KEGG   PATHWAY: dnm05417
Entry
dnm05417                    Pathway                                
Name
Lipid and atherosclerosis - Dasypus novemcinctus (nine-banded armadillo)
Description
Atherosclerosis is a chronic inflammatory disease marked by a narrowing of the arteries from lipid-rich plaques present within the walls of arterial blood vessels. It represents the root cause of the majority of cardiovascular diseases (CVDs) and their complications, including conditions such as coronary artery disease, myocardial infarction and stroke.  An elevated level of low density lipoprotein (LDL) cholesterol constitutes a major risk factor for genesis of atherosclerosis. LDL can accumulate within the blood vessel wall and undergo modification by oxidation. Oxidized LDL (oxLDL) leads to endothelial dysfunction leading to expression of adhesion molecules and recruitment of monocyte in subendothelial space. The monocytes proliferate, differentiate into macrophages, and take up the lipoproteins, forming cholesterol-engorged "foam cells." With the time, the foam cells die, leaving a 'necrotic core' of crystalline cholesterol and cell debris. Smooth muscle cells proliferate and migrate into the region, laying down a protective cap over the lesion. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), which mediates the recognition and internalization of oxLDL, is involved in all of these events critical in the pathogenesis of atherosclerosis.
Class
Human Diseases; Cardiovascular disease
Pathway map
dnm05417  Lipid and atherosclerosis
dnm05417

Organism
Dasypus novemcinctus (nine-banded armadillo) [GN:dnm]
Gene
101425566  APOB; LOW QUALITY PROTEIN: apolipoprotein B-100 [KO:K14462]
101432298  APOA4; apolipoprotein A-IV [KO:K08760]
101432754  APOA1; apolipoprotein A-I [KO:K08757]
101411649  LDLR; low-density lipoprotein receptor [KO:K12473]
101418828  OLR1; oxidized low-density lipoprotein receptor 1 [KO:K08763]
101437125  ARHGEF1; rho guanine nucleotide exchange factor 1 [KO:K12330]
101432285  interstitial collagenase-like [KO:K01388] [EC:3.4.24.7]
101411093  MMP1; interstitial collagenase [KO:K01388] [EC:3.4.24.7]
101443396  transforming protein RhoA-like isoform X1 [KO:K04513]
101413434  RHOA; transforming protein RhoA [KO:K04513]
101428161  LOW QUALITY PROTEIN: rho-associated protein kinase 2-like [KO:K17388] [EC:2.7.11.1]
101433723  NOS3; LOW QUALITY PROTEIN: nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
101444276  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101443761  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101426945  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101423744  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
101435351  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101433347  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101419022  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101428799  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101445813  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101432154  BAX; apoptosis regulator BAX [KO:K02159]
101414407  BAD; bcl2-associated agonist of cell death [KO:K02158]
101427892  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
101445333  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
101423710  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
101416102  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101421932  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101426028  SOD2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
101447838  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101422998  POU2F3; POU domain, class 2, transcription factor 3 isoform X1 [KO:K09364]
101420836  POU2F2; POU domain, class 2, transcription factor 2 [KO:K09364]
101426439  POU2F1; POU domain, class 2, transcription factor 1 [KO:K09364]
101440382  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
101426835  CD40LG; CD40 ligand [KO:K03161]
101423437  cytochrome P450 1A1 isoform X1 [KO:K07408] [EC:1.14.14.1]
101447575  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
101411038  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
101438656  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
101439086  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
101439781  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
101440653  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
101440211  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
101437056  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
101438376  AGER; advanced glycosylation end product-specific receptor [KO:K19722]
101435396  cytochrome b-245 heavy chain isoform X3 [KO:K21421] [EC:1.-.-.-]
101422303  neutrophil cytosol factor 1-like [KO:K08011]
101439361  NCF2; neutrophil cytosol factor 2 [KO:K08010]
101422829  NCF4; neutrophil cytosol factor 4 [KO:K08012]
101421086  RAC1; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101426457  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
101416389  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
101444225  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
101421534  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101415898  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
101420451  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101431782  FOS; proto-oncogene c-Fos [KO:K04379]
101412001  JUN; transcription factor AP-1 [KO:K04448]
101422028  C-C motif chemokine 2 [KO:K14624]
101422470  monocyte chemotactic protein 1B-like [KO:K14624]
101427372  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
101441641  CXCL8; interleukin-8 precursor [KO:K10030]
101431376  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
101425795  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101426841  MAPK13; mitogen-activated protein kinase 13 isoform X2 [KO:K04441] [EC:2.7.11.24]
101415496  MAPK12; mitogen-activated protein kinase 12 isoform X2 [KO:K04441] [EC:2.7.11.24]
101416217  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
101419480  HRAS; GTPase HRas isoform X1 [KO:K02833]
101412233  KRAS; GTPase KRas isoform X4 [KO:K07827]
101430817  NRAS; GTPase NRas [KO:K07828]
101414240  LOW QUALITY PROTEIN: GTPase NRas-like [KO:K07828]
101430570  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101435742  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101417885  RELA; transcription factor p65 [KO:K04735]
101437556  NFKB1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
101443096  SELE; E-selectin isoform X2 [KO:K06494]
101446112  SELP; P-selectin isoform X1 [KO:K06496]
101433545  VCAM1; vascular cell adhesion protein 1 isoform X1 [KO:K06527]
101447627  stromelysin-1 [KO:K01394] [EC:3.4.24.17]
101438233  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
101413233  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
101445167  IL1B; interleukin-1 beta [KO:K04519]
101429481  LOW QUALITY PROTEIN: interleukin-6-like [KO:K05405]
101443963  IL6; interleukin-6 [KO:K05405]
101420445  TNF; tumor necrosis factor [KO:K03156]
101416344  HSPD1; 60 kDa heat shock protein, mitochondrial [KO:K04077] [EC:5.6.1.7]
101420025  heat shock 70 kDa protein 1-like [KO:K03283]
101419752  heat shock-related 70 kDa protein 2-like [KO:K03283]
101411149  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
101414850  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
101419052  HSPA2; LOW QUALITY PROTEIN: heat shock-related 70 kDa protein 2 [KO:K26598]
101418570  HSPA4; heat shock 70 kDa protein 4 isoform X1 [KO:K09489]
101442872  heat shock protein HSP 90-alpha A2 [KO:K04079]
101438170  HSP90B1; endoplasmin [KO:K09487]
101421345  TLR2; toll-like receptor 2 [KO:K10159]
111765424  lipopolysaccharide-binding protein-like isoform X1 [KO:K05399]
101432584  lipopolysaccharide-binding protein isoform X2 [KO:K05399]
101432619  lipopolysaccharide-binding protein-like [KO:K05399]
101425522  monocyte differentiation antigen CD14-like [KO:K04391]
101428020  monocyte differentiation antigen CD14 [KO:K04391]
101413961  LY96; lymphocyte antigen 96 [KO:K05400]
101436464  TLR4; toll-like receptor 4 [KO:K10160]
101445854  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
101431630  MYD88; LOW QUALITY PROTEIN: myeloid differentiation primary response protein MyD88 [KO:K04729]
101411653  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
101419116  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
101438500  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101412966  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
101447376  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
101416090  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101429772  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
101411204  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
101439489  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101412730  NFKBIA; LOW QUALITY PROTEIN: NF-kappa-B inhibitor alpha [KO:K04734]
101433072  TICAM2; TIR domain-containing adapter molecule 2 [KO:K05409]
101433765  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
101437632  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
101426746  MIB1; E3 ubiquitin-protein ligase MIB1 [KO:K10645] [EC:2.3.2.27]
101443730  MIB2; E3 ubiquitin-protein ligase MIB2 [KO:K10645] [EC:2.3.2.27]
101429222  TANK; TRAF family member-associated NF-kappa-B activator [KO:K12650]
101413159  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
101429820  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
101422123  IRF7; interferon regulatory factor 7 [KO:K09447]
101415954  IRF3; interferon regulatory factor 3 [KO:K05411]
101447879  interferon alpha-2-like [KO:K05414]
101432987  interferon alpha-3-like [KO:K05414]
101425111  interferon alpha-2-like [KO:K05414]
101418868  interferon alpha-2-like [KO:K05414]
101419317  interferon alpha-2-like [KO:K05414]
101419758  interferon alpha-2-like [KO:K05414]
101410923  IFNB1; interferon beta [KO:K05415]
101447090  CD36; LOW QUALITY PROTEIN: platelet glycoprotein 4 [KO:K06259]
101418117  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
101411907  RXRA; retinoic acid receptor RXR-alpha isoform X2 [KO:K08524]
101414688  RXRB; LOW QUALITY PROTEIN: retinoic acid receptor RXR-beta [KO:K08525]
101428198  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
101429842  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
101420176  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
101446965  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
101416459  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
101429660  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
100913181  TLR6; toll-like receptor 6 precursor [KO:K10169]
101412472  ras-related protein Rap-1A-like [KO:K04353]
101431654  RAP1A; ras-related protein Rap-1A [KO:K04353]
101431477  ras-related protein Rap-1b-like protein [KO:K07836]
101421103  RAP1B; ras-related protein Rap-1b [KO:K07836]
101438491  CCL5; C-C motif chemokine 5 isoform X2 [KO:K12499]
101440785  C-C motif chemokine 3-like isoform X1 [KO:K05408]
101441498  C-C motif chemokine 3-like [KO:K05408]
101441948  C-C motif chemokine 3-like [KO:K05408]
101442965  growth-regulated protein homolog gamma-like [KO:K05505]
101443410  growth-regulated protein homolog gamma-like [KO:K05505]
101425226  IL12A; LOW QUALITY PROTEIN: interleukin-12 subunit alpha [KO:K05406]
101432053  IL12B; interleukin-12 subunit beta [KO:K05425]
101435494  NLRP3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800]
101427328  IL18; interleukin-18 [KO:K05482]
101433325  HSPA5; 78 kDa glucose-regulated protein [KO:K09490] [EC:3.6.4.10]
101411485  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
101427474  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
101428798  ERO1A; ERO1-like protein alpha [KO:K10950] [EC:1.8.4.-]
101429543  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
101442429  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X2 [KO:K04515] [EC:2.7.11.17]
101445683  CAMK2B; LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
101438745  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X4 [KO:K04515] [EC:2.7.11.17]
101427403  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
101414351  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X3 [KO:K08860] [EC:2.7.11.1]
101421250  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
101410933  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101410879  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
101435833  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
101412100  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
101411083  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
101422727  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
101417886  ABCA1; ATP-binding cassette sub-family A member 1 [KO:K05641]
101433778  ABCG1; ATP-binding cassette sub-family G member 1 [KO:K05679]
101420654  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
101413966  PYCARD; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
101418396  CASP1; caspase-1 isoform X1 [KO:K01370] [EC:3.4.22.36]
101422102  VLDLR; very low-density lipoprotein receptor isoform X1 [KO:K20053]
101432391  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
101417330  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101427882  NFATC1; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
101417008  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
101424450  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X2 [KO:K17333]
101420315  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
101419878  PLCB4; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
101413654  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X2 [KO:K05858] [EC:3.1.4.11]
101427179  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X2 [KO:K05858] [EC:3.1.4.11]
101411498  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
101430299  calmodulin-like [KO:K02183]
101416595  CALM2; calmodulin-2 [KO:K02183]
105744587  calmodulin-like [KO:K02183]
101417995  CALM1; calmodulin-1 [KO:K02183]
101437415  calmodulin-like protein 3 [KO:K02183]
101412843  CALML4; calmodulin-like protein 4 isoform X2 [KO:K02183]
101426965  CALM3; calmodulin-3 [KO:K02183]
101435854  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101420075  PPP3CC; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
101427629  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101440970  calcineurin subunit B type 2 [KO:K06268]
101435481  TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721]
101438083  TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K04722]
101431862  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101417353  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
101432853  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
101438266  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
111763660  cytochrome c-like [KO:K08738]
111764560  cytochrome c-like [KO:K08738]
101413106  cytochrome c [KO:K08738]
101433110  cytochrome c-like [KO:K08738]
101442884  cytochrome c-like [KO:K08738]
101413908  cytochrome c [KO:K08738]
101416149  cytochrome c [KO:K08738]
111759729  cytochrome c-like [KO:K08738]
101432735  APAF1; apoptotic protease-activating factor 1 isoform X2 [KO:K02084]
101432519  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
101421085  CASP6; caspase-6 isoform X1 [KO:K04396] [EC:3.4.22.59]
101441936  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
101429170  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
101416069  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00187  Cholesterol
C00338  Lipopolysaccharide
C00422  Triacylglycerol
C00704  Superoxide
C00865  Phospholipid
C01245  D-myo-Inositol 1,4,5-trisphosphate
C02530  Cholesterol ester
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:23899566
  Authors
Hopkins PN
  Title
Molecular biology of atherosclerosis.
  Journal
Physiol Rev 93:1317-542 (2013)
DOI:10.1152/physrev.00004.2012
Reference
PMID:22064431
  Authors
Weber C, Noels H
  Title
Atherosclerosis: current pathogenesis and therapeutic options.
  Journal
Nat Med 17:1410-22 (2011)
DOI:10.1038/nm.2538
Reference
PMID:25869663
  Authors
Tabas I, Garcia-Cardena G, Owens GK
  Title
Recent insights into the cellular biology of atherosclerosis.
  Journal
J Cell Biol 209:13-22 (2015)
DOI:10.1083/jcb.201412052
Reference
PMID:25614320
  Authors
Tall AR, Yvan-Charvet L
  Title
Cholesterol, inflammation and innate immunity.
  Journal
Nat Rev Immunol 15:104-16 (2015)
DOI:10.1038/nri3793
Reference
PMID:31336709
  Authors
Kattoor AJ, Goel A, Mehta JL
  Title
LOX-1: Regulation, Signaling and Its Role in Atherosclerosis.
  Journal
Antioxidants (Basel) 8:E218 (2019)
DOI:10.3390/antiox8070218
Reference
PMID:11985903
  Authors
Mehta JL, Li D
  Title
Identification, regulation and function of a novel lectin-like oxidized low-density lipoprotein receptor.
  Journal
J Am Coll Cardiol 39:1429-35 (2002)
DOI:10.1016/s0735-1097(02)01803-x
Reference
PMID:19286611
  Authors
Li D, Mehta JL
  Title
Intracellular signaling of LOX-1 in endothelial cell apoptosis.
  Journal
Circ Res 104:566-8 (2009)
DOI:10.1161/CIRCRESAHA.109.194209
Reference
PMID:24886290
  Authors
Lubrano V, Balzan S
  Title
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Related
pathway
dnm04020  Calcium signaling pathway
dnm04115  p53 signaling pathway
dnm04141  Protein processing in endoplasmic reticulum
dnm04151  PI3K-Akt signaling pathway
dnm04210  Apoptosis
dnm04620  Toll-like receptor signaling pathway
dnm04621  NOD-like receptor signaling pathway
dnm04668  TNF signaling pathway
dnm04670  Leukocyte transendothelial migration
dnm04975  Fat digestion and absorption
dnm04979  Cholesterol metabolism
dnm05418  Fluid shear stress and atherosclerosis
KO pathway
ko05417   
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