Entry Name Axon guidance - Mus pahari (shrew mouse)
Description Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.
Class Organismal Systems; Development and regenerationBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Mus pahari (shrew mouse) [GN:
mpah ]
Gene 110319649 Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116 ] [EC:3.1.4.11 ]
110327455 Trpc1; short transient receptor potential channel 1 isoform X1 [KO:K04964 ]
110319826 Trpc3; short transient receptor potential channel 3 isoform X1 [KO:K04966 ]
110319800 Trpc4; short transient receptor potential channel 4 isoform X1 [KO:K04967 ]
110327426 Trpc6; short transient receptor potential channel 6 isoform X1 [KO:K04969 ]
110321008 Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
110325335 Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
110325367 Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
110319175 Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
110337199 Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
110326013 Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334 ]
110339030 Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
110334678 Rac2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860 ]
110331528 Rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861 ]
110322847 Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393 ]
110318312 Myl9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755 ]
110319976 Lrig2; leucine-rich repeats and immunoglobulin-like domains protein 2 isoform X1 [KO:K24609 ]
110314435 guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630 ]
110327202 Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630 ]
110319821 Gnai3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630 ]
110315157 Srgap3; SLIT-ROBO Rho GTPase-activating protein 3 isoform X1 [KO:K07526 ]
110326453 Srgap1; SLIT-ROBO Rho GTPase-activating protein 1 isoform X1 [KO:K07526 ]
110324879 Rhod; rho-related GTP-binding protein RhoD isoform X1 [KO:K07530 ]
110326005 Dpysl2; dihydropyrimidinase-related protein 2 isoform X1 [KO:K07528 ]
110331006 Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
110320932 Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
110332832 Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
110325574 Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
110323448 Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
110319750 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
110327251 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
110328811 Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
110336420 Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
110322865 Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
110337228 Pard6a; partitioning defective 6 homolog alpha isoform X1 [KO:K06093 ]
Compound Reference Authors Guan KL, Rao Y.
Title Signalling mechanisms mediating neuronal responses to guidance cues.
Journal Reference Authors Govek EE, Newey SE, Van Aelst L.
Title The role of the Rho GTPases in neuronal development.
Journal Reference Authors Huber AB, Kolodkin AL, Ginty DD, Cloutier JF.
Title Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance.
Journal Reference Authors Negishi M, Oinuma I, Katoh H.
Title Plexins: axon guidance and signal transduction.
Journal Reference Authors Huot J.
Title Ephrin signaling in axon guidance.
Journal Reference Authors Patel BN, Van Vactor DL.
Title Axon guidance: the cytoplasmic tail.
Journal Reference Authors Yu TW, Bargmann CI.
Title Dynamic regulation of axon guidance.
Journal Reference Authors Dickson BJ.
Title Molecular mechanisms of axon guidance.
Journal Reference Authors Barallobre MJ, Pascual M, Del Rio JA, Soriano E.
Title The Netrin family of guidance factors: emphasis on Netrin-1 signalling.
Journal Reference Authors Sabatier C, Plump AS, Le Ma, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M.
Title The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.
Journal Reference Authors Fujita Y, Yamashita T
Title Axon growth inhibition by RhoA/ROCK in the central nervous system.
Journal Reference Authors Yamashita T, Mueller BK, Hata K
Title Neogenin and repulsive guidance molecule signaling in the central nervous system.
Journal Reference Authors van Erp S, van den Heuvel DMA, Fujita Y, Robinson RA, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers JAA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ
Title Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.
Journal Related mpah04060 Cytokine-cytokine receptor interaction
KO pathway LinkDB All DBs
