KEGG   PATHWAY: mpuf05208
Entry
mpuf05208                   Pathway                                
Name
Chemical carcinogenesis - reactive oxygen species - Mustela putorius furo (domestic ferret)
Description
It is well established that cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. In the majority of instances, chemical carcinogens, directly or after xenobiotic metabolism, induce DNA damage and act in a 'genotoxic' manner. There is, however, a group of carcinogens that induce cancer via nongenotoxic mechanisms. The biochemical modes of action for nongenotoxic carcinogens are diverse, one example of which is induction of oxidative stress. Trace metals and organic xenobiotics are typical classes of environmental pollutants with prooxidant effects. Trace metals generate reactive oxygen species (ROS) depending on their ability to lose electrons and catalyze Haber Weiss and Fenton reactions. ROS are also generated due to induction of various cytochrome P450 isoenzymes during detoxification of chemical carcinogens. Increased ROS generation often has been linked to DNA damage that can lead to mutations and may, therefore, play an important role in the initiation and progression of multistage carcinogenesis. Besides causing DNA damage, ROS further induce multiple intracellular signaling pathways, notably NF-kappa B, JNK/SAPK/p38, as well as Erk/MAPK. These signaling routes can lead to transcriptional induction of target genes that could promote proliferation or confer apoptosis resistance to exposed cells.
Class
Human Diseases; Cancer: overview
Pathway map
mpuf05208  Chemical carcinogenesis - reactive oxygen species
mpuf05208

Organism
Mustela putorius furo (domestic ferret) [GN:mpuf]
Gene
101693640  AS3MT; arsenite methyltransferase [KO:K07755] [EC:2.1.1.137]
101684855  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
101685339  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
101685649  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
101673392  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
101686134  GSTT2B; LOW QUALITY PROTEIN: glutathione S-transferase theta-2B [KO:K00799] [EC:2.5.1.18]
101692693  GSTA4; glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
101692996  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
101693435  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
101693728  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
101693902  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
106003279  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
101682665  GSTO1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
101669998  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
101689566  MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
101683542  GSTO2; glutathione S-transferase omega-2 isoform X2 [KO:K00799] [EC:2.5.1.18]
101677793  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
101684378  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
101677220  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
101694351  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
101679801  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial [KO:K03944]
101683103  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
101681305  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
101671885  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
101678258  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
101678946  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
101671166  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
101688416  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
101673253  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
101686920  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
101675000  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
101680168  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
101693615  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
101679477  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
101682163  acyl carrier protein, mitochondrial [KO:K03955]
101684673  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
101674482  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
101679389  NDUFA13; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
101694062  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
101674641  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial isoform X2 [KO:K03958]
101683892  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
101691663  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
101687434  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
101688606  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
101675882  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
101675804  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
101682240  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
101681324  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
101682983  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
101693700  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
101688652  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
101686313  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
101674933  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
101684469  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
101692362  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial-like [KO:K03939]
101688718  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
101674706  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
101679983  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
101691647  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
101678403  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
101678731  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
101692858  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
101685355  LOW QUALITY PROTEIN: succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236]
101680264  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
101694292  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
101674608  cytochrome c1, heme protein, mitochondrial [KO:K00413]
101694055  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
101672152  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
101685926  LOW QUALITY PROTEIN: cytochrome b-c1 complex subunit 2, mitochondrial-like [KO:K00415]
101681748  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
101680018  cytochrome b-c1 complex subunit 7 [KO:K00417]
101683221  cytochrome b-c1 complex subunit 8 [KO:K00418]
101677535  cytochrome b-c1 complex subunit 9 isoform X1 [KO:K00419]
101690736  cytochrome b-c1 complex subunit 10 [KO:K00420]
101680163  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
101676075  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263]
101679783  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
101684324  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
101679257  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
106003852  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
101689659  cytochrome c oxidase subunit 6B1 [KO:K02267]
101670731  cytochrome c oxidase subunit 6B2 [KO:K02267]
101693169  cytochrome c oxidase subunit 6C [KO:K02268]
101672219  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
101693652  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
101682432  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
101672021  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
101691909  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
101673376  ATP5A1; ATP synthase subunit alpha, mitochondrial [KO:K02132]
101670112  ATP5B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
101689814  ATP5C1; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
101677101  ATP5D; ATP synthase subunit delta, mitochondrial [KO:K02134]
101683533  ATP5F1; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
101672934  ATP5G1; ATP synthase F(0) complex subunit C1, mitochondrial isoform X1 [KO:K02128]
101673943  ATP5G2; LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
106005210  LOW QUALITY PROTEIN: uncharacterized protein LOC106005210 [KO:K02128]
106006495  LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
101690076  ATP5G3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
101693434  ATP5H; ATP synthase subunit d, mitochondrial [KO:K02138]
101677485  ATP5O; ATP synthase subunit O, mitochondrial [KO:K02137]
101678985  ATP5J; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
101678830  SOD2; superoxide dismutase [Mn], mitochondrial isoform X1 [KO:K04564] [EC:1.15.1.1]
101679422  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
101674296  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
101687790  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
101694615  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
101688977  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
101689099  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
101683729  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
101676150  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
101670031  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
101682593  CAT; catalase [KO:K03781] [EC:1.11.1.6]
101676779  SLC26A1; sulfate anion transporter 1 [KO:K14700]
101685815  SLC26A2; sulfate transporter [KO:K14701]
101692940  solute carrier family 26 member 6 isoform X1 [KO:K14704]
101685800  SLC26A9; solute carrier family 26 member 9 isoform X1 [KO:K14706]
101677117  cytochrome P450 1A2-like isoform X2 [KO:K07409] [EC:1.14.14.1]
101673971  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
101675002  cytochrome P450 2F5 isoform X1 [KO:K07416] [EC:1.14.14.1]
101676222  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
101676151  cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
106003316  EPHX1; epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
101689697  EPHX2; bifunctional epoxide hydrolase 2 isoform X2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
101673413  EPHX3; epoxide hydrolase 3 isoform X1 [KO:K22368] [EC:3.3.2.10]
101673167  EPHX4; epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
101688596  AKR1A1; alcohol dehydrogenase [NADP(+)] [KO:K00002] [EC:1.1.1.2]
101678776  prostaglandin F synthase 1-like isoform X1 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
101688330  NQO1; NAD(P)H dehydrogenase [quinone] 1 isoform X2 [KO:K00355] [EC:1.6.5.2]
101678900  carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
101693597  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
101682526  AHR; aryl hydrocarbon receptor [KO:K09093]
101694000  LPO; lactoperoxidase [KO:K12550] [EC:1.11.1.7]
101683815  NOX4; NADPH oxidase 4 isoform X2 [KO:K21423] [EC:1.6.3.-]
101672987  cytochrome b-245 light chain [KO:K08009]
101689704  NOX1; NADPH oxidase 1 [KO:K08008]
101688498  NCF1; neutrophil cytosol factor 1 [KO:K08011]
101686243  NCF2; neutrophil cytosol factor 2 [KO:K08010]
101682951  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
101685824  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
101677610  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
101675655  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
101685370  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
101681860  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101675757  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101681355  HRAS; GTPase HRas isoform X1 [KO:K02833]
101681333  KRAS; GTPase KRas isoform X3 [KO:K07827]
101683038  NRAS; GTPase NRas [KO:K07828]
101687799  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
101671970  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
101690482  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101680975  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101678743  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101679748  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101671073  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101686402  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
101692465  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
101690814  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
101672072  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101681349  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101676423  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101684873  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
101692143  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
101686271  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
101684009  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101680348  JUN; transcription factor AP-1 [KO:K04448]
101685236  FOS; proto-oncogene c-Fos [KO:K04379]
101680399  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101683594  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
101683710  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101681650  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101676567  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101684443  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101693834  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
101687213  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
101679776  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101687324  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101676895  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101684130  FOXO3; forkhead box protein O3 [KO:K09408]
101686427  BAD; bcl2-associated agonist of cell death [KO:K02158]
101677842  PTPN1; tyrosine-protein phosphatase non-receptor type 1 isoform X1 [KO:K05696] [EC:3.1.3.48]
101670064  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
101680658  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
101686932  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
101671648  IKBKG; NF-kappa-B essential modulator [KO:K07210]
101693829  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101680239  RELA; transcription factor p65 [KO:K04735]
101680542  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101675130  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
101682925  PTPRJ; receptor-type tyrosine-protein phosphatase eta [KO:K05698] [EC:3.1.3.48]
101687662  ACP1; low molecular weight phosphotyrosine protein phosphatase [KO:K14394] [EC:3.1.3.2 3.1.3.48]
101678858  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
101688002  tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
106003305  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
101689921  ABL1; tyrosine-protein kinase ABL1 [KO:K06619] [EC:2.7.10.2]
101684271  ABL2; Abelson tyrosine-protein kinase 2 isoform X1 [KO:K08887] [EC:2.7.10.2]
101673635  PRKD2; serine/threonine-protein kinase D2 isoform X1 [KO:K06070] [EC:2.7.11.13]
101689311  PRKD1; serine/threonine-protein kinase D1 [KO:K06070] [EC:2.7.11.13]
101671282  PRKD3; serine/threonine-protein kinase D3 isoform X2 [KO:K06070] [EC:2.7.11.13]
101681759  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
101672904  PLD1; phospholipase D1 isoform X3 [KO:K01115] [EC:3.1.4.4]
101690285  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
101688261  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
101692645  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
101677663  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
101675945  VEGFA; vascular endothelial growth factor A [KO:K05448]
101678742  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
101672411  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
101685452  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
Compound
C00001  H2O
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00007  Oxygen
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00023  Iron
C00027  Hydrogen peroxide
C00051  Glutathione
C00070  Copper
C00084  Acetaldehyde
C00127  Glutathione disulfide
C00146  Phenol
C00291  Nickel
C00469  Ethanol
C00472  p-Benzoquinone
C00530  Hydroquinone
C00704  Superoxide
C00951  Estradiol-17beta
C01407  Benzene
C01413  Cadmium
C01782  Benzene oxide
C02389  p-Benzosemiquinone
C02575  Pentachlorophenol
C02814  Benzene-1,2,4-triol
C03434  Tetrachlorohydroquinone
C03622  N-Hydroxy-4-aminobiphenyl
C04623  DDT
C05301  2-Hydroxyestradiol
C05309  Semiquinone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06268  Chromium
C06269  Arsenic
C06696  Lead
C07294  Methylarsonate
C07295  Methanearsonous acid
C07308  Cacodylate
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C10998  4-Aminobiphenyl
C14209  4-Hydroxy-17beta-estradiol
C14850  Benzo[a]pyrene-7,8-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16844  Hydroxyl radical
C18205  2,2',4,4'-Tetrabromodiphenyl ether
C18933  Chloranil
C19171  Cobalt
C20300  Dimethylarsinous acid
C20316  4-Nitrosobiphenyl
C20319  Hydronitroxide radical
C22355  Benzo[a]pyrene-7,8-diol
C22356  Benzo[a]pyrene-7,8-dione
C22357  17beta-Estradiol-2,3-quinone
C22381  Reactive oxygen species
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Related
pathway
mpuf00190  Oxidative phosphorylation
mpuf00980  Metabolism of xenobiotics by cytochrome P450
mpuf04010  MAPK signaling pathway
mpuf04064  NF-kappa B signaling pathway
mpuf04066  HIF-1 signaling pathway
mpuf04151  PI3K-Akt signaling pathway
mpuf04370  VEGF signaling pathway
mpuf05207  Chemical carcinogenesis - receptor activation
mpuf05211  Renal cell carcinoma
mpuf05215  Prostate cancer
mpuf05219  Bladder cancer
mpuf05221  Acute myeloid leukemia
mpuf05222  Small cell lung cancer
mpuf05223  Non-small cell lung cancer
mpuf05224  Breast cancer
mpuf05225  Hepatocellular carcinoma
KO pathway
ko05208   
LinkDB

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