KEGG   PATHWAY: elk04151
Entry
elk04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Enhydra lutris kenyoni (northern sea otter)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
elk04151  PI3K-Akt signaling pathway
elk04151

Other DBs
GO: 0043491
Organism
Enhydra lutris kenyoni (northern sea otter) [GN:elk]
Gene
111156359  pro-epidermal growth factor isoform X1 [KO:K04357]
111148116  protransforming growth factor alpha [KO:K08774]
111149369  proepiregulin [KO:K09784]
111149348  amphiregulin [KO:K09782]
111156955  fibroblast growth factor 1 isoform X1 [KO:K18496]
111156005  LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
111141219  fibroblast growth factor 18 [KO:K04358]
111144621  fibroblast growth factor 20 [KO:K04358]
111159982  fibroblast growth factor 7 isoform X1 [KO:K04358]
111157192  fibroblast growth factor 17 isoform X1 [KO:K04358]
111159837  fibroblast growth factor 6 [KO:K04358]
111160943  fibroblast growth factor 16 [KO:K04358]
111145249  fibroblast growth factor 8 isoform X1 [KO:K04358]
111149486  fibroblast growth factor 3 [KO:K04358]
111150307  fibroblast growth factor 4 [KO:K04358]
111159933  fibroblast growth factor 9 [KO:K04358]
111149253  fibroblast growth factor 5 isoform X1 [KO:K04358]
111141115  fibroblast growth factor 10 [KO:K04358]
111161630  fibroblast growth factor 22 [KO:K04358]
111149408  fibroblast growth factor 19 [KO:K22603]
111160539  fibroblast growth factor 21 [KO:K22429]
111159771  LOW QUALITY PROTEIN: fibroblast growth factor 23 [KO:K22428]
111143419  beta-nerve growth factor [KO:K02582]
111143447  beta-nerve growth factor [KO:K02582]
111150176  LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
111159818  neurotrophin-3 [KO:K04356]
111160824  neurotrophin-4 [KO:K12457]
111150279  insulin [KO:K04526]
111142293  insulin-like growth factor I [KO:K05459]
111142036  insulin-like growth factor I isoform X1 [KO:K05459]
111150034  insulin-like growth factor II isoform X1 [KO:K13769]
111145884  platelet-derived growth factor subunit A isoform X1 [KO:K04359]
111157534  platelet-derived growth factor subunit B isoform X1 [KO:K17386]
111155335  platelet-derived growth factor C [KO:K05450]
111153783  platelet-derived growth factor D isoform X1 [KO:K05450]
111143313  macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
111142191  kit ligand [KO:K05461]
111160696  fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
111147726  vascular endothelial growth factor A [KO:K05448]
111149705  vascular endothelial growth factor B isoform X1 [KO:K16858]
111148570  placenta growth factor isoform X1 [KO:K16859]
111157184  vascular endothelial growth factor D [KO:K05449]
111144527  vascular endothelial growth factor C [KO:K05449]
111155271  hepatocyte growth factor isoform X1 [KO:K05460]
111146656  angiopoietin-1 isoform X1 [KO:K05465]
111144573  angiopoietin-2 isoform X1 [KO:K05466]
111141561  angiopoietin-4 isoform X1 [KO:K05467]
111161900  ephrin-A2 [KO:K05462]
111139033  ephrin-A3 [KO:K05462]
111139068  ephrin-A4 isoform X1 [KO:K05462]
111148415  ephrin-A5 isoform X1 [KO:K05462]
111138977  ephrin-A1 isoform X1 [KO:K05462]
111141293  glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
111161633  neurturin [KO:K25414]
111142769  artemin [KO:K25415]
111161809  persephin [KO:K25416]
111157042  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
111151268  receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
111160180  receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
111138855  receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
111144420  fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
111145037  fibroblast growth factor receptor 2-like [KO:K05093] [EC:2.7.10.1]
111144712  fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
111149137  fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
111140867  fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
111151744  tumor necrosis factor receptor superfamily member 16 [KO:K02583]
111138872  high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
111153613  BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
111161798  insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
111152643  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
111148924  platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
111140848  platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
111140850  LOW QUALITY PROTEIN: macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
111148912  mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
111158528  receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
111158583  vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
111158898  vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
111149192  vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
111151956  hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
111159847  angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
111154665  LOW QUALITY PROTEIN: ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
111145007  proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
111160411  growth factor receptor-bound protein 2 [KO:K04364]
111158354  son of sevenless homolog 1 isoform X1 [KO:K03099]
111160889  son of sevenless homolog 2 isoform X1 [KO:K03099]
111140316  GTPase HRas isoform X1 [KO:K02833]
111159984  GTPase KRas isoform X1 [KO:K07827]
111143238  GTPase NRas [KO:K07828]
111144322  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111153158  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
111161815  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
111162236  LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
111142759  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111143995  insulin receptor substrate 1 [KO:K16172]
111154734  toll-like receptor 2 [KO:K10159]
111146042  toll-like receptor 4 isoform X1 [KO:K10160]
111145636  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
111153538  tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
111162308  B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
111144693  phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230]
111158084  somatotropin isoform X1 [KO:K05438]
111138630  prolactin isoform X1 [KO:K05439]
111160020  oncostatin-M [KO:K05418]
111154869  interleukin-2 [KO:K05429]
111140799  interleukin-3-like [KO:K04736]
111147365  interleukin-6 isoform X1 [KO:K05405]
111141099  interleukin-4 [KO:K05430]
111156814  interleukin-7 isoform X1 [KO:K05431]
111140482  interferon alpha-1/2-like [KO:K05414]
111159856  interferon alpha-1/2-like [KO:K05414]
111159858  interferon alpha-1/2-like [KO:K05414]
111159859  interferon alpha-1/2-like [KO:K05414]
111159861  interferon alpha-1/2-like [KO:K05414]
111159862  interferon alpha-1/2-like [KO:K05414]
111156578  interferon alpha-2-like [KO:K05414]
111156593  interferon alpha-1/2-like [KO:K05414]
111156594  interferon alpha-1/2-like [KO:K05414]
111156604  interferon alpha-like [KO:K05414]
111140592  interferon alpha-1/2-like [KO:K05414]
111156606  interferon alpha-1/2-like [KO:K05414]
111156609  interferon alpha-1/2-like [KO:K05414]
111140329  interferon alpha-1/2-like [KO:K05414]
111140335  interferon alpha-1/2-like [KO:K05414]
111140336  interferon alpha-1/2-like [KO:K05414]
111156577  interferon beta [KO:K05415]
111145625  erythropoietin [KO:K05437]
111151817  granulocyte colony-stimulating factor [KO:K05423]
111140951  growth hormone receptor [KO:K05080]
111141177  prolactin receptor isoform X1 [KO:K05081]
111141176  oncostatin-M-specific receptor subunit beta [KO:K05057]
111158621  interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
111157559  interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
111161041  cytokine receptor common subunit gamma [KO:K05070]
111157156  interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
111138952  interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
111162191  interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
111141253  interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
111155707  interferon alpha/beta receptor 1 [KO:K05130]
111155645  interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
111162487  erythropoietin receptor [KO:K05079]
111143352  granulocyte colony-stimulating factor receptor [KO:K05061]
111142881  tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
111153517  tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
111143876  tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
111151317  collagen alpha-1(I) chain isoform X1 [KO:K06236]
111147195  collagen alpha-2(I) chain [KO:K06236]
111157855  collagen alpha-1(II) chain isoform X1 [KO:K19719]
111142203  collagen alpha-3(IV) chain [KO:K06237]
111146901  collagen alpha-1(IV) chain [KO:K06237]
111161271  collagen alpha-5(IV) chain [KO:K06237]
111161277  collagen alpha-6(IV) chain [KO:K06237]
111147037  collagen alpha-2(IV) chain [KO:K06237]
111143029  collagen alpha-4(IV) chain [KO:K06237]
111141881  collagen alpha-3(VI) chain isoform X1 [KO:K06238]
111154965  collagen alpha-4(VI) chain-like [KO:K06238]
111155113  collagen alpha-5(VI) chain [KO:K06238]
111155151  collagen alpha-6(VI) chain [KO:K06238]
111155778  collagen alpha-2(VI) chain isoform X1 [KO:K06238]
111155800  collagen alpha-1(VI) chain [KO:K06238]
111143302  LOW QUALITY PROTEIN: collagen alpha-2(IX) chain [KO:K08131]
111141418  collagen alpha-3(IX) chain [KO:K08131]
111152338  collagen alpha-1(IX) chain [KO:K08131]
111142456  laminin subunit alpha-1 [KO:K05637]
111147662  laminin subunit alpha-2 [KO:K05637]
111142476  laminin subunit alpha-3 isoform X1 [KO:K06240]
111141516  laminin subunit alpha-5 isoform X1 [KO:K06240]
111158255  laminin subunit alpha-4 isoform X1 [KO:K06241]
111155260  laminin subunit beta-1 isoform X1 [KO:K05636]
111144053  laminin subunit beta-2 isoform X1 [KO:K06243]
111162354  laminin subunit beta-3 [KO:K06244]
111155309  laminin subunit beta-4 [KO:K06245]
111150738  laminin subunit gamma-1 [KO:K05635]
111150870  laminin subunit gamma-2 [KO:K06246]
111145465  laminin subunit gamma-3-like [KO:K06247]
111145932  laminin subunit gamma-3 [KO:K06247]
111151500  LOW QUALITY PROTEIN: chondroadherin [KO:K06248]
111155225  reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
111161597  thrombospondin-1 [KO:K16857]
111158682  thrombospondin-2 [KO:K04659]
111148277  LOW QUALITY PROTEIN: thrombospondin-4 [KO:K04659]
111139020  LOW QUALITY PROTEIN: thrombospondin-3 [KO:K04659]
111144008  cartilage oligomeric matrix protein [KO:K04659]
111143733  fibronectin isoform X1 [KO:K05717]
111155535  osteopontin isoform X1 [KO:K06250]
111151505  vitronectin [KO:K06251]
111150918  tenascin-N [KO:K06252]
111150683  tenascin-R [KO:K06252]
111146196  tenascin [KO:K06252]
111152238  tenascin-X [KO:K06252]
111159823  von Willebrand factor isoform X1 [KO:K03900]
111157488  bone sialoprotein 2 isoform X1 [KO:K06253]
111140770  integrin alpha-1 [KO:K06480]
111141135  integrin alpha-2 [KO:K06481]
111158126  integrin alpha-IIb isoform X1 [KO:K06476]
111151764  integrin alpha-3 [KO:K06482]
111160297  integrin alpha-4 isoform X1 [KO:K06483]
111157949  integrin alpha-5 isoform X1 [KO:K06484]
111144193  integrin alpha-6 isoform X1 [KO:K06485]
111160156  integrin alpha-7 isoform X1 [KO:K06583]
111155529  integrin alpha-8 isoform X1 [KO:K06584]
111159088  integrin alpha-9 isoform X1 [KO:K06585]
111162005  integrin alpha-10 isoform X1 [KO:K06586]
111153129  integrin alpha-11 [KO:K06587]
111155043  integrin alpha-V isoform X1 [KO:K06487]
111155558  integrin beta-1 isoform X1 [KO:K05719]
111158107  integrin beta-3 [KO:K06493]
111160262  integrin beta-4 [KO:K06525]
111155029  integrin beta-5 [KO:K06588]
111142308  integrin beta-6 isoform X1 [KO:K06589]
111157851  integrin beta-7 [KO:K06590]
111147337  integrin beta-8 [KO:K06591]
111146744  focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
111155003  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
111147545  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111154641  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
111143470  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
111155224  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111143790  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
111148319  proteinase-activated receptor 1 [KO:K03914]
111150081  muscarinic acetylcholine receptor M1 [KO:K04129]
111152067  muscarinic acetylcholine receptor M2 [KO:K04130]
111145805  lysophosphatidic acid receptor 1 [KO:K04289]
111144147  lysophosphatidic acid receptor 2 [KO:K04291]
111143684  lysophosphatidic acid receptor 3 [KO:K04294]
111160942  lysophosphatidic acid receptor 4 [KO:K04275]
111159825  lysophosphatidic acid receptor 5 [KO:K08390]
111146912  lysophosphatidic acid receptor 6 [KO:K04273]
111154601  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
111145586  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1 [KO:K04537]
111159773  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
111148588  guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
111140421  guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
111159618  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1 [KO:K07826]
111149566  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
111160502  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
111143000  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
111161718  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
111160835  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
111145828  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
111147333  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
111162432  uncharacterized LOC105372280 homolog [KO:K04347]
111142967  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
111156207  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
111147281  guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
111151818  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
111155215  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
111161090  phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
111161150  phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
111156293  3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
111161896  serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
111143318  5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
111141175  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
111145063  DNA damage-inducible transcript 4 protein [KO:K08270]
111145731  hamartin isoform X1 [KO:K07206]
111156259  tuberin isoform X1 [KO:K07207]
111154404  GTP-binding protein Rheb [KO:K07208]
111156180  target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
111154883  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
111160429  regulatory-associated protein of mTOR isoform X1 [KO:K07204]
111144538  eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
111146502  eukaryotic translation initiation factor 4E type 1B-like [KO:K03259]
111146503  eukaryotic translation initiation factor 4E type 1B-like [KO:K03259]
111157179  eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
111150366  eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
111141077  eukaryotic translation initiation factor 4E type 1B [KO:K03259]
111149588  ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
111151757  ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
111157728  eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
111156567  40S ribosomal protein S6 [KO:K02991]
111148822  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
111158087  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
111162406  serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
111143223  serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
111146126  serine/threonine-protein kinase N3 isoform X1 [KO:K23692] [EC:2.7.11.13]
111147659  serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
111141638  serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
111155378  serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
111161374  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111148765  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111150885  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111144009  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
111155266  LOW QUALITY PROTEIN: membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
111144778  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
111162045  acyl-coenzyme A thioesterase THEM4 isoform X1 [KO:K16339] [EC:3.1.2.2]
111141024  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
111144543  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
111153735  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
111160772  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
111144887  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
111156936  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
111149174  protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
111154409  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
111159912  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
111155025  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
111157091  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
111150668  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
111149986  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
111160383  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
111147753  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
111148624  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
111147500  heat shock protein HSP 90-beta [KO:K04079]
111148518  heat shock protein HSP 90-alpha [KO:K04079]
111142066  endoplasmin isoform X1 [KO:K09487]
111162447  hsp90 co-chaperone Cdc37 [KO:K09554]
111138927  LOW QUALITY PROTEIN: CREB-regulated transcription coactivator 2 [KO:K16333]
111154258  PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
111152971  PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
111148747  T-cell leukemia/lymphoma protein 1B [KO:K16836]
111139203  protein p13 MTCP-1 [KO:K16837]
111154402  nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
111151634  breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
111149921  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
111161347  glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
111160708  glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
111160112  phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
111141629  phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
111158028  glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
111145783  glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
111151665  glucose-6-phosphatase isoform X1 [KO:K01084] [EC:3.1.3.9]
111146783  myc proto-oncogene protein [KO:K04377]
111149458  G1/S-specific cyclin-D1 [KO:K04503]
111147618  cyclin-dependent kinase inhibitor 1 [KO:K06625]
111142072  cyclin-dependent kinase inhibitor 1B [KO:K06624]
111142115  cyclin-dependent kinase inhibitor 1B [KO:K06624]
111160135  cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
111160230  cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
111147246  cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
111159766  G1/S-specific cyclin-D2 [KO:K10151]
111147855  G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
111161443  G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
111146791  G1/S-specific cyclin-E2 [KO:K06626]
111158279  forkhead box protein O3 [KO:K09408]
111157436  retinoblastoma-like protein 2 isoform X1 [KO:K16332]
111150819  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
111150909  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
111158508  bcl-2-like protein 11 isoform X1 [KO:K16341]
111154124  14-3-3 protein theta [KO:K16197]
111141382  14-3-3 protein beta/alpha [KO:K16197]
111146608  14-3-3 protein zeta/delta [KO:K16197]
111151387  14-3-3 protein epsilon [KO:K06630]
111160059  14-3-3 protein eta [KO:K16198]
111146124  14-3-3 protein gamma [KO:K16198]
111149975  bcl2-associated agonist of cell death [KO:K02158]
111141775  bcl-2-like protein 1 [KO:K04570]
111154217  apoptosis regulator Bcl-2 [KO:K02161]
111154673  caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
111147575  cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
111142901  cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
111157635  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
111151973  cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
111146280  cyclic AMP-responsive element-binding protein 3 [KO:K09048]
111150050  cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
111138943  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
111161856  cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
111147321  cyclic AMP-responsive element-binding protein 5 [KO:K09047]
111152366  cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
111161960  induced myeloid leukemia cell differentiation protein Mcl-1 homolog isoform X1 [KO:K02539]
111161961  induced myeloid leukemia cell differentiation protein Mcl-1 homolog isoform X1 [KO:K02539]
111146039  retinoic acid receptor RXR-alpha [KO:K08524]
111157882  nuclear receptor subfamily 4 group A member 1 [KO:K04465]
111139191  NF-kappa-B essential modulator [KO:K07210]
111144921  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
111144397  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
111149956  transcription factor p65 [KO:K04735]
111153611  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
111147604  transcriptional activator Myb isoform X1 [KO:K09420]
111142120  E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
111161133  cellular tumor antigen p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
elk00010  Glycolysis / Gluconeogenesis
elk04010  MAPK signaling pathway
elk04012  ErbB signaling pathway
elk04062  Chemokine signaling pathway
elk04064  NF-kappa B signaling pathway
elk04068  FoxO signaling pathway
elk04110  Cell cycle
elk04115  p53 signaling pathway
elk04150  mTOR signaling pathway
elk04210  Apoptosis
elk04370  VEGF signaling pathway
elk04510  Focal adhesion
elk04620  Toll-like receptor signaling pathway
elk04630  JAK-STAT signaling pathway
elk04662  B cell receptor signaling pathway
elk04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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