KEGG   PATHWAY: clud05010
Entry
clud05010                   Pathway                                
Name
Alzheimer disease - Canis lupus dingo (dingo)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
clud05010  Alzheimer disease
clud05010

Organism
Canis lupus dingo (dingo) [GN:clud]
Gene
112675851  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
112664856  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 isoform X2 [KO:K06059] [EC:3.4.24.86]
112661802  amyloid-beta precursor protein isoform X3 [KO:K04520]
112646460  NAE1; NEDD8-activating enzyme E1 regulatory subunit isoform X1 [KO:K04532]
112667548  APBB1; amyloid beta precursor protein binding family B member 1 isoform X1 [KO:K04529]
112667656  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
112671671  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
112671933  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
112675328  GAPDH; glyceraldehyde-3-phosphate dehydrogenase isoform X3 [KO:K00134] [EC:1.2.1.12]
112675472  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
112641811  glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
112653839  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
112676311  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
118350505  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
112653716  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
112655580  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
125752298  glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
112667617  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
125755382  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
112648422  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
112650474  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
112671268  BACE1; beta-secretase 1 isoform X1 [KO:K04521] [EC:3.4.23.46]
112661680  BACE2; beta-secretase 2 [KO:K07747] [EC:3.4.23.45]
112659525  RTN3; reticulon-3 isoform X1 [KO:K20723]
112672359  RTN4; reticulon-4 isoform X1 [KO:K20720]
112643621  PSENEN; gamma-secretase subunit PEN-2 [KO:K06170]
112658022  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
112648798  PSEN2; presenilin-2 isoform X3 [KO:K04522] [EC:3.4.23.-]
112642992  NCSTN; nicastrin [KO:K06171]
112664016  APH1A; gamma-secretase subunit APH-1A [KO:K06172]
112675800  APH1B; gamma-secretase subunit APH-1B [KO:K06172]
112672060  IDE; insulin-degrading enzyme isoform X1 [KO:K01408] [EC:3.4.24.56]
112652529  MME; neprilysin isoform X1 [KO:K01389] [EC:3.4.24.11]
112653038  MAPT; microtubule-associated protein tau isoform X4 [KO:K04380]
112647056  NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
112659341  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
112648058  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
112669177  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
112649282  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
112663986  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
112655613  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
112669712  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
112658832  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
112653127  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like [KO:K03946]
112651067  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
125752483  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
112671733  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
112677988  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 isoform X1 [KO:K03948]
112674847  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
112675526  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
112659729  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
112643457  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
112675938  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
112649746  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
112675011  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
118354020  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
112657429  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
112666700  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
112666407  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
112677158  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 isoform X1 [KO:K03952]
112669059  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
112670006  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
112640237  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
112651654  acyl carrier protein, mitochondrial-like [KO:K03955]
112666355  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 isoform X4 [KO:K03956]
112654563  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
112666789  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 isoform X1 [KO:K11353]
118351720  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
112646040  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
118355324  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
118355555  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
112650992  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial isoform X1 [KO:K03958]
112649336  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial-like [KO:K03958]
112656283  NDUFB3; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
112677535  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 isoform X2 [KO:K03960]
112662850  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
112644265  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial-like [KO:K03961]
112650486  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
112678755  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6-like [KO:K03962]
112666636  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
112672201  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
112662129  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
112640558  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
112648012  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10-like [KO:K03966]
112673263  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
112656793  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934] [EC:7.1.1.2]
112643024  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
112663336  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
112651294  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
112646084  NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial-like [KO:K03937]
112642341  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 isoform X1 [KO:K03938]
112662703  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
112666186  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
112659312  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X3 [KO:K03941] [EC:7.1.1.2]
112667486  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial-like [KO:K03941] [EC:7.1.1.2]
112669293  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
112642121  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
112662906  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
112660061  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X1 [KO:K00235] [EC:1.3.5.1]
112675119  succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial-like [KO:K00235] [EC:1.3.5.1]
112643036  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
112671340  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
112645623  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
112662205  cytochrome c1, heme protein, mitochondrial [KO:K00413]
112665750  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
112640264  cytochrome b-c1 complex subunit 2, mitochondrial isoform X2 [KO:K00415]
112669654  cytochrome b-c1 complex subunit 2, mitochondrial-like [KO:K00415]
112642556  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
112650722  cytochrome b-c1 complex subunit 7 isoform X1 [KO:K00417]
112650058  cytochrome b-c1 complex subunit 8 isoform X1 [KO:K00418]
112676792  cytochrome b-c1 complex subunit 9 isoform X2 [KO:K00419]
112666200  cytochrome b-c1 complex subunit 10 [KO:K00420]
112646773  cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform X1 [KO:K02263]
112673765  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
112669019  cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
112675573  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
112670808  cytochrome c oxidase subunit 5B, mitochondrial isoform X1 [KO:K02265]
112669031  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
112640146  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
112676672  cytochrome c oxidase subunit 6A1, mitochondrial isoform X1 [KO:K02266]
112667822  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
112655679  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
112644991  cytochrome c oxidase subunit 6B2 [KO:K02267]
112660066  cytochrome c oxidase subunit 6B1-like [KO:K02267]
112665643  cytochrome c oxidase subunit 6B1 [KO:K02267]
112643623  cytochrome c oxidase subunit 6B1 isoform X1 [KO:K02267]
112657639  cytochrome c oxidase subunit 6B1-like [KO:K02267]
112678400  cytochrome c oxidase subunit 6C [KO:K02268]
112643625  cytochrome c oxidase subunit 7A1, mitochondrial isoform X1 [KO:K02270]
112658567  cytochrome c oxidase subunit 7A2, mitochondrial isoform X1 [KO:K02270]
112664458  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
118355483  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
112671885  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
112652117  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
112643473  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
112650945  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
112664558  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
118352292  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
112678421  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
112653522  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
112675990  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
112671697  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
112669591  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
125753053  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
112659430  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
112671942  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
112653719  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
112647792  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
112661675  LOW QUALITY PROTEIN: ATP synthase subunit alpha, mitochondrial-like [KO:K02132]
112678005  ATP5F1B; ATP synthase subunit beta, mitochondrial isoform X5 [KO:K02133] [EC:7.1.2.2]
112666177  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
112674194  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
112640661  ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
112655310  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
112667173  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
112668135  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
112662982  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
118355186  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
112648876  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
112655416  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
118350644  ATP synthase F(0) complex subunit C3, mitochondrial-like [KO:K02128]
112647980  ATP synthase subunit d, mitochondrial-like [KO:K02138]
112670682  ATP synthase subunit d, mitochondrial-like [KO:K02138]
112654881  ATP synthase subunit d, mitochondrial-like [KO:K02138]
112655980  ATP synthase subunit d, mitochondrial-like [KO:K02138]
112659988  ATP synthase subunit d, mitochondrial [KO:K02138]
112668567  ATP synthase subunit d, mitochondrial-like [KO:K02138]
112641957  ATP synthase subunit d, mitochondrial-like [KO:K02138]
125754599  ATP synthase subunit d, mitochondrial-like [KO:K02138]
125754631  ATP synthase subunit d, mitochondrial-like [KO:K02138]
112672785  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
112661712  ATP5PO; ATP synthase subunit O, mitochondrial isoform X1 [KO:K02137]
112668013  ATP synthase subunit O, mitochondrial-like [KO:K02137]
112645053  ATP synthase subunit O, mitochondrial-like [KO:K02137]
112678736  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
112661929  ATP5PF; ATP synthase-coupling factor 6, mitochondrial isoform X1 [KO:K02131]
112673073  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
112654797  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
118350204  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
112671433  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1-like [KO:K05862]
112651940  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
112656506  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X2 [KO:K15041]
112654613  voltage-dependent anion-selective channel protein 3-like [KO:K15041]
112673224  voltage-dependent anion-selective channel protein 3-like [KO:K15041]
112649317  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
112651963  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
112675217  SLC25A4; ADP/ATP translocase 1 isoform X1 [KO:K05863]
112642775  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
112651452  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
112669794  LPL; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
112645324  APOE; apolipoprotein E [KO:K04524]
112677991  LRP1; prolow-density lipoprotein receptor-related protein 1 isoform X1 [KO:K04550]
112656223  FAS; tumor necrosis factor receptor superfamily member 6 isoform X2 [KO:K04390]
112669080  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X2 [KO:K03158]
112663192  FADD; FAS-associated death domain protein isoform X1 [KO:K02373]
112656364  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
112667429  LOW QUALITY PROTEIN: BH3-interacting domain death agonist [KO:K04726]
118352478  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
112655674  calmodulin-1-like [KO:K02183]
112645263  CALM3; calmodulin-3 isoform X1 [KO:K02183]
112656898  CALM1; calmodulin-1 [KO:K02183]
112658063  calmodulin-1-like [KO:K02183]
112659069  CALML5; calmodulin-like protein 5 [KO:K02183]
112646988  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
112671784  CALM2; calmodulin-2 isoform X3 [KO:K02183]
112675698  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
112659017  calmodulin-like protein 3 [KO:K02183]
112644642  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
112669758  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
112651490  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
112650031  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
112673922  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
112659359  BAD; bcl2-associated agonist of cell death [KO:K02158]
112670591  cytochrome c [KO:K08738]
112678206  LOW QUALITY PROTEIN: cytochrome c-like [KO:K08738]
112653556  LOW QUALITY PROTEIN: cytochrome c-like [KO:K08738]
112654697  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
112659987  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
112675231  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
112659439  CHRM1; muscarinic acetylcholine receptor M1 isoform X1 [KO:K04129]
112660873  CHRM3; muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131]
112676193  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
112642041  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
112644686  guanine nucleotide-binding protein G(q) subunit alpha isoform X2 [KO:K04634]
112659377  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
112673608  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2 [KO:K05858] [EC:3.1.4.11]
112673609  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
112676127  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X5 [KO:K05858] [EC:3.1.4.11]
112677485  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
112640386  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
112665422  GRIN2B; glutamate receptor ionotropic, NMDA 2B isoform X1 [KO:K05210]
112672773  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
112645204  GRIN2D; glutamate receptor ionotropic, NMDA 2D isoform X1 [KO:K05212]
112668971  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X3 [KO:K04850]
112665919  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
112673110  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
112667091  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
112653340  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 isoform X4 [KO:K04809]
112652024  MCU; calcium uniporter protein, mitochondrial isoform X4 [KO:K20858]
112640050  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
112677029  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112669083  mitogen-activated protein kinase 3-like [KO:K04371] [EC:2.7.11.24]
112676192  RYR3; ryanodine receptor 3 isoform X1 [KO:K04963]
112662581  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
112665544  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
112641421  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X3 [KO:K04960]
112677516  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
112640026  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
112676523  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X3 [KO:K05853] [EC:7.2.2.10]
112643044  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
112676769  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
112677982  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
112652886  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
112664364  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
112677465  TRAF2; TNF receptor-associated factor 2 isoform X2 [KO:K03173] [EC:2.3.2.27]
112644173  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
112666418  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
112645941  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
112659577  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
112671968  MAPK8; mitogen-activated protein kinase 8 isoform X3 [KO:K04440] [EC:2.7.11.24]
112658058  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
112667576  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
112657128  PSMA6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
112651142  LOW QUALITY PROTEIN: proteasome subunit alpha type-6-like [KO:K02730] [EC:3.4.25.1]
112661294  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
112662212  PSMA4; proteasome subunit alpha type-4 isoform X1 [KO:K02728] [EC:3.4.25.1]
112647941  PSMA8; proteasome subunit alpha-type 8 isoform X1 [KO:K02731] [EC:3.4.25.1]
112674222  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
112640716  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
112657136  proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
112667667  PSMA1; proteasome subunit alpha type-1 isoform X2 [KO:K02725] [EC:3.4.25.1]
112662342  proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
112669358  proteasome subunit alpha type-1-like [KO:K02725] [EC:3.4.25.1]
112641493  proteasome subunit alpha type-1-like [KO:K02725] [EC:3.4.25.1]
112678369  proteasome subunit alpha type-1-like [KO:K02725] [EC:3.4.25.1]
112645056  proteasome subunit alpha type-1-like [KO:K02725] [EC:3.4.25.1]
112653675  proteasome subunit alpha type-1-like [KO:K02725] [EC:3.4.25.1]
112675844  proteasome subunit alpha type-1-like [KO:K02725] [EC:3.4.25.1]
125754355  proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
112657247  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
112647521  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
112677182  PSMB7; proteasome subunit beta type-7 isoform X2 [KO:K02739] [EC:3.4.25.1]
112655657  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
112658404  proteasome subunit beta type-3-like [KO:K02735] [EC:3.4.25.1]
112642411  PSMB2; proteasome subunit beta type-2 isoform X1 [KO:K02734] [EC:3.4.25.1]
112657343  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
112658266  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
112663964  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
112661487  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
112656874  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
112659172  26S proteasome regulatory subunit 4-like [KO:K03062]
112645470  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
112657073  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
112663330  PSMC3; 26S proteasome regulatory subunit 6A isoform X1 [KO:K03065]
112671786  26S proteasome regulatory subunit 6A-like [KO:K03065]
112652916  PSMC5; 26S proteasome regulatory subunit 8 [KO:K03066]
112662784  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
112669877  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
112655117  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
112676500  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
112652946  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 isoform X1 [KO:K03035]
112655095  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
112666018  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 isoform X1 [KO:K03037]
112646563  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
112663553  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
112663973  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
112674684  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
112645523  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
112674229  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
112669413  26S proteasome complex subunit SEM1 [KO:K10881]
112674881  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
112671425  caspase-12 isoform X1 [KO:K04741] [EC:3.4.22.-]
112676630  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
112659212  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
112648848  CAPN2; calpain-2 catalytic subunit isoform X2 [KO:K03853] [EC:3.4.22.53]
112655150  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
112647745  SLC39A1; zinc transporter ZIP1 isoform X1 [KO:K14709]
112654829  SLC39A2; zinc transporter ZIP2 isoform X1 [KO:K14709]
112666237  SLC39A3; zinc transporter ZIP3 [KO:K14709]
112662165  SLC39A4; zinc transporter ZIP4 [KO:K14710]
112678023  SLC39A5; zinc transporter ZIP5 [KO:K14711]
112647866  SLC39A6; zinc transporter ZIP6 [KO:K14712]
112641394  SLC39A7; zinc transporter SLC39A7 isoform X1 [KO:K14713]
112644603  SLC39A8; metal cation symporter ZIP8 isoform X1 [KO:K14714]
112656847  SLC39A9; zinc transporter ZIP9 isoform X1 [KO:K14715]
112656667  SLC39A10; zinc transporter ZIP10 isoform X1 [KO:K14716]
112672739  SLC39A11; zinc transporter ZIP11 isoform X1 [KO:K14717]
112658964  SLC39A12; zinc transporter ZIP12 isoform X1 [KO:K14718]
112663326  SLC39A13; zinc transporter ZIP13 isoform X1 [KO:K14719]
112669761  SLC39A14; metal cation symporter ZIP14 isoform X4 [KO:K14720]
112678331  SLC11A2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
112663900  CDK5; cyclin-dependent kinase 5 [KO:K02090] [EC:2.7.11.22]
112677588  GSK3B; glycogen synthase kinase-3 beta isoform X3 [KO:K03083] [EC:2.7.11.26]
112672357  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
112656264  DKK1; dickkopf-related protein 1 [KO:K02165]
112656401  DKK4; dickkopf-related protein 4 [KO:K02165]
112671607  DKK2; dickkopf-related protein 2 [KO:K02165]
112678279  WNT1; proto-oncogene Wnt-1 isoform X1 [KO:K03209]
112670801  WNT2; protein Wnt-2 isoform X2 [KO:K00182]
112663902  WNT2B; protein Wnt-2b [KO:K00182]
112652965  WNT3; proto-oncogene Wnt-3 [KO:K00312]
112665303  WNT3A; protein Wnt-3a [KO:K00312]
112660019  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
112668992  WNT5B; protein Wnt-5b [KO:K00444]
112665934  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
112656503  WNT6; protein Wnt-6 [KO:K00445]
112660989  WNT7A; protein Wnt-7a isoform X1 [KO:K00572]
112666027  WNT7B; protein Wnt-7b isoform X5 [KO:K00572]
112672198  WNT8B; protein Wnt-8b [KO:K00714]
112650067  WNT8A; protein Wnt-8a isoform X1 [KO:K00714]
112652984  WNT9B; protein Wnt-9b [KO:K01064]
112665302  WNT9A; protein Wnt-9a [KO:K01064]
112656502  WNT10A; protein Wnt-10a [KO:K01357]
112678278  WNT10B; protein Wnt-10b isoform X2 [KO:K01357]
112642157  WNT11; protein Wnt-11 [KO:K01384]
112678075  WNT16; protein Wnt-16 [KO:K01558]
112674955  FZD1; frizzled-1 [KO:K02432]
112656639  FZD7; frizzled-7 [KO:K02432]
112655297  FZD2; frizzled-2 [KO:K02235]
112669675  FZD3; frizzled-3 isoform X1 [KO:K02329]
112642049  FZD4; frizzled-4 [KO:K02354]
112678994  FZD8; frizzled-8 [KO:K02375]
112656460  FZD5; frizzled-5 [KO:K02375]
112662097  FZD6; frizzled-6 isoform X1 [KO:K02376]
112646159  FZD9; frizzled-9 [KO:K02842]
112676414  FZD10; frizzled-10 [KO:K02842]
112659229  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
112665398  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
112668073  CSNK1E; casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
112647012  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
112647486  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
112662657  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X2 [KO:K02353]
112672132  proto-oncogene FRAT1-like [KO:K03069]
112672133  LOW QUALITY PROTEIN: GSK-3-binding protein FRAT2-like [KO:K03096]
112660103  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
112673738  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
112641305  CSNK2B; casein kinase II subunit beta isoform X1 [KO:K03115]
112640639  AXIN1; axin-1 isoform X2 [KO:K02157]
112652925  AXIN2; axin-2 isoform X1 [KO:K04385]
112653650  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
112666189  APC2; adenomatous polyposis coli protein 2 isoform X3 [KO:K02085]
112668716  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
112651839  CSNK1A1; casein kinase I isoform X3 [KO:K08957] [EC:2.7.11.1]
112677975  KIF5A; kinesin heavy chain isoform X1 [KO:K10396]
112670360  KIF5B; kinesin-1 heavy chain [KO:K10396]
112649490  KIF5C; kinesin heavy chain [KO:K10396]
112645307  KLC3; kinesin light chain 3 isoform X2 [KO:K10407]
112641611  KLC4; kinesin light chain 4 [KO:K10407]
112657137  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
112667043  tubulin alpha chain-like isoform X1 [KO:K07374]
112656371  tubulin alpha-1B chain isoform X1 [KO:K07374]
112656372  TUBA4A; tubulin alpha-4A chain isoform X1 [KO:K07374]
112678286  tubulin alpha-1B chain isoform X1 [KO:K07374]
112678287  tubulin alpha-1A chain [KO:K07374]
112678288  tubulin alpha-1C chain isoform X1 [KO:K07374]
112659064  TUBAL3; tubulin alpha chain-like 3 isoform X1 [KO:K07374]
112668951  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
112677006  tubulin alpha-3 chain-like [KO:K07374]
112677007  tubulin alpha-3 chain [KO:K07374]
112677497  TUBB4B; tubulin beta-4B chain isoform X1 [KO:K07375]
112668213  tubulin beta chain-like isoform X1 [KO:K07375]
112646852  TUBB3; tubulin beta-3 chain [KO:K07375]
112659313  TUBB2A; tubulin beta-2A chain isoform X4 [KO:K07375]
112648004  LOW QUALITY PROTEIN: tubulin beta chain [KO:K07375]
112648102  TUBB6; tubulin beta-6 chain [KO:K07375]
112674192  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
112641255  TUBB; tubulin beta chain [KO:K07375]
112666377  TUBB4A; tubulin beta-4A chain [KO:K07375]
112641348  AGER; advanced glycosylation end product-specific receptor [KO:K19722]
112663536  HRAS; GTPase HRas isoform X1 [KO:K02833]
112665533  KRAS; GTPase KRas isoform X1 [KO:K07827]
112664166  NRAS; GTPase NRas [KO:K07828]
112673245  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
112650991  BRAF; serine/threonine-protein kinase B-raf isoform X5 [KO:K04365] [EC:2.7.11.1]
112661394  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
112675721  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
112666294  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
112649429  NOX1; NADPH oxidase 1 isoform X1 [KO:K08008]
112655047  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
112642040  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
112659193  RELA; transcription factor p65 isoform X1 [KO:K04735]
112644595  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
112677685  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
112648518  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
112641287  TNF; tumor necrosis factor [KO:K03156]
112670562  IL6; interleukin-6 [KO:K05405]
112664387  IL1A; interleukin-1 alpha [KO:K04383]
112664386  IL1B; interleukin-1 beta [KO:K04519]
112640696  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
112645357  SNCA; alpha-synuclein isoform X4 [KO:K04528]
112664523  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
112672189  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
112656000  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
112668352  IKBKG; NF-kappa-B essential modulator isoform X6 [KO:K07210]
112663225  INS; insulin [KO:K04526]
112666443  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
112669817  IRS1; insulin receptor substrate 1 [KO:K16172]
112655863  IRS2; insulin receptor substrate 2 isoform X2 [KO:K07187]
112649305  IRS4; insulin receptor substrate 4 [KO:K17446]
112666735  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
112660199  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112642563  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
112646871  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X5 [KO:K00922] [EC:2.7.1.153]
112661215  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
112662621  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112658031  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112648737  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112645463  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112678102  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
112676397  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
112647287  ULK2; serine/threonine-protein kinase ULK2 isoform X2 [KO:K08269] [EC:2.7.11.1]
112667239  ATG101; autophagy-related protein 101 [KO:K19730]
112663299  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
112678441  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
112663298  AMBRA1; LOW QUALITY PROTEIN: activating molecule in BECN1-regulated autophagy protein 1 [KO:K17985]
112655399  BECN1; beclin-1 isoform X1 [KO:K08334]
112648727  BECN2; beclin-2 isoform X1 [KO:K08334]
112661148  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 isoform X1 [KO:K08333] [EC:2.7.11.1]
112657096  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
112651329  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
112647820  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
112657714  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
112659323  ATG2A; LOW QUALITY PROTEIN: autophagy-related protein 2 homolog A [KO:K17906]
112646361  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X2 [KO:K17908]
112653018  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:15232608
  Authors
Dickson DW
  Title
Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect?
  Journal
J Clin Invest 114:23-7 (2004)
DOI:10.1172/JCI22317
Reference
PMID:15750290
  Authors
Takuma K, Yan SS, Stern DM, Yamada K
  Title
Mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis in Alzheimer's disease.
  Journal
J Pharmacol Sci 97:312-6 (2005)
DOI:10.1254/jphs.CPJ04006X
Reference
PMID:18675468
  Authors
Bezprozvanny I, Mattson MP
  Title
Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease.
  Journal
Trends Neurosci 31:454-63 (2008)
DOI:10.1016/j.tins.2008.06.005
Reference
PMID:9848086
  Authors
Holscher C
  Title
Possible causes of Alzheimer's disease: amyloid fragments, free radicals, and calcium homeostasis.
  Journal
Neurobiol Dis 5:129-41 (1998)
DOI:10.1006/nbdi.1998.0193
Reference
PMID:18035450
  Authors
Bojarski L, Herms J, Kuznicki J
  Title
Calcium dysregulation in Alzheimer's disease.
  Journal
Neurochem Int 52:621-33 (2008)
DOI:10.1016/j.neuint.2007.10.002
Reference
PMID:25450339
  Authors
Kondratskyi A, Kondratska K, Skryma R, Prevarskaya N
  Title
Ion channels in the regulation of apoptosis.
  Journal
Biochim Biophys Acta 1848:2532-46 (2015)
DOI:10.1016/j.bbamem.2014.10.030
Reference
PMID:29890840
  Authors
Popugaeva E, Pchitskaya E, Bezprozvanny I
  Title
Dysregulation of Intracellular Calcium Signaling in Alzheimer's Disease.
  Journal
Antioxid Redox Signal 29:1176-1188 (2018)
DOI:10.1089/ars.2018.7506
Reference
PMID:25767489
  Authors
Tan Y, Deng Y, Qing H
  Title
Calcium channel blockers and Alzheimer's disease.
  Journal
Neural Regen Res 7:137-40 (2012)
DOI:10.3969/j.issn.1673-5374.2012.02.010
Reference
PMID:11484003
  Authors
Small DH, Mok SS, Bornstein JC
  Title
Alzheimer's disease and Abeta toxicity: from top to bottom.
  Journal
Nat Rev Neurosci 2:595-8 (2001)
DOI:10.1038/35086072
Reference
PMID:15177383
  Authors
Parihar MS, Hemnani T
  Title
Alzheimer's disease pathogenesis and therapeutic interventions.
  Journal
J Clin Neurosci 11:456-67 (2004)
DOI:10.1016/j.jocn.2003.12.007
Reference
PMID:17568632
  Authors
Cowburn RF, Popescu BO, Ankarcrona M, Dehvari N, Cedazo-Minguez A
  Title
Presenilin-mediated signal transduction.
  Journal
Physiol Behav 92:93-7 (2007)
DOI:10.1016/j.physbeh.2007.05.053
Reference
PMID:22842534
  Authors
Honarnejad K, Herms J
  Title
Presenilins: role in calcium homeostasis.
  Journal
Int J Biochem Cell Biol 44:1983-6 (2012)
DOI:10.1016/j.biocel.2012.07.019
Reference
PMID:21663966
  Authors
Supnet C, Bezprozvanny I
  Title
Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis.
  Journal
Cell Calcium 50:303-9 (2011)
DOI:10.1016/j.ceca.2011.05.013
Reference
PMID:16677790
  Authors
Hauptmann S, Keil U, Scherping I, Bonert A, Eckert A, Muller WE
  Title
Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease.
  Journal
Exp Gerontol 41:668-73 (2006)
DOI:10.1016/j.exger.2006.03.012
Reference
PMID:14557245
  Authors
Chen Y, Liu W, McPhie DL, Hassinger L, Neve RL
  Title
APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain.
  Journal
J Cell Biol 163:27-33 (2003)
DOI:10.1083/jcb.200304003
Reference
PMID:24051203
  Authors
Eckert A, Nisbet R, Grimm A, Gotz J
  Title
March separate, strike together--role of phosphorylated TAU in mitochondrial dysfunction in Alzheimer's disease.
  Journal
Biochim Biophys Acta 1842:1258-66 (2014)
DOI:10.1016/j.bbadis.2013.08.013
Reference
PMID:30741722
  Authors
Strickland MR, Holtzman DM
  Title
Dr. Jekyll and Mr. Hyde: ApoE explains opposing effects of neuronal LRP1.
  Journal
J Clin Invest 129:969-971 (2019)
DOI:10.1172/JCI127578
Reference
PMID:10527810
  Authors
Ivins KJ, Thornton PL, Rohn TT, Cotman CW
  Title
Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8.
  Journal
Neurobiol Dis 6:440-9 (1999)
DOI:10.1006/nbdi.1999.0268
Reference
PMID:31655116
  Authors
Sushma, Mondal AC
  Title
Role of GPCR signaling and calcium dysregulation in Alzheimer's disease.
  Journal
Mol Cell Neurosci 101:103414 (2019)
DOI:10.1016/j.mcn.2019.103414
Reference
PMID:18648507
  Authors
Sanz-Blasco S, Valero RA, Rodriguez-Crespo I, Villalobos C, Nunez L
  Title
Mitochondrial Ca2+ overload underlies Abeta oligomers neurotoxicity providing an unexpected mechanism of neuroprotection by NSAIDs.
  Journal
PLoS One 3:e2718 (2008)
DOI:10.1371/journal.pone.0002718
Reference
PMID:20332425
  Authors
Mattson MP
  Title
ER calcium and Alzheimer's disease: in a state of flux.
  Journal
Sci Signal 3:pe10 (2010)
DOI:10.1126/scisignal.3114pe10
Reference
PMID:16394273
  Authors
Lee SY, Hwang DY, Kim YK, Lee JW, Shin IC, Oh KW, Lee MK, Lim JS, Yoon DY, Hwang SJ, Hong JT
  Title
PS2 mutation increases neuronal cell vulnerability to neurotoxicants through activation of caspase-3 by enhancing of ryanodine receptor-mediated calcium release.
  Journal
FASEB J 20:151-3 (2006)
DOI:10.1096/fj.05-4017fje;1
Reference
PMID:11551913
  Authors
Katayama T, Imaizumi K, Honda A, Yoneda T, Kudo T, Takeda M, Mori K, Rozmahel R, Fraser P, George-Hyslop PS, Tohyama M
  Title
Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer's disease-linked presenilin-1 mutations.
  Journal
J Biol Chem 276:43446-54 (2001)
DOI:10.1074/jbc.M104096200
Reference
PMID:28057414
  Authors
Lane-Donovan C, Herz J
  Title
ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease.
  Journal
Trends Endocrinol Metab 28:273-284 (2017)
DOI:10.1016/j.tem.2016.12.001
Reference
PMID:27994051
  Authors
Wasser CR, Herz J
  Title
Reelin: Neurodevelopmental Architect and Homeostatic Regulator of Excitatory Synapses.
  Journal
J Biol Chem 292:1330-1338 (2017)
DOI:10.1074/jbc.R116.766782
Reference
PMID:21116052
  Authors
Lilja AM, Porras O, Storelli E, Nordberg A, Marutle A
  Title
Functional interactions of fibrillar and oligomeric amyloid-beta with alpha7 nicotinic receptors in Alzheimer's disease.
  Journal
J Alzheimers Dis 23:335-47 (2011)
DOI:10.3233/JAD-2010-101242
Reference
PMID:24847263
  Authors
Anastasio TJ
  Title
Computational identification of potential multitarget treatments for ameliorating the adverse effects of amyloid-beta on synaptic plasticity.
  Journal
Front Pharmacol 5:85 (2014)
DOI:10.3389/fphar.2014.00085
Reference
PMID:29378302
  Authors
Vargas LM, Cerpa W, Munoz FJ, Zanlungo S, Alvarez AR
  Title
Amyloid-beta oligomers synaptotoxicity: The emerging role of EphA4/c-Abl signaling in Alzheimer's disease.
  Journal
Biochim Biophys Acta Mol Basis Dis 1864:1148-1159 (2018)
DOI:10.1016/j.bbadis.2018.01.023
Reference
PMID:25394486
  Authors
Tu S, Okamoto S, Lipton SA, Xu H
  Title
Oligomeric Abeta-induced synaptic dysfunction in Alzheimer's disease.
  Journal
Mol Neurodegener 9:48 (2014)
DOI:10.1186/1750-1326-9-48
Reference
PMID:31191253
  Authors
Palomer E, Buechler J, Salinas PC
  Title
Wnt Signaling Deregulation in the Aging and Alzheimer's Brain.
  Journal
Front Cell Neurosci 13:227 (2019)
DOI:10.3389/fncel.2019.00227
Reference
PMID:27807401
  Authors
Vallee A, Lecarpentier Y
  Title
Alzheimer Disease: Crosstalk between the Canonical Wnt/Beta-Catenin Pathway and PPARs Alpha and Gamma.
  Journal
Front Neurosci 10:459 (2016)
DOI:10.3389/fnins.2016.00459
Reference
PMID:19903023
  Authors
Origlia N, Arancio O, Domenici L, Yan SS
  Title
MAPK, beta-amyloid and synaptic dysfunction: the role of RAGE.
  Journal
Expert Rev Neurother 9:1635-45 (2009)
DOI:10.1586/ern.09.107
Reference
PMID:19464758
  Authors
Srikanth V, Maczurek A, Phan T, Steele M, Westcott B, Juskiw D, Munch G
  Title
Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease.
  Journal
Neurobiol Aging 32:763-77 (2011)
DOI:10.1016/j.neurobiolaging.2009.04.016
Reference
PMID:12805290
  Authors
Pigino G, Morfini G, Pelsman A, Mattson MP, Brady ST, Busciglio J
  Title
Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport.
  Journal
J Neurosci 23:4499-508 (2003)
DOI:10.1523/JNEUROSCI.23-11-04499.2003
Reference
PMID:15645263
  Authors
Roy S, Zhang B, Lee VM, Trojanowski JQ
  Title
Axonal transport defects: a common theme in neurodegenerative diseases.
  Journal
Acta Neuropathol 109:5-13 (2005)
DOI:10.1007/s00401-004-0952-x
Reference
PMID:26074767
  Authors
Ferreira ST, Lourenco MV, Oliveira MM, De Felice FG
  Title
Soluble amyloid-beta oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease.
  Journal
Front Cell Neurosci 9:191 (2015)
DOI:10.3389/fncel.2015.00191
Reference
PMID:24529521
  Authors
De Felice FG, Lourenco MV, Ferreira ST
  Title
How does brain insulin resistance develop in Alzheimer's disease?
  Journal
Alzheimers Dement 10:S26-32 (2014)
DOI:10.1016/j.jalz.2013.12.004
Reference
PMID:26136647
  Authors
Bedse G, Di Domenico F, Serviddio G, Cassano T
  Title
Aberrant insulin signaling in Alzheimer's disease: current knowledge.
  Journal
Front Neurosci 9:204 (2015)
DOI:10.3389/fnins.2015.00204
Reference
PMID:20101724
  Authors
Funderburk SF, Marcellino BK, Yue Z
  Title
Cell "self-eating" (autophagy) mechanism in Alzheimer's disease.
  Journal
Mt Sinai J Med 77:59-68 (2010)
DOI:10.1002/msj.20161
Related
pathway
clud00190  Oxidative phosphorylation
clud03050  Proteasome
clud04020  Calcium signaling pathway
clud04140  Autophagy - animal
clud04141  Protein processing in endoplasmic reticulum
clud04210  Apoptosis
clud04310  Wnt signaling pathway
clud04910  Insulin signaling pathway
clud04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05010   
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