KEGG   PATHWAY: ccan05152
Entry
ccan05152                   Pathway                                
Name
Tuberculosis - Castor canadensis (American beaver)
Description
Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent infections, and about 10% of latent infections develop active diseases when their immune system is impaired due to the age, other diseases such as AIDS or exposure to immunosuppressive drugs. TB is transmitted through the air and primarily attacks the lungs, then it can spread by the circulatory system to other parts of body. Once TB bacilli have entered the host by the respiratory route and infected macrophages in the lungs, they interfere with phagosomal maturation, antigen presentation, apoptosis and host immune system to establish persistent or latent infection.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
ccan05152  Tuberculosis
ccan05152

Organism
Castor canadensis (American beaver) [GN:ccan]
Gene
109690391  Tnf; tumor necrosis factor isoform X1 [KO:K03156]
109682791  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
109694060  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
109700274  Fadd; FAS-associated death domain protein [KO:K02373]
109689613  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
109678444  caspase-3 [KO:K02187] [EC:3.4.22.56]
109678454  caspase-3-like [KO:K02187] [EC:3.4.22.56]
109678183  Bid; BH3-interacting domain death agonist isoform X1 [KO:K04726]
109682703  Bax; apoptosis regulator BAX [KO:K02159]
109679656  cytochrome c-like [KO:K08738]
109697493  cytochrome c, somatic [KO:K08738]
109690717  cytochrome c-like [KO:K08738]
109692548  Casp9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
109690039  Apaf1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
109688536  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109691810  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109686235  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109683261  Bad; bcl2-associated agonist of cell death [KO:K02158]
109693757  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
109685908  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
109685909  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
109690704  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
109696394  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
109676142  Ifng; interferon gamma [KO:K04687]
109697033  Ifngr1; LOW QUALITY PROTEIN: interferon gamma receptor 1 [KO:K05132]
109686803  Ifngr2; interferon gamma receptor 2 [KO:K05133]
109699504  Jak1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
109692635  Jak2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
109679865  LOW QUALITY PROTEIN: signal transducer and activator of transcription 1-alpha/beta-like [KO:K11220]
109682738  Stat1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
109696703  Ciita; MHC class II transactivator isoform X1 [KO:K08060] [EC:2.7.11.1]
109681226  Rfx5; DNA-binding protein RFX5 [KO:K08061]
109699147  Rfxank; DNA-binding protein RFXANK [KO:K08062]
109699608  Rfxap; regulatory factor X-associated protein [KO:K08063]
109697681  Nfya; nuclear transcription factor Y subunit alpha isoform X1 [KO:K08064]
109675830  Nfyb; nuclear transcription factor Y subunit beta [KO:K08065]
109686440  nuclear transcription factor Y subunit beta [KO:K08065]
109692254  Nfyc; nuclear transcription factor Y subunit gamma isoform X1 [KO:K08066]
109691946  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
109674702  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DRB1-15 beta chain-like [KO:K06752]
109674703  HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752]
109674664  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
109674665  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
109685982  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
109686704  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
109686705  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
109686673  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
109686675  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
109686676  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
109695178  rano class II histocompatibility antigen, A beta chain-like [KO:K06752]
109695186  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
109695196  HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752]
109682519  Cd74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505]
109681682  Crebbp; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
109690951  Ep300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
109688365  Il10; interleukin-10 [KO:K05443]
109694495  Il10ra; interleukin-10 receptor subunit alpha [KO:K05134]
109699946  Il10rb; interleukin-10 receptor subunit beta [KO:K05135]
109681200  Ctss; cathepsin S [KO:K01368] [EC:3.4.22.27]
109697607  Clec4e; C-type lectin domain family 4 member E isoform X1 [KO:K10059]
109693208  Fcer1g; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983]
109681394  Clec7a; C-type lectin domain family 7 member A [KO:K10074]
109689714  C-type lectin domain family 7 member A-like [KO:K10074]
109702281  proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
109688078  Syk; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
109699034  Card9; caspase recruitment domain-containing protein 9 [KO:K12794]
109690912  Malt1; LOW QUALITY PROTEIN: mucosa-associated lymphoid tissue lymphoma translocation protein 1 [KO:K07369] [EC:3.4.22.-]
109695042  Bcl10; B-cell lymphoma/leukemia 10 [KO:K07368]
109701706  Nod2; nucleotide-binding oligomerization domain-containing protein 2 [KO:K10165]
109690126  Ripk2; receptor-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K08846] [EC:2.7.11.1]
109681366  Hspa9; stress-70 protein, mitochondrial [KO:K04043]
109681926  Hspd1; 60 kDa heat shock protein, mitochondrial [KO:K04077] [EC:5.6.1.7]
109692098  Lbp; LOW QUALITY PROTEIN: lipopolysaccharide-binding protein [KO:K05399]
109701180  Tlr2; toll-like receptor 2 [KO:K10159]
109685160  Tlr1; toll-like receptor 1 [KO:K05398]
109685161  Tlr6; toll-like receptor 6 [KO:K10169]
109700701  Tlr4; toll-like receptor 4 isoform X1 [KO:K10160]
109682106  Cd14; monocyte differentiation antigen CD14 [KO:K04391]
109698469  Tirap; toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
109684529  Myd88; LOW QUALITY PROTEIN: myeloid differentiation primary response protein MyD88 [KO:K04729]
109684435  interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
109690874  Irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
109688956  Irak2; interleukin-1 receptor-associated kinase-like 2 isoform X1 [KO:K04731] [EC:2.7.11.1]
109693564  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
109682963  Nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
109687142  Rela; transcription factor p65 isoform X1 [KO:K04735]
109697389  Mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
109689865  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
109689849  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
109697648  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
109683259  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
109684381  Mapk1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
109686728  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
109686738  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
109703004  mitogen-activated protein kinase 10-like [KO:K04440] [EC:2.7.11.24]
109693015  Nos2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
109679557  Il6; interleukin-6 [KO:K05405]
109692199  Il12a; interleukin-12 subunit alpha [KO:K05406]
109677112  Il12b; interleukin-12 subunit beta [KO:K05425]
109699439  Il18; interleukin-18 isoform X1 [KO:K05482]
109686122  Il23a; interleukin-23 subunit alpha [KO:K05426]
109702296  Il1a; interleukin-1 alpha [KO:K04383]
109701168  Il1b; interleukin-1 beta isoform X1 [KO:K04519]
109692610  Cebpb; CCAAT/enhancer-binding protein beta [KO:K10048]
109696902  Cebpg; CCAAT/enhancer-binding protein gamma [KO:K10049]
109685353  Tlr9; toll-like receptor 9 [KO:K10161]
109690928  interferon alpha-21-like [KO:K05414]
109702568  interferon alpha-2-like [KO:K05414]
109688729  interferon alpha-21-like [KO:K05414]
109688957  interferon alpha-21-like [KO:K05414]
109689103  interferon alpha-4-like [KO:K05414]
109689580  interferon alpha-1/13-like [KO:K05414]
109689888  interferon alpha-17-like [KO:K05414]
109689666  interferon alpha-1/13-like [KO:K05414]
109690286  interferon alpha-10-like [KO:K05414]
109689981  interferon alpha-4-like [KO:K05414]
109690431  interferon alpha-10-like [KO:K05414]
109680042  CD209 antigen-like protein C [KO:K06563]
109680043  CD209 antigen-like protein C [KO:K06563]
109680045  CD209 antigen-like protein E [KO:K06563]
109703036  CD209 antigen-like protein C [KO:K06563]
109703037  CD209 antigen-like protein C [KO:K06563]
109688211  Arhgef12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
109697844  Rhoa; transforming protein RhoA [KO:K04513]
109690388  transforming protein RhoA-like isoform X1 [KO:K04513]
109689774  Lsp1; lymphocyte-specific protein 1 isoform X1 [KO:K14957]
109702194  Plk3; serine/threonine-protein kinase PLK3 [KO:K08862] [EC:2.7.11.21]
109693018  Ksr1; kinase suppressor of Ras 1 isoform X1 [KO:K14958]
109694940  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
109685632  Tgfb1; transforming growth factor beta-1 [KO:K13375]
109698650  Tgfb2; transforming growth factor beta-2 isoform X1 [KO:K13376]
109686152  Tgfb3; transforming growth factor beta-3 [KO:K13377]
109686086  25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial [KO:K07438] [EC:1.14.15.18]
109691617  Vdr; vitamin D3 receptor [KO:K08539]
109699008  Camp; cathelicidin antimicrobial peptide [KO:K13916]
109694300  C3; complement C3 [KO:K03990]
109698715  complement C3 [KO:K03990]
109675114  complement component receptor 1-like protein [KO:K04011]
109685443  LOW QUALITY PROTEIN: complement receptor type 1-like [KO:K04011]
109702039  integrin beta-2-like [KO:K06464]
109694990  Itgb2; integrin beta-2 isoform X1 [KO:K06464]
109696521  LOW QUALITY PROTEIN: integrin alpha-M-like [KO:K06461]
109674645  LOW QUALITY PROTEIN: C-type mannose receptor 2-like [KO:K06560]
109697399  Mrc1; macrophage mannose receptor 1 [KO:K06560]
109697857  Pla2r1; LOW QUALITY PROTEIN: secretory phospholipase A2 receptor [KO:K06560]
109685588  Sphk1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
109682695  Sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
109674958  serine/threonine-protein phosphatase with EF-hands 1-like [KO:K02183]
109674302  calmodulin-alpha-like [KO:K02183]
109691449  Calml6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
109696281  Calm2; calmodulin [KO:K02183]
109688234  Calml4; calmodulin-like protein 4 [KO:K02183]
109699140  Calm1; calmodulin [KO:K02183]
109700840  Calml5; calmodulin-like protein 5 [KO:K02183]
109700844  calmodulin-like protein 3 [KO:K02183]
109691756  calmodulin-alpha-like [KO:K02183]
109691221  Calm3; calmodulin [KO:K02183]
109700908  calmodulin [KO:K02183]
109680203  calmodulin-alpha-like [KO:K02183]
109701401  Pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
109703335  ras-related protein Rab-5A-like [KO:K07887]
109692646  Rab5a; ras-related protein Rab-5A [KO:K07887]
109698573  Rab5b; ras-related protein Rab-5B [KO:K07888]
109695774  Rab5c; ras-related protein Rab-5C [KO:K07889]
109698460  early endosome antigen 1 [KO:K12478]
109696482  Rab7a; ras-related protein Rab-7a [KO:K07897]
109689769  Ctsd; cathepsin D isoform X1 [KO:K01379] [EC:3.4.23.5]
109684877  Atp6v0a2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
109687326  Atp6v0a1; LOW QUALITY PROTEIN: V-type proton ATPase 116 kDa subunit a [KO:K02154]
109692077  Tcirg1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
109696209  Atp6v0d2; LOW QUALITY PROTEIN: V-type proton ATPase subunit d 2 [KO:K02146]
109691245  Atp6v0d1; V-type proton ATPase subunit d 1 [KO:K02146]
109687455  Atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
109691912  Atp6ap1; LOW QUALITY PROTEIN: V-type proton ATPase subunit S1 [KO:K03662]
109689939  Atp6v0c; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
109695496  Atp6v0b; LOW QUALITY PROTEIN: V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
109698510  Lamp2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
109686931  Lamp1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
109688186  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like [KO:K04348] [EC:3.1.3.16]
109681777  Ppp3cc; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
109682626  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
109696247  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
109693705  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
109683288  Coro1a; coronin-1A isoform X1 [KO:K13882]
109677916  uncharacterized protein LOC109677916 [KO:K06856]
109677124  high affinity immunoglobulin gamma Fc receptor I-like isoform X1 [KO:K06498]
109693506  Fcgr2a; low affinity immunoglobulin gamma Fc region receptor II-a isoform X1 [KO:K06472]
109693504  Fcgr2b; low affinity immunoglobulin gamma Fc region receptor II-b isoform X1 [KO:K12560]
109693505  low affinity immunoglobulin gamma Fc region receptor III-A-like [KO:K06463]
Compound
C00076  Calcium cation
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C01561  Calcidiol
C01673  Calcitriol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C06124  Sphingosine 1-phosphate
C19190  Trehalose-6,6'-dibehenate
C21790  Mycobacterial trehalose dimycolate
G13101  Lipomannan
G13105  Triacylated phosphatidyl-myo-inositol pentamannoside
G13106  Triacylated phosphatidyl-myo-inositol hexamannoside
G13108  Triacylated phosphatidyl-myo-inositol dimannoside
G13109  Tetraacylated phosphatidyl-myo-inositol dimannoside
G13112  Tetraacylated phosphatidyl-myo-inositol hexamannoside
G13113  Tetraacylated phosphatidyl-myo-inositol pentamannoside
G13114  Lipoarabinomannan
G13115  Mannose-capped lipoarabinomannan
Reference
PMID:21274449
  Authors
Saiga H, Shimada Y, Takeda K
  Title
Innate immune effectors in mycobacterial infection.
  Journal
Clin Dev Immunol 2011:347594 (2011)
DOI:10.1155/2011/347594
Reference
PMID:20415982
  Authors
Dheda K, Schwander SK, Zhu B, van Zyl-Smit RN, Zhang Y
  Title
The immunology of tuberculosis: from bench to bedside.
  Journal
Respirology 15:433-50 (2010)
DOI:10.1111/j.1440-1843.2010.01739.x
Reference
PMID:11932234
  Authors
van Crevel R, Ottenhoff TH, van der Meer JW
  Title
Innate immunity to Mycobacterium tuberculosis.
  Journal
Clin Microbiol Rev 15:294-309 (2002)
DOI:10.1128/CMR.15.2.294-309.2002
Reference
PMID:18288961
  Authors
Torrelles JB, Azad AK, Henning LN, Carlson TK, Schlesinger LS
  Title
Role of C-type lectins in mycobacterial infections.
  Journal
Curr Drug Targets 9:102-12 (2008)
DOI:10.2174/138945008783502467
Reference
PMID:17359235
  Authors
Jo EK, Yang CS, Choi CH, Harding CV
  Title
Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors.
  Journal
Cell Microbiol 9:1087-98 (2007)
DOI:10.1111/j.1462-5822.2007.00914.x
Reference
PMID:21274433
  Authors
Marakalala MJ, Graham LM, Brown GD
  Title
The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections.
  Journal
Clin Dev Immunol 2010:567571 (2010)
DOI:10.1155/2010/567571
Reference
PMID:15083155
  Authors
Koul A, Herget T, Klebl B, Ullrich A
  Title
Interplay between mycobacteria and host signalling pathways.
  Journal
Nat Rev Microbiol 2:189-202 (2004)
DOI:10.1038/nrmicro840
Reference
PMID:20199890
  Authors
Torrelles JB, Schlesinger LS
  Title
Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host.
  Journal
Tuberculosis (Edinb) 90:84-93 (2010)
DOI:10.1016/j.tube.2010.02.003
Reference
PMID:15228522
  Authors
Briken V, Porcelli SA, Besra GS, Kremer L
  Title
Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response.
  Journal
Mol Microbiol 53:391-403 (2004)
DOI:10.1111/j.1365-2958.2004.04183.x
Reference
PMID:19563525
  Authors
Baena A, Porcelli SA
  Title
Evasion and subversion of antigen presentation by Mycobacterium tuberculosis.
  Journal
Tissue Antigens 74:189-204 (2009)
DOI:10.1111/j.1399-0039.2009.01301.x
Reference
PMID:19369951
  Authors
Flannagan RS, Cosio G, Grinstein S
  Title
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies.
  Journal
Nat Rev Microbiol 7:355-66 (2009)
DOI:10.1038/nrmicro2128
Reference
PMID:18541216
  Authors
Pieters J
  Title
Mycobacterium tuberculosis and the macrophage: maintaining a balance.
  Journal
Cell Host Microbe 3:399-407 (2008)
DOI:10.1016/j.chom.2008.05.006
Reference
PMID:19634703
  Authors
Scherr N, Jayachandran R, Mueller P, Pieters J
  Title
Interference of Mycobacterium tuberculosis with macrophage responses.
  Journal
Indian J Exp Biol 47:401-6 (2009)
Reference
PMID:16200082
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
PMID:17785780
  Authors
Rothfuchs AG, Bafica A, Feng CG, Egen JG, Williams DL, Brown GD, Sher A
  Title
Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells.
  Journal
J Immunol 179:3463-71 (2007)
DOI:10.4049/jimmunol.179.6.3463
Reference
PMID:18407066
  Authors
Master SS, Rampini SK, Davis AS, Keller C, Ehlers S, Springer B, Timmins GS, Sander P, Deretic V
  Title
Mycobacterium tuberculosis prevents inflammasome activation.
  Journal
Cell Host Microbe 3:224-32 (2008)
DOI:10.1016/j.chom.2008.03.003
Reference
PMID:11378475
  Authors
Shtrichman R, Samuel CE
  Title
The role of gamma interferon in antimicrobial immunity.
  Journal
Curr Opin Microbiol 4:251-9 (2001)
DOI:10.1016/S1369-5274(00)00199-5
Related
pathway
ccan04010  MAPK signaling pathway
ccan04210  Apoptosis
ccan04612  Antigen processing and presentation
ccan04620  Toll-like receptor signaling pathway
ccan04621  NOD-like receptor signaling pathway
ccan04630  JAK-STAT signaling pathway
KO pathway
ko05152   
LinkDB

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