KEGG   PATHWAY: mmyo04145
Entry
mmyo04145                   Pathway                                
Name
Phagosome - Myotis myotis (greater mouse-eared bat)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
mmyo04145  Phagosome
mmyo04145

Other DBs
GO: 0045335
Organism
Myotis myotis (greater mouse-eared bat) [GN:mmyo]
Gene
118676405  VAMP3; vesicle-associated membrane protein 3 isoform X1 [KO:K13505]
118676121  STX12; syntaxin-12 isoform X1 [KO:K13813]
118660024  STX7; syntaxin-7 isoform X1 [KO:K08488]
118659361  ACTB; actin, cytoplasmic 1 [KO:K05692]
118674776  LOW QUALITY PROTEIN: actin-like [KO:K05692]
118671408  ACTG1; actin, cytoplasmic 2 [KO:K05692]
118656598  CORO1A; coronin-1A [KO:K13882]
118666398  STX18; syntaxin-18 isoform X1 [KO:K08492]
118672918  SEC22B; vesicle-trafficking protein SEC22b [KO:K08517]
118658369  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
118679578  patr class I histocompatibility antigen, B-1 alpha chain-like isoform X1 [KO:K06751]
118652788  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
118659954  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
118659955  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
118659956  patr class I histocompatibility antigen, A-2 alpha chain-like isoform X1 [KO:K06751]
118659957  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
118662409  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
118655123  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
118655161  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like isoform X1 [KO:K06751]
118655171  class I histocompatibility antigen, Gogo-C*0203 alpha chain-like [KO:K06751]
118679500  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
118679523  RLA class II histocompatibility antigen, DP alpha-1 chain-like [KO:K06752]
118679525  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
118679591  LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
118679613  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
118679614  HLA class II histocompatibility antigen, DQ alpha 2 chain-like isoform X1 [KO:K06752]
118679619  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
118679624  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like isoform X1 [KO:K06752]
118679625  boLa class II histocompatibility antigen, DQB*0101 beta chain-like [KO:K06752]
118679626  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like isoform X1 [KO:K06752]
118679627  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
118679628  boLa class II histocompatibility antigen, DQB*0101 beta chain-like isoform X1 [KO:K06752]
118679633  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
118679640  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
118660487  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
118668224  RAB5A; ras-related protein Rab-5A isoform X1 [KO:K07887]
118652144  RAB5B; ras-related protein Rab-5B [KO:K07888]
118671515  RAB5C; ras-related protein Rab-5C isoform X1 [KO:K07889]
118649858  EEA1; early endosome antigen 1 isoform X1 [KO:K12478]
118662908  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
118675500  TFRC; transferrin receptor protein 1 isoform X1 [KO:K06503]
118672472  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
118676142  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
118657996  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
118668877  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
118669278  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
118670702  ATP6V1C1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
118656775  ATP6V1D; V-type proton ATPase subunit D isoform X1 [KO:K02149]
118650310  ATP6V1E1; V-type proton ATPase subunit E 1 isoform X1 [KO:K02150]
118669485  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
118666428  ATP6V1F; V-type proton ATPase subunit F isoform X1 [KO:K02151]
118666304  V-type proton ATPase subunit G 1-like [KO:K02152]
118678759  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
118667098  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
118667222  V-type proton ATPase subunit G 1-like [KO:K02152]
118679590  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
118658031  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
118665948  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
118662111  V-type proton ATPase subunit e 1-like [KO:K02153]
118666617  ATP6V0A4; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
118655501  ATP6V0A2; V-type proton ATPase 116 kDa subunit a2 isoform X1 [KO:K02154]
118671503  ATP6V0A1; V-type proton ATPase 116 kDa subunit a1 isoform X1 [KO:K02154]
118665201  TCIRG1; V-type proton ATPase 116 kDa subunit a3 [KO:K02154]
118670455  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
118674875  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
118670820  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
118655969  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
118676845  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
118654072  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
118662569  RAB7A; ras-related protein Rab-7a isoform X1 [KO:K07897]
118673367  RAB7B; ras-related protein Rab-7b isoform X1 [KO:K07898]
118671906  rab-interacting lysosomal protein isoform X1 [KO:K13883]
118659937  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
118664379  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
118666196  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
118661343  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
118674186  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
118668268  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 isoform X1 [KO:K10416]
118650258  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
118650856  tubulin alpha-1B chain-like [KO:K07374]
118666216  tubulin alpha-1C chain-like [KO:K07374]
118673521  tubulin alpha-1B chain-like [KO:K07374]
118678375  LOW QUALITY PROTEIN: putative tubulin-like protein alpha-4B [KO:K07374]
118678448  LOW QUALITY PROTEIN: tubulin alpha-3 chain-like [KO:K07374]
118652035  tubulin alpha-1A chain [KO:K07374]
118661080  TUBA4A; tubulin alpha-4A chain [KO:K07374]
118661627  tubulin alpha-1D chain isoform X1 [KO:K07374]
118672614  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
118658764  TUBB4A; tubulin beta-4A chain isoform X1 [KO:K07375]
118679650  TUBB; tubulin beta chain [KO:K07375]
118652991  TUBB3; tubulin beta-3 chain [KO:K07375]
118655285  TUBB4B; tubulin beta-4B chain [KO:K07375]
118662962  TUBB1; tubulin beta-1 chain [KO:K07375]
118663023  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
118675862  tubulin beta-2B chain isoform X1 [KO:K07375]
118676275  TUBB2B; tubulin beta-2B chain [KO:K07375]
118651797  LAMP1; lysosome-associated membrane glycoprotein 1 isoform X1 [KO:K06528]
118653371  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
118661148  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
118652114  M6PR; cation-dependent mannose-6-phosphate receptor isoform X1 [KO:K10089]
118678505  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
118671763  MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
118650031  cathepsin L2-like [KO:K01365] [EC:3.4.22.15]
118667405  cathepsin L1-like isoform X1 [KO:K01365] [EC:3.4.22.15]
118667406  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118667617  cathepsin L1 [KO:K01365] [EC:3.4.22.15]
118667634  cathepsin L1-like isoform X1 [KO:K01365] [EC:3.4.22.15]
118654537  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118672753  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
118677323  SEC61A2; protein transport protein Sec61 subunit alpha isoform X1 [KO:K10956]
118662873  SEC61A1; protein transport protein Sec61 subunit alpha [KO:K10956]
118651566  protein transport protein Sec61 subunit beta-like [KO:K09481]
118667262  SEC61B; protein transport protein Sec61 subunit beta [KO:K09481]
118665902  SEC61G; protein transport protein Sec61 subunit gamma isoform X1 [KO:K07342]
118679553  TAP1; antigen peptide transporter 1 isoform X1 [KO:K05653] [EC:7.4.2.14]
118679593  TAP2; antigen peptide transporter 2 isoform X1 [KO:K05654] [EC:7.4.2.14]
118652589  CALR; calreticulin [KO:K08057]
118657848  CANX; calnexin [KO:K08054]
118673015  FCGR1A; high affinity immunoglobulin gamma Fc receptor I [KO:K06498]
118673376  low affinity immunoglobulin gamma Fc region receptor III-like isoform X1 [KO:K06472]
118673458  low affinity immunoglobulin gamma Fc region receptor II-like isoform X1 [KO:K12560]
118673542  low affinity immunoglobulin gamma Fc region receptor III-B-like isoform X1 [KO:K06463]
118651308  C1R; complement C1r subcomponent [KO:K01330] [EC:3.4.21.41]
118676535  ITGB2; integrin beta-2 isoform X1 [KO:K06464]
118658864  C3; LOW QUALITY PROTEIN: complement C3 [KO:K03990]
118669315  COLEC11; collectin-11 [KO:K10066]
118662647  COLEC12; collectin-12 isoform X1 [KO:K10062]
118670199  mannose-binding protein A-like isoform X1 [KO:K03991]
118670247  MBL2; mannose-binding protein C [KO:K03991]
118670360  pulmonary surfactant-associated protein A-like isoform X1 [KO:K10067]
118661050  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
118655743  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
118650963  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
118676628  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
118671715  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
118675382  ITGB5; integrin beta-5 [KO:K06588]
118649603  THBS1; thrombospondin-1 [KO:K16857]
118660255  THBS2; thrombospondin-2 [KO:K04659]
118656424  THBS4; thrombospondin-4 [KO:K04659]
118657572  cartilage oligomeric matrix protein [KO:K04659]
118672802  THBS3; thrombospondin-3 [KO:K04659]
118658736  TLR2; toll-like receptor 2 [KO:K10159]
118667626  TLR6; toll-like receptor 6 [KO:K10169]
118667106  TLR4; toll-like receptor 4 [KO:K10160]
118659273  CD14; monocyte differentiation antigen CD14 [KO:K04391]
118674242  MRC1; macrophage mannose receptor 1 isoform X1 [KO:K06560]
118661691  PLA2R1; secretory phospholipase A2 receptor isoform X1 [KO:K06560]
118671795  MRC2; C-type mannose receptor 2 isoform X1 [KO:K06560]
118659194  CD209 antigen-like protein C isoform X1 [KO:K06563]
118651802  CLEC7A; C-type lectin domain family 7 member A isoform X1 [KO:K10074]
118651202  MSR1; macrophage scavenger receptor types I and II isoform X1 [KO:K06558]
118662003  MARCO; macrophage receptor MARCO [KO:K13884]
118651403  OLR1; oxidized low-density lipoprotein receptor 1 isoform X1 [KO:K08763]
118655512  SCARB1; scavenger receptor class B member 1 isoform X1 [KO:K13885]
118666052  CD36; platelet glycoprotein 4 [KO:K06259]
118674356  cytochrome b-245 light chain isoform X1 [KO:K08009]
118653335  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
118657696  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
118656018  NCF1; neutrophil cytosol factor 1 [KO:K08011]
118673121  NCF2; neutrophil cytosol factor 2 [KO:K08010]
118651703  NCF4; neutrophil cytosol factor 4 [KO:K08012]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
mmyo04142  Lysosome
mmyo04144  Endocytosis
mmyo04610  Complement and coagulation cascades
mmyo04612  Antigen processing and presentation
mmyo04620  Toll-like receptor signaling pathway
mmyo04666  Fc gamma R-mediated phagocytosis
KO pathway
ko04145   
LinkDB

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