Entry Name Axon guidance - Microcebus murinus (gray mouse lemur)
Description Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.
Class Organismal Systems; Development and regenerationBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Microcebus murinus (gray mouse lemur) [GN:
mmur ]
Gene 105865830 PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116 ] [EC:3.1.4.11 ]
105870064 TRPC1; short transient receptor potential channel 1 isoform X1 [KO:K04964 ]
105882105 TRPC3; short transient receptor potential channel 3 isoform X1 [KO:K04966 ]
105862084 TRPC4; short transient receptor potential channel 4 isoform X1 [KO:K04967 ]
105874578 TRPC6; short transient receptor potential channel 6 isoform X2 [KO:K04969 ]
105868798 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
105863295 PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
105857150 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
105872262 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
105858914 NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
105866622 NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334 ]
105868254 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
105883746 RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860 ]
105878067 RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861 ]
105873610 CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393 ]
105875996 ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532 ]
105878739 LRIG2; leucine-rich repeats and immunoglobulin-like domains protein 2 isoform X1 [KO:K24609 ]
105874990 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
105864008 GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630 ]
105879338 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
105868907 SRGAP2; SLIT-ROBO Rho GTPase-activating protein 2 isoform X1 [KO:K07526 ]
105869066 SRGAP3; SLIT-ROBO Rho GTPase-activating protein 3 isoform X1 [KO:K07526 ]
105880959 SRGAP1; SLIT-ROBO Rho GTPase-activating protein 1 isoform X1 [KO:K07526 ]
105884382 DPYSL5; dihydropyrimidinase-related protein 5 isoform X1 [KO:K07529 ]
105877120 DPYSL2; dihydropyrimidinase-related protein 2 isoform X1 [KO:K07528 ]
105868864 CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
105879489 CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X2 [KO:K04515 ] [EC:2.7.11.17 ]
105858406 CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
105862660 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
105855821 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
105886063 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
105881219 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
105855026 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
105877483 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
105872272 PARD6B; partitioning defective 6 homolog beta isoform X1 [KO:K06093 ]
105859026 PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093 ]
Compound Reference Authors Guan KL, Rao Y.
Title Signalling mechanisms mediating neuronal responses to guidance cues.
Journal Reference Authors Govek EE, Newey SE, Van Aelst L.
Title The role of the Rho GTPases in neuronal development.
Journal Reference Authors Huber AB, Kolodkin AL, Ginty DD, Cloutier JF.
Title Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance.
Journal Reference Authors Negishi M, Oinuma I, Katoh H.
Title Plexins: axon guidance and signal transduction.
Journal Reference Authors Huot J.
Title Ephrin signaling in axon guidance.
Journal Reference Authors Patel BN, Van Vactor DL.
Title Axon guidance: the cytoplasmic tail.
Journal Reference Authors Yu TW, Bargmann CI.
Title Dynamic regulation of axon guidance.
Journal Reference Authors Dickson BJ.
Title Molecular mechanisms of axon guidance.
Journal Reference Authors Barallobre MJ, Pascual M, Del Rio JA, Soriano E.
Title The Netrin family of guidance factors: emphasis on Netrin-1 signalling.
Journal Reference Authors Sabatier C, Plump AS, Le Ma, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M.
Title The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.
Journal Reference Authors Fujita Y, Yamashita T
Title Axon growth inhibition by RhoA/ROCK in the central nervous system.
Journal Reference Authors Yamashita T, Mueller BK, Hata K
Title Neogenin and repulsive guidance molecule signaling in the central nervous system.
Journal Reference Authors van Erp S, van den Heuvel DMA, Fujita Y, Robinson RA, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers JAA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ
Title Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.
Journal Related mmur04060 Cytokine-cytokine receptor interaction
KO pathway LinkDB All DBs
