KEGG   PATHWAY: cmy04144
Entry
cmy04144                    Pathway                                
Name
Endocytosis - Chelonia mydas (green sea turtle)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
cmy04144  Endocytosis
cmy04144

Other DBs
GO: 0006897
Organism
Chelonia mydas (green sea turtle) [GN:cmy]
Gene
102947926  ADP-ribosylation factor 6 isoform X1 [KO:K07941]
119566486  ARF6; ADP-ribosylation factor 6 [KO:K07941]
102940695  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
102947100  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X4 [KO:K00889] [EC:2.7.1.68]
102947027  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
102932642  PIP5KL1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1 [KO:K13712] [EC:2.7.1.68]
102945664  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
102945038  DNM1; dynamin-1 isoform X9 [KO:K01528] [EC:3.6.5.5]
102930568  DNM3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
102933091  DNM2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
102934071  CLTA; clathrin light chain A isoform X1 [KO:K04644]
102932530  CLTB; clathrin light chain B isoform X1 [KO:K04645]
102930702  CLTC; clathrin heavy chain 1 isoform X2 [KO:K04646]
102941617  clathrin heavy chain 2 isoform X1 [KO:K04646]
102942674  AP2A2; AP-2 complex subunit alpha-2 isoform X6 [KO:K11824]
102946352  AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825]
102934507  AP2M1; AP-2 complex subunit mu isoform X1 [KO:K11826]
102944700  AP2S1; AP-2 complex subunit sigma isoform X2 [KO:K11827]
102935551  EHD2; LOW QUALITY PROTEIN: EH domain-containing protein 2 [KO:K12469]
102942001  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
102947040  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
102946534  LOW QUALITY PROTEIN: TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
102940003  ZFYVE16; zinc finger FYVE domain-containing protein 16 isoform X2 [KO:K04679]
102930941  ZFYVE9; zinc finger FYVE domain-containing protein 9 [KO:K04679]
102944212  protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
102947589  protein PML isoform X7 [KO:K10054] [EC:2.3.2.-]
102940642  SMAD2; mothers against decapentaplegic homolog 2 isoform X3 [KO:K04500]
102946629  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
102932579  TFRC; transferrin receptor protein 1 isoform X1 [KO:K06503]
102933326  EGFR; epidermal growth factor receptor isoform X2 [KO:K04361] [EC:2.7.10.1]
102935642  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102938554  FGFR2; fibroblast growth factor receptor 2 isoform X3 [KO:K05093] [EC:2.7.10.1]
102939991  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
102930286  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
102941686  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
102937369  CBL; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
102943844  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
102935495  SH3KBP1; SH3 domain-containing kinase-binding protein 1 isoform X3 [KO:K12470]
102940980  SH3GL3; endophilin-A3 isoform X1 [KO:K11247]
102930309  SH3GL1; endophilin-A2 isoform X2 [KO:K11247]
102939213  SH3GL2; endophilin-A1 isoform X1 [KO:K11247]
102946722  SH3GLB1; endophilin-B1 isoform X3 [KO:K11248]
102929690  SH3GLB2; endophilin-B2 isoform X1 [KO:K21269]
102930903  BIN1; myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
102940438  AMPH; amphiphysin isoform X1 [KO:K12562]
102930816  EPN1; epsin-1 isoform X1 [KO:K12471]
102941402  EPN2; epsin-2 isoform X1 [KO:K12471]
102932379  EPN3; epsin-3 isoform X1 [KO:K12471]
102931725  EPS15L1; epidermal growth factor receptor substrate 15-like 1 isoform X8 [KO:K12472]
102941498  EPS15; epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
102939978  SPART; spartin isoform X2 [KO:K19366]
102941997  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
102934363  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
102948375  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
102938959  TRAF6; TNF receptor-associated factor 6 isoform X2 [KO:K03175] [EC:2.3.2.27]
102945657  RNF41; E3 ubiquitin-protein ligase NRDP1 isoform X1 [KO:K11981] [EC:2.3.2.27]
102942150  ITCH; E3 ubiquitin-protein ligase Itchy homolog isoform X2 [KO:K05632] [EC:2.3.2.26]
102932568  SMURF2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
102944839  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
102941009  WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
102937401  LDLR; low-density lipoprotein receptor isoform X1 [KO:K12473]
102933449  LDLRAP1; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
102939051  low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
102944853  DAB2; disabled homolog 2 isoform X1 [KO:K12475]
102942912  C-C chemokine receptor type 5 isoform X2 [KO:K04180]
102930284  C-C chemokine receptor type 5 [KO:K04180]
102942686  C-C chemokine receptor type 5 [KO:K04180]
102935676  C-X-C chemokine receptor type 2 [KO:K05050]
102947229  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
102942787  GRK1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
102935951  GRK7; rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
102947181  GRK2; beta-adrenergic receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
102946005  GRK3; beta-adrenergic receptor kinase 2 isoform X2 [KO:K00910] [EC:2.7.11.15]
102948318  G protein-coupled receptor kinase 5 isoform X2 [KO:K08291] [EC:2.7.11.16]
102936492  GRK4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
102943434  GRK5; G protein-coupled receptor kinase 5 isoform X2 [KO:K08291] [EC:2.7.11.16]
102944452  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
102933073  ARRB1; beta-arrestin-1 isoform X3 [KO:K04439]
102933050  WASL; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
102930625  actin-related protein 2-B [KO:K17260]
102933572  ACTR2; actin-related protein 2 isoform X2 [KO:K17260]
102947890  ACTR3B; LOW QUALITY PROTEIN: actin-related protein 3B [KO:K18584]
102943280  ACTR3; actin-related protein 3 [KO:K18584]
102938039  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
102938264  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
102934111  ARPC2; actin-related protein 2/3 complex subunit 2 isoform X1 [KO:K05758]
102931677  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
102940324  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
102931984  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
102942455  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
102939788  WIPF1; WAS/WASL-interacting protein family member 1 [KO:K19475]
102930057  WIPF2; WAS/WASL-interacting protein family member 2 [KO:K19475]
102933923  WIPF3; WAS/WASL-interacting protein family member 3 [KO:K19475]
102932979  heat shock 70 kDa protein 1A [KO:K03283]
102932086  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
102935471  LOW QUALITY PROTEIN: heat shock 70 kDa protein 1A [KO:K03283]
102947120  heat shock cognate 71 kDa protein [KO:K03283]
102945280  DNAJC6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
102947253  WASHC4; WASH complex subunit 4 isoform X1 [KO:K18465]
102942584  WASHC5; WASH complex subunit 5 [KO:K18464]
102937143  WASH complex subunit 2A isoform X3 [KO:K18462]
102936850  WASHC1; WASH complex subunit 1 isoform X1 [KO:K18461]
102933299  WASHC3; WASH complex subunit 3 isoform X1 [KO:K18463]
102942206  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
102930120  CAPZA1; F-actin-capping protein subunit alpha-1 isoform X2 [KO:K10364]
102933081  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
119567201  F-actin-capping protein subunit alpha-1-like [KO:K10364]
102937526  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
102936945  VPS29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
102935357  vacuolar protein sorting-associated protein 29-like [KO:K18467]
102934501  VPS26B; vacuolar protein sorting-associated protein 26B [KO:K18466]
102939707  VPS26A; vacuolar protein sorting-associated protein 26A isoform X1 [KO:K18466]
102942902  VPS35; vacuolar protein sorting-associated protein 35 isoform X2 [KO:K18468]
102933934  SNX12; sorting nexin-12 isoform X1 [KO:K17918]
102932198  SNX3; sorting nexin-3 isoform X2 [KO:K17918]
102938345  USP8; ubiquitin carboxyl-terminal hydrolase 8 isoform X1 [KO:K11839] [EC:3.4.19.12]
102946719  STAM-binding protein [KO:K11866] [EC:3.4.19.12]
102945633  RAB7A; ras-related protein Rab-7a [KO:K07897]
102936133  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
102942512  STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705]
102943489  STAM; signal transducing adapter molecule 1 isoform X1 [KO:K04705]
102935426  TSG101; tumor susceptibility gene 101 protein [KO:K12183]
102939438  MVB12B; multivesicular body subunit 12B isoform X2 [KO:K12186]
102944981  MVB12A; multivesicular body subunit 12A isoform X1 [KO:K12186]
102939245  VPS28; vacuolar protein sorting-associated protein 28 homolog isoform X1 [KO:K12184]
102938355  VPS37D; vacuolar protein sorting-associated protein 37D isoform X1 [KO:K12185]
102937009  VPS37C; vacuolar protein sorting-associated protein 37C isoform X4 [KO:K12185]
102930777  VPS37B; vacuolar protein sorting-associated protein 37B [KO:K12185]
102929697  VPS37A; vacuolar protein sorting-associated protein 37A isoform X1 [KO:K12185]
102937506  SNF8; vacuolar-sorting protein SNF8 isoform X1 [KO:K12188]
102937212  VPS36; vacuolar protein-sorting-associated protein 36 isoform X1 [KO:K12190]
102944270  VPS25; vacuolar protein-sorting-associated protein 25 isoform X2 [KO:K12189]
102945166  CHMP6; charged multivesicular body protein 6 [KO:K12195]
102941478  CHMP4B; charged multivesicular body protein 4b isoform X1 [KO:K12194]
102931585  CHMP4C; charged multivesicular body protein 4c [KO:K24782]
102944235  CHMP2A; charged multivesicular body protein 2a [KO:K12191]
102933951  CHMP2B; charged multivesicular body protein 2b isoform X2 [KO:K12192]
102945355  CHMP7; charged multivesicular body protein 7 isoform X3 [KO:K15053]
102947817  VPS4B; vacuolar protein sorting-associated protein 4B [KO:K12196]
102934928  VPS4A; vacuolar protein sorting-associated protein 4A isoform X4 [KO:K12196]
102936189  VTA1; vacuolar protein sorting-associated protein VTA1 homolog isoform X1 [KO:K12199]
102945387  CHMP1B; charged multivesicular body protein 1b [KO:K12197]
102930782  CHMP1A; charged multivesicular body protein 1a [KO:K12197]
102946087  CHMP5; charged multivesicular body protein 5 [KO:K12198]
102929548  IST1; IST1 homolog isoform X1 [KO:K19476]
102930263  programmed cell death 6-interacting protein isoform X1 [KO:K12200]
102938076  SPG21; maspardin [KO:K19367]
102937133  IGF2R; cation-independent mannose-6-phosphate receptor isoform X1 [KO:K06564]
102938525  SNX1; sorting nexin-1 isoform X1 [KO:K17917]
102941063  SNX2; sorting nexin-2 isoform X1 [KO:K17917]
102938675  SNX32; sorting nexin-32 isoform X2 [KO:K17920]
102937585  SNX5; sorting nexin-5 isoform X1 [KO:K17920]
102931626  SNX6; sorting nexin-6 isoform X2 [KO:K17920]
102939716  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
102946454  HRAS; GTPase HRas [KO:K02833]
102937403  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
102936500  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
102933244  IL2RG; cytokine receptor common subunit gamma isoform X3 [KO:K05070]
102933456  transforming protein RhoA isoform X2 [KO:K04513]
102939658  RHOA; transforming protein RhoA [KO:K04513]
102930774  class I histocompatibility antigen, F10 alpha chain isoform X1 [KO:K06751]
102937624  class I histocompatibility antigen, F10 alpha chain isoform X1 [KO:K06751]
102936111  class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751]
102929674  class I histocompatibility antigen, F10 alpha chain isoform X1 [KO:K06751]
102930327  H-2 class I histocompatibility antigen, Q9 alpha chain isoform X1 [KO:K06751]
102940274  class I histocompatibility antigen, F10 alpha chain isoform X1 [KO:K06751]
102941992  class I histocompatibility antigen, F10 alpha chain isoform X1 [KO:K06751]
102945483  class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751]
119566026  class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751]
119566027  class I histocompatibility antigen, F10 alpha chain isoform X1 [KO:K06751]
102934511  riboflavin-binding protein [KO:K13649]
102929386  folate receptor gamma isoform X3 [KO:K13649]
102936645  RTBDN; retbindin isoform X1 [KO:K13649]
119567468  folate receptor gamma-like isoform X1 [KO:K13649]
102946208  CAV1; caveolin-1 isoform X1 [KO:K06278]
102932255  CAV2; caveolin-2 [KO:K12958]
102937725  CAV3; caveolin-3 [KO:K12959]
102931651  EHD3; EH domain-containing protein 3 [KO:K12476]
102948182  EHD4; EH domain-containing protein 4 [KO:K12477]
102946277  EEA1; early endosome antigen 1 isoform X1 [KO:K12478]
102943972  RAB5A; ras-related protein Rab-5A [KO:K07887]
102944451  RAB5B; ras-related protein Rab-5B [KO:K07888]
102932413  RAB5C; ras-related protein Rab-5C [KO:K07889]
102935439  RABEP1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
102938097  RBSN; rabenosyn-5 isoform X1 [KO:K12481]
102938587  RAB4A; ras-related protein Rab-4A [KO:K07879]
102935424  RUFY1; RUN and FYVE domain-containing protein 1 isoform X2 [KO:K12482]
102931891  RUFY2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
102937227  EHD1; EH domain-containing protein 1 [KO:K12483]
102944399  VPS45; vacuolar protein sorting-associated protein 45 isoform X1 [KO:K12479]
102946765  SNX4; sorting nexin-4 isoform X1 [KO:K17919]
102934697  RAB22A; ras-related protein Rab-22A [KO:K07891]
102931990  RAB31; ras-related protein Rab-31 isoform X2 [KO:K07891]
102938021  ras-related protein Rab-10 isoform X1 [KO:K07903]
102938549  RAB10; ras-related protein Rab-10 [KO:K07903]
102930684  RAB8A; ras-related protein Rab-8A isoform X1 [KO:K07901]
102932847  ras-related protein Rab-35 [KO:K07876]
102932102  RAB35; ras-related protein Rab-35 [KO:K07876]
102944668  RAB11A; ras-related protein Rab-11A isoform X1 [KO:K07904]
102937282  ras-related protein Rab-11A [KO:K07904]
102937795  RAB11B; ras-related protein Rab-11B [KO:K07905]
102930982  RAB11FIP1; rab11 family-interacting protein 1 isoform X1 [KO:K12484]
102944535  RAB11FIP2; rab11 family-interacting protein 2 isoform X1 [KO:K12484]
114018485  RAB11FIP5; rab11 family-interacting protein 5 isoform X2 [KO:K12484]
102931883  ZFYVE27; protrudin isoform X1 [KO:K19368]
102946221  KIF5B; kinesin-1 heavy chain isoform X7 [KO:K10396]
102945877  KIF5C; kinesin heavy chain isoform X1 [KO:K10396]
119564312  KIF5A; kinesin heavy chain isoform X1 [KO:K10396]
102938164  RAB11FIP3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
102934380  RAB11FIP4; rab11 family-interacting protein 4 isoform X2 [KO:K12485]
102936016  PARD3; partitioning defective 3 homolog isoform X2 [KO:K04237]
102937533  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
102930784  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
102946694  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
102936764  PRKCZ; protein kinase C zeta type isoform X5 [KO:K18952] [EC:2.7.11.13]
102942221  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
102931327  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102930899  SMAP1; stromal membrane-associated protein 1 isoform X1 [KO:K12486]
102943279  SMAP2; stromal membrane-associated protein 2 isoform X1 [KO:K12486]
102938832  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
102944511  GIT2; ARF GTPase-activating protein GIT2 isoform X2 [KO:K12487]
102933852  ASAP2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
102931959  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
102931030  ASAP1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X3 [KO:K12488]
102936595  ASAP3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12488]
102937841  ACAP2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X3 [KO:K12489]
102933458  ACAP3; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12489]
102930011  ARAP1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
102939724  ARAP2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K18440]
102941861  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
102940633  AGAP3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12491]
102929673  AGAP1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X7 [KO:K12491]
102947698  AGAP2; LOW QUALITY PROTEIN: arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 [KO:K17848]
102937343  ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1 isoform X2 [KO:K12492]
102945375  ARFGAP3; ADP-ribosylation factor GTPase-activating protein 3 isoform X2 [KO:K12493]
102942215  ARFGAP2; ADP-ribosylation factor GTPase-activating protein 2 isoform X1 [KO:K12493]
102932475  PSD4; PH and SEC7 domain-containing protein 4 isoform X1 [KO:K12494]
102943248  PSD; PH and SEC7 domain-containing protein 1 isoform X2 [KO:K12494]
102937332  PSD3; PH and SEC7 domain-containing protein 3 isoform X1 [KO:K12494]
102946313  PSD2; PH and SEC7 domain-containing protein 2 [KO:K12494]
102937229  IQSEC3; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
102931899  IQSEC1; IQ motif and SEC7 domain-containing protein 1 isoform X9 [KO:K12495]
114018212  IQSEC2; IQ motif and SEC7 domain-containing protein 2 [KO:K12495]
102930141  CYTH1; cytohesin-1 isoform X2 [KO:K18441]
102935823  CYTH4; cytohesin-4 isoform X1 [KO:K18441]
102946215  CYTH2; cytohesin-2 [KO:K18441]
102946235  CYTH3; cytohesin-3 isoform X1 [KO:K18441]
102938299  ARFGEF1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X1 [KO:K18442]
102947666  ARFGEF2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1 [KO:K18442]
102943684  GBF1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
102933772  ARF1; ADP-ribosylation factor 1 [KO:K07937]
102941438  ADP-ribosylation factor 2 [KO:K07937]
102937363  ARF3; ADP-ribosylation factor 3 [KO:K07938]
102945637  ARF4; ADP-ribosylation factor 4 [KO:K07939]
102946427  ARF5; ADP-ribosylation factor 5 isoform X1 [KO:K07940]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
cmy04060  Cytokine-cytokine receptor interaction
cmy04070  Phosphatidylinositol signaling system
cmy04130  SNARE interactions in vesicular transport
cmy04142  Lysosome
cmy04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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