforming protein RhoA [KO:K04513]
122442064  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
122451688  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
122445271  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
122444906  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
122440740  PIK3R2; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
122454626  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
122437038  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
122420500  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122452448  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122455107  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122421035  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
122430652  BAD; bcl2-associated agonist of cell death [KO:K02158]
122448845  BCL2L1; bcl-2-like protein 1 [KO:K04570]
122449331  bcl-2-like protein 1 [KO:K04570]
122441342  bcl-2-like protein 1 [KO:K04570]
122425862  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
122440572  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
122428339  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
122446321  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
122433966  SOD2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
122424748  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
122420169  POU2F2; POU domain, class 2, transcription factor 2 isoform X1 [KO:K09364]
122450384  POU2F3; POU domain, class 2, transcription factor 3 isoform X1 [KO:K09364]
122429663  POU2F1; POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364]
122448626  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
122436029  CD40LG; CD40 ligand [KO:K03161]
122419730  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
122436913  cytochrome P450 2J2-like isoform X1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
122436914  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
122436915  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
122436916  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
122429906  AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
122435041  NOX1; NADPH oxidase 1 [KO:K08008]
122435269  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
122432985  NCF1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
122420817  cytochrome b-245 light chain [KO:K08009]
122452111  NCF2; neutrophil cytosol factor 2 [KO:K08010]
122423869  NCF4; neutrophil cytosol factor 4 [KO:K08012]
122448567  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
122433321  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
122448145  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
122452858  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
122441604  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
122426807  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
122445001  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
122428005  dual specificity mitogen-activated protein kinase kinase 4-like [KO:K04430] [EC:2.7.12.2]
122440347  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
122443873  FOS; proto-oncogene C-Fos [KO:K04379]
122436906  JUN; transcription factor AP-1 [KO:K04448]
122449214  C-C motif chemokine 2 [KO:K14624]
122440432  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
122428451  CXCL8; interleukin-8 [KO:K10030]
122428482  C-X-C motif chemokine 15-like isoform X1 [KO:K10030]
122443696  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
122429019  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
122429123  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
122429963  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
122423531  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
122423529  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
122430591  HRAS; GTPase HRas isoform X1 [KO:K02833]
122423876  KRAS; GTPase KRas isoform X1 [KO:K07827]
122446047  GTPase KRas [KO:K07827]
122435924  NRAS; GTPase NRas [KO:K07828]
122447261  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
122433033  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
122455309  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122430633  RELA; transcription factor p65 isoform X1 [KO:K04735]
122422050  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
122452289  SELE; E-selectin [KO:K06494]
122452136  P-selectin [KO:K06496]
122436633  vascular cell adhesion protein 1-like isoform X1 [KO:K06527]
122436632  vascular cell adhesion protein 1-like [KO:K06527]
122450308  stromelysin-1-like [KO:K01394] [EC:3.4.24.17]
122448603  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
122446181  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
122441784  IL1B; interleukin-1 beta [KO:K04519]
122438196  IL6; interleukin-6 [KO:K05405]
122430072  TNF; tumor necrosis factor [KO:K03156]
122426157  HSPD1; 60 kDa heat shock protein, mitochondrial [KO:K04077] [EC:5.6.1.7]
122444622  LOW QUALITY PROTEIN: 60 kDa heat shock protein, mitochondrial-like [KO:K04077] [EC:5.6.1.7]
122450003  HSPA8; LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein [KO:K03283]
122450010  heat shock cognate 71 kDa protein-like [KO:K03283]
122423465  heat shock cognate 71 kDa protein-like [KO:K03283]
122430152  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
122428193  heat shock cognate 71 kDa protein [KO:K03283]
122430141  heat shock 70 kDa protein 1B [KO:K03283]
122430140  heat shock 70 kDa protein 1B-like [KO:K03283]
122430139  heat shock 70 kDa protein 1-like isoform X1 [KO:K03283]
122443747  HSPA2; heat shock-related 70 kDa protein 2 [KO:K26598]
122439928  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
122429164  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
122421313  heat shock protein HSP 90-alpha-like [KO:K04079]
122455223  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
122427662  heat shock protein HSP 90-alpha-like [KO:K04079]
122423312  HSP90B1; endoplasmin [KO:K09487]
122435267  endoplasmin-like [KO:K09487]
122451361  TLR2; toll-like receptor 2 [KO:K10159]
122448230  lipopolysaccharide-binding protein [KO:K05399]
122448352  lipopolysaccharide-binding protein-like [KO:K05399]
122439825  CD14; monocyte differentiation antigen CD14 [KO:K04391]
122451162  LY96; lymphocyte antigen 96 [KO:K05400]
122431924  TLR4; toll-like receptor 4 [KO:K10160]
122431228  toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
122424834  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
122427504  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
122434303  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
122449806  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
122423255  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
122433842  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
122422588  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
122446045  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
122432633  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
122434540  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
122455294  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
122442957  TIR domain-containing adapter molecule 2 isoform X1 [KO:K05409]
122440258  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
122454978  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
122452560  MIB2; E3 ubiquitin-protein ligase MIB2 isoform X1 [KO:K10645] [EC:2.3.2.27]
122425752  MIB1; E3 ubiquitin-protein ligase MIB1 [KO:K10645] [EC:2.3.2.27]
122453649  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
122451810  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
122427358  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
122430585  IRF7; interferon regulatory factor 7 [KO:K09447]
122421010  IRF3; interferon regulatory factor 3 [KO:K05411]
122452950  LOW QUALITY PROTEIN: interferon alpha-3-like [KO:K05414]
122453310  interferon alpha-1-like [KO:K05414]
122453141  interferon alpha-1-like [KO:K05414]
122452999  interferon alpha-1-like [KO:K05414]
122453000  interferon alpha-1-like [KO:K05414]
122453001  interferon alpha-1 [KO:K05414]
122452998  interferon alpha-1-like [KO:K05414]
122453350  interferon alpha-1-like [KO:K05414]
122453394  interferon beta-2-like [KO:K05415]
122453400  interferon beta-2-like [KO:K05415]
122453398  interferon beta-2 [KO:K05415]
122453396  interferon beta-2-like [KO:K05415]
122453397  interferon beta-2-like [KO:K05415]
122453395  interferon beta-2-like [KO:K05415]
122438254  LOW QUALITY PROTEIN: platelet glycoprotein 4-like [KO:K06259]
122438253  platelet glycoprotein 4-like [KO:K06259]
122438252  platelet glycoprotein 4 [KO:K06259]
122424564  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
122442371  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
122429967  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
122429874  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
122451060  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
122451056  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
122440314  VAV1; proto-oncogene vav [KO:K05730]
122442367  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
122436609  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
122421979  TLR6; toll-like receptor 6 [KO:K10169]
122436539  RAP1A; ras-related protein Rap-1A [KO:K04353]
122427076  RAP1B; ras-related protein Rap-1b [KO:K07836]
122449542  C-C motif chemokine 5 [KO:K12499]
122449580  C-C motif chemokine 3-like [KO:K05408]
122449577  C-C motif chemokine 3-like [KO:K05408]
122449589  C-C motif chemokine 3 [KO:K05408]
122449603  WAP four-disulfide core domain protein 3-like isoform X1 [KO:K05408]
122428192  growth-regulated protein homolog beta-like [KO:K05505]
122428375  growth-regulated protein homolog beta-like [KO:K05505]
122428376  growth-regulated protein homolog beta [KO:K05505]
122444988  IL12A; interleukin-12 subunit alpha [KO:K05406]
122439617  IL12B; interleukin-12 subunit beta [KO:K05425]
122449941  IL18; interleukin-18 isoform X1 [KO:K05482]
122442163  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
122430102  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
122427416  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
122443029  ERO1A; ERO1-like protein alpha [KO:K10950] [EC:1.8.4.-]
122424343  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
122438529  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
122439705  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
122422042  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
122446388  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
122441770  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
122440684  LOW QUALITY PROTEIN: eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237]
122443773  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
122423084  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
122444829  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
122439524  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
122442423  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
122433913  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
122421504  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
122431656  ABCA1; phospholipid-transporting ATPase ABCA1 isoform X1 [KO:K05641]
122445375  ABCG1; ATP-binding cassette sub-family G member 1 isoform X1 [KO:K05679]
122453600  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
122433435  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
122449949  CASP1; caspase-1 isoform X1 [KO:K01370] [EC:3.4.22.36]
122453008  VLDLR; very low-density lipoprotein receptor [KO:K20053]
122432732  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
122445589  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
122425388  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
122448615  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
122420851  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
122448381  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
122448380  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
122430651  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
122443383  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
122448704  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
122420755  CALM3; calmodulin-3 [KO:K02183]
122420753  calmodulin-1-like [KO:K02183]
122448900  calmodulin-2/4-like [KO:K02183]
122448285  calmodulin-like [KO:K02183]
122441648  CALM2; calmodulin-2 [KO:K02183]
122453208  calmodulin-1-like [KO:K02183]
122443081  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
122451732  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
122443955  CALM1; calmodulin-1 isoform X1 [KO:K02183]
122445547  calmodulin-1 [KO:K02183]
122422203  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122431708  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122446399  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122431959  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
122441856  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
122444929  TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721]
122432089  tumor necrosis factor receptor superfamily member 10A-like isoform X1 [KO:K04722]
122432087  tumor necrosis factor receptor superfamily member 10A-like isoform X1 [KO:K04722]
122423229  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
122452409  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
122426570  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
122423034  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
122438479  cytochrome c [KO:K08738]
122440592  cytochrome c [KO:K08738]
122432475  cytochrome c-like [KO:K08738]
122434040  cytochrome c [KO:K08738]
122435448  cytochrome c [KO:K08738]
122443337  cytochrome c-like [KO:K08738]
122453615  cytochrome c [KO:K08738]
122444772  cytochrome c-like [KO:K08738]
122454513  cytochrome c-like [KO:K08738]
122436938  cytochrome c-like [KO:K08738]
122423286  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
122452241  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
122422049  CASP6; caspase-6 isoform X1 [KO:K04396] [EC:3.4.22.59]
122432443  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
122446263  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
122445826  TP53; cellular tumor antigen P53 [KO:K04451]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00187  Cholesterol
C00338  Lipopolysaccharide
C00422  Triacylglycerol
C00704  Superoxide
C00865  Phospholipid
C01245  D-myo-Inositol 1,4,5-trisphosphate
C02530  Cholesterol ester
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:23899566
  Authors
Hopkins PN
  Title
Molecular biology of atherosclerosis.
  Journal
Physiol Rev 93:1317-542 (2013)
DOI:10.1152/physrev.00004.2012
Reference
PMID:22064431
  Authors
Weber C, Noels H
  Title
Atherosclerosis: current pathogenesis and therapeutic options.
  Journal
Nat Med 17:1410-22 (2011)
DOI:10.1038/nm.2538
Reference
PMID:25869663
  Authors
Tabas I, Garcia-Cardena G, Owens GK
  Title
Recent insights into the cellular biology of atherosclerosis.
  Journal
J Cell Biol 209:13-22 (2015)
DOI:10.1083/jcb.201412052
Reference
PMID:25614320
  Authors
Tall AR, Yvan-Charvet L
  Title
Cholesterol, inflammation and innate immunity.
  Journal
Nat Rev Immunol 15:104-16 (2015)
DOI:10.1038/nri3793
Reference
PMID:31336709
  Authors
Kattoor AJ, Goel A, Mehta JL
  Title
LOX-1: Regulation, Signaling and Its Role in Atherosclerosis.
  Journal
Antioxidants (Basel) 8:E218 (2019)
DOI:10.3390/antiox8070218
Reference
PMID:11985903
  Authors
Mehta JL, Li D
  Title
Identification, regulation and function of a novel lectin-like oxidized low-density lipoprotein receptor.
  Journal
J Am Coll Cardiol 39:1429-35 (2002)
DOI:10.1016/s0735-1097(02)01803-x
Reference
PMID:19286611
  Authors
Li D, Mehta JL
  Title
Intracellular signaling of LOX-1 in endothelial cell apoptosis.
  Journal
Circ Res 104:566-8 (2009)
DOI:10.1161/CIRCRESAHA.109.194209
Reference
PMID:24886290
  Authors
Lubrano V, Balzan S
  Title
LOX-1 and ROS, inseparable factors in the process of endothelial damage.
  Journal
Free Radic Res 48:841-8 (2014)
DOI:10.3109/10715762.2014.929122
Reference
PMID:23124189
  Authors
Xu S, Ogura S, Chen J, Little PJ, Moss J, Liu P
  Title
LOX-1 in atherosclerosis: biological functions and pharmacological modifiers.
  Journal
Cell Mol Life Sci 70:2859-72 (2013)
DOI:10.1007/s00018-012-1194-z
Reference
PMID:21947818
  Authors
Mitra S, Goyal T, Mehta JL
  Title
Oxidized LDL, LOX-1 and atherosclerosis.
  Journal
Cardiovasc Drugs Ther 25:419-29 (2011)
DOI:10.1007/s10557-011-6341-5
Reference
PMID:21338316
  Authors
Lu J, Mitra S, Wang X, Khaidakov M, Mehta JL
  Title
Oxidative stress and lectin-like ox-LDL-receptor LOX-1 in atherogenesis and tumorigenesis.
  Journal
Antioxid Redox Signal 15:2301-33 (2011)
DOI:10.1089/ars.2010.3792
Reference
PMID:20203069
  Authors
Ou HC, Song TY, Yeh YC, Huang CY, Yang SF, Chiu TH, Tsai KL, Chen KL, Wu YJ, Tsai CS, Chang LY, Kuo WW, Lee SD
  Title
EGCG protects against oxidized LDL-induced endothelial dysfunction by inhibiting LOX-1-mediated signaling.
  Journal
J Appl Physiol (1985) 108:1745-56 (2010)
DOI:10.1152/japplphysiol.00879.2009
Reference
PMID:17614937
  Authors
Chen XP, Zhang TT, Du GH
  Title
Lectin-like oxidized low-density lipoprotein receptor-1, a new promising target for the therapy of atherosclerosis?
  Journal
Cardiovasc Drug Rev 25:146-61 (2007)
DOI:10.1111/j.1527-3466.2007.00009.x
Reference
PMID:20181930
  Authors
Mattaliano MD, Wooters J, Shih HH, Paulsen JE
  Title
ROCK2 associates with lectin-like oxidized LDL receptor-1 and mediates oxidized LDL-induced IL-8 production.
  Journal
Am J Physiol Cell Physiol 298:C1180-7 (2010)
DOI:10.1152/ajpcell.00483.2009
Reference
PMID:27073018
  Authors
Salvador B, Arranz A, Francisco S, Cordoba L, Punzon C, Llamas MA, Fresno M
  Title
Modulation of endothelial function by Toll like receptors.
  Journal
Pharmacol Res 108:46-56 (2016)
DOI:10.1016/j.phrs.2016.03.038
Reference
PMID:23995626
  Authors
Moore KJ, Sheedy FJ, Fisher EA
  Title
Macrophages in atherosclerosis: a dynamic balance.
  Journal
Nat Rev Immunol 13:709-21 (2013)
DOI:10.1038/nri3520
Reference
PMID:25403963
  Authors
Butoi E, Gan AM, Manduteanu I
  Title
Molecular and functional interactions among monocytes/macrophages and smooth muscle cells and their relevance for atherosclerosis.
  Journal
Crit Rev Eukaryot Gene Expr 24:341-55 (2014)
DOI:10.1615/critreveukaryotgeneexpr.2014012157
Reference
PMID:24048132
  Authors
Sheedy FJ, Moore KJ
  Title
IL-1 signaling in atherosclerosis: sibling rivalry.
  Journal
Nat Immunol 14:1030-2 (2013)
DOI:10.1038/ni.2711
Reference
PMID:21529710
  Authors
Moore KJ, Tabas I
  Title
Macrophages in the pathogenesis of atherosclerosis.
  Journal
Cell 145:341-55 (2011)
DOI:10.1016/j.cell.2011.04.005
Reference
PMID:22577254
  Authors
Gui T, Shimokado A, Sun Y, Akasaka T, Muragaki Y
  Title
Diverse roles of macrophages in atherosclerosis: from inflammatory biology to biomarker discovery.
  Journal
Mediators Inflamm 2012:693083 (2012)
DOI:10.1155/2012/693083
Reference
PMID:17442283
  Authors
Collot-Teixeira S, Martin J, McDermott-Roe C, Poston R, McGregor JL
  Title
CD36 and macrophages in atherosclerosis.
  Journal
Cardiovasc Res 75:468-77 (2007)
DOI:10.1016/j.cardiores.2007.03.010
Reference
PMID:19065049
  Authors
Park YM, Febbraio M, Silverstein RL
  Title
CD36 modulates migration of mouse and human macrophages in response to oxidized LDL and may contribute to macrophage trapping in the arterial intima.
  Journal
J Clin Invest 119:136-45 (2009)
DOI:10.1172/JCI35535
Reference
PMID:24903227
  Authors
Park YM
  Title
CD36, a scavenger receptor implicated in atherosclerosis.
  Journal
Exp Mol Med 46:e99 (2014)
DOI:10.1038/emm.2014.38
Reference
PMID:21035758
  Authors
Seimon TA, Nadolski MJ, Liao X, Magallon J, Nguyen M, Feric NT, Koschinsky ML, Harkewicz R, Witztum JL, Tsimikas S, Golenbock D, Moore KJ, Tabas I
  Title
Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress.
  Journal
Cell Metab 12:467-82 (2010)
DOI:10.1016/j.cmet.2010.09.010
Reference
PMID:25869517
  Authors
Nimgulkar C, Ghosh S, Sankar AB, Uday KP, Surekha MV, Madhusudhanachary P, Annapurna BR, Raghu P, Bharatraj DK
  Title
Combination of spices and herbal extract restores macrophage foam cell migration and abrogates the athero-inflammatory signalling cascade of atherogenesis.
  Journal
Vascul Pharmacol 72:53-63 (2015)
DOI:10.1016/j.vph.2015.02.014
Reference
PMID:23928573
  Authors
Canton J, Neculai D, Grinstein S
  Title
Scavenger receptors in homeostasis and immunity.
  Journal
Nat Rev Immunol 13:621-34 (2013)
DOI:10.1038/nri3515
Reference
PMID:20375591
  Authors
Erridge C
  Title
The roles of Toll-like receptors in atherosclerosis.
  Journal
J Innate Immun 1:340-9 (2009)
DOI:10.1159/000191413
Reference
PMID:21884686
  Authors
Seneviratne AN, Sivagurunathan B, Monaco C
  Title
Toll-like receptors and macrophage activation in atherosclerosis.
  Journal
Clin Chim Acta 413:3-14 (2012)
DOI:10.1016/j.cca.2011.08.021
Reference
PMID:21252151
  Authors
Miller YI, Choi SH, Wiesner P, Fang L, Harkewicz R, Hartvigsen K, Boullier A, Gonen A, Diehl CJ, Que X, Montano E, Shaw PX, Tsimikas S, Binder CJ, Witztum JL
  Title
Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity.
  Journal
Circ Res 108:235-48 (2011)
DOI:10.1161/CIRCRESAHA.110.223875
Reference
PMID:20884885
  Authors
Tabas I
  Title
The role of endoplasmic reticulum stress in the progression of atherosclerosis.
  Journal
Circ Res 107:839-50 (2010)
DOI:10.1161/CIRCRESAHA.110.224766
Reference
PMID:29360955
  Authors
Grootaert MOJ, Moulis M, Roth L, Martinet W, Vindis C, Bennett MR, De Meyer GRY
  Title
Vascular smooth muscle cell death, autophagy and senescence in atherosclerosis.
  Journal
Cardiovasc Res 114:622-634 (2018)
DOI:10.1093/cvr/cvy007
Reference
PMID:12730091
  Authors
Lipskaia L, Pourci ML, Delomenie C, Combettes L, Goudouneche D, Paul JL, Capiod T, Lompre AM
  Title
Phosphatidylinositol 3-kinase and calcium-activated transcription pathways are required for VLDL-induced smooth muscle cell proliferation.
  Journal
Circ Res 92:1115-22 (2003)
DOI:10.1161/01.RES.0000074880.25540.D0
Reference
PMID:28230726
  Authors
Cervantes Gracia K, Llanas-Cornejo D, Husi H
  Title
CVD and Oxidative Stress.
  Journal
J Clin Med 6:E22 (2017)
DOI:10.3390/jcm6020022
Reference
PMID:21321594
  Authors
Hansson GK, Hermansson A
  Title
The immune system in atherosclerosis.
  Journal
Nat Immunol 12:204-12 (2011)
DOI:10.1038/ni.2001
Reference
PMID:19301036
  Authors
Roy H, Bhardwaj S, Yla-Herttuala S
  Title
Molecular genetics of atherosclerosis.
  Journal
Hum Genet 125:467-91 (2009)
DOI:10.1007/s00439-009-0654-5
Reference
PMID:15451808
  Authors
Lusis AJ, Fogelman AM, Fonarow GC
  Title
Genetic basis of atherosclerosis: part I: new genes and pathways.
  Journal
Circulation 110:1868-73 (2004)
DOI:10.1161/01.CIR.0000143041.58692.CC
Reference
PMID:15485348
  Authors
Lusis AJ, Mar R, Pajukanta P
  Title
Genetics of atherosclerosis.
  Journal
Annu Rev Genomics Hum Genet 5:189-218 (2004)
DOI:10.1146/annurev.genom.5.061903.175930
Related
pathway
ccad04020  Calcium signaling pathway
ccad04115  p53 signaling pathway
ccad04141  Protein processing in endoplasmic reticulum
ccad04151  PI3K-Akt signaling pathway
ccad04210  Apoptosis
ccad04620  Toll-like receptor signaling pathway
ccad04621  NOD-like receptor signaling pathway
ccad04668  TNF signaling pathway
ccad04670  Leukocyte transendothelial migration
ccad04975  Fat digestion and absorption
ccad04979  Cholesterol metabolism
ccad05418  Fluid shear stress and atherosclerosis
KO pathway
ko05417   
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