KEGG   PATHWAY: cimi05417
Entry
cimi05417                   Pathway                                
Name
Lipid and atherosclerosis - Cebus imitator (Panamanian white-faced capuchin)
Description
Atherosclerosis is a chronic inflammatory disease marked by a narrowing of the arteries from lipid-rich plaques present within the walls of arterial blood vessels. It represents the root cause of the majority of cardiovascular diseases (CVDs) and their complications, including conditions such as coronary artery disease, myocardial infarction and stroke.  An elevated level of low density lipoprotein (LDL) cholesterol constitutes a major risk factor for genesis of atherosclerosis. LDL can accumulate within the blood vessel wall and undergo modification by oxidation. Oxidized LDL (oxLDL) leads to endothelial dysfunction leading to expression of adhesion molecules and recruitment of monocyte in subendothelial space. The monocytes proliferate, differentiate into macrophages, and take up the lipoproteins, forming cholesterol-engorged "foam cells." With the time, the foam cells die, leaving a 'necrotic core' of crystalline cholesterol and cell debris. Smooth muscle cells proliferate and migrate into the region, laying down a protective cap over the lesion. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), which mediates the recognition and internalization of oxLDL, is involved in all of these events critical in the pathogenesis of atherosclerosis.
Class
Human Diseases; Cardiovascular disease
Pathway map
cimi05417  Lipid and atherosclerosis
cimi05417

Organism
Cebus imitator (Panamanian white-faced capuchin) [GN:cimi]
Gene
108302851  APOB; apolipoprotein B-100 isoform X1 [KO:K14462]
108300557  APOA4; apolipoprotein A-IV [KO:K08760]
108300558  APOA1; apolipoprotein A-I [KO:K08757]
108282022  LDLR; low-density lipoprotein receptor [KO:K12473]
108315804  OLR1; oxidized low-density lipoprotein receptor 1 isoform X1 [KO:K08763]
108285727  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X6 [KO:K12330]
108315434  MMP1; interstitial collagenase [KO:K01388] [EC:3.4.24.7]
108296753  transforming protein RhoA [KO:K04513]
108301473  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
108297770  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
108287732  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108300786  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108286022  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108312772  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
108284538  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
108295514  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
108285792  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108306856  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108287186  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108287107  apoptosis regulator BAX-like [KO:K02159]
108283911  BAX; apoptosis regulator BAX [KO:K02159]
108310302  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
108293471  BCL2L1; bcl-2-like protein 1 [KO:K04570]
108304605  BCL2; apoptosis regulator Bcl-2 isoform X2 [KO:K02161]
108315696  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
108286678  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
108295228  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
108310971  SOD2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
108281637  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
108308315  POU2F1; POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364]
108300656  POU2F3; POU domain, class 2, transcription factor 3 [KO:K09364]
108285736  POU2F2; POU domain, class 2, transcription factor 2 isoform X5 [KO:K09364]
108313050  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
108292985  CD40LG; CD40 ligand [KO:K03161]
108298444  CYP1A1; cytochrome P450 1A1 isoform X1 [KO:K07408] [EC:1.14.14.1]
108285668  CYP2B6; cytochrome P450 2B6 [KO:K17709] [EC:1.14.14.-]
108281688  CYP2C8; cytochrome P450 2C20 [KO:K17718] [EC:1.14.14.1]
108314910  CYP2J2; cytochrome P450 2J2 isoform X1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
108300106  AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
108287449  NOX1; NADPH oxidase 1 isoform X1 [KO:K08008]
108297293  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
108314429  NCF1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
108314702  cytochrome b-245 light chain isoform X1 [KO:K08009]
108285264  LOW QUALITY PROTEIN: neutrophil cytosol factor 2-like [KO:K08010]
108301258  NCF2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
108289458  NCF4; neutrophil cytosol factor 4 [KO:K08012]
108303482  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
108307873  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
108291826  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
108281443  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
108289826  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
108296617  cell division control protein 42 homolog [KO:K04393]
108317207  cell division control protein 42 homolog [KO:K04393]
108306463  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
108283651  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
108304440  FOS; proto-oncogene c-Fos [KO:K04379]
108314896  JUN; transcription factor AP-1 [KO:K04448]
108308445  CCL2; C-C motif chemokine 2 [KO:K14624]
108283590  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
108292201  CXCL8; interleukin-8 [KO:K10030]
108290685  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
108281677  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
108300002  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
108300003  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
108286818  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
108286819  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
108288791  HRAS; GTPase HRas isoform X1 [KO:K02833]
108300272  KRAS; GTPase KRas isoform X2 [KO:K07827]
108289201  GTPase NRas-like [KO:K07828]
108301162  NRAS; GTPase NRas isoform X2 [KO:K07828]
108296669  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
108296197  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108310400  RELA; transcription factor p65 isoform X2 [KO:K04735]
108289254  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
108308342  SELE; E-selectin [KO:K06494]
108308341  P-selectin isoform X1 [KO:K06496]
108317274  VCAM1; vascular cell adhesion protein 1 isoform X1 [KO:K06527]
108315431  MMP3; stromelysin-1 [KO:K01394] [EC:3.4.24.17]
108313047  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
108290337  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
108318634  IL1B; interleukin-1 beta [KO:K04519]
108303199  IL6; interleukin-6 isoform X1 [KO:K05405]
108299857  TNF; tumor necrosis factor [KO:K03156]
108287785  60 kDa heat shock protein, mitochondrial [KO:K04077] [EC:5.6.1.7]
108303460  LOW QUALITY PROTEIN: 60 kDa heat shock protein, mitochondrial-like [KO:K04077] [EC:5.6.1.7]
108315707  HSPD1; 60 kDa heat shock protein, mitochondrial [KO:K04077] [EC:5.6.1.7]
108299822  heat shock 70 kDa protein 1A [KO:K03283]
108299825  heat shock 70 kDa protein 1A [KO:K03283]
108291804  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
108292110  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
108299823  heat shock 70 kDa protein 1-like [KO:K03283]
108300687  HSPA8; LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein [KO:K03283]
108303918  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
108314196  heat shock cognate 71 kDa protein-like [KO:K03283]
108293618  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
108305837  heat shock cognate 71 kDa protein-like [KO:K03283]
108308246  HSPA2; heat shock-related 70 kDa protein 2 [KO:K26598]
108307152  HSPA4; heat shock 70 kDa protein 4 isoform X1 [KO:K09489]
108284042  LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079]
108290619  LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079]
108304038  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
108317063  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
108312418  HSP90B1; endoplasmin [KO:K09487]
108282777  toll-like receptor 2 [KO:K10159]
108291674  lipopolysaccharide-binding protein [KO:K05399]
108310098  CD14; monocyte differentiation antigen CD14 [KO:K04391]
108299552  LY96; lymphocyte antigen 96 isoform X1 [KO:K05400]
108286470  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
108302842  toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
108289112  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
108305262  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
108294753  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
108305750  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
108315297  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
108287389  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
108311469  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
108306378  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
108316185  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
108298093  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
108306065  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
108285029  TIR domain-containing adapter molecule 2 isoform X1 [KO:K05409]
108304274  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
108304024  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
108282806  MIB1; E3 ubiquitin-protein ligase MIB1 [KO:K10645] [EC:2.3.2.27]
108313942  MIB2; E3 ubiquitin-protein ligase MIB2 isoform X1 [KO:K10645] [EC:2.3.2.27]
108317391  TANK; TRAF family member-associated NF-kappa-B activator isoform X2 [KO:K12650]
108301897  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
108288399  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
108288787  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
108298392  IRF3; interferon regulatory factor 3 isoform X3 [KO:K05411]
108296181  interferon alpha-8-like [KO:K05414]
108296168  interferon alpha-8-like [KO:K05414]
108296165  IFNA21; interferon alpha-21 [KO:K05414]
108296167  interferon alpha-2-like [KO:K05414]
108296180  interferon alpha-5-like [KO:K05414]
108296183  interferon alpha-1/13 [KO:K05414]
108296184  interferon alpha-8-like [KO:K05414]
108296169  IFNB1; interferon beta [KO:K05415]
108300344  CD36; platelet glycoprotein 4 [KO:K06259]
108284639  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
108304340  retinoic acid receptor RXR-alpha-like [KO:K08524]
108292290  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
108300058  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
108308292  RXRG; retinoic acid receptor RXR-gamma [KO:K08526]
108306729  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
108284810  PTK2; focal adhesion kinase 1 isoform X11 [KO:K05725] [EC:2.7.10.2]
108292302  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
108304214  VAV1; proto-oncogene vav [KO:K05730]
108285172  VAV3; guanine nucleotide exchange factor VAV3 isoform X2 [KO:K05730]
108303455  TLR6; toll-like receptor 6 [KO:K10169]
108301226  RAP1A; ras-related protein Rap-1A [KO:K04353]
108300232  RAP1B; ras-related protein Rap-1b [KO:K07836]
108308410  CCL5; C-C motif chemokine 5 [KO:K12499]
108312132  CCL3L3; C-C motif chemokine 3-like 1 [KO:K05408]
108292194  C-X-C motif chemokine 2 [KO:K05505]
108292198  C-X-C motif chemokine 2-like [KO:K05505]
108284144  IL12A; interleukin-12 subunit alpha [KO:K05406]
108285116  IL12B; interleukin-12 subunit beta [KO:K05425]
108315794  NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
108300504  IL18; interleukin-18 [KO:K05482]
108318239  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
108293602  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
108309731  DDIT3; LOW QUALITY PROTEIN: DNA damage-inducible transcript 3 protein [KO:K04452]
108291925  ERO1A; ERO1-like protein alpha [KO:K10950] [EC:1.8.4.-]
108292033  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
108318509  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
108290441  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
108313439  calcium/calmodulin-dependent protein kinase type II subunit delta-like [KO:K04515] [EC:2.7.11.17]
108293811  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
108306397  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
108310018  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
119468660  eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237]
108284112  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
108293817  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
108315292  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
108295573  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
108287258  TRAF2; TNF receptor-associated factor 2 isoform X2 [KO:K03173] [EC:2.3.2.27]
108305646  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
108283240  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
108303831  ABCA1; phospholipid-transporting ATPase ABCA1 isoform X1 [KO:K05641]
108311228  ABCG1; ATP-binding cassette sub-family G member 1 isoform X1 [KO:K05679]
108307320  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
108293914  PYCARD; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
108315450  CASP1; caspase-1 isoform X2 [KO:K01370] [EC:3.4.22.36]
108281419  VLDLR; very low-density lipoprotein receptor isoform X1 [KO:K20053]
108291018  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
108292532  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
108286599  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
108281338  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
108311834  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
108310295  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
108300913  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
108300966  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2 [KO:K05858] [EC:3.1.4.11]
108306142  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
108291487  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
108292098  CALM2; calmodulin-2 isoform X1 [KO:K02183]
108283821  CALM3; calmodulin-3 [KO:K02183]
108292329  CALML5; calmodulin-like protein 5 [KO:K02183]
108292331  CALML3; calmodulin-like protein 3 [KO:K02183]
108292617  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
108314009  CALML6; calmodulin-like protein 6 [KO:K02183]
108296938  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
108318563  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
108291170  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
108299682  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
108303844  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
108305297  TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721]
108318569  TNFRSF10A; tumor necrosis factor receptor superfamily member 10A [KO:K04722]
108318570  TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K04722]
108316345  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
108305379  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
108305380  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
108315757  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
108294856  BID; BH3-interacting domain death agonist [KO:K04726]
108281951  cytochrome c, somatic-like [KO:K08738]
108288191  cytochrome c-like [KO:K08738]
108288636  cytochrome c-like [KO:K08738]
108299683  cytochrome c-like [KO:K08738]
108290168  cytochrome c [KO:K08738]
108290453  cytochrome c-like [KO:K08738]
108303234  cytochrome c [KO:K08738]
108305303  cytochrome c, somatic-like [KO:K08738]
108306377  cytochrome c, somatic-like [KO:K08738]
108311641  cytochrome c, testis-specific-like [KO:K08738]
108304381  cytochrome c-like [KO:K08738]
108313879  cytochrome c-like [KO:K08738]
108293847  cytochrome c [KO:K08738]
108305848  cytochrome c-like [KO:K08738]
108307291  cytochrome c-like [KO:K08738]
108290860  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
108286842  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
108289866  CASP6; caspase-6 isoform X1 [KO:K04396] [EC:3.4.22.59]
108288114  CASP3; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
108310786  caspase-3-like [KO:K02187] [EC:3.4.22.56]
108310545  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
108306559  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00187  Cholesterol
C00338  Lipopolysaccharide
C00422  Triacylglycerol
C00704  Superoxide
C00865  Phospholipid
C01245  D-myo-Inositol 1,4,5-trisphosphate
C02530  Cholesterol ester
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:23899566
  Authors
Hopkins PN
  Title
Molecular biology of atherosclerosis.
  Journal
Physiol Rev 93:1317-542 (2013)
DOI:10.1152/physrev.00004.2012
Reference
PMID:22064431
  Authors
Weber C, Noels H
  Title
Atherosclerosis: current pathogenesis and therapeutic options.
  Journal
Nat Med 17:1410-22 (2011)
DOI:10.1038/nm.2538
Reference
PMID:25869663
  Authors
Tabas I, Garcia-Cardena G, Owens GK
  Title
Recent insights into the cellular biology of atherosclerosis.
  Journal
J Cell Biol 209:13-22 (2015)
DOI:10.1083/jcb.201412052
Reference
PMID:25614320
  Authors
Tall AR, Yvan-Charvet L
  Title
Cholesterol, inflammation and innate immunity.
  Journal
Nat Rev Immunol 15:104-16 (2015)
DOI:10.1038/nri3793
Reference
PMID:31336709
  Authors
Kattoor AJ, Goel A, Mehta JL
  Title
LOX-1: Regulation, Signaling and Its Role in Atherosclerosis.
  Journal
Antioxidants (Basel) 8:E218 (2019)
DOI:10.3390/antiox8070218
Reference
PMID:11985903
  Authors
Mehta JL, Li D
  Title
Identification, regulation and function of a novel lectin-like oxidized low-density lipoprotein receptor.
  Journal
J Am Coll Cardiol 39:1429-35 (2002)
DOI:10.1016/s0735-1097(02)01803-x
Reference
PMID:19286611
  Authors
Li D, Mehta JL
  Title
Intracellular signaling of LOX-1 in endothelial cell apoptosis.
  Journal
Circ Res 104:566-8 (2009)
DOI:10.1161/CIRCRESAHA.109.194209
Reference
PMID:24886290
  Authors
Lubrano V, Balzan S
  Title
LOX-1 and ROS, inseparable factors in the process of endothelial damage.
  Journal
Free Radic Res 48:841-8 (2014)
DOI:10.3109/10715762.2014.929122
Reference
PMID:23124189
  Authors
Xu S, Ogura S, Chen J, Little PJ, Moss J, Liu P
  Title
LOX-1 in atherosclerosis: biological functions and pharmacological modifiers.
  Journal
Cell Mol Life Sci 70:2859-72 (2013)
DOI:10.1007/s00018-012-1194-z
Reference
PMID:21947818
  Authors
Mitra S, Goyal T, Mehta JL
  Title
Oxidized LDL, LOX-1 and atherosclerosis.
  Journal
Cardiovasc Drugs Ther 25:419-29 (2011)
DOI:10.1007/s10557-011-6341-5
Reference
PMID:21338316
  Authors
Lu J, Mitra S, Wang X, Khaidakov M, Mehta JL
  Title
Oxidative stress and lectin-like ox-LDL-receptor LOX-1 in atherogenesis and tumorigenesis.
  Journal
Antioxid Redox Signal 15:2301-33 (2011)
DOI:10.1089/ars.2010.3792
Reference
PMID:20203069
  Authors
Ou HC, Song TY, Yeh YC, Huang CY, Yang SF, Chiu TH, Tsai KL, Chen KL, Wu YJ, Tsai CS, Chang LY, Kuo WW, Lee SD
  Title
EGCG protects against oxidized LDL-induced endothelial dysfunction by inhibiting LOX-1-mediated signaling.
  Journal
J Appl Physiol (1985) 108:1745-56 (2010)
DOI:10.1152/japplphysiol.00879.2009
Reference
PMID:17614937
  Authors
Chen XP, Zhang TT, Du GH
  Title
Lectin-like oxidized low-density lipoprotein receptor-1, a new promising target for the therapy of atherosclerosis?
  Journal
Cardiovasc Drug Rev 25:146-61 (2007)
DOI:10.1111/j.1527-3466.2007.00009.x
Reference
PMID:20181930
  Authors
Mattaliano MD, Wooters J, Shih HH, Paulsen JE
  Title
ROCK2 associates with lectin-like oxidized LDL receptor-1 and mediates oxidized LDL-induced IL-8 production.
  Journal
Am J Physiol Cell Physiol 298:C1180-7 (2010)
DOI:10.1152/ajpcell.00483.2009
Reference
PMID:27073018
  Authors
Salvador B, Arranz A, Francisco S, Cordoba L, Punzon C, Llamas MA, Fresno M
  Title
Modulation of endothelial function by Toll like receptors.
  Journal
Pharmacol Res 108:46-56 (2016)
DOI:10.1016/j.phrs.2016.03.038
Reference
PMID:23995626
  Authors
Moore KJ, Sheedy FJ, Fisher EA
  Title
Macrophages in atherosclerosis: a dynamic balance.
  Journal
Nat Rev Immunol 13:709-21 (2013)
DOI:10.1038/nri3520
Reference
PMID:25403963
  Authors
Butoi E, Gan AM, Manduteanu I
  Title
Molecular and functional interactions among monocytes/macrophages and smooth muscle cells and their relevance for atherosclerosis.
  Journal
Crit Rev Eukaryot Gene Expr 24:341-55 (2014)
DOI:10.1615/critreveukaryotgeneexpr.2014012157
Reference
PMID:24048132
  Authors
Sheedy FJ, Moore KJ
  Title
IL-1 signaling in atherosclerosis: sibling rivalry.
  Journal
Nat Immunol 14:1030-2 (2013)
DOI:10.1038/ni.2711
Reference
PMID:21529710
  Authors
Moore KJ, Tabas I
  Title
Macrophages in the pathogenesis of atherosclerosis.
  Journal
Cell 145:341-55 (2011)
DOI:10.1016/j.cell.2011.04.005
Reference
PMID:22577254
  Authors
Gui T, Shimokado A, Sun Y, Akasaka T, Muragaki Y
  Title
Diverse roles of macrophages in atherosclerosis: from inflammatory biology to biomarker discovery.
  Journal
Mediators Inflamm 2012:693083 (2012)
DOI:10.1155/2012/693083
Reference
PMID:17442283
  Authors
Collot-Teixeira S, Martin J, McDermott-Roe C, Poston R, McGregor JL
  Title
CD36 and macrophages in atherosclerosis.
  Journal
Cardiovasc Res 75:468-77 (2007)
DOI:10.1016/j.cardiores.2007.03.010
Reference
PMID:19065049
  Authors
Park YM, Febbraio M, Silverstein RL
  Title
CD36 modulates migration of mouse and human macrophages in response to oxidized LDL and may contribute to macrophage trapping in the arterial intima.
  Journal
J Clin Invest 119:136-45 (2009)
DOI:10.1172/JCI35535
Reference
PMID:24903227
  Authors
Park YM
  Title
CD36, a scavenger receptor implicated in atherosclerosis.
  Journal
Exp Mol Med 46:e99 (2014)
DOI:10.1038/emm.2014.38
Reference
PMID:21035758
  Authors
Seimon TA, Nadolski MJ, Liao X, Magallon J, Nguyen M, Feric NT, Koschinsky ML, Harkewicz R, Witztum JL, Tsimikas S, Golenbock D, Moore KJ, Tabas I
  Title
Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress.
  Journal
Cell Metab 12:467-82 (2010)
DOI:10.1016/j.cmet.2010.09.010
Reference
PMID:25869517
  Authors
Nimgulkar C, Ghosh S, Sankar AB, Uday KP, Surekha MV, Madhusudhanachary P, Annapurna BR, Raghu P, Bharatraj DK
  Title
Combination of spices and herbal extract restores macrophage foam cell migration and abrogates the athero-inflammatory signalling cascade of atherogenesis.
  Journal
Vascul Pharmacol 72:53-63 (2015)
DOI:10.1016/j.vph.2015.02.014
Reference
PMID:23928573
  Authors
Canton J, Neculai D, Grinstein S
  Title
Scavenger receptors in homeostasis and immunity.
  Journal
Nat Rev Immunol 13:621-34 (2013)
DOI:10.1038/nri3515
Reference
PMID:20375591
  Authors
Erridge C
  Title
The roles of Toll-like receptors in atherosclerosis.
  Journal
J Innate Immun 1:340-9 (2009)
DOI:10.1159/000191413
Reference
PMID:21884686
  Authors
Seneviratne AN, Sivagurunathan B, Monaco C
  Title
Toll-like receptors and macrophage activation in atherosclerosis.
  Journal
Clin Chim Acta 413:3-14 (2012)
DOI:10.1016/j.cca.2011.08.021
Reference
PMID:21252151
  Authors
Miller YI, Choi SH, Wiesner P, Fang L, Harkewicz R, Hartvigsen K, Boullier A, Gonen A, Diehl CJ, Que X, Montano E, Shaw PX, Tsimikas S, Binder CJ, Witztum JL
  Title
Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity.
  Journal
Circ Res 108:235-48 (2011)
DOI:10.1161/CIRCRESAHA.110.223875
Reference
PMID:20884885
  Authors
Tabas I
  Title
The role of endoplasmic reticulum stress in the progression of atherosclerosis.
  Journal
Circ Res 107:839-50 (2010)
DOI:10.1161/CIRCRESAHA.110.224766
Reference
PMID:29360955
  Authors
Grootaert MOJ, Moulis M, Roth L, Martinet W, Vindis C, Bennett MR, De Meyer GRY
  Title
Vascular smooth muscle cell death, autophagy and senescence in atherosclerosis.
  Journal
Cardiovasc Res 114:622-634 (2018)
DOI:10.1093/cvr/cvy007
Reference
PMID:12730091
  Authors
Lipskaia L, Pourci ML, Delomenie C, Combettes L, Goudouneche D, Paul JL, Capiod T, Lompre AM
  Title
Phosphatidylinositol 3-kinase and calcium-activated transcription pathways are required for VLDL-induced smooth muscle cell proliferation.
  Journal
Circ Res 92:1115-22 (2003)
DOI:10.1161/01.RES.0000074880.25540.D0
Reference
PMID:28230726
  Authors
Cervantes Gracia K, Llanas-Cornejo D, Husi H
  Title
CVD and Oxidative Stress.
  Journal
J Clin Med 6:E22 (2017)
DOI:10.3390/jcm6020022
Reference
PMID:21321594
  Authors
Hansson GK, Hermansson A
  Title
The immune system in atherosclerosis.
  Journal
Nat Immunol 12:204-12 (2011)
DOI:10.1038/ni.2001
Reference
PMID:19301036
  Authors
Roy H, Bhardwaj S, Yla-Herttuala S
  Title
Molecular genetics of atherosclerosis.
  Journal
Hum Genet 125:467-91 (2009)
DOI:10.1007/s00439-009-0654-5
Reference
PMID:15451808
  Authors
Lusis AJ, Fogelman AM, Fonarow GC
  Title
Genetic basis of atherosclerosis: part I: new genes and pathways.
  Journal
Circulation 110:1868-73 (2004)
DOI:10.1161/01.CIR.0000143041.58692.CC
Reference
PMID:15485348
  Authors
Lusis AJ, Mar R, Pajukanta P
  Title
Genetics of atherosclerosis.
  Journal
Annu Rev Genomics Hum Genet 5:189-218 (2004)
DOI:10.1146/annurev.genom.5.061903.175930
Related
pathway
cimi04020  Calcium signaling pathway
cimi04115  p53 signaling pathway
cimi04141  Protein processing in endoplasmic reticulum
cimi04151  PI3K-Akt signaling pathway
cimi04210  Apoptosis
cimi04620  Toll-like receptor signaling pathway
cimi04621  NOD-like receptor signaling pathway
cimi04668  TNF signaling pathway
cimi04670  Leukocyte transendothelial migration
cimi04975  Fat digestion and absorption
cimi04979  Cholesterol metabolism
cimi05418  Fluid shear stress and atherosclerosis
KO pathway
ko05417   
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