KEGG   PATHWAY: mni04144
Entry
mni04144                    Pathway                                
Name
Endocytosis - Macaca nemestrina (pig-tailed macaque)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
mni04144  Endocytosis
mni04144

Other DBs
GO: 0006897
Organism
Macaca nemestrina (pig-tailed macaque) [GN:mni]
Gene
105481853  ARF6; ADP-ribosylation factor 6 [KO:K07941]
105485468  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
105497845  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
105491781  PIP5K1B; LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
105463965  PIP5KL1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 [KO:K13712] [EC:2.7.1.68]
105465688  PLD1; LOW QUALITY PROTEIN: phospholipase D1 [KO:K01115] [EC:3.1.4.4]
105472332  PLD2; phospholipase D2 isoform X2 [KO:K01115] [EC:3.1.4.4]
105463975  DNM1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
105484426  DNM3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
105474181  DNM2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
105485766  CLTA; clathrin light chain A isoform X1 [KO:K04644]
105480938  CLTB; clathrin light chain B isoform X1 [KO:K04645]
105476842  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
105480735  CLTCL1; clathrin heavy chain 2 isoform X1 [KO:K04646]
105497180  AP2A1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
105494175  AP2A2; LOW QUALITY PROTEIN: AP-2 complex subunit alpha-2 [KO:K11824]
105485130  AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825]
105480122  AP2M1; AP-2 complex subunit mu isoform X1 [KO:K11826]
105478594  AP2S1; AP-2 complex subunit sigma isoform X1 [KO:K11827]
105478613  EH domain-containing protein 2 [KO:K12469]
105477209  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
105470963  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
105475073  ZFYVE16; zinc finger FYVE domain-containing protein 16 isoform X1 [KO:K04679]
105495054  ZFYVE9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
105463766  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
105489370  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
105488126  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
105470763  TFRC; LOW QUALITY PROTEIN: transferrin receptor protein 1 [KO:K06503]
105493061  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
105463522  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105469674  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
105483839  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
105484062  FGFR4; fibroblast growth factor receptor 4 isoform X5 [KO:K05095] [EC:2.7.10.1]
105479398  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
105476372  CBL; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
105477589  CBLB; E3 ubiquitin-protein ligase CBL-B [KO:K22517] [EC:2.3.2.27]
105478670  CBLC; E3 ubiquitin-protein ligase CBL-C [KO:K22518] [EC:2.3.2.27]
105478200  SH3KBP1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
105485289  SH3GL1; endophilin-A2 isoform X1 [KO:K11247]
105497466  SH3GL3; endophilin-A3 isoform X1 [KO:K11247]
105489072  SH3GL2; endophilin-A1 isoform X1 [KO:K11247]
105482787  SH3GLB1; endophilin-B1 isoform X1 [KO:K11248]
105464002  SH3GLB2; endophilin-B2 isoform X1 [KO:K21269]
105497766  AMPH; amphiphysin isoform X1 [KO:K12562]
105492432  BIN1; myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
105488147  EPN1; epsin-1 isoform X1 [KO:K12471]
105493346  EPN2; epsin-2 isoform X1 [KO:K12471]
105472387  EPN3; epsin-3 isoform X1 [KO:K12471]
105492908  EPS15L1; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
105495236  EPS15; epidermal growth factor receptor substrate 15 [KO:K12472]
105486046  SPART; spartin [KO:K19366]
105493093  NEDD4; E3 ubiquitin-protein ligase NEDD4 [KO:K10591] [EC:2.3.2.26]
105477069  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
105473404  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
105471571  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
105474149  RNF41; E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
105496239  ITCH; E3 ubiquitin-protein ligase Itchy homolog isoform X1 [KO:K05632] [EC:2.3.2.26]
105469005  SMURF2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
105498089  SMURF1; E3 ubiquitin-protein ligase SMURF1 [KO:K04678] [EC:2.3.2.26]
105477150  WWP1; LOW QUALITY PROTEIN: NEDD4-like E3 ubiquitin-protein ligase WWP1 [KO:K05633] [EC:2.3.2.26]
105486920  LDLR; low-density lipoprotein receptor [KO:K12473]
105494471  LDLRAP1; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
105473110  DAB2; disabled homolog 2 isoform X1 [KO:K12475]
105480352  CCR5; C-C chemokine receptor type 5 [KO:K04180]
105481204  CXCR1; C-X-C chemokine receptor type 1 [KO:K04175]
105481202  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
105492570  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
105485244  GRK1; rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
105469988  GRK7; rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
105495703  GRK3; beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
105469669  GRK2; beta-adrenergic receptor kinase 1 isoform X1 [KO:K00910] [EC:2.7.11.15]
105467774  GRK5; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
105483861  GRK4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
105484049  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
105468761  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
105472261  ARRB2; beta-arrestin-2 isoform X3 [KO:K04439]
105475007  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
105465161  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
105474937  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
105492525  ACTR3; actin-related protein 3 [KO:K18584]
105497678  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
105497684  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
105481206  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
105487152  ARPC3; LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 3 [KO:K05756]
105477669  ARPC4; actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
105463913  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
105484569  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
105475930  WIPF3; WAS/WASL-interacting protein family member 3 [KO:K19475]
105483207  WIPF1; WAS/WASL-interacting protein family member 1 [KO:K19475]
105472221  WIPF2; WAS/WASL-interacting protein family member 2 [KO:K19475]
105476325  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
105497606  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
105497607  heat shock 70 kDa protein 1 isoform X1 [KO:K03283]
105498221  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
105498547  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
105498457  DNAJC6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
105497705  WASHC4; WASH complex subunit 4 isoform X1 [KO:K18465]
105468465  WASHC5; WASH complex subunit 5 [KO:K18464]
105486711  WASH complex subunit 2A [KO:K18462]
105463797  WASHC1; WASH complex subunit 1 isoform X1 [KO:K18461]
105493823  WASHC3; WASH complex subunit 3 isoform X1 [KO:K18463]
105475615  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
105479186  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
105481385  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
105483111  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
105493419  VPS29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
105476155  VPS26B; vacuolar protein sorting-associated protein 26B [KO:K18466]
105466102  VPS26A; vacuolar protein sorting-associated protein 26A isoform X2 [KO:K18466]
105492212  VPS35; vacuolar protein sorting-associated protein 35 isoform X1 [KO:K18468]
105476656  SNX12; sorting nexin-12 [KO:K17918]
105492037  SNX3; sorting nexin-3 isoform X1 [KO:K17918]
105490448  USP8; ubiquitin carboxyl-terminal hydrolase 8 isoform X1 [KO:K11839] [EC:3.4.19.12]
105465273  STAMBP; STAM-binding protein [KO:K11866] [EC:3.4.19.12]
105477787  RAB7A; ras-related protein Rab-7a [KO:K07897]
105469305  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]
105488228  STAM; signal transducing adapter molecule 1 isoform X1 [KO:K04705]
105492661  STAM2; signal transducing adapter molecule 2 [KO:K04705]
105486984  TSG101; tumor susceptibility gene 101 protein isoform X1 [KO:K12183]
105463931  MVB12B; multivesicular body subunit 12B isoform X3 [KO:K12186]
105490046  MVB12A; multivesicular body subunit 12A isoform X1 [KO:K12186]
105464252  uncharacterized protein LOC105464252 [KO:K12184]
112423573  VPS28; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
105464652  VPS37C; vacuolar protein sorting-associated protein 37C [KO:K12185]
105463739  VPS37A; vacuolar protein sorting-associated protein 37A isoform X1 [KO:K12185]
105466407  VPS37D; vacuolar protein sorting-associated protein 37D [KO:K12185]
105494228  VPS37B; vacuolar protein sorting-associated protein 37B isoform X1 [KO:K12185]
105472334  SNF8; vacuolar-sorting protein SNF8 isoform X1 [KO:K12188]
105490763  VPS36; LOW QUALITY PROTEIN: vacuolar protein-sorting-associated protein 36 [KO:K12190]
105472100  VPS25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
105469281  CHMP6; charged multivesicular body protein 6 [KO:K12195]
105496521  CHMP4B; charged multivesicular body protein 4b [KO:K12194]
105494194  charged multivesicular body protein 4a [KO:K12194]
105483509  CHMP4C; charged multivesicular body protein 4c [KO:K24782]
105488036  CHMP2A; charged multivesicular body protein 2a isoform X1 [KO:K12191]
105485504  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
105482064  CHMP7; charged multivesicular body protein 7 [KO:K15053]
105476998  VPS4B; vacuolar protein sorting-associated protein 4B [KO:K12196]
105491359  VPS4A; vacuolar protein sorting-associated protein 4A [KO:K12196]
105465742  VTA1; vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
105488867  CHMP1A; charged multivesicular body protein 1a [KO:K12197]
105478906  CHMP1B; charged multivesicular body protein 1b [KO:K12197]
105485663  CHMP5; charged multivesicular body protein 5 [KO:K12198]
105491319  IST1; IST1 homolog isoform X1 [KO:K19476]
105470924  PDCD6IP; programmed cell death 6-interacting protein isoform X1 [KO:K12200]
105488542  SPG21; maspardin [KO:K19367]
105492011  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
105463140  SNX2; LOW QUALITY PROTEIN: sorting nexin-2 [KO:K17917]
105488745  SNX1; sorting nexin-1 isoform X1 [KO:K17917]
105486848  SNX5; sorting nexin-5 isoform X1 [KO:K17920]
105477960  SNX6; sorting nexin-6 [KO:K17920]
105469598  SNX32; sorting nexin-32 isoform X1 [KO:K17920]
105496309  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
105494134  HRAS; GTPase HRas isoform X1 [KO:K02833]
105494366  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
105464497  IL2RB; interleukin-2 receptor subunit beta isoform X2 [KO:K05069]
105476651  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
105480439  RHOA; transforming protein RhoA [KO:K04513]
105464138  MANE-B; LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-67 alpha chain [KO:K06751]
105468977  Mane-B; class I histocompatibility antigen, Gogo-B*0103 alpha chain-like precursor [KO:K06751]
105464135  Mane-B; class I histocompatibility antigen, Gogo-B*0101 alpha chain-like precursor [KO:K06751]
105467986  Mane-B; HLA class I histocompatibility antigen, B-45 alpha chain-like precursor [KO:K06751]
105466239  class I histocompatibility antigen, Gogo-B*0103 alpha chain [KO:K06751]
105466487  MANE-B; class I histocompatibility antigen, Gogo-B*0102 alpha chain isoform X1 [KO:K06751]
105498605  MANE-E; popy class I histocompatibility antigen, alpha chain E isoform X2 [KO:K06751]
105467297  class I histocompatibility antigen, Gogo-B*0101 alpha chain [KO:K06751]
105498584  MANE-A; LOW QUALITY PROTEIN: popy Class I histocompatibility antigen, A-1 alpha chain [KO:K06751]
105498640  MANE-E; patr class I histocompatibility antigen, alpha chain E [KO:K06751]
105498601  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
105464109  MANE-B; HLA class I histocompatibility antigen, B-14 alpha chain [KO:K06751]
105466472  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like isoform X1 [KO:K06751]
105491567  MANE-F; mamu class I histocompatibility antigen, alpha chain F [KO:K06751]
105491570  HLA class I histocompatibility antigen, A-24 alpha chain [KO:K06751]
105469851  LOW QUALITY PROTEIN: popy Class I histocompatibility antigen, A-1 alpha chain [KO:K06751]
105497653  HLA class I histocompatibility antigen, B-14 alpha chain-like isoform X1 [KO:K06751]
105497650  HLA class I histocompatibility antigen, B-14 alpha chain-like [KO:K06751]
105471000  MANE-B; class I histocompatibility antigen, Gogo-B*0101 alpha chain [KO:K06751]
105468694  folate receptor gamma [KO:K13649]
105468697  FOLR1; folate receptor alpha [KO:K13649]
105468698  FOLR2; folate receptor beta [KO:K13649]
105475632  CAV1; caveolin-1 isoform X1 [KO:K06278]
105475647  CAV2; caveolin-2 isoform X1 [KO:K12958]
105477644  CAV3; caveolin-3 [KO:K12959]
105479698  EHD3; EH domain-containing protein 3 [KO:K12476]
105491775  EHD4; EH domain-containing protein 4 [KO:K12477]
105483719  EEA1; early endosome antigen 1 isoform X1 [KO:K12478]
105488903  RAB5A; ras-related protein Rab-5A [KO:K07887]
105474165  RAB5B; ras-related protein Rab-5B [KO:K07888]
105472127  RAB5C; ras-related protein Rab-5C [KO:K07889]
105472584  RABEP1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
105477761  RBSN; rabenosyn-5 [KO:K12481]
105499137  RAB4A; ras-related protein Rab-4A isoform X1 [KO:K07879]
105466120  RUFY2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
105484009  RUFY1; RUN and FYVE domain-containing protein 1 isoform X1 [KO:K12482]
105469537  EHD1; EH domain-containing protein 1 isoform X1 [KO:K12483]
105497797  VPS45; vacuolar protein sorting-associated protein 45 isoform X1 [KO:K12479]
105470421  SNX4; sorting nexin-4 [KO:K17919]
105478891  RAB31; ras-related protein Rab-31 [KO:K07891]
105470590  RAB22A; ras-related protein Rab-22A [KO:K07891]
105479792  RAB10; ras-related protein Rab-10 [KO:K07903]
105493781  RAB8A; ras-related protein Rab-8A [KO:K07901]
105494843  RAB35; ras-related protein Rab-35 isoform X1 [KO:K07876]
105488335  RAB11A; ras-related protein Rab-11A [KO:K07904]
105482838  RAB11B; ras-related protein Rab-11B [KO:K07905]
105476578  RAB11FIP1; rab11 family-interacting protein 1 isoform X1 [KO:K12484]
105465260  RAB11FIP5; rab11 family-interacting protein 5 isoform X1 [KO:K12484]
105467530  RAB11FIP2; rab11 family-interacting protein 2 isoform X1 [KO:K12484]
105478437  ZFYVE27; protrudin isoform X1 [KO:K19368]
105474097  KIF5A; kinesin heavy chain [KO:K10396]
105479932  KIF5B; kinesin-1 heavy chain [KO:K10396]
105492692  KIF5C; kinesin heavy chain [KO:K10396]
105485913  RAB11FIP3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
105485203  RAB11FIP4; rab11 family-interacting protein 4 isoform X2 [KO:K12485]
105495968  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
105489258  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
105491416  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
105470680  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
105496712  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
105465838  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
105494398  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
105479478  SMAP1; stromal membrane-associated protein 1 isoform X1 [KO:K12486]
105494805  SMAP2; stromal membrane-associated protein 2 [KO:K12486]
105476692  GIT1; ARF GTPase-activating protein GIT1 isoform X4 [KO:K05737]
105493434  GIT2; ARF GTPase-activating protein GIT2 isoform X1 [KO:K12487]
105486513  ASAP2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
105492844  ASAP1; LOW QUALITY PROTEIN: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 [KO:K12488]
105494422  ASAP3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 [KO:K12488]
105473417  ACAP1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12489]
105498312  ACAP3; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12489]
105470801  ACAP2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12489]
105468707  ARAP1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
105487761  ARAP2; LOW QUALITY PROTEIN: arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 [KO:K18440]
105466976  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
105473862  AGAP1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X8 [KO:K12491]
105474909  AGAP3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12491]
112429224  LOW QUALITY PROTEIN: arf-GAP with GTPase, ANK repeat and PH domain-containing protein 11-like [KO:K12491]
105474082  AGAP2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
105470498  ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
105464334  ARFGAP3; ADP-ribosylation factor GTPase-activating protein 3 [KO:K12493]
105471676  ARFGAP2; ADP-ribosylation factor GTPase-activating protein 2 isoform X1 [KO:K12493]
105478348  PSD; PH and SEC7 domain-containing protein 1 isoform X1 [KO:K12494]
105467051  PSD2; PH and SEC7 domain-containing protein 2 isoform X1 [KO:K12494]
105482130  PSD3; PH and SEC7 domain-containing protein 3 isoform X1 [KO:K12494]
105471777  PSD4; PH and SEC7 domain-containing protein 4 isoform X1 [KO:K12494]
105463799  IQSEC3; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
105477737  IQSEC1; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
105493788  LOW QUALITY PROTEIN: IQ motif and SEC7 domain-containing protein 2-like [KO:K12495]
105464492  CYTH4; cytohesin-4 [KO:K18441]
105497921  CYTH3; cytohesin-3 [KO:K18441]
105478640  CYTH2; cytohesin-2 isoform X1 [KO:K18441]
105469247  CYTH1; cytohesin-1 isoform X1 [KO:K18441]
105482169  ARFGEF1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X1 [KO:K18442]
105470707  ARFGEF2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1 [KO:K18442]
105478352  GBF1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
105499662  ARF1; ADP-ribosylation factor 1 [KO:K07937]
105492892  ARF3; ADP-ribosylation factor 3 isoform X1 [KO:K07938]
105482717  ARF4; ADP-ribosylation factor 4 isoform X1 [KO:K07939]
105474776  ARF5; ADP-ribosylation factor 5 [KO:K07940]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
mni04060  Cytokine-cytokine receptor interaction
mni04070  Phosphatidylinositol signaling system
mni04130  SNARE interactions in vesicular transport
mni04142  Lysosome
mni04350  TGF-beta signaling pathway
KO pathway
ko04144   
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