KEGG   PATHWAY: mjv04510
Entry
mjv04510                    Pathway                                
Name
Focal adhesion - Manis javanica (Malayan pangolin)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
mjv04510  Focal adhesion
mjv04510

Other DBs
GO: 0005925
Organism
Manis javanica (Malayan pangolin) [GN:mjv]
Gene
108398405  COL1A2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
108385124  COL1A1; collagen alpha-1(I) chain [KO:K06236]
108392454  COL2A1; collagen alpha-1(II) chain [KO:K19719]
108406100  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
108391617  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
108397219  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
108397237  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
108401312  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
108395182  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
108409564  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
108406673  collagen alpha-6(VI) chain isoform X1 [KO:K06238]
108406785  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
108402426  LOW QUALITY PROTEIN: collagen alpha-5(VI) chain-like [KO:K06238]
108409560  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
108404568  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
108399163  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
108408944  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
108397227  LAMA2; laminin subunit alpha-2 [KO:K05637]
108400452  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
108399156  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
108401680  LAMA3; laminin subunit alpha-3 [KO:K06240]
108399832  LAMA4; laminin subunit alpha-4 [KO:K06241]
108404581  LAMB1; laminin subunit beta-1 [KO:K05636]
108383249  LAMB2; laminin subunit beta-2 [KO:K06243]
108392348  LAMB4; laminin subunit beta-4 [KO:K06245]
108410039  LAMC1; laminin subunit gamma-1 [KO:K05635]
108410040  LAMC2; laminin subunit gamma-2 [KO:K06246]
108408192  LAMC3; laminin subunit gamma-3 [KO:K06247]
108384403  CHAD; chondroadherin [KO:K06248]
108407456  RELN; reelin [KO:K06249] [EC:3.4.21.-]
108400147  THBS1; thrombospondin-1 [KO:K16857]
108406027  cartilage oligomeric matrix protein [KO:K04659]
108407292  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
108406777  THBS2; thrombospondin-2 isoform X1 [KO:K04659]
108390191  THBS4; thrombospondin-4 [KO:K04659]
108407058  FN1; fibronectin isoform X1 [KO:K05717]
108401269  SPP1; osteopontin isoform X1 [KO:K06250]
108396937  VTN; vitronectin [KO:K06251]
108394274  TNR; tenascin-R isoform X3 [KO:K06252]
108401015  TNC; tenascin isoform X1 [KO:K06252]
108404459  VWF; von Willebrand factor [KO:K03900]
108401268  bone sialoprotein 2 [KO:K06253]
108400786  ITGA1; integrin alpha-1 isoform X2 [KO:K06480]
108386296  ITGA2; integrin alpha-2 [KO:K06481]
108410024  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
108385122  ITGA3; integrin alpha-3 [KO:K06482]
108408834  ITGA4; integrin alpha-4 [KO:K06483]
108408507  ITGA5; LOW QUALITY PROTEIN: integrin alpha-5 [KO:K06484]
108405577  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
108395928  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
108396731  ITGA8; integrin alpha-8 [KO:K06584]
108393230  ITGA9; integrin alpha-9 [KO:K06585]
108400389  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
108401199  ITGA11; integrin alpha-11 [KO:K06587]
108396573  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
108397161  integrin beta-1 isoform X1 [KO:K05719]
118970953  integrin beta-1-like [KO:K05719]
108401068  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
108400639  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
108410150  ITGB5; integrin beta-5 [KO:K06588]
108390684  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
108405384  ITGB7; integrin beta-7 [KO:K06590]
108391499  ITGB8; integrin beta-8 [KO:K06591]
108401099  EMP2; epithelial membrane protein 2 [KO:K26256]
118970652  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
108397360  PDGFB; platelet-derived growth factor subunit B isoform X4 [KO:K17386]
108393368  PDGFC; platelet-derived growth factor C isoform X4 [KO:K05450]
108390154  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
108408073  EGF; pro-epidermal growth factor [KO:K04357]
108410340  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
108407135  VEGFA; vascular endothelial growth factor A [KO:K05448]
108407564  VEGFB; vascular endothelial growth factor B isoform X3 [KO:K16858]
108399226  PGF; placenta growth factor isoform X1 [KO:K16859]
108391501  VEGFC; vascular endothelial growth factor C [KO:K05449]
108384371  VEGFD; vascular endothelial growth factor D [KO:K05449]
108399212  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
108385741  PDGFRA; LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
108385397  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
108403280  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
108400781  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
108397962  EGFR; epidermal growth factor receptor isoform X5 [KO:K04361] [EC:2.7.10.1]
108385338  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
108408755  vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
108399322  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
108390012  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
108390542  EMP1; epithelial membrane protein 1 [KO:K26255]
108401592  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
118969433  rho GTPase-activating protein 35-like [KO:K05732]
108398868  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
108392987  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
108383250  transforming protein RhoA [KO:K04513]
108399530  LOW QUALITY PROTEIN: protein diaphanous homolog 1-like [KO:K05740]
108384170  protein diaphanous homolog 1-like [KO:K05740]
108391302  ROCK1; rho-associated protein kinase 1 isoform X3 [KO:K04514] [EC:2.7.11.1]
108409101  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
108400560  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
108394026  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
108387031  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
108404603  MYL10; myosin regulatory light chain 10 isoform X2 [KO:K12756]
108407219  myosin regulatory light chain 12B [KO:K12757]
108407220  myosin regulatory light polypeptide 9 isoform X1 [KO:K12757]
108404503  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
108407321  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
108393155  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
108400557  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
108408094  PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
108396329  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X3 [KO:K17457]
108396719  MYLK; myosin light chain kinase, smooth muscle isoform X4 [KO:K00907] [EC:2.7.11.18]
108393093  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
108402114  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
108385316  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
108393271  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
108393051  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X4 [KO:K00889] [EC:2.7.1.68]
108403623  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
108399416  ACTB; actin, cytoplasmic 1 [KO:K05692]
108409874  ACTG1; actin, cytoplasmic 2 [KO:K05692]
108389020  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
108400832  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
108391826  ACTN1; alpha-actinin-1 isoform X3 [KO:K05699]
108399501  ACTN4; alpha-actinin-4 isoform X3 [KO:K05699]
108406886  TLN1; talin-1 isoform X1 [KO:K06271]
108408578  TLN2; talin-2 isoform X1 [KO:K06271]
108387997  FLNA; filamin-A isoform X2 [KO:K04437]
118967041  filamin-A isoform X1 [KO:K04437]
108394917  FLNB; filamin-B isoform X4 [KO:K27392]
118969555  filamin-B-like [KO:K27392]
108397691  PXN; paxillin isoform X1 [KO:K05760]
108384232  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
108404386  ZYX; zyxin isoform X1 [KO:K06273]
108392084  vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
108398761  VCL; vinculin isoform X1 [KO:K05700]
108390853  PARVA; alpha-parvin [KO:K06275]
108403218  PARVB; beta-parvin isoform X1 [KO:K06275]
108403219  PARVG; gamma-parvin [KO:K06275]
108399811  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X3 [KO:K06276] [EC:2.7.11.1]
108397433  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108390484  AKT2; RAC-beta serine/threonine-protein kinase isoform X3 [KO:K04456] [EC:2.7.11.1]
108393746  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108389003  GSK3B; glycogen synthase kinase-3 beta isoform X5 [KO:K03083] [EC:2.7.11.26]
108387548  CTNNB1; catenin beta-1 [KO:K02105]
108387768  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
108385666  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
108395733  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
108394624  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
108406544  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108390365  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108400388  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108383561  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
108390475  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
108395975  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
108397450  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
108388194  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
108401794  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
108394631  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
108407595  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
108392664  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
108384279  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
108391169  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
108409892  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
108395451  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
108394258  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
118966805  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
108391531  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
108396170  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
108408988  CRKL; crk-like protein [KO:K04438]
108394533  CRK; adapter molecule crk isoform X1 [KO:K04438]
108408449  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
108406801  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X18 [KO:K06277]
108395546  RAP1A; ras-related protein Rap-1A [KO:K04353]
108407356  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
108392641  LOW QUALITY PROTEIN: ras-related protein Rap-1b-like [KO:K07836]
108396943  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
108384893  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
108385635  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
108386817  JUN; transcription factor AP-1 [KO:K04448]
108387830  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
108394305  LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf-like [KO:K04365] [EC:2.7.11.1]
108399323  CAV1; caveolin-1 isoform X1 [KO:K06278]
108399324  CAV2; caveolin-2 isoform X1 [KO:K12958]
118973391  caveolin-2-like [KO:K12958]
108401772  CAV3; caveolin-3 [KO:K12959]
108396080  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
108407280  SHC-transforming protein 1 isoform X1 [KO:K06279]
118972101  SHC-transforming protein 1-like isoform X1 [KO:K06279]
108391745  SHC2; SHC-transforming protein 2 isoform X2 [KO:K17447]
108394387  SHC3; SHC-transforming protein 3 isoform X1 [KO:K17448]
108402352  SHC4; SHC-transforming protein 4 [KO:K17449]
108400653  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
108391894  SOS2; son of sevenless homolog 2 [KO:K03099]
108385648  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
108408627  HRAS; GTPase HRas isoform X1 [KO:K02833]
118967667  GTPase HRas-like isoform X1 [KO:K02833]
108394341  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
108392139  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
108398454  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
108400663  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108401876  ELK1; ETS domain-containing protein Elk-1 isoform X2 [KO:K04375]
108388480  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
108403976  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
108405335  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
108389053  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
108389075  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
108391115  E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
108407571  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
108385222  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
mjv04010  MAPK signaling pathway
mjv04060  Cytokine-cytokine receptor interaction
mjv04070  Phosphatidylinositol signaling system
mjv04110  Cell cycle
mjv04151  PI3K-Akt signaling pathway
mjv04310  Wnt signaling pathway
mjv04512  ECM-receptor interaction
mjv04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
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