KEGG   PATHWAY: ccae04510
Entry
ccae04510                   Pathway                                
Name
Focal adhesion - Cyanistes caeruleus (blue tit)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
ccae04510  Focal adhesion
ccae04510

Other DBs
GO: 0005925
Organism
Cyanistes caeruleus (blue tit) [GN:ccae]
Gene
111924397  COL1A2; collagen alpha-2(I) chain [KO:K06236]
111940513  COL2A1; collagen alpha-1(II) chain [KO:K19719]
111928689  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
111928695  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
111922729  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
111933540  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
111933625  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
111944813  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
111931858  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
111931825  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
111931829  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
111923538  COL6A6; collagen alpha-6(VI) chain isoform X1 [KO:K06238]
111938078  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
111925824  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
111939163  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
111924007  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
111927276  LAMA2; laminin subunit alpha-2 [KO:K05637]
111924827  laminin subunit alpha-3-like [KO:K06240]
111938064  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
111924930  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
111927161  LAMA4; LOW QUALITY PROTEIN: laminin subunit alpha-4 [KO:K06241]
111923008  LAMB1; laminin subunit beta-1 [KO:K05636]
111935299  LAMB2; laminin subunit beta-2 [KO:K06243]
111935032  LOW QUALITY PROTEIN: laminin subunit beta-2-like [KO:K06243]
111939699  LAMB3; laminin subunit beta-3 [KO:K06244]
111923011  LAMB4; laminin subunit beta-4 [KO:K06245]
111932552  LAMC1; laminin subunit gamma-1 isoform X1 [KO:K05635]
111932553  LAMC2; laminin subunit gamma-2 isoform X1 [KO:K06246]
111937006  LAMC3; laminin subunit gamma-3 [KO:K06247]
111937351  CHAD; chondroadherin [KO:K06248]
111923294  RELN; reelin [KO:K06249] [EC:3.4.21.-]
111930312  THBS1; thrombospondin-1 [KO:K16857]
111941434  THBS4; thrombospondin-4 [KO:K04659]
111939534  THBS3; thrombospondin-3 [KO:K04659]
111940269  COMP; cartilage oligomeric matrix protein [KO:K04659]
111926911  THBS2; LOW QUALITY PROTEIN: thrombospondin-2 [KO:K04659]
111931693  FN1; fibronectin [KO:K05717]
111928876  SPP1; osteopontin isoform X1 [KO:K06250]
111937756  VTN; vitronectin [KO:K06251]
111932479  TNN; LOW QUALITY PROTEIN: tenascin-N [KO:K06252]
111932577  TNR; LOW QUALITY PROTEIN: tenascin-R [KO:K06252]
111936808  LOW QUALITY PROTEIN: tenascin-X-like [KO:K06252]
111936845  TNC; tenascin [KO:K06252]
111923395  VWF; von Willebrand factor [KO:K03900]
111943282  bone sialoprotein 2-like [KO:K06253]
111928879  IBSP; bone sialoprotein 2 [KO:K06253]
111941525  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
111941464  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
111932032  ITGA4; integrin alpha-4 [KO:K06483]
111932082  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
111924384  ITGA8; integrin alpha-8 [KO:K06584]
111923914  ITGA9; integrin alpha-9 [KO:K06585]
111942418  integrin alpha-10-like [KO:K06586]
111941993  integrin alpha-11-like [KO:K06587]
111931704  ITGAV; integrin alpha-V [KO:K06487]
111924368  ITGB1; integrin beta-1 [KO:K05719]
111940101  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
111937302  ITGB4; integrin beta-4 [KO:K06525]
111932261  ITGB5; integrin beta-5 [KO:K06588]
111932160  ITGB6; integrin beta-6 [KO:K06589]
111924297  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
111935930  EMP2; epithelial membrane protein 2 [KO:K26256]
111936274  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
111934907  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
111927858  PDGFC; platelet-derived growth factor C [KO:K05450]
111923382  PDGFD; platelet-derived growth factor D [KO:K05450]
111927782  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
111936136  IGF1; insulin-like growth factor I [KO:K05459]
111927585  VEGFA; vascular endothelial growth factor A [KO:K05448]
111929568  PGF; placenta growth factor [KO:K16859]
111927934  vascular endothelial growth factor C-like [KO:K05449]
111927936  vascular endothelial growth factor C-like isoform X1 [KO:K05449]
111922840  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
111923284  hepatocyte growth factor-like [KO:K05460]
111923285  HGF; hepatocyte growth factor [KO:K05460]
111928019  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
111935543  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
111933868  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
111928018  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
111923657  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
111923182  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
111929245  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
111943904  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
111935550  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
111931552  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
111943846  hepatocyte growth factor receptor-like [KO:K05099] [EC:2.7.10.1]
111944944  receptor tyrosine-protein kinase erbB-2-like [KO:K05083] [EC:2.7.10.1]
111930843  EMP1; epithelial membrane protein 1 [KO:K26255]
111938254  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
111930868  ARHGAP5; rho GTPase-activating protein 5 [KO:K13709]
111935135  RHOA; transforming protein RhoA [KO:K04513]
111924950  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
111925960  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
111936417  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
111938346  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
111937685  MYL10; myosin regulatory light chain 10 [KO:K12756]
111923992  myosin regulatory light chain 2, smooth muscle minor isoform isoform X1 [KO:K12757]
111927633  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
111936713  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
111933170  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
111939610  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
111940063  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
111923845  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
111932252  MYLK; LOW QUALITY PROTEIN: myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
111934649  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
111938138  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
111945579  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like [KO:K00889] [EC:2.7.1.68]
111940280  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
111940733  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
111946142  actin, cytoplasmic 2-like [KO:K05692]
111936114  ACTB; actin, cytoplasmic 1 [KO:K05692]
111933843  ras-specific guanine nucleotide-releasing factor 1-like [KO:K04349]
111926249  CAPN2; calpain-2 catalytic subunit isoform X1 [KO:K03853] [EC:3.4.22.53]
111930279  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
111942417  uncharacterized protein LOC111942417 [KO:K05699]
111934216  TLN2; talin-2 [KO:K06271]
111941027  TLN1; talin-1 isoform X1 [KO:K06271]
111935101  FLNB; filamin-B isoform X1 [KO:K27392]
111936752  PXN; paxillin [KO:K05760]
111943737  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
111938046  ZYX; zyxin isoform X1 [KO:K06273]
111931065  VCL; vinculin isoform X1 [KO:K05700]
111930853  PARVA; alpha-parvin [KO:K06275]
111923369  PARVB; beta-parvin isoform X1 [KO:K06275]
111923370  PARVG; gamma-parvin [KO:K06275]
111936219  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
111929760  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111922589  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
111927570  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111938905  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
111923578  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
111937433  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
111936199  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
111925177  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
111933356  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111933753  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
111938683  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
111933104  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
111941370  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111940405  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
111931632  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
111937047  VAV2; LOW QUALITY PROTEIN: guanine nucleotide exchange factor VAV2 [KO:K05730]
111932616  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
111936023  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
111944780  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
111937502  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
111925537  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
111933722  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
111928712  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
111945870  serine/threonine-protein kinase CST20-like [KO:K05733] [EC:2.7.11.1]
111945306  serine/threonine-protein kinase PAK 3-like [KO:K05733] [EC:2.7.11.1]
111929207  serine/threonine-protein kinase PAK 3-like isoform X1 [KO:K05733] [EC:2.7.11.1]
111942145  serine/threonine-protein kinase PAK 3-like [KO:K05733] [EC:2.7.11.1]
111942867  serine/threonine-protein kinase PAK 3-like [KO:K05733] [EC:2.7.11.1]
111922426  serine/threonine-protein kinase PAK 3-like [KO:K05733] [EC:2.7.11.1]
111945986  serine/threonine-protein kinase PAK 3-like [KO:K05733] [EC:2.7.11.1]
111941729  serine/threonine-protein kinase PAK 3-like isoform X1 [KO:K05733] [EC:2.7.11.1]
111926462  PAK5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
111930494  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
111938571  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
111934540  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
111936642  CRKL; crk-like protein [KO:K04438]
111937736  CRK; adapter molecule crk isoform X1 [KO:K04438]
111930975  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
111937012  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
111939824  RAP1A; ras-related protein Rap-1A [KO:K04353]
111932715  RAP1B; LOW QUALITY PROTEIN: ras-related protein Rap-1b [KO:K07836]
111928823  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
111935562  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
111931141  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
111932998  JUN; transcription factor AP-1 [KO:K04448]
111936843  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
111937042  CAV1; caveolin-1 [KO:K06278]
111922633  CAV2; caveolin-2 [KO:K12958]
111934858  CAV3; caveolin-3 [KO:K12959]
111927157  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
111939466  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
111940286  SHC2; SHC-transforming protein 2 isoform X1 [KO:K17447]
111941731  SHC3; SHC-transforming protein 3 isoform X1 [KO:K17448]
111934113  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
111937316  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
111929515  SOS2; son of sevenless homolog 2 [KO:K03099]
111926571  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
111930717  HRAS; GTPase HRas [KO:K02833]
111935240  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111933966  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
111936534  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111930656  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
111930045  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
111939904  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
111924350  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
111928676  XIAP; E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
111923860  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
ccae04010  MAPK signaling pathway
ccae04060  Cytokine-cytokine receptor interaction
ccae04070  Phosphatidylinositol signaling system
ccae04110  Cell cycle
ccae04310  Wnt signaling pathway
ccae04512  ECM-receptor interaction
ccae04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
LinkDB

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