KEGG   PATHWAY: mpuf05014
Entry
mpuf05014                   Pathway                                
Name
Amyotrophic lateral sclerosis - Mustela putorius furo (domestic ferret)
Description
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by a progressive degeneration of motor neurons in the brain and spinal cord. In 90% of patients, ALS is sporadic, with no clear genetic linkage. On the other hand, the remaining 10% of cases show familial inheritance, with mutations in SOD1, TDP43(TARDBP), FUS, or C9orf72 genes being the most frequent causes. In spite of such difference, familial ALS and sporadic ALS have similarities in their pathological features. Proposed disease mechanisms contributing to motor neuron degeneration in ALS are: impaired proteostasis, aberrant RNA processing, mitochondrial disfunction and oxidative stress, microglia activation, and axonal dysfunction.
Class
Human Diseases; Neurodegenerative disease
Pathway map
mpuf05014  Amyotrophic lateral sclerosis
mpuf05014

Organism
Mustela putorius furo (domestic ferret) [GN:mpuf]
Gene
101677794  TP53; cellular tumor antigen p53 [KO:K04451]
101686636  BID; BH3-interacting domain death agonist [KO:K04726]
101681070  BH3-interacting domain death agonist-like [KO:K04726]
101681308  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
101674297  BCL2L1; bcl-2-like protein 1 [KO:K04570]
101686802  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
101686427  BAD; bcl2-associated agonist of cell death [KO:K02158]
101691091  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
106003371  cytochrome c, testis-specific [KO:K08738]
101690488  cytochrome c [KO:K08738]
101681290  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
101690858  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
101670031  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
101677220  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
101694351  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
101679801  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial [KO:K03944]
101683103  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
101681305  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
101671885  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
101678258  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
101678946  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
101671166  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
101688416  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
101673253  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
101686920  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
101675000  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
101680168  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
101693615  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
101679477  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
101682163  acyl carrier protein, mitochondrial [KO:K03955]
101684673  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
101674482  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
101679389  NDUFA13; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
101694062  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
101674641  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial isoform X2 [KO:K03958]
101683892  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
101691663  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
101687434  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
101688606  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
101675882  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
101675804  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
101682240  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
101681324  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
101682983  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
101693700  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
101688652  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
101686313  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
101674933  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
101684469  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
101692362  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial-like [KO:K03939]
101688718  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
101674706  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
101679983  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
101691647  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
101678403  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
101678731  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
101692858  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
101685355  LOW QUALITY PROTEIN: succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236]
101680264  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
101694292  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
101674608  cytochrome c1, heme protein, mitochondrial [KO:K00413]
101694055  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
101672152  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
101685926  LOW QUALITY PROTEIN: cytochrome b-c1 complex subunit 2, mitochondrial-like [KO:K00415]
101681748  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
101680018  cytochrome b-c1 complex subunit 7 [KO:K00417]
101683221  cytochrome b-c1 complex subunit 8 [KO:K00418]
101677535  cytochrome b-c1 complex subunit 9 isoform X1 [KO:K00419]
101690736  cytochrome b-c1 complex subunit 10 [KO:K00420]
101680163  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
101676075  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263]
101679783  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
101684324  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
101679257  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
106003852  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
101689659  cytochrome c oxidase subunit 6B1 [KO:K02267]
101670731  cytochrome c oxidase subunit 6B2 [KO:K02267]
101693169  cytochrome c oxidase subunit 6C [KO:K02268]
101672219  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
101693652  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
101682432  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
101672021  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
101691909  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
101673376  ATP5A1; ATP synthase subunit alpha, mitochondrial [KO:K02132]
101670112  ATP5B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
101689814  ATP5C1; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
101677101  ATP5D; ATP synthase subunit delta, mitochondrial [KO:K02134]
101683533  ATP5F1; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
101672934  ATP5G1; ATP synthase F(0) complex subunit C1, mitochondrial isoform X1 [KO:K02128]
101673943  ATP5G2; LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
106005210  LOW QUALITY PROTEIN: uncharacterized protein LOC106005210 [KO:K02128]
106006495  LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
101690076  ATP5G3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
101693434  ATP5H; ATP synthase subunit d, mitochondrial [KO:K02138]
101677485  ATP5O; ATP synthase subunit O, mitochondrial [KO:K02137]
101678985  ATP5J; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
101679422  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
101678959  TOMM40L; mitochondrial import receptor subunit TOM40B [KO:K11518]
101680015  TOMM40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
101679131  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
101682150  PINK1; serine/threonine-protein kinase PINK1, mitochondrial [KO:K05688] [EC:2.7.11.1]
101689578  PARK2; E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
101684024  OPTN; optineurin [KO:K19946]
101680892  SQSTM1; sequestosome-1 [KO:K14381]
101675711  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
101675872  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
101676992  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
101694085  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
101687944  WDR41; WD repeat-containing protein 41 [KO:K23610]
101670526  SMCR8; Smith-Magenis syndrome chromosomal region candidate gene 8 protein [KO:K23611]
101687732  protein C9orf72 homolog [KO:K23609]
101687916  RAB8A; ras-related protein Rab-8A isoform X1 [KO:K07901]
101682696  RAB39B; ras-related protein Rab-39B [KO:K07925]
101682931  RAB1A; ras-related protein Rab-1A [KO:K07874]
101676245  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
101670633  ULK1; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
101682377  ULK2; LOW QUALITY PROTEIN: serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
101682698  serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
101675999  ATG101; autophagy-related protein 101 [KO:K19730]
101679604  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
101692151  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
101680997  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
101680757  BECN1; beclin-1 isoform X2 [KO:K08334]
101684048  BECN2; beclin-2 [KO:K08334]
101684646  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
101681569  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
101679553  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
101691773  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
101674575  ATG2A; autophagy-related protein 2 homolog A isoform X2 [KO:K17906]
101688271  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 [KO:K17908]
101676578  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
101679702  ALS2; alsin isoform X1 [KO:K04575]
101684536  RAB5A; ras-related protein Rab-5A [KO:K07887]
101693834  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
101671627  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
101692520  FIG4; polyphosphoinositide phosphatase isoform X1 [KO:K22913] [EC:3.1.3.-]
101673468  SPG11; spatacsin [KO:K19026]
101675854  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101675984  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101682554  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101675380  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
101688800  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
101678576  UBQLN3; ubiquilin-3 [KO:K04523]
101692800  UBQLN1; ubiquilin-1 isoform X1 [KO:K04523]
101687513  UBQLN4; ubiquilin-4 [KO:K04523]
101684064  UBQLN2; ubiquilin-2 [KO:K04523]
101692211  VCP; transitional endoplasmic reticulum ATPase isoform X1 [KO:K13525]
101673904  DERL1; derlin-1 [KO:K11519]
101694465  PSMA6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
101682226  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
101688003  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
101685934  PSMA8; proteasome subunit alpha type-7-like [KO:K02731] [EC:3.4.25.1]
101678084  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
101688820  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
101691417  LOW QUALITY PROTEIN: proteasome subunit alpha type-1-like [KO:K02725] [EC:3.4.25.1]
101693287  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
101681087  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
101689827  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
101673192  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
101682336  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
101681952  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
101684806  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
101677063  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
101692243  PSMB4; proteasome subunit beta type-4 isoform X3 [KO:K02736] [EC:3.4.25.1]
101689387  26S protease regulatory subunit 7-like [KO:K03061]
101691078  PSMC2; 26S protease regulatory subunit 7 [KO:K03061]
101691713  PSMC1; 26S protease regulatory subunit 4 [KO:K03062]
101689211  PSMC4; 26S protease regulatory subunit 6B [KO:K03063]
101689832  PSMC6; 26S protease regulatory subunit 10B isoform X1 [KO:K03064]
101688313  PSMC3; 26S protease regulatory subunit 6A [KO:K03065]
106004683  ATP-dependent zinc metalloprotease YME1L1-like [KO:K03066]
101671803  PSMC5; 26S protease regulatory subunit 8 isoform X1 [KO:K03066]
101679423  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
101677647  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
101689542  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
101681801  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
101682559  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
101682352  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
101670551  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
101690051  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
101674526  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 isoform X2 [KO:K03039]
101672325  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 [KO:K03029]
101670572  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
101687128  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
101687725  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
101683996  SHFM1; 26S proteasome complex subunit DSS1 [KO:K10881]
101675514  HDAC6; histone deacetylase 6 isoform X1 [KO:K11407] [EC:3.5.1.98]
101671013  LOW QUALITY PROTEIN: TAR DNA-binding protein 43-like [KO:K23600]
101677431  TARDBP; TAR DNA-binding protein 43 [KO:K23600]
101673938  FUS; RNA-binding protein FUS isoform X3 [KO:K13098]
101678595  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
101672373  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
101675044  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
106003941  heterogeneous nuclear ribonucleoprotein A1-like isoform X1 [KO:K12741]
101676267  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
101689596  HNRNPA1; heterogeneous nuclear ribonucleoprotein A1 [KO:K12741]
101677527  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
101690633  heterogeneous nuclear ribonucleoprotein A3 [KO:K12741]
101671815  HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 [KO:K12741]
101691031  heterogeneous nuclear ribonucleoprotein A1 [KO:K12741]
101692078  heterogeneous nuclear ribonucleoproteins A2/B1 isoform X1 [KO:K13158]
101692283  HNRNPA2B1; heterogeneous nuclear ribonucleoproteins A2/B1 isoform X1 [KO:K13158]
101691584  ATXN2; ataxin-2 [KO:K23625]
101680666  ATXN2L; ataxin-2-like protein [KO:K23625]
101671595  MATR3; matrin-3 isoform X1 [KO:K13213]
101689519  ANG; LOW QUALITY PROTEIN: angiogenin [KO:K16631] [EC:3.1.27.-]
101684208  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
101689685  ALYREF; THO complex subunit 4 [KO:K12881]
101672180  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
101679222  SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
101679560  NXF5; nuclear RNA export factor 5 [KO:K14284]
101684398  NXF1; nuclear RNA export factor 1 [KO:K14284]
101679069  NXT1; NTF2-related export protein 1 [KO:K14285]
101680646  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
101681527  GLE1; nucleoporin GLE1 isoform X2 [KO:K18723]
101670082  TPR; nucleoprotein TPR isoform X2 [KO:K09291]
101678334  NUP50; nuclear pore complex protein Nup50 isoform X1 [KO:K14295]
101681083  NUP153; nuclear pore complex protein Nup153 [KO:K14296]
101672206  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X4 [KO:K14297]
101686013  RAE1; mRNA export factor isoform X1 [KO:K14298]
101682321  SEC13; protein SEC13 homolog [KO:K14004]
101681660  SEH1L; nucleoporin SEH1 isoform X1 [KO:K14299]
101691135  NUP133; nuclear pore complex protein Nup133 [KO:K14300]
101691126  NUP107; nuclear pore complex protein Nup107 isoform X1 [KO:K14301]
101680419  NUP37; nucleoporin Nup37 [KO:K14302]
101681466  NUP160; nuclear pore complex protein Nup160 [KO:K14303]
101685865  NUP85; nuclear pore complex protein Nup85 isoform X1 [KO:K14304]
101692041  NUP43; nucleoporin Nup43 isoform X1 [KO:K14305]
101673640  NUP62CL; nucleoporin-62 C-terminal-like protein isoform X1 [KO:K14306]
106003382  NUP62; nuclear pore glycoprotein p62 [KO:K14306]
101689422  NUPL1; nucleoporin p58/p45 [KO:K14307]
101692004  NUP54; nucleoporin p54 isoform X1 [KO:K14308]
101681211  NUP93; nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
101691820  NUP205; nuclear pore complex protein Nup205 isoform X1 [KO:K14310]
101694227  NUP188; nucleoporin NUP188 homolog [KO:K14311]
101677797  NUP155; nuclear pore complex protein Nup155 [KO:K14312]
101676376  NUP35; nucleoporin NUP53 isoform X1 [KO:K14313]
101686590  NUP210; nuclear pore membrane glycoprotein 210 [KO:K14314]
101682122  NUP210L; nuclear pore membrane glycoprotein 210-like isoform X2 [KO:K14314]
101686445  NDC1; nucleoporin NDC1 isoform X1 [KO:K14315]
101691413  POM121L2; POM121-like protein 2 [KO:K14316]
101678899  POM121C; nuclear envelope pore membrane protein POM 121C isoform X1 [KO:K14316]
101688383  NUP214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
101676432  NUP88; nuclear pore complex protein Nup88 [KO:K14318]
101679310  RANBP2; E3 SUMO-protein ligase RanBP2 isoform X2 [KO:K12172] [EC:2.3.2.-]
101680482  SETX; probable helicase senataxin isoform X2 [KO:K10706] [EC:5.6.2.5 5.6.2.3]
101691540  CHCHD10; coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial [KO:K22759]
101693461  HSPA5; 78 kDa glucose-regulated protein [KO:K09490] [EC:3.6.4.10]
101691521  VAPB; vesicle-associated membrane protein-associated protein B/C isoform X1 [KO:K10707]
101689116  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
101684783  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
101689378  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
101682738  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
101691230  TRAF2; TNF receptor-associated factor 2 isoform X2 [KO:K03173] [EC:2.3.2.27]
101686402  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
101670985  caspase-12-like [KO:K04741] [EC:3.4.22.-]
101689747  EIF2AK3; LOW QUALITY PROTEIN: eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
101692556  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
101680524  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101694124  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
101688102  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
101683740  SIGMAR1; sigma non-opioid intracellular receptor 1 [KO:K20719]
101687148  TNF; tumor necrosis factor isoform X1 [KO:K03156]
101676562  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101689344  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
101684105  DAXX; death domain-associated protein 6 isoform X3 [KO:K02308]
101679855  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
101670597  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
101684873  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
101692143  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
101686271  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
101684009  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101692439  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
101679788  CCS; copper chaperone for superoxide dismutase isoform X1 [KO:K04569]
101671982  GPX8; probable glutathione peroxidase 8 isoform X1 [KO:K00432] [EC:1.11.1.9]
101680193  GPX1; glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
101686834  GPX7; glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
101688198  GPX5; epididymal secretory glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
101675537  GPX3; glutathione peroxidase 3 [KO:K00432] [EC:1.11.1.9]
101682223  GPX2; glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
101689040  GPX6; glutathione peroxidase 6 [KO:K00432] [EC:1.11.1.9]
101682593  CAT; catalase [KO:K03781] [EC:1.11.1.6]
101693665  PRPH; peripherin [KO:K07607]
101689653  NEFL; neurofilament light polypeptide [KO:K04572]
101689943  NEFM; neurofilament medium polypeptide [KO:K04573]
101681011  NEFH; neurofilament heavy polypeptide isoform X1 [KO:K04574]
101687256  PFN3; profilin-3 [KO:K05759]
101677962  PFN2; profilin-2 isoform X1 [KO:K05759]
101690515  PFN4; profilin-4 [KO:K05759]
101671559  PFN1; profilin-1 [KO:K05759]
101679540  ACTG1; actin, cytoplasmic 2 [KO:K05692]
101686268  ACTB; actin, cytoplasmic 1 [KO:K05692]
101675147  ANXA11; annexin A11 [KO:K17095]
101671702  ANXA7; annexin A7 isoform X1 [KO:K17095]
101672332  KIF5B; kinesin-1 heavy chain [KO:K10396]
101689294  KIF5A; kinesin heavy chain isoform 5A [KO:K10396]
101684053  KIF5C; kinesin heavy chain isoform 5C [KO:K10396]
101685097  KLC1; kinesin light chain 1 isoform X7 [KO:K10407]
101693620  KLC3; kinesin light chain 3 [KO:K10407]
101687767  KLC2; kinesin light chain 2 [KO:K10407]
101676637  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
101678877  tubulin alpha-8 chain [KO:K07374]
101692890  tubulin alpha-1A chain-like [KO:K07374]
101679966  tubulin alpha-1C chain [KO:K07374]
101680178  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
101680276  tubulin alpha-1B chain [KO:K07374]
101675663  TUBA3E; tubulin alpha-3E chain isoform X1 [KO:K07374]
101689201  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
101677236  TUBA4A; tubulin alpha-4A chain [KO:K07374]
101685931  TUBB6; tubulin beta-6 chain [KO:K07375]
101686650  tubulin beta-2B chain [KO:K07375]
101680362  TUBB3; tubulin beta-3 chain [KO:K07375]
101693433  TUBB4A; tubulin beta-4A chain [KO:K07375]
101674529  TUBB; tubulin beta chain [KO:K07375]
101670624  tubulin beta chain [KO:K07375]
101671254  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
101691057  TUBB4B; tubulin beta-4B chain isoform X1 [KO:K07375]
101672848  DCTN1; dynactin subunit 1 isoform X7 [KO:K04648]
101688644  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
101682549  DCTN3; dynactin subunit 3 isoform X2 [KO:K10425]
101677994  DCTN4; dynactin subunit 4 isoform X1 [KO:K10426]
101680068  DCTN5; dynactin subunit 5 [KO:K10427]
101686473  DCTN6; dynactin subunit 6 [KO:K10428]
101678441  ACTR1A; alpha-centractin [KO:K16575]
101684030  ACTR1B; beta-centractin isoform X1 [KO:K16575]
101686683  ACTR10; actin-related protein 10 [KO:K16576]
101687210  LOW QUALITY PROTEIN: huntingtin-associated protein 1 [KO:K04647]
101691572  DNAH7; dynein heavy chain 7, axonemal [KO:K10408]
101679291  DNAH12; dynein heavy chain 12, axonemal isoform X1 [KO:K10408]
101673236  DNAH11; dynein heavy chain 11, axonemal isoform X1 [KO:K10408]
101673976  DNAH1; dynein heavy chain 1, axonemal isoform X1 [KO:K10408]
101674259  DNAH9; dynein heavy chain 9, axonemal isoform X4 [KO:K10408]
101693416  DNAH6; dynein heavy chain 6, axonemal [KO:K10408]
101674625  DNAH5; dynein heavy chain 5, axonemal [KO:K10408]
101680905  DNAH14; dynein heavy chain 14, axonemal isoform X5 [KO:K10408]
101674881  DNAH17; dynein heavy chain 17, axonemal isoform X5 [KO:K10408]
101682048  DNAH8; dynein heavy chain 8, axonemal isoform X1 [KO:K10408]
101682372  DNAH10; dynein heavy chain 10, axonemal isoform X1 [KO:K10408]
101677023  DNAH2; dynein heavy chain 2, axonemal isoform X1 [KO:K10408]
101671134  DNAH3; dynein heavy chain 3, axonemal isoform X1 [KO:K10408]
101692651  DNALI1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
101679241  DNAI1; dynein intermediate chain 1, axonemal isoform X2 [KO:K10409]
101682859  DNAI2; dynein intermediate chain 2, axonemal [KO:K11143]
101679103  DNAL1; dynein light chain 1, axonemal isoform X2 [KO:K10411]
101672760  DNAL4; dynein light chain 4, axonemal [KO:K10412]
101687335  SLC1A2; excitatory amino acid transporter 2 isoform X1 [KO:K05613]
101694448  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
101691708  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
101694457  GRIA2; glutamate receptor 2 isoform X5 [KO:K05198]
101683487  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
101672107  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
101683074  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
101674678  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
101691917  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
101685410  NRG1; pro-neuregulin-1, membrane-bound isoform isoform X1 [KO:K05455]
101680227  NRG2; pro-neuregulin-2, membrane-bound isoform [KO:K05456]
101685564  NRG3; pro-neuregulin-3, membrane-bound isoform [KO:K05457]
101672764  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
Compound
C00001  H2O
C00008  ADP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00039  DNA
C00046  RNA
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C16844  Hydroxyl radical
C16845  Peroxynitrite
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Related
pathway
mpuf00190  Oxidative phosphorylation
mpuf03013  Nucleocytoplasmic transport
mpuf03050  Proteasome
mpuf04010  MAPK signaling pathway
mpuf04012  ErbB signaling pathway
mpuf04020  Calcium signaling pathway
mpuf04115  p53 signaling pathway
mpuf04137  Mitophagy - animal
mpuf04140  Autophagy - animal
mpuf04141  Protein processing in endoplasmic reticulum
mpuf04210  Apoptosis
mpuf04724  Glutamatergic synapse
mpuf04810  Regulation of actin cytoskeleton
KO pathway
ko05014   
LinkDB

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