KEGG   PATHWAY: mcf05417
Entry
mcf05417                    Pathway                                
Name
Lipid and atherosclerosis - Macaca fascicularis (crab-eating macaque)
Description
Atherosclerosis is a chronic inflammatory disease marked by a narrowing of the arteries from lipid-rich plaques present within the walls of arterial blood vessels. It represents the root cause of the majority of cardiovascular diseases (CVDs) and their complications, including conditions such as coronary artery disease, myocardial infarction and stroke.  An elevated level of low density lipoprotein (LDL) cholesterol constitutes a major risk factor for genesis of atherosclerosis. LDL can accumulate within the blood vessel wall and undergo modification by oxidation. Oxidized LDL (oxLDL) leads to endothelial dysfunction leading to expression of adhesion molecules and recruitment of monocyte in subendothelial space. The monocytes proliferate, differentiate into macrophages, and take up the lipoproteins, forming cholesterol-engorged "foam cells." With the time, the foam cells die, leaving a 'necrotic core' of crystalline cholesterol and cell debris. Smooth muscle cells proliferate and migrate into the region, laying down a protective cap over the lesion. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), which mediates the recognition and internalization of oxLDL, is involved in all of these events critical in the pathogenesis of atherosclerosis.
Class
Human Diseases; Cardiovascular disease
Pathway map
mcf05417  Lipid and atherosclerosis
mcf05417

Organism
Macaca fascicularis (crab-eating macaque) [GN:mcf]
Gene
102121781  APOB; apolipoprotein B-100 [KO:K14462]
102143439  APOA4; apolipoprotein A-IV [KO:K08760]
101925978  APOA1; apolipoprotein A-I [KO:K08757]
102127361  LDLR; low-density lipoprotein receptor isoform X1 [KO:K12473]
102117699  OLR1; oxidized low-density lipoprotein receptor 1 isoform X1 [KO:K08763]
102143411  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X9 [KO:K12330]
102142258  MMP1; interstitial collagenase [KO:K01388] [EC:3.4.24.7]
101865630  RHOA; transforming protein RhoA [KO:K04513]
102133054  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
102143504  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
102143464  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102142026  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102122725  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102137291  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
101866246  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102124804  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102144461  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102142406  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102132744  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102132255  BAX; apoptosis regulator BAX isoform X6 [KO:K02159]
102121921  BAD; bcl2-associated agonist of cell death [KO:K02158]
102140222  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
102138212  BCL2; apoptosis regulator Bcl-2 isoform X2 [KO:K02161]
102118497  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102126339  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102121272  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
102123902  SOD2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
102135875  PRKCA; protein kinase C alpha type isoform X4 [KO:K02677] [EC:2.7.11.13]
102115793  POU2F1; POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364]
102118430  POU2F2; POU domain, class 2, transcription factor 2 isoform X14 [KO:K09364]
102115798  POU2F3; POU domain, class 2, transcription factor 3 isoform X1 [KO:K09364]
102118696  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
102138630  CD40LG; CD40 ligand [KO:K03161]
102129994  CYP1A1; cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
102122745  CYP2A24; cytochrome P450 2A6 [KO:K17683] [EC:1.14.14.-]
102124427  CYP2B6; cytochrome P450 2B6 isoform X1 [KO:K17709] [EC:1.14.14.-]
102117212  CYP2C8; cytochrome P450 2C20 isoform X3 [KO:K17718] [EC:1.14.14.1]
102119308  CYP2C93; cytochrome P450 2C20-like [KO:K17718] [EC:1.14.14.1]
102116849  cytochrome P450 2C20-like isoform X1 [KO:K17718] [EC:1.14.14.1]
102115450  CYP2C9; cytochrome P450 2C9 isoform X1 [KO:K17719] [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
102147103  CYP2C19; cytochrome P450 2C9 [KO:K17719] [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
102119662  CYP2J2; cytochrome P450 2J2 isoform X1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
102121124  AGER; advanced glycosylation end product-specific receptor [KO:K19722]
102116010  NOX1; NADPH oxidase 1 isoform X1 [KO:K08008]
102122418  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
102124562  NCF1; neutrophil cytosol factor 1 [KO:K08011]
102143777  cytochrome b-245 light chain isoform X2 [KO:K08009]
102123175  NCF2; neutrophil cytosol factor 2 [KO:K08010]
102143747  NCF4; neutrophil cytosol factor 4 isoform X1 [KO:K08012]
101866593  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
102134837  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
102116225  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
102119008  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
102118402  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
101925934  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102125726  cell division control protein 42 homolog [KO:K04393]
102124817  cell division control protein 42 homolog [KO:K04393]
102125035  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
102126975  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X2 [KO:K04431] [EC:2.7.12.2]
102143716  FOS; proto-oncogene c-Fos [KO:K04379]
102126446  JUN; transcription factor AP-1 [KO:K04448]
102135739  CCL2; C-C motif chemokine 2 [KO:K14624]
102138837  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
102127272  CXCL8; interleukin-8 [KO:K10030]
102116823  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
101925060  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X3 [KO:K04433] [EC:2.7.12.2]
101867352  MAPK13; mitogen-activated protein kinase 13 isoform X2 [KO:K04441] [EC:2.7.11.24]
101926770  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
102134421  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
101867305  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
102118744  HRAS; GTPase HRas isoform X1 [KO:K02833]
102131483  KRAS; GTPase KRas isoform X1 [KO:K07827]
102137913  NRAS; GTPase NRas [KO:K07828]
102145011  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102116996  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
101867324  RELA; transcription factor p65 isoform X1 [KO:K04735]
102138273  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102143564  SELE; E-selectin [KO:K06494]
102141875  P-selectin [KO:K06496]
102131307  VCAM1; vascular cell adhesion protein 1 [KO:K06527]
102142651  MMP3; stromelysin-1 [KO:K01394] [EC:3.4.24.17]
102117693  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
102119749  IL1B; interleukin-1 beta [KO:K04519]
102138971  IL6; interleukin-6 precursor [KO:K05405]
102139631  TNF; tumor necrosis factor isoform X1 [KO:K03156]
101926186  HSPD1; 60 kDa heat shock protein, mitochondrial [KO:K04077] [EC:5.6.1.7]
102121908  60 kDa heat shock protein, mitochondrial-like [KO:K04077] [EC:5.6.1.7]
102143176  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
102129925  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
101925240  HSPA1A; heat shock 70 kDa protein 1A [KO:K03283]
102131294  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
101926012  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
123572795  heat shock 70 kDa protein 1A [KO:K03283]
102116937  HSPA2; heat shock-related 70 kDa protein 2 [KO:K26598]
102136503  HSPA4; heat shock 70 kDa protein 4 isoform X1 [KO:K09489]
101926380  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
102123807  LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like [KO:K04079]
101866865  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
101926487  HSP90B1; endoplasmin [KO:K09487]
102136375  LOW QUALITY PROTEIN: endoplasmin-like [KO:K09487]
102146068  TLR2; toll-like receptor 2 [KO:K10159]
102124806  lipopolysaccharide-binding protein [KO:K05399]
102129342  CD14; monocyte differentiation antigen CD14 precursor [KO:K04391]
102118398  LY96; lymphocyte antigen 96 isoform X2 [KO:K05400]
102136906  TLR4; toll-like receptor 4 isoform X2 [KO:K10160]
101866832  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
102140231  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
102134829  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
102128596  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
102122493  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
101865975  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
102140498  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
102115964  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
102146604  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
102115368  IKBKG; NF-kappa-B essential modulator isoform X5 [KO:K07210]
101867458  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
102142245  TICAM2; TIR domain-containing adapter molecule 2 [KO:K05409]
102122857  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
102141355  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
102135896  MIB1; E3 ubiquitin-protein ligase MIB1 isoform X1 [KO:K10645] [EC:2.3.2.27]
102127571  MIB2; E3 ubiquitin-protein ligase MIB2 isoform X5 [KO:K10645] [EC:2.3.2.27]
102128025  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
102126428  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
102144774  TBK1; serine/threonine-protein kinase TBK1 isoform X2 [KO:K05410] [EC:2.7.11.10]
102130894  IRF7; interferon regulatory factor 7 isoform X2 [KO:K09447]
102132745  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
102146717  interferon alpha-17 [KO:K05414]
102140303  interferon alpha-1/13 [KO:K05414]
102140954  IFNA8; interferon alpha-8 [KO:K05414]
102141744  interferon alpha-1/13 [KO:K05414]
102141352  interferon alpha-1/13-like [KO:K05414]
102143043  IFNA6; interferon alpha-6 [KO:K05414]
102144479  interferon alpha-14 [KO:K05414]
102144833  interferon alpha-4-like [KO:K05414]
102145208  interferon alpha-10 [KO:K05414]
102145962  interferon alpha-17 [KO:K05414]
102115289  interferon alpha-17 [KO:K05414]
102142148  IFNA2; interferon alpha-2 [KO:K05414]
123569038  interferon alpha-17-like [KO:K05414]
102146344  interferon alpha-17-like [KO:K05414]
102147079  interferon alpha-17-like [KO:K05414]
102115670  IFNB1; interferon beta [KO:K05415]
101926577  CD36; platelet glycoprotein 4 [KO:K06259]
102120453  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
102133330  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
102132522  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
101864810  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
102118154  LYN; tyrosine-protein kinase Lyn isoform X2 [KO:K05854] [EC:2.7.10.2]
101925550  PTK2; focal adhesion kinase 1 isoform X6 [KO:K05725] [EC:2.7.10.2]
101865181  VAV3; guanine nucleotide exchange factor VAV3 isoform X2 [KO:K05730]
101867234  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
102137531  VAV2; guanine nucleotide exchange factor VAV2 isoform X3 [KO:K05730]
102139888  TLR6; toll-like receptor 6 [KO:K10169]
102144586  RAP1A; ras-related protein Rap-1A isoform X3 [KO:K04353]
102133022  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
107127795  CCL5; C-C motif chemokine 5 [KO:K12499]
102119743  C-C motif chemokine 3-like [KO:K05408]
102118223  C-C motif chemokine 3-like 1 [KO:K05408]
102136134  C-C motif chemokine 3 [KO:K05408]
102123272  CXCL2; C-X-C motif chemokine 2 [KO:K05505]
102126138  CXCL1; growth-regulated alpha protein [KO:K05505]
102123657  growth-regulated alpha protein [KO:K05505]
102115316  IL12A; interleukin-12 subunit alpha [KO:K05406]
102124858  IL12B; interleukin-12 subunit beta [KO:K05425]
102142532  NLRP3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800]
102135101  IL18; interleukin-18 isoform X1 [KO:K05482]
102140826  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
102135853  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X4 [KO:K09054]
102131632  DDIT3; DNA damage-inducible transcript 3 protein isoform X2 [KO:K04452]
102123310  ERO1A; ERO1-like protein alpha [KO:K10950] [EC:1.8.4.-]
101865389  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
101926613  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
102126681  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101865637  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
101866326  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
102117377  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
101925386  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
102117938  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
102116193  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
101925175  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
101925657  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
102122252  XBP1; X-box-binding protein 1 isoform X1 [KO:K09027]
102117645  ABCA1; phospholipid-transporting ATPase ABCA1 isoform X2 [KO:K05641]
102128526  ABCG1; ATP-binding cassette sub-family G member 1 isoform X3 [KO:K05679]
102138754  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X2 [KO:K05638]
102144771  PYCARD; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
102118885  CASP1; caspase-1 [KO:K01370] [EC:3.4.22.36]
101865787  VLDLR; very low-density lipoprotein receptor isoform X1 [KO:K20053]
101866379  3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
102133756  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
102133233  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
102136960  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
102136724  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
101925220  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2 [KO:K05858] [EC:3.1.4.11]
102140615  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
102136896  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
102123165  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
102138726  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
102119159  CALML6; calmodulin-like protein 6 [KO:K02183]
102114795  CALML3; calmodulin-like protein 3 [KO:K02183]
102146976  CALML5; calmodulin-like protein 5 [KO:K02183]
102131162  CALM1; calmodulin-1 [KO:K02183]
101866377  CALM3; calmodulin-3 [KO:K02183]
101865168  CALM2; calmodulin-2 [KO:K02183]
102122343  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
102144138  calmodulin-1 [KO:K02183]
101926738  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102134477  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101866070  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102137250  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
101866439  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
101864918  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
102139560  TNFRSF10A; tumor necrosis factor receptor superfamily member 10A [KO:K04722]
102133727  TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K04722]
102135285  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102139406  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
101865354  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
102143226  BID; BH3-interacting domain death agonist isoform X2 [KO:K04726]
102117102  cytochrome c-like [KO:K08738]
102120205  cytochrome c [KO:K08738]
102125088  cytochrome c-like [KO:K08738]
102136392  cytochrome c-like [KO:K08738]
102127614  cytochrome c-like [KO:K08738]
102141866  cytochrome c-like [KO:K08738]
107127908  cytochrome c-like [KO:K08738]
102120841  cytochrome c-like [KO:K08738]
102123704  cytochrome c-like [KO:K08738]
107130218  cytochrome c-like [KO:K08738]
102137473  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
102126830  CASP9; LOW QUALITY PROTEIN: caspase-9 [KO:K04399] [EC:3.4.22.62]
101867077  CASP6; caspase-6 isoform X3 [KO:K04396] [EC:3.4.22.59]
102144182  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
102127213  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
102135998  TP53; cellular tumor antigen p53 isoform X2 [KO:K04451]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00187  Cholesterol
C00338  Lipopolysaccharide
C00422  Triacylglycerol
C00704  Superoxide
C00865  Phospholipid
C01245  D-myo-Inositol 1,4,5-trisphosphate
C02530  Cholesterol ester
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:23899566
  Authors
Hopkins PN
  Title
Molecular biology of atherosclerosis.
  Journal
Physiol Rev 93:1317-542 (2013)
DOI:10.1152/physrev.00004.2012
Reference
PMID:22064431
  Authors
Weber C, Noels H
  Title
Atherosclerosis: current pathogenesis and therapeutic options.
  Journal
Nat Med 17:1410-22 (2011)
DOI:10.1038/nm.2538
Reference
PMID:25869663
  Authors
Tabas I, Garcia-Cardena G, Owens GK
  Title
Recent insights into the cellular biology of atherosclerosis.
  Journal
J Cell Biol 209:13-22 (2015)
DOI:10.1083/jcb.201412052
Reference
PMID:25614320
  Authors
Tall AR, Yvan-Charvet L
  Title
Cholesterol, inflammation and innate immunity.
  Journal
Nat Rev Immunol 15:104-16 (2015)
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Related
pathway
mcf04020  Calcium signaling pathway
mcf04115  p53 signaling pathway
mcf04141  Protein processing in endoplasmic reticulum
mcf04151  PI3K-Akt signaling pathway
mcf04210  Apoptosis
mcf04620  Toll-like receptor signaling pathway
mcf04621  NOD-like receptor signaling pathway
mcf04668  TNF signaling pathway
mcf04670  Leukocyte transendothelial migration
mcf04975  Fat digestion and absorption
mcf04979  Cholesterol metabolism
mcf05418  Fluid shear stress and atherosclerosis
KO pathway
ko05417   
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