KEGG   PATHWAY: ecb04144
Entry
ecb04144                    Pathway                                
Name
Endocytosis - Equus caballus (horse)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
ecb04144  Endocytosis
ecb04144

Other DBs
GO: 0006897
Organism
Equus caballus (horse) [GN:ecb]
Gene
100065920  ARF6; ADP-ribosylation factor 6 [KO:K07941]
100050520  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
100059655  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
111774175  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
100070364  phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1 [KO:K13712] [EC:2.7.1.68]
100070387  PIP5KL1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1 [KO:K13712] [EC:2.7.1.68]
100072863  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
100057774  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
100070282  DNM1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
100060156  DNM3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
100057627  DNM2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
100055375  CLTA; clathrin light chain A isoform X1 [KO:K04644]
100068882  CLTB; clathrin light chain B isoform X3 [KO:K04645]
100057364  CLTC; clathrin heavy chain 1 isoform X2 [KO:K04646]
100053137  clathrin heavy chain 2 isoform X1 [KO:K04646]
100056103  AP2A1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
100056318  AP2A2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
100058050  AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825]
100058961  AP2M1; AP-2 complex subunit mu isoform X1 [KO:K11826]
100071193  AP2S1; AP-2 complex subunit sigma [KO:K11827]
100073053  EHD2; EH domain-containing protein 2 [KO:K12469]
100034117  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
100033860  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
100062152  ZFYVE9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
100065363  ZFYVE16; zinc finger FYVE domain-containing protein 16 [KO:K04679]
100062744  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
100033843  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
100033845  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
100034089  TFRC; transferrin receptor protein 1 [KO:K06503]
100067755  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100059815  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100033956  FGFR2; fibroblast growth factor receptor 2 precursor [KO:K05093] [EC:2.7.10.1]
100034114  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100068679  FGFR4; fibroblast growth factor receptor 4 isoform X2 [KO:K05095] [EC:2.7.10.1]
100055698  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100071403  CBL; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
100061819  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
100147299  CBLC; E3 ubiquitin-protein ligase CBL-C isoform X1 [KO:K22518] [EC:2.3.2.27]
100058644  SH3KBP1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
100063235  SH3GL2; endophilin-A1 [KO:K11247]
100146122  SH3GL1; endophilin-A2 isoform X1 [KO:K11247]
100067811  endophilin-A3 isoform X6 [KO:K11247]
100052441  SH3GLB1; endophilin-B1 isoform X1 [KO:K11248]
100070104  SH3GLB2; endophilin-B2 isoform X1 [KO:K21269]
100062724  AMPH; amphiphysin isoform X3 [KO:K12562]
100052213  BIN1; myc box-dependent-interacting protein 1 isoform X2 [KO:K12562]
100056408  EPN3; epsin-3 isoform X2 [KO:K12471]
100050807  EPN1; epsin-1 isoform X1 [KO:K12471]
100073176  EPN2; epsin-2 isoform X1 [KO:K12471]
100062532  EPS15; epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
100069848  EPS15L1; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
100062426  SPART; spartin isoform X2 [KO:K19366]
100054735  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X2 [KO:K10591] [EC:2.3.2.26]
100054395  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X7 [KO:K13305] [EC:2.3.2.26]
100052084  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
100052296  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
100052095  RNF41; E3 ubiquitin-protein ligase NRDP1 isoform X1 [KO:K11981] [EC:2.3.2.27]
100069340  ITCH; E3 ubiquitin-protein ligase Itchy homolog [KO:K05632] [EC:2.3.2.26]
100063241  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
100064082  SMURF2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
100055725  WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
100057389  LDLR; low-density lipoprotein receptor [KO:K12473]
100071282  LDLRAP1; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
100066655  DAB2; disabled homolog 2 isoform X1 [KO:K12475]
100048935  CCR5; C-C chemokine receptor type 5 [KO:K04180]
100058291  C-X-C chemokine receptor type 2 [KO:K04175]
100055552  CXCR2; C-X-C chemokine receptor type 2 isoform X1 [KO:K05050]
100050974  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
100062922  GRK7; rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
100069151  GRK1; rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
100065495  GRK3; beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
100059001  GRK2; beta-adrenergic receptor kinase 1 isoform X1 [KO:K00910] [EC:2.7.11.15]
111767400  GRK3; beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
100068570  GRK6; G protein-coupled receptor kinase 6 isoform X4 [KO:K08291] [EC:2.7.11.16]
100053624  GRK4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
100065919  GRK5; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
100064657  ARRB1; beta-arrestin-1 isoform X4 [KO:K04439]
100072892  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
100071546  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
111770701  uncharacterized protein LOC111770701 [KO:K23612]
100063005  ACTR2; actin-related protein 2 isoform X2 [KO:K17260]
100065073  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
100033909  ACTR3; actin-related protein 3 [KO:K18584]
100059256  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
100059292  ARPC1B; actin-related protein 2/3 complex subunit 1B isoform X1 [KO:K05757]
100058331  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
100058336  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
100058358  actin-related protein 2/3 complex subunit 4 isoform X14 [KO:K05755]
100067289  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
100051848  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
100064973  WIPF1; WAS/WASL-interacting protein family member 1 [KO:K19475]
106783281  WIPF2; WAS/WASL-interacting protein family member 2 isoform X2 [KO:K19475]
100069699  WIPF3; WAS/WASL-interacting protein family member 3 [KO:K19475]
100050827  HSPA1A; heat shock 70kDa protein 1A [KO:K03283]
100051595  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
100050904  heat shock 70 kDa protein 1-like [KO:K03283]
100009679  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
111769297  LOW QUALITY PROTEIN: heat shock 70 kDa protein 1-like [KO:K03283]
100069605  DNAJC6; putative tyrosine-protein phosphatase auxilin isoform X4 [KO:K09526]
100068154  WASHC4; WASH complex subunit 4 isoform X1 [KO:K18465]
100057703  WASHC5; WASH complex subunit 5 isoform X1 [KO:K18464]
100062210  WASH complex subunit 2 isoform X1 [KO:K18462]
100050616  WASHC1; WASH complex subunit 1 isoform X2 [KO:K18461]
100053117  WASHC3; WASH complex subunit 3 isoform X2 [KO:K18463]
100071181  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
100067825  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
100063967  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
111773934  F-actin-capping protein subunit alpha-3 [KO:K10364]
111773936  F-actin-capping protein subunit alpha-3 [KO:K10364]
100071897  CAPZB; F-actin-capping protein subunit beta isoform X2 [KO:K10365]
100058295  VPS29; vacuolar protein sorting-associated protein 29 isoform X2 [KO:K18467]
100072671  VPS26A; vacuolar protein sorting-associated protein 26A [KO:K18466]
100072880  VPS26B; vacuolar protein sorting-associated protein 26B isoform X1 [KO:K18466]
102149786  VPS26A; vacuolar protein sorting-associated protein 26A isoform X1 [KO:K18466]
100056512  VPS35; vacuolar protein sorting-associated protein 35 [KO:K18468]
100066515  SNX3; sorting nexin-3 [KO:K17918]
106781357  SNX12; sorting nexin-12 isoform X1 [KO:K17918]
100055443  USP8; ubiquitin carboxyl-terminal hydrolase 8 isoform X1 [KO:K11839] [EC:3.4.19.12]
100049814  STAMBP; STAM-binding protein isoform X3 [KO:K11866] [EC:3.4.19.12]
100050015  RAB7A; ras-related protein Rab-7a [KO:K07897]
100055613  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
100057966  STAM2; signal transducing adapter molecule 2 [KO:K04705]
100068325  STAM; signal transducing adapter molecule 1 isoform X1 [KO:K04705]
100057099  TSG101; tumor susceptibility gene 101 protein [KO:K12183]
100070171  MVB12A; multivesicular body subunit 12A isoform X3 [KO:K12186]
100070649  MVB12B; multivesicular body subunit 12B isoform X1 [KO:K12186]
100063246  VPS28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
100061734  VPS37D; vacuolar protein sorting-associated protein 37D isoform X1 [KO:K12185]
100058900  VPS37B; vacuolar protein sorting-associated protein 37B isoform X2 [KO:K12185]
100059152  VPS37C; vacuolar protein sorting-associated protein 37C isoform X1 [KO:K12185]
100050168  VPS37A; vacuolar protein sorting-associated protein 37A [KO:K12185]
100055830  SNF8; vacuolar-sorting protein SNF8 [KO:K12188]
100147348  VPS36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
100147466  VPS25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
100050276  CHMP6; charged multivesicular body protein 6 [KO:K12195]
100069227  CHMP4B; charged multivesicular body protein 4b [KO:K12194]
100051233  CHMP4A; LOW QUALITY PROTEIN: charged multivesicular body protein 4a [KO:K12194]
100057184  CHMP4C; charged multivesicular body protein 4c isoform X1 [KO:K24782]
100066925  CHMP3; charged multivesicular body protein 3 isoform X3 [KO:K12193]
100064860  CHMP2A; charged multivesicular body protein 2a isoform X1 [KO:K12191]
100070130  CHMP2B; charged multivesicular body protein 2b isoform X1 [KO:K12192]
100053928  CHMP7; charged multivesicular body protein 7 isoform X2 [KO:K15053]
100051010  VPS4B; vacuolar protein sorting-associated protein 4B [KO:K12196]
100067034  VPS4A; vacuolar protein sorting-associated protein 4A isoform X1 [KO:K12196]
100060736  VTA1; vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
100071734  charged multivesicular body protein 1b-2 [KO:K12197]
100052260  CHMP1A; charged multivesicular body protein 1a [KO:K12197]
102149828  CHMP1B; charged multivesicular body protein 1b [KO:K12197]
100068283  CHMP5; charged multivesicular body protein 5 [KO:K12198]
100146422  IST1; IST1 homolog isoform X1 [KO:K19476]
100050741  PDCD6IP; programmed cell death 6-interacting protein isoform X2 [KO:K12200]
100053578  SPG21; maspardin isoform X1 [KO:K19367]
100058539  IGF2R; cation-independent mannose-6-phosphate receptor isoform X2 [KO:K06564]
100066873  SNX1; sorting nexin-1 isoform X1 [KO:K17917]
100073099  SNX2; sorting nexin-2 [KO:K17917]
100051682  SNX32; sorting nexin-32 isoform X3 [KO:K17920]
100057360  SNX6; sorting nexin-6 isoform X1 [KO:K17920]
100062401  SNX5; sorting nexin-5 [KO:K17920]
100069870  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100055481  HRAS; GTPase HRas isoform X1 [KO:K02833]
100070292  IL2RA; interleukin-2 receptor subunit alpha precursor [KO:K05068]
100069676  IL2RB; interleukin-2 receptor subunit beta isoform X2 [KO:K05069]
100055911  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
100053343  RHOA; transforming protein RhoA [KO:K04513]
100034212  MHCB3; MHC class I heavy chain precursor [KO:K06751]
100056062  MHC class I antigen 9.2 precursor [KO:K06751]
100034210  EQMHCB2; MHC class I heavy chain precursor [KO:K06751]
100054114  HLA class I histocompatibility antigen, alpha chain G isoform X1 [KO:K06751]
100051657  7-51 putative nonclassical MHC class I antigen precursor [KO:K06751]
100057920  HLA class I histocompatibility antigen, Cw-12 alpha chain isoform X2 [KO:K06751]
100050550  EQMCE1; MHC class I antigen 3.7 precursor [KO:K06751]
100056182  HLA class I histocompatibility antigen, B-40 alpha chain isoform X1 [KO:K06751]
100056391  MHCX1; MHC class I antigen 3.5 precursor [KO:K06751]
100034211  EQMHCC1; MHC class I heavy chain precursor [KO:K06751]
100049798  class I histocompatibility antigen, Gogo-OKO alpha chain isoform X12 [KO:K06751]
100050473  class I histocompatibility antigen, Gogo-B*0103 alpha chain isoform X1 [KO:K06751]
100050706  saoe class I histocompatibility antigen, A alpha chain isoform X1 [KO:K06751]
100053918  HLA class I histocompatibility antigen, B-46 alpha chain isoform X2 [KO:K06751]
100054397  saoe class I histocompatibility antigen, A alpha chain [KO:K06751]
100054448  HLA class I histocompatibility antigen, alpha chain G isoform X3 [KO:K06751]
100056309  HLA class I histocompatibility antigen, B-15 alpha chain-like [KO:K06751]
100056099  HLA class I histocompatibility antigen, alpha chain G isoform X1 [KO:K06751]
100056231  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
100059994  HLA class I histocompatibility antigen, B-15 alpha chain isoform X1 [KO:K06751]
100060096  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
100066084  FOLR1; folate receptor alpha isoform X2 [KO:K13649]
100052723  FOLR3; folate receptor gamma [KO:K13649]
100066065  FOLR2; folate receptor beta [KO:K13649]
100059683  folate receptor alpha-like [KO:K13649]
100055975  CAV1; caveolin-1 [KO:K06278]
100071136  CAV2; caveolin-2 [KO:K12958]
100058881  CAV3; caveolin-3 [KO:K12959]
100070691  EHD3; EH domain-containing protein 3 [KO:K12476]
100071046  EHD4; EH domain-containing protein 4 [KO:K12477]
100064347  EEA1; early endosome antigen 1 isoform X1 [KO:K12478]
100051997  RAB5A; ras-related protein Rab-5A [KO:K07887]
100059099  RAB5B; ras-related protein Rab-5B [KO:K07888]
100053004  RAB5C; ras-related protein Rab-5C [KO:K07889]
100072805  RABEP1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
100056078  RBSN; rabenosyn-5 [KO:K12481]
100066087  RAB4A; ras-related protein Rab-4A isoform X1 [KO:K07879]
100067514  RUFY1; RUN and FYVE domain-containing protein 1 isoform X1 [KO:K12482]
100063098  RUFY2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
100050576  EHD1; EH domain-containing protein 1 [KO:K12483]
100054447  VPS45; vacuolar protein sorting-associated protein 45 isoform X1 [KO:K12479]
100060493  SNX4; sorting nexin-4 isoform X1 [KO:K17919]
100056212  RAB22A; ras-related protein Rab-22A isoform X1 [KO:K07891]
100055265  RAB31; ras-related protein Rab-31 isoform X1 [KO:K07891]
100055747  RAB10; ras-related protein Rab-10 isoform X1 [KO:K07903]
100147248  RAB8A; ras-related protein Rab-8A isoform X2 [KO:K07901]
100053915  RAB35; ras-related protein Rab-35 [KO:K07876]
100066116  RAB11A; ras-related protein Rab-11A [KO:K07904]
100146180  RAB11B; ras-related protein Rab-11B [KO:K07905]
100058765  RAB11FIP2; rab11 family-interacting protein 2 [KO:K12484]
100059616  RAB11FIP1; rab11 family-interacting protein 1 isoform X3 [KO:K12484]
100059236  RAB11FIP5; rab11 family-interacting protein 5 isoform X1 [KO:K12484]
100060913  ZFYVE27; protrudin isoform X1 [KO:K19368]
100061228  KIF5B; kinesin-1 heavy chain [KO:K10396]
100050542  KIF5A; kinesin heavy chain isoform X1 [KO:K10396]
100056413  KIF5C; kinesin heavy chain isoform X1 [KO:K10396]
100058609  RAB11FIP4; rab11 family-interacting protein 4 isoform X1 [KO:K12485]
100066724  RAB11FIP3; rab11 family-interacting protein 3 [KO:K12485]
100060218  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
100065587  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
100053411  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
100052187  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
100064240  PRKCZ; protein kinase C zeta type isoform X3 [KO:K18952] [EC:2.7.11.13]
100063737  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
100058188  CDC42; cell division control protein 42 homolog [KO:K04393]
100070988  SMAP1; stromal membrane-associated protein 1 isoform X1 [KO:K12486]
100068190  SMAP2; stromal membrane-associated protein 2 [KO:K12486]
100146940  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
100066470  GIT2; ARF GTPase-activating protein GIT2 [KO:K12487]
100071599  ASAP3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 [KO:K12488]
100072516  ASAP2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
100068654  ASAP1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
100072970  ACAP1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12489]
100069317  ACAP2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X7 [KO:K12489]
100147589  ACAP3; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12489]
100052506  ARAP1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
100065339  ARAP2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K18440]
100072169  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
100065931  AGAP1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12491]
100064153  AGAP3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12491]
100050853  AGAP2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X4 [KO:K17848]
111770054  ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
100051105  ARFGAP2; ADP-ribosylation factor GTPase-activating protein 2 isoform X2 [KO:K12493]
100071070  ARFGAP3; ADP-ribosylation factor GTPase-activating protein 3 isoform X1 [KO:K12493]
100051830  PSD3; PH and SEC7 domain-containing protein 3 isoform X12 [KO:K12494]
100065242  PSD4; PH and SEC7 domain-containing protein 4 [KO:K12494]
100069969  PSD; PH and SEC7 domain-containing protein 1 isoform X1 [KO:K12494]
100072453  PSD2; PH and SEC7 domain-containing protein 2 isoform X1 [KO:K12494]
100055011  IQSEC1; IQ motif and SEC7 domain-containing protein 1 isoform X8 [KO:K12495]
100057096  IQSEC3; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
106781352  IQSEC2; IQ motif and SEC7 domain-containing protein 2 isoform X1 [KO:K12495]
100053821  CYTH2; cytohesin-2 isoform X1 [KO:K18441]
100057600  CYTH1; cytohesin-1 isoform X1 [KO:K18441]
100061994  CYTH3; cytohesin-3 isoform X3 [KO:K18441]
100069735  CYTH4; cytohesin-4 isoform X2 [KO:K18441]
100063272  ARFGEF1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 [KO:K18442]
100071351  ARFGEF2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 [KO:K18442]
100060013  GBF1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X2 [KO:K18443]
100060911  ARF1; ADP-ribosylation factor 1 [KO:K07937]
100049809  ARF2; ADP-ribosylation factor 4 [KO:K07937]
100051578  ARF3; ADP-ribosylation factor 3 [KO:K07938]
100050816  ARF4; ADP-ribosylation factor 4 [KO:K07939]
100056654  ARF5; ADP-ribosylation factor 5 isoform X1 [KO:K07940]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
ecb04060  Cytokine-cytokine receptor interaction
ecb04070  Phosphatidylinositol signaling system
ecb04130  SNARE interactions in vesicular transport
ecb04142  Lysosome
ecb04350  TGF-beta signaling pathway
KO pathway
ko04144   
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