KEGG   PATHWAY: etl04810
Entry
etl04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Empidonax traillii (willow flycatcher)
Class
Cellular Processes; Cell motility
Pathway map
etl04810  Regulation of actin cytoskeleton
etl04810

Other DBs
GO: 0030036
Organism
Empidonax traillii (willow flycatcher) [GN:etl]
Gene
114072958  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
114069483  lysophosphatidic acid receptor 1-B-like [KO:K04289]
114072973  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
114065169  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
114058191  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
114055885  CXCL12; stromal cell-derived factor 1 [KO:K10031]
114057696  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
114058944  F2; prothrombin isoform X1 [KO:K01313] [EC:3.4.21.5]
114057079  F2R; proteinase-activated receptor 1 [KO:K03914]
114059852  INS; insulin isoform X1 [KO:K04526]
114062174  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
114066997  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
114061094  FGF2; fibroblast growth factor 2 [KO:K18497]
114070490  FGF17; fibroblast growth factor 17 [KO:K04358]
114057693  FGF9; fibroblast growth factor 9 [KO:K04358]
114071700  FGF8; fibroblast growth factor 8 [KO:K04358]
114056046  FGF10; fibroblast growth factor 10 [KO:K04358]
114066378  FGF22; fibroblast growth factor 22 [KO:K04358]
114065451  FGF20; fibroblast growth factor 20 [KO:K04358]
114067986  FGF3; fibroblast growth factor 3 [KO:K04358]
114067993  FGF4; fibroblast growth factor 4 [KO:K04358]
114067083  FGF6; fibroblast growth factor 6 [KO:K04358]
114068193  fibroblast growth factor 18-like [KO:K04358]
114063992  FGF16; fibroblast growth factor 16 [KO:K04358]
114059950  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
114067983  FGF19; fibroblast growth factor 19 [KO:K22603]
114067080  FGF23; fibroblast growth factor 23 [KO:K22428]
114054750  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
114055364  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
114057056  PDGFC; platelet-derived growth factor C [KO:K05450]
114065863  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
114071557  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
114057239  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
114066493  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
114065192  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
114061475  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
114063827  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
114058301  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
114063193  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
114060672  FN1; fibronectin isoform X1 [KO:K05717]
114072612  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
114072581  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
114071998  ITGA2B; integrin alpha-IIb [KO:K06476]
114069038  ITGA3; integrin alpha-3 [KO:K06482]
114055780  ITGA4; integrin alpha-4 [KO:K06483]
114054920  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
114070096  ITGA7; integrin alpha-7 [KO:K06583]
114066138  ITGA9; integrin alpha-9 [KO:K06585]
114072101  ITGA10; integrin alpha-10 [KO:K06586]
114070862  integrin alpha-11-like [KO:K06587]
114059422  ITGAV; integrin alpha-V [KO:K06487]
114059485  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
114068111  ITGB2; integrin beta-2 [KO:K06464]
114066945  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
114063396  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
114058115  ITGB5; integrin beta-5 [KO:K06588]
114054917  ITGB6; integrin beta-6 [KO:K06589]
114054615  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
114060796  KNG1; kininogen-1 [KO:K03898]
114056933  BDKRB1; B1 bradykinin receptor [KO:K03915]
114056932  BDKRB2; B2 bradykinin receptor [KO:K03916]
114064295  CHRM2; muscarinic acetylcholine receptor M2 isoform X1 [KO:K04130]
114063479  CHRM3; muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131]
114059091  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
114055326  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
114058497  C5; complement C5 [KO:K03994]
114063714  C6; complement component C6 [KO:K03995]
114063720  C7; complement component C7 [KO:K03996]
114055187  C8A; complement component C8 alpha chain [KO:K03997]
114055186  C8B; complement component C8 beta chain isoform X1 [KO:K03998]
114064149  C8G; complement component C8 gamma chain [KO:K03999]
114055016  C9; complement component C9 isoform X1 [KO:K04000]
114060163  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
114060688  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
114061073  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
114059860  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 [KO:K05722]
114061597  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
114069815  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
114060458  CRK; adapter molecule crk isoform X1 [KO:K04438]
114061504  CRKL; crk-like protein isoform X1 [KO:K04438]
114065397  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
114058090  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
114060067  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
114070305  SOS2; son of sevenless homolog 2 [KO:K03099]
114064818  HRAS; GTPase HRas [KO:K02833]
114068618  KRAS; GTPase KRas isoform X1 [KO:K07827]
114064402  NRAS; GTPase NRas [KO:K07828]
114060401  RRAS2; ras-related protein R-Ras2 [KO:K07830]
114055508  MRAS; LOW QUALITY PROTEIN: ras-related protein M-Ras [KO:K07831]
114065670  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
114057709  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
114056876  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
114062399  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
114056772  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
114062212  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
114069500  phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
114055870  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
114059103  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
114069404  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
114056183  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
114059216  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
114060214  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
114055284  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
114068839  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
114061800  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
114066717  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114059171  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114059900  RGCC; regulator of cell cycle RGCC [KO:K26108]
114062104  regulator of cell cycle RGCC-like [KO:K26108]
114066793  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
114071940  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
114058660  RHOA; transforming protein RhoA [KO:K04513]
114065927  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
114055413  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
114060329  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
114066848  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
114065462  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
114070521  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
114059678  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
114069844  cyclin-dependent kinase 11B-like [KO:K05733] [EC:2.7.11.1]
114054674  serine/threonine-protein kinase PAK 3-like [KO:K05733] [EC:2.7.11.1]
114071414  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
114057360  PAK5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
114067942  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
114059827  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
114061237  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
114056505  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
114061910  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
114071985  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
114058107  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
114063040  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
114070606  myosin light chain kinase 3-like [KO:K00907] [EC:2.7.11.18]
114060388  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
114055006  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
114063365  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
114064849  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
114063665  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
114064784  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
114062679  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
114059723  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
114056697  MYL10; myosin regulatory light chain 10 isoform X1 [KO:K12756]
114058741  MYL12B; myosin regulatory light chain 12B isoform X1 [KO:K12757]
114055435  MYH9; myosin-9 [KO:K10352]
114058251  MYH11; myosin-11 isoform X1 [KO:K10352]
114064109  MYH10; myosin-10 isoform X1 [KO:K10352]
114056039  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
114068051  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
114056552  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
114070570  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
114072474  putative PIP5K1A and PSMD4-like protein [KO:K00889] [EC:2.7.1.68]
114073474  phosphatidylinositol 5-phosphate 4-kinase type-2 gamma-like [KO:K00920] [EC:2.7.1.149]
114070672  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
114059320  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
114055769  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
114063800  LIMK1; LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
114056632  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
114061944  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
114068212  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
114073699  ENAH; protein enabled homolog isoform X1 [KO:K05746]
114062851  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
114071330  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
114066258  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
114058331  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
114059431  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
114055762  ABI2; abl interactor 2 isoform X1 [KO:K05751]
114058678  BRK1; protein BRICK1 [KO:K05752]
114065529  WASF1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753]
114054872  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
114069440  actin-related protein 3B [KO:K18584]
114066807  ACTR3; actin-related protein 3 [KO:K18584]
114060185  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
114060196  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
114055430  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
114054959  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
114056815  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
114066108  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
114061990  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
114068207  ACTG1; actin, cytoplasmic 2 [KO:K05692]
114059764  actin, cytoplasmic type 5 [KO:K05692]
114060184  ACTB; actin, cytoplasmic 1 [KO:K05692]
114061416  PFN2; profilin-2 isoform X1 [KO:K05759]
114056612  PXN; paxillin [KO:K05760]
114068504  EZR; ezrin isoform X1 [KO:K08007]
114058013  RDX; radixin isoform X1 [KO:K05762]
114067640  MSN; moesin [KO:K05763]
114068932  TMSB4X; thymosin beta-4 [KO:K05764]
114065208  thymosin beta-12-like [KO:K05764]
114060582  CFL2; cofilin-2 [KO:K05765]
114061250  SSH2; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
114067862  SSH3; protein phosphatase Slingshot homolog 3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
114062642  SSH1; protein phosphatase Slingshot homolog 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
114063678  VCL; vinculin isoform X1 [KO:K05700]
114064288  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
114069938  IQGAP3; ras GTPase-activating-like protein IQGAP3 [KO:K05767]
114057035  IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
114054588  SCIN; adseverin [KO:K05768]
114058482  GSN; gelsolin [KO:K05768]
114061337  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
114066385  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
114054675  APC; adenomatous polyposis coli protein [KO:K02085]
114057616  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
114064687  ARHGEF4; rho guanine nucleotide exchange factor 4 isoform X1 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
etl04010  MAPK signaling pathway
etl04510  Focal adhesion
etl04520  Adherens junction
KO pathway
ko04810   
LinkDB

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