KEGG   PATHWAY: efus04921
Entry
efus04921                   Pathway                                
Name
Oxytocin signaling pathway - Eptesicus fuscus (big brown bat)
Description
Oxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and peripheral effects. However, its best-known and most well-established roles are stimulation of uterine contractions during parturition and milk release during lactation. Oxytocin also influences cardiovascular regulation and various social behaviors. The actions of OT are all mediated by one type of OT receptor (OTR). This is a transmembrane receptor belonging to the G-protein-coupled receptor superfamily. The main signaling pathway is the Gq/PLC/Ins3 pathway, but the MAPK and the RhoA/Rho kinase pathways are also activated, contributing to increased prostaglandin production and direct contractile effect on myometrial cells. In the cardiovascular system, OTR is associated with the ANP-cGMP and NO-cGMP pathways, which reduce the force and rate of contraction and increase vasodilatation.
Class
Organismal Systems; Endocrine system
Pathway map
efus04921  Oxytocin signaling pathway
efus04921

Organism
Eptesicus fuscus (big brown bat) [GN:efus]
Gene
103285624  OXT; oxytocin-neurophysin 1 [KO:K05243]
103295274  OXTR; oxytocin receptor [KO:K04229]
129147180  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
103302548  HRAS; GTPase HRas isoform X1 [KO:K02833]
103285154  KRAS; GTPase KRas isoform X1 [KO:K07827]
103291212  NRAS; GTPase NRas [KO:K07828]
103295757  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
103283794  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
103294231  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103287001  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
103296283  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103287344  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
103287518  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
103287517  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
103290127  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
103290037  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
103283781  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
103299365  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
103284067  JUN; transcription factor Jun [KO:K04448]
103283560  FOS; protein c-Fos [KO:K04379]
103305251  MEF2C; myocyte-specific enhancer factor 2C isoform X2 [KO:K04454]
103290903  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
103296406  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
103284712  RYR1; ryanodine receptor 1 isoform X1 [KO:K04961]
103293520  RYR2; ryanodine receptor 2 [KO:K04962]
103287492  RYR3; ryanodine receptor 3 [KO:K04963]
103294529  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
103289778  TRPM2; transient receptor potential cation channel subfamily M member 2 isoform X1 [KO:K04977] [EC:3.6.1.13]
114227988  KCNJ2; inward rectifier potassium channel 2 [KO:K04996]
103303988  KCNJ12; ATP-sensitive inward rectifier potassium channel 12 [KO:K05005]
129147107  ATP-sensitive inward rectifier potassium channel 12-like [KO:K05005]
103288867  KCNJ4; LOW QUALITY PROTEIN: inward rectifier potassium channel 4 [KO:K04998]
103297785  KCNJ14; ATP-sensitive inward rectifier potassium channel 14 [KO:K05007]
103302044  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
103287505  PLCB2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
103285666  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
103285667  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
103293119  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
103296210  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
103303678  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
103296295  EEF2K; eukaryotic elongation factor 2 kinase isoform X1 [KO:K08292] [EC:2.7.11.20]
103294234  EEF2; elongation factor 2 [KO:K03234]
103296724  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
103290420  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
103301304  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
103303711  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
103297130  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X2 [KO:K04862]
103292593  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
103285249  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
103283409  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
103293241  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
103298527  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X2 [KO:K04859]
103290416  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
103296758  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
103293123  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
103288904  CACNG2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
103296211  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
103293121  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
103293120  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
103303689  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
103303687  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
129147700  CACNG8; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
103300420  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
103285158  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
103303043  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
103292236  CALM1; calmodulin-1 isoform X2 [KO:K02183]
103298572  CALML5; calmodulin-like protein 5 [KO:K02183]
103304916  calmodulin-1-like [KO:K02183]
103305414  CALM2; calmodulin-2 [KO:K02183]
103297693  CALM3; calmodulin-3 isoform X1 [KO:K02183]
103298573  calmodulin-like protein 3 [KO:K02183]
103293186  calmodulin-1-like [KO:K02183]
129148572  calmodulin-1-like [KO:K02183]
103283955  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
129150189  CALML6; calmodulin-like protein 6 [KO:K02183]
103289468  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103295071  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
103299789  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
103286378  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
103291470  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
103304832  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
103285754  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
103284606  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
103301468  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
103293476  RGS2; regulator of G-protein signaling 2 [KO:K18154]
103289921  RCAN1; calcipressin-1 isoform X1 [KO:K17901]
103287031  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2 [KO:K07359] [EC:2.7.11.17]
103298839  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
103284058  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
103287096  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
103298845  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
103285258  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X2 [KO:K07200]
103289309  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200]
103301776  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 [KO:K07200]
103292057  5'-AMP-activated protein kinase subunit gamma-1-like [KO:K07200]
103290075  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
103294025  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
103295391  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X3 [KO:K08794] [EC:2.7.11.17]
103295749  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
103298154  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
103303624  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
103289578  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
103288726  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
103301781  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
103299252  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
103288856  GUCY1A1; guanylate cyclase soluble subunit alpha-1 isoform X1 [KO:K12318] [EC:4.6.1.2]
103288840  GUCY1B1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
103295621  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
103295419  NPPA; natriuretic peptides A [KO:K12334]
103298936  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
103286438  NPR2; atrial natriuretic peptide receptor 2 isoform X2 [KO:K12324] [EC:4.6.1.2]
103295907  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
103285582  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
103298735  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
103301893  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
103292416  MYL6B; myosin light chain 6B [KO:K12751]
103292418  MYL6; myosin light polypeptide 6 isoform X1 [KO:K12751]
103293324  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
103299154  ACTB; actin, cytoplasmic 1 [KO:K05692]
103298235  ACTG1; actin, cytoplasmic 2 [KO:K05692]
103298865  RHOA; transforming protein RhoA [KO:K04513]
103295254  transforming protein RhoA-like [KO:K04513]
103303158  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
103305588  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
103287049  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X2 [KO:K06269] [EC:3.1.3.16]
103290927  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
103297381  serine/threonine-protein phosphatase PP1-gamma catalytic subunit B-like isoform X2 [KO:K06269] [EC:3.1.3.16]
103305499  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
103288089  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
103302945  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X3 [KO:K12329]
103303380  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
103285782  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X4 [KO:K04632]
103285922  neuroendocrine secretory protein 55-like [KO:K04632]
103303616  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
103305103  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
103305553  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
103301470  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
103298761  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
103285248  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
103295862  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
103302409  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
103286155  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
103300989  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X2 [KO:K04345] [EC:2.7.11.11]
103284158  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
103291154  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
103293295  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
103298642  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
103295848  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X3 [KO:K04534]
103293615  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
103296965  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
103296863  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
103293309  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
103283400  KCNJ3; G protein-activated inward rectifier potassium channel 1 [KO:K04997]
103289816  KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
103297575  KCNJ9; G protein-activated inward rectifier potassium channel 3 [KO:K05002]
103286923  KCNJ5; G protein-activated inward rectifier potassium channel 4 [KO:K04999]
103294241  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
103295571  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00238  Potassium cation
C00427  Prostaglandin H2
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C13050  Cyclic ADP-ribose
Reference
PMID:18655881
  Authors
Devost D, Wrzal P, Zingg HH
  Title
Oxytocin receptor signalling.
  Journal
Prog Brain Res 170:167-76 (2008)
DOI:10.1016/S0079-6123(08)00415-9
Reference
PMID:20626426
  Authors
Viero C, Shibuya I, Kitamura N, Verkhratsky A, Fujihara H, Katoh A, Ueta Y, Zingg HH, Chvatal A, Sykova E, Dayanithi G
  Title
REVIEW: Oxytocin: Crossing the bridge between basic science and pharmacotherapy.
  Journal
CNS Neurosci Ther 16:e138-56 (2010)
DOI:10.1111/j.1755-5949.2010.00185.x
Reference
PMID:21981277
  Authors
Gutkowska J, Jankowski M
  Title
Oxytocin revisited: its role in cardiovascular regulation.
  Journal
J Neuroendocrinol 24:599-608 (2012)
DOI:10.1111/j.1365-2826.2011.02235.x
Reference
PMID:22190926
  Authors
Vrachnis N, Malamas FM, Sifakis S, Deligeoroglou E, Iliodromiti Z
  Title
The oxytocin-oxytocin receptor system and its antagonists as tocolytic agents.
  Journal
Int J Endocrinol 2011:350546 (2011)
DOI:10.1155/2011/350546
Reference
PMID:19840865
  Authors
Tom N, Assinder SJ
  Title
Oxytocin in health and disease.
  Journal
Int J Biochem Cell Biol 42:202-5 (2010)
DOI:10.1016/j.biocel.2009.10.008
Reference
PMID:9575824
  Authors
Strakova Z, Copland JA, Lolait SJ, Soloff MS
  Title
ERK2 mediates oxytocin-stimulated PGE2 synthesis.
  Journal
Am J Physiol 274:E634-41 (1998)
DOI:10.1152/ajpendo.1998.274.4.E634
Reference
PMID:12009385
  Authors
Slater DM, Zervou S, Thornton S
  Title
Prostaglandins and prostanoid receptors in human pregnancy and parturition.
  Journal
J Soc Gynecol Investig 9:118-24 (2002)
Reference
PMID:16787565
  Authors
Shmygol A, Gullam J, Blanks A, Thornton S
  Title
Multiple mechanisms involved in oxytocin-induced modulation of myometrial contractility.
  Journal
Acta Pharmacol Sin 27:827-32 (2006)
DOI:10.1111/j.1745-7254.2006.00393.x
Reference
PMID:11861513
  Authors
Tahara M, Morishige K, Sawada K, Ikebuchi Y, Kawagishi R, Tasaka K, Murata Y
  Title
RhoA/Rho-kinase cascade is involved in oxytocin-induced rat uterine contraction.
  Journal
Endocrinology 143:920-9 (2002)
DOI:10.1210/endo.143.3.8696
Reference
PMID:12433531
  Authors
Slattery MM, Morrison JJ
  Title
Preterm delivery.
  Journal
Lancet 360:1489-97 (2002)
DOI:10.1016/S0140-6736(02)11476-0
Reference
PMID:22902539
  Authors
Pont JN, McArdle CA, Lopez Bernal A
  Title
Oxytocin-stimulated NFAT transcriptional activation in human myometrial cells.
  Journal
Mol Endocrinol 26:1743-56 (2012)
DOI:10.1210/me.2012-1057
Reference
PMID:9326674
  Authors
Gutkowska J, Jankowski M, Lambert C, Mukaddam-Daher S, Zingg HH, McCann SM
  Title
Oxytocin releases atrial natriuretic peptide by combining with oxytocin receptors in the heart.
  Journal
Proc Natl Acad Sci U S A 94:11704-9 (1997)
DOI:10.1073/pnas.94.21.11704
Reference
PMID:14715914
  Authors
Antunes-Rodrigues J, de Castro M, Elias LL, Valenca MM, McCann SM
  Title
Neuroendocrine control of body fluid metabolism.
  Journal
Physiol Rev 84:169-208 (2004)
DOI:10.1152/physrev.00017.2003
Reference
PMID:18555543
  Authors
Lee ES, Uhm KO, Lee YM, Kwon J, Park SH, Soo KH
  Title
Oxytocin stimulates glucose uptake in skeletal muscle cells through the calcium-CaMKK-AMPK pathway.
  Journal
Regul Pept 151:71-4 (2008)
DOI:10.1016/j.regpep.2008.05.001
Reference
PMID:9219843
  Authors
Cassoni P, Sapino A, Fortunati N, Munaron L, Chini B, Bussolati G
  Title
Oxytocin inhibits the proliferation of MDA-MB231 human breast-cancer cells via cyclic adenosine monophosphate and protein kinase A.
  Journal
Int J Cancer 72:340-4 (1997)
DOI:10.1002/(SICI)1097-0215(19970717)72:2<340::AID-IJC23>3.0.CO;2-I
Reference
PMID:23356278
  Authors
Busnelli M, Peverelli E, Mantovani G, Spada A, Chini B
  Title
Deciphering the specific role of G(alphai/o) isoforms: functional selective oxytocin ligands and somatostatin SST5 receptor mutants.
  Journal
Biochem Soc Trans 41:166-71 (2013)
DOI:10.1042/BST20120306
Reference
PMID:16966388
  Authors
Reversi A, Rimoldi V, Brambillasca S, Chini B
  Title
Effects of cholesterol manipulation on the signaling of the human oxytocin receptor.
  Journal
Am J Physiol Regul Integr Comp Physiol 291:R861-9 (2006)
DOI:10.1152/ajpregu.00333.2006
Reference
PMID:20141572
  Authors
Salmina AB, Lopatina O, Ekimova MV, Mikhutkina SV, Higashida H
  Title
CD38/cyclic ADP-ribose system: a new player for oxytocin secretion and regulation of social behaviour.
  Journal
J Neuroendocrinol 22:380-92 (2010)
DOI:10.1111/j.1365-2826.2010.01970.x
Reference
PMID:22227279
  Authors
Higashida H, Yokoyama S, Kikuchi M, Munesue T
  Title
CD38 and its role in oxytocin secretion and social behavior.
  Journal
Horm Behav 61:351-8 (2012)
DOI:10.1016/j.yhbeh.2011.12.011
Reference
PMID:23335873
  Authors
Lopatina O, Inzhutova A, Salmina AB, Higashida H
  Title
The roles of oxytocin and CD38 in social or parental behaviors.
  Journal
Front Neurosci 6:182 (2012)
DOI:10.3389/fnins.2012.00182
Reference
PMID:16156781
  Authors
Guse AH
  Title
Second messenger function and the structure-activity relationship of cyclic adenosine diphosphoribose (cADPR).
  Journal
FEBS J 272:4590-7 (2005)
DOI:10.1111/j.1742-4658.2005.04863.x
Related
pathway
efus00590  Arachidonic acid metabolism
efus04010  MAPK signaling pathway
efus04020  Calcium signaling pathway
efus04110  Cell cycle
KO pathway
ko04921   
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