KEGG   PATHWAY: nle04144
Entry
nle04144                    Pathway                                
Name
Endocytosis - Nomascus leucogenys (northern white-cheeked gibbon)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
nle04144  Endocytosis
nle04144

Other DBs
GO: 0006897
Organism
Nomascus leucogenys (northern white-cheeked gibbon) [GN:nle]
Gene
100598238  ARF6; ADP-ribosylation factor 6 [KO:K07941]
100582763  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
100599403  LOW QUALITY PROTEIN: putative PIP5K1A and PSMD4-like protein [KO:K00889] [EC:2.7.1.68]
100586076  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
100589134  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X4 [KO:K00889] [EC:2.7.1.68]
100588455  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
100587274  PIP5KL1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 [KO:K13712] [EC:2.7.1.68]
100605600  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
100601695  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
100599465  DNM1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
100594555  DNM3; dynamin-3 isoform X6 [KO:K01528] [EC:3.6.5.5]
100590132  DNM2; LOW QUALITY PROTEIN: dynamin-2 [KO:K23484] [EC:3.6.5.5]
100591078  CLTA; clathrin light chain A isoform X4 [KO:K04644]
100588698  CLTB; clathrin light chain B isoform X1 [KO:K04645]
100591957  CLTCL1; clathrin heavy chain 2 isoform X1 [KO:K04646]
100597617  CLTC; clathrin heavy chain 1 isoform X7 [KO:K04646]
100587068  AP2A1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
100579581  AP2A2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
100594930  AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825]
100580778  AP2M1; AP-2 complex subunit mu [KO:K11826]
100586458  AP2S1; AP-2 complex subunit sigma [KO:K11827]
100580222  EHD2; EH domain-containing protein 2 [KO:K12469]
100592854  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
100606849  TGFBR2; TGF-beta receptor type-2 isoform X2 [KO:K04388] [EC:2.7.11.30]
100600941  ZFYVE9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
100593655  ZFYVE16; zinc finger FYVE domain-containing protein 16 isoform X1 [KO:K04679]
115838246  LOW QUALITY PROTEIN: zinc finger FYVE domain-containing protein 9-like [KO:K04679]
100584080  LOW QUALITY PROTEIN: zinc finger FYVE domain-containing protein 9-like [KO:K04679]
100607016  PML; protein PML [KO:K10054] [EC:2.3.2.-]
100589735  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
100583279  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
100605411  transferrin receptor protein 1 [KO:K06503]
115833935  transferrin receptor protein 1-like [KO:K06503]
115833954  LOW QUALITY PROTEIN: transferrin receptor protein 1-like [KO:K06503]
101178200  TFRC; transferrin receptor protein 1 [KO:K06503]
100597255  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100603207  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100598157  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
100591839  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100582351  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
100593288  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
100607272  CBL; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
100588040  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
100591706  CBLC; E3 ubiquitin-protein ligase CBL-C isoform X1 [KO:K22518] [EC:2.3.2.27]
100591281  SH3KBP1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
100607656  SH3GL2; endophilin-A1 isoform X3 [KO:K11247]
100602750  SH3GL3; endophilin-A3 isoform X1 [KO:K11247]
100595571  SH3GL1; endophilin-A2 isoform X1 [KO:K11247]
100599095  SH3GLB1; endophilin-B1 isoform X1 [KO:K11248]
100603537  SH3GLB2; endophilin-B2 isoform X1 [KO:K21269]
100599872  BIN1; myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
100600277  amphiphysin isoform X1 [KO:K12562]
100605504  EPN1; epsin-1 isoform X1 [KO:K12471]
100597979  EPN2; epsin-2 isoform X1 [KO:K12471]
100588095  EPN3; epsin-3 isoform X1 [KO:K12471]
100603836  EPS15; epidermal growth factor receptor substrate 15 [KO:K12472]
100596582  EPS15L1; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
100580733  SPART; spartin [KO:K19366]
100600829  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
100589832  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
100601465  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X2 [KO:K06643] [EC:2.3.2.27]
100595327  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
100592433  RNF41; E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
100599625  ITCH; E3 ubiquitin-protein ligase Itchy homolog isoform X1 [KO:K05632] [EC:2.3.2.26]
100583345  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
100603634  SMURF2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
100580729  WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
100591481  LDLR; low-density lipoprotein receptor [KO:K12473]
100579860  LDLRAP1; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
100593149  DAB2; disabled homolog 2 [KO:K12475]
115834714  CCR5; C-C chemokine receptor type 5 [KO:K04180]
100580192  LOW QUALITY PROTEIN: C-X-C chemokine receptor type 1 [KO:K04175]
100598264  C-X-C chemokine receptor type 1 [KO:K04175]
100596676  C-X-C chemokine receptor type 2 [KO:K05050]
100604120  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
100596640  GRK7; rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
100604826  GRK2; beta-adrenergic receptor kinase 1 isoform X1 [KO:K00910] [EC:2.7.11.15]
100582671  GRK3; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
100592067  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
100593251  GRK5; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
100595255  GRK4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
100598721  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
100599882  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
100581906  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
115832900  basic proline-rich protein-like [KO:K23612]
100587384  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
100587269  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
100606041  ACTR3; actin-related protein 3 [KO:K18584]
100584005  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
100589804  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
100597015  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
100601579  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
100596861  ARPC4; actin-related protein 2/3 complex subunit 4 isoform X2 [KO:K05755]
100598106  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
100581707  ARPC5; actin-related protein 2/3 complex subunit 5 isoform X2 [KO:K05754]
100580744  WIPF1; WAS/WASL-interacting protein family member 1 isoform X1 [KO:K19475]
100603146  WIPF2; WAS/WASL-interacting protein family member 2 [KO:K19475]
100602207  WIPF3; WAS/WASL-interacting protein family member 3 [KO:K19475]
100579396  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
100579550  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
100594395  heat shock 70 kDa protein 1 [KO:K03283]
115832445  HSPA1A; heat shock 70 kDa protein 1A [KO:K03283]
100605907  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
100602288  DNAJC6; putative tyrosine-protein phosphatase auxilin isoform X4 [KO:K09526]
100579618  WASHC4; WASH complex subunit 4 isoform X1 [KO:K18465]
100607529  WASHC5; WASH complex subunit 5 isoform X1 [KO:K18464]
100600399  WASHC2C; WASH complex subunit 2A isoform X1 [KO:K18462]
100592141  WASHC1; WASH complex subunit 1 isoform X1 [KO:K18461]
100593788  WASHC3; WASH complex subunit 3 isoform X1 [KO:K18463]
100580515  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
100581050  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
100607107  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
100599958  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
100600132  VPS29; vacuolar protein sorting-associated protein 29 isoform X2 [KO:K18467]
100581247  VPS26B; vacuolar protein sorting-associated protein 26B [KO:K18466]
100596592  VPS26A; vacuolar protein sorting-associated protein 26A isoform X1 [KO:K18466]
100599794  vacuolar protein sorting-associated protein 35 [KO:K18468]
100592183  SNX3; sorting nexin-3 isoform X1 [KO:K17918]
100585177  sorting nexin-12 [KO:K17918]
115830335  SNX12; sorting nexin-12 [KO:K17918]
100586159  USP8; ubiquitin carboxyl-terminal hydrolase 8 isoform X1 [KO:K11839] [EC:3.4.19.12]
100580627  STAMBP; LOW QUALITY PROTEIN: STAM-binding protein [KO:K11866] [EC:3.4.19.12]
100607787  RAB7A; ras-related protein Rab-7a isoform X1 [KO:K07897]
100595673  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
100603017  STAM2; signal transducing adapter molecule 2 [KO:K04705]
100606951  STAM; signal transducing adapter molecule 1 isoform X1 [KO:K04705]
100606250  TSG101; tumor susceptibility gene 101 protein [KO:K12183]
100594882  MVB12A; multivesicular body subunit 12A isoform X1 [KO:K12186]
100603650  MVB12B; multivesicular body subunit 12B [KO:K12186]
100591730  VPS28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
100587445  VPS37C; vacuolar protein sorting-associated protein 37C [KO:K12185]
100604839  VPS37A; vacuolar protein sorting-associated protein 37A isoform X1 [KO:K12185]
100581136  VPS37B; vacuolar protein sorting-associated protein 37B isoform X1 [KO:K12185]
100583556  VPS37D; vacuolar protein sorting-associated protein 37D [KO:K12185]
100582912  SNF8; vacuolar-sorting protein SNF8 isoform X2 [KO:K12188]
100585198  VPS36; vacuolar protein-sorting-associated protein 36 isoform X1 [KO:K12190]
100606624  VPS25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
100589597  CHMP6; charged multivesicular body protein 6 [KO:K12195]
101176291  putative charged multivesicular body protein 4B-like protein CHMP4BP1 [KO:K12194]
100583467  CHMP4A; charged multivesicular body protein 4a [KO:K12194]
100599282  CHMP4B; charged multivesicular body protein 4b [KO:K12194]
100590197  CHMP4C; charged multivesicular body protein 4c [KO:K24782]
100586164  charged multivesicular body protein 3 [KO:K12193]
100580124  CHMP2A; charged multivesicular body protein 2a [KO:K12191]
100592357  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
100603228  CHMP7; charged multivesicular body protein 7 isoform X1 [KO:K15053]
100600466  VPS4A; vacuolar protein sorting-associated protein 4A isoform X1 [KO:K12196]
100599923  VPS4B; vacuolar protein sorting-associated protein 4B [KO:K12196]
100579429  VTA1; vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
100586589  CHMP1A; charged multivesicular body protein 1a [KO:K12197]
100598294  CHMP1B; charged multivesicular body protein 1b [KO:K12197]
100591297  CHMP5; charged multivesicular body protein 5 [KO:K12198]
100582475  IST1; IST1 homolog isoform X1 [KO:K19476]
100590910  PDCD6IP; programmed cell death 6-interacting protein isoform X2 [KO:K12200]
100601613  SPG21; maspardin [KO:K19367]
115834474  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
100607779  SNX2; sorting nexin-2 isoform X2 [KO:K17917]
100583500  SNX1; sorting nexin-1 isoform X1 [KO:K17917]
100593893  SNX6; sorting nexin-6 isoform X1 [KO:K17920]
100580978  SNX32; sorting nexin-32 isoform X1 [KO:K17920]
100580517  SNX5; sorting nexin-5 [KO:K17920]
100602214  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100595274  HRAS; GTPase HRas isoform X1 [KO:K02833]
100582107  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
100581366  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
100585758  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
100607291  RHOA; transforming protein RhoA [KO:K04513]
100579523  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-67 alpha chain [KO:K06751]
100588639  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A-11 alpha chain-like [KO:K06751]
100592911  popy class I histocompatibility antigen, alpha chain E isoform X1 [KO:K06751]
100587765  HLA class I histocompatibility antigen, A-3 alpha chain [KO:K06751]
115830427  patr class I histocompatibility antigen, CH28 alpha chain isoform X1 [KO:K06751]
100602874  HLA class I histocompatibility antigen, B-46 alpha chain-like [KO:K06751]
100591000  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
100589102  folate receptor beta isoform X1 [KO:K13649]
100589656  FOLR3; folate receptor gamma isoform X1 [KO:K13649]
100595808  CAV1; caveolin-1 [KO:K06278]
100596151  CAV2; caveolin-2 isoform X1 [KO:K12958]
100591755  CAV3; caveolin-3 [KO:K12959]
100597308  EHD3; EH domain-containing protein 3 isoform X1 [KO:K12476]
100592554  EHD4; EH domain-containing protein 4 [KO:K12477]
100600546  EEA1; early endosome antigen 1 isoform X2 [KO:K12478]
100585666  RAB5A; ras-related protein Rab-5A [KO:K07887]
100593361  RAB5B; ras-related protein Rab-5B [KO:K07888]
115830348  RAB5C; ras-related protein Rab-5C [KO:K07889]
100606170  RABEP1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
100592652  RBSN; rabenosyn-5 isoform X1 [KO:K12481]
100588652  RAB4A; ras-related protein Rab-4A isoform X1 [KO:K07879]
100589920  RUFY1; RUN and FYVE domain-containing protein 1 [KO:K12482]
100588121  RUFY2; RUN and FYVE domain-containing protein 2 [KO:K12482]
100605028  EHD1; EH domain-containing protein 1 [KO:K12483]
100598409  VPS45; vacuolar protein sorting-associated protein 45 isoform X1 [KO:K12479]
100585869  SNX4; sorting nexin-4 [KO:K17919]
100594346  RAB31; ras-related protein Rab-31 [KO:K07891]
100583796  RAB22A; ras-related protein Rab-22A [KO:K07891]
100592114  RAB10; ras-related protein Rab-10 [KO:K07903]
100593627  RAB8A; ras-related protein Rab-8A [KO:K07901]
100603966  RAB35; ras-related protein Rab-35 isoform X1 [KO:K07876]
100606559  RAB11A; ras-related protein Rab-11A [KO:K07904]
100580919  RAB11B; ras-related protein Rab-11B [KO:K07905]
100588207  RAB11FIP2; rab11 family-interacting protein 2 isoform X2 [KO:K12484]
100583706  RAB11FIP5; rab11 family-interacting protein 5 isoform X1 [KO:K12484]
100602094  RAB11FIP1; rab11 family-interacting protein 1 isoform X1 [KO:K12484]
100591908  ZFYVE27; protrudin isoform X1 [KO:K19368]
100589788  KIF5B; kinesin-1 heavy chain [KO:K10396]
100579859  KIF5A; kinesin heavy chain isoform X1 [KO:K10396]
100591941  KIF5C; kinesin heavy chain [KO:K10396]
100586514  RAB11FIP3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
100582346  RAB11FIP4; rab11 family-interacting protein 4 isoform X1 [KO:K12485]
100592712  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
100586482  PARD6A; partitioning defective 6 homolog alpha isoform X6 [KO:K06093]
100597121  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
100585698  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
100599635  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
100605245  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
100603901  SMAP1; stromal membrane-associated protein 1 isoform X1 [KO:K12486]
100581081  SMAP2; stromal membrane-associated protein 2 isoform X4 [KO:K12486]
100582553  GIT1; ARF GTPase-activating protein GIT1 isoform X2 [KO:K05737]
100593999  GIT2; ARF GTPase-activating protein GIT2 isoform X2 [KO:K12487]
100581096  ASAP1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
100604148  ASAP2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
100583081  ASAP3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 [KO:K12488]
100592189  ACAP3; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12489]
100579573  ACAP2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X7 [KO:K12489]
100607184  ACAP1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12489]
100594751  ARAP1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
100598521  ARAP2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K18440]
100598122  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
100595465  AGAP1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X11 [KO:K12491]
100595310  AGAP3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12491]
115833813  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5-like isoform X1 [KO:K12491]
115831272  LOW QUALITY PROTEIN: arf-GAP with GTPase, ANK repeat and PH domain-containing protein 11-like [KO:K12491]
115830349  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5 isoform X1 [KO:K12491]
100586848  LOW QUALITY PROTEIN: arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5 [KO:K12491]
100606689  AGAP2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
100587248  ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1 isoform X3 [KO:K12492]
100604069  ARFGAP2; ADP-ribosylation factor GTPase-activating protein 2 isoform X2 [KO:K12493]
100584157  ARFGAP3; ADP-ribosylation factor GTPase-activating protein 3 isoform X1 [KO:K12493]
100598343  PSD2; PH and SEC7 domain-containing protein 2 isoform X1 [KO:K12494]
100592487  PSD; PH and SEC7 domain-containing protein 1 isoform X2 [KO:K12494]
100581529  PH and SEC7 domain-containing protein 3 [KO:K12494]
100590587  PSD4; PH and SEC7 domain-containing protein 4 [KO:K12494]
115834816  PH and SEC7 domain-containing protein 3-like [KO:K12494]
100607863  IQSEC3; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
100590915  IQSEC2; IQ motif and SEC7 domain-containing protein 2 isoform X1 [KO:K12495]
100582828  IQSEC1; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
100603872  CYTH3; cytohesin-3 [KO:K18441]
100580572  CYTH1; cytohesin-1 isoform X1 [KO:K18441]
100599015  CYTH4; cytohesin-4 isoform X1 [KO:K18441]
100587300  CYTH2; cytohesin-2 [KO:K18441]
100588636  ARFGEF2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1 [KO:K18442]
100589212  ARFGEF1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X1 [KO:K18442]
100592148  GBF1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
100607404  ARF1; ADP-ribosylation factor 1 [KO:K07937]
100580640  ARF3; ADP-ribosylation factor 3 [KO:K07938]
100601113  ARF4; ADP-ribosylation factor 4 [KO:K07939]
100588250  ARF5; ADP-ribosylation factor 5 [KO:K07940]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
nle04060  Cytokine-cytokine receptor interaction
nle04070  Phosphatidylinositol signaling system
nle04130  SNARE interactions in vesicular transport
nle04142  Lysosome
nle04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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