KEGG   PATHWAY: oaa05169
Entry
oaa05169                    Pathway                                
Name
Epstein-Barr virus infection - Ornithorhynchus anatinus (platypus)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
oaa05169  Epstein-Barr virus infection
oaa05169

Organism
Ornithorhynchus anatinus (platypus) [GN:oaa]
Gene
100084581  complement receptor type 1-like [KO:K04012]
107546899  CD19; B-lymphocyte antigen CD19 [KO:K06465]
100079322  ORAN-DRA; MHC class II DR alpha precursor [KO:K06752]
100088072  LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
100088053  HLA class II histocompatibility antigen, DR beta 5 chain [KO:K06752]
114807636  class II histocompatibility antigen, M beta 1 chain [KO:K06752]
114807666  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
103166389  RLA class II histocompatibility antigen, DP alpha-1 chain-like isoform X1 [KO:K06752]
100081248  TLR2; toll-like receptor 2 [KO:K10159]
100077067  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
100093279  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
100077683  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
100077058  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
100091969  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
100074866  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
100076229  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
100082351  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
100078925  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
100073613  IKBKG; NF-kappa-B essential modulator [KO:K07210]
100090081  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
100083819  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100074633  RELA; transcription factor p65 isoform X1 [KO:K04735]
100085643  TNF; tumor necrosis factor [KO:K03156]
100083298  IL6; interleukin-6 [KO:K05405]
100078060  DDX58; antiviral innate immune response receptor RIG-I isoform X1 [KO:K12646] [EC:5.6.2.6]
103169896  mitochondrial antiviral-signaling protein [KO:K12648]
100075919  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
100076520  TBK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
100077063  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
103167211  IRF7; interferon regulatory factor 7 [KO:K09447]
114814621  IRF3; interferon regulatory factor 3 [KO:K05411]
100075323  IFN3; type I interferon 3 [KO:K05414]
100082925  IFNB1; interferon beta [KO:K05415]
100083477  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
103170687  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
100082981  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
100681576  TYK2; LOW QUALITY PROTEIN: non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
100087266  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
100087549  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
103165236  IRF9; interferon regulatory factor 9 [KO:K04693]
100077821  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
103170563  C-X-C motif chemokine 10 isoform X1 [KO:K12671]
103170573  C-X-C motif chemokine 10-like [KO:K12671]
114809060  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
103165091  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
100075638  FADD; FAS-associated death domain protein [KO:K02373]
100082949  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
100087835  caspase-8-like [KO:K04398] [EC:3.4.22.61]
100088569  BID; BH3-interacting domain death agonist [KO:K04726]
100073859  BCL2L11; bcl-2-like protein 11 isoform X2 [KO:K16341]
114807635  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
114814649  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
114813317  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
100077443  cytochrome c [KO:K08738]
100073402  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
100092345  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
100087105  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
103164647  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
100090795  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
100090811  T-cell surface glycoprotein CD3 delta chain-like isoform X1 [KO:K06450]
100082718  CD247; T-cell surface glycoprotein CD3 zeta chain isoform X1 [KO:K06453]
100076569  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
100088021  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
100088836  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
100093302  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
100080509  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
114815139  PSMC5; 26S proteasome regulatory subunit 8 [KO:K03066]
100076043  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
100077344  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
100080824  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
100079412  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 isoform X1 [KO:K03035]
103166362  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
100092874  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
100078921  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
100092761  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
100077210  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
100073491  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
100074418  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
100093442  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
100088116  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
100529066  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
114807670  tapasin [KO:K08058]
100088193  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
100091528  calreticulin [KO:K08057]
120638088  CALR; calreticulin [KO:K08057]
100078585  MHC class I-2 antigen [KO:K06751]
100085024  class I histocompatibility antigen, Non-RT1.A alpha-1 chain-like [KO:K06751]
100086501  zinc-alpha-2-glycoprotein-like isoform X1 [KO:K06751]
100086751  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
100091425  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
100093248  H-2 class I histocompatibility antigen, alpha chain-like [KO:K06751]
114805429  zinc-alpha-2-glycoprotein-like isoform X1 [KO:K06751]
103169177  zinc-alpha-2-glycoprotein-like [KO:K06751]
103167834  major histocompatibility complex class I-related gene protein-like [KO:K06751]
100529072  MHC class I-1 antigen precursor [KO:K06751]
100089934  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
100093242  class I histocompatibility antigen, Non-RT1.A alpha-1 chain-like isoform X1 [KO:K06751]
114818227  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
103166556  zinc-alpha-2-glycoprotein-like [KO:K06751]
100078249  BOLA class I histocompatibility antigen, alpha chain BL3-7 [KO:K06751]
791104  B2M; beta-2-microglobulin precursor [KO:K08055]
100073600  SNW1; SNW domain-containing protein 1 [KO:K06063]
100081304  SIN3A; paired amphipathic helix protein Sin3a [KO:K11644]
100093591  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
100078158  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
100074498  NCOR2; nuclear receptor corepressor 2 isoform X1 [KO:K06065]
100075515  SAP30; LOW QUALITY PROTEIN: histone deacetylase complex subunit SAP30 [KO:K19202]
100076901  SAP30L; histone deacetylase complex subunit SAP30L [KO:K19202]
100084368  CIR1; corepressor interacting with RBPJ 1 [KO:K06066]
100083614  RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
100087009  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
100081083  HES1; transcription factor HES-1 [KO:K06054]
114812014  HES4; transcription factor HES-4 isoform X1 [KO:K06054]
103168129  FCER2; low affinity immunoglobulin epsilon Fc receptor isoform X1 [KO:K06468]
100093473  RUNX3; runt-related transcription factor 3 [KO:K09279]
100079391  MYC; myc proto-oncogene protein [KO:K04377]
100074824  USP7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
100080712  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
100092821  TP53; cellular tumor antigen p53 [KO:K04451]
114813305  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100081893  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
100088212  DDB2; DNA damage-binding protein 2 [KO:K10140]
100077423  POLK; DNA polymerase kappa isoform X2 [KO:K03511] [EC:2.7.7.7]
100078367  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
100086270  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100073788  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100074273  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100080187  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
100082075  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
103167126  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
100083320  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100081473  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100090267  AKT2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100085554  MAP3K14; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
114812073  RELB; LOW QUALITY PROTEIN: transcription factor RelB [KO:K09253]
100079514  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
100079508  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
114812052  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
100083673  NFKBIE; NF-kappa-B inhibitor epsilon [KO:K05872]
100091407  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
100089737  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X3 [KO:K04431] [EC:2.7.12.2]
100073424  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100076033  MAPK8; mitogen-activated protein kinase 8 isoform X2 [KO:K04440] [EC:2.7.11.24]
100082590  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100681935  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
100681066  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
100079746  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
114805391  receptor-interacting serine/threonine-protein kinase 1-like isoform X1 [KO:K02861] [EC:2.7.11.1]
100080734  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X2 [KO:K04432] [EC:2.7.12.2]
100078394  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
100078507  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
100091330  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
100092264  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
100093026  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100078824  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
100086706  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
103168734  ectonucleoside triphosphate diphosphohydrolase 8-like [KO:K01510] [EC:3.6.1.5]
114807825  ectonucleoside triphosphate diphosphohydrolase 8-like [KO:K01510] [EC:3.6.1.5]
114806068  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
100076581  CD44; CD44 antigen isoform X1 [KO:K06256]
100090742  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
100092512  VIM; vimentin [KO:K07606]
100075332  TNFAIP3; tumor necrosis factor alpha-induced protein 3 isoform X2 [KO:K11859] [EC:3.4.19.12]
100085612  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
100087932  STAT3; signal transducer and activator of transcription 3 isoform X2 [KO:K04692]
100079507  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
114808729  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
103167269  LOW QUALITY PROTEIN: tyrosine-protein kinase SYK-like [KO:K05855] [EC:2.7.10.2]
100083335  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
100076220  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103166634  Ig heavy chain Mem5 [KO:K06856]
100080912  BTK; tyrosine-protein kinase BTK isoform X1 [KO:K07370] [EC:2.7.10.2]
100074213  BLNK; B-cell linker protein isoform X1 [KO:K07371]
100076776  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
103166602  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
100090228  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
100075081  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100088940  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100088334  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
100091822  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
100080719  CCNA1; cyclin-A1 isoform X2 [KO:K06627]
100082357  CCNA2; cyclin-A2 [KO:K06627]
100075784  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
100087197  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
114814505  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
100083537  RB1; retinoblastoma-associated protein [KO:K06618]
100087014  E2F1; transcription factor E2F1 [KO:K17454]
100085053  E2F2; transcription factor E2F2 [KO:K09389]
100090475  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15510157
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
PMID:21372216
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
  Journal
Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
Reference
PMID:21429244
  Authors
Ning S
  Title
Innate immune modulation in EBV infection.
  Journal
Herpesviridae 2:1 (2011)
DOI:10.1186/2042-4280-2-1
Reference
PMID:28408983
  Authors
Stanfield BA, Luftig MA
  Title
Recent advances in understanding Epstein-Barr virus.
  Journal
F1000Res 6:386 (2017)
DOI:10.12688/f1000research.10591.1
Reference
PMID:24586164
  Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
  Journal
PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
DOI:10.1016/j.tim.2013.06.006
Reference
PMID:25704559
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
  Journal
Trends Immunol 36:124-38 (2015)
DOI:10.1016/j.it.2015.01.004
Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
PMID:23303627
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
  Journal
J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189
Reference
PMID:29116588
  Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
  Journal
Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
PMID:23435233
  Authors
Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
Reference
PMID:19498380
  Authors
Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
  Journal
Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
Reference
PMID:18977445
  Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
  Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
  Journal
Semin Cancer Biol 18:397-408 (2008)
DOI:10.1016/j.semcancer.2008.10.008
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:27886133
  Authors
Ghosh Roy S, Robertson ES, Saha A
  Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
  Journal
Biomolecules 6:E46 (2016)
DOI:10.3390/biom6040046
Reference
PMID:22249143
  Authors
Dawson CW, Port RJ, Young LS
  Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
  Journal
Semin Cancer Biol 22:144-53 (2012)
DOI:10.1016/j.semcancer.2012.01.004
Reference
PMID:25613730
  Authors
Cai Q, Chen K, Young KH
  Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
  Journal
Exp Mol Med 47:e133 (2015)
DOI:10.1038/emm.2014.105
Reference
PMID:17601372
  Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
  Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
  Journal
Cell Mol Immunol 4:185-96 (2007)
Reference
PMID:23793113
  Authors
Ersing I, Bernhardt K, Gewurz BE
  Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
  Journal
Viruses 5:1587-606 (2013)
DOI:10.3390/v5061587
Reference
PMID:28835489
  Authors
Wang LW, Jiang S, Gewurz BE
  Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
  Journal
J Virol 91:e01718-16 (2017)
DOI:10.1128/JVI.01718-16
Reference
PMID:12740915
  Authors
Mori N, Morishita M, Tsukazaki T, Yamamoto N
  Title
Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
  Journal
Int J Cancer 105:661-8 (2003)
DOI:10.1002/ijc.11146
Reference
PMID:25873381
  Authors
Edwards RH, Marquitz AR, Raab-Traub N
  Title
Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
  Journal
MBio 6:e00441-15 (2015)
DOI:10.1128/mBio.00441-15
Reference
PMID:11905817
  Authors
Thorley-Lawson DA
  Title
Epstein-Barr virus: exploiting the immune system.
  Journal
Nat Rev Immunol 1:75-82 (2001)
DOI:10.1038/35095584
Reference
PMID:11669605
  Authors
Eliopoulos AG, Young LS
  Title
LMP1 structure and signal transduction.
  Journal
Semin Cancer Biol 11:435-44 (2001)
DOI:10.1006/scbi.2001.0410
Reference
PMID:14506283
  Authors
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
  Title
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
  Journal
J Biol Chem 278:47753-61 (2003)
DOI:10.1074/jbc.M307200200
Reference
PMID:25403939
  Authors
Kang H, Kiess A, Chung CH
  Title
Emerging biomarkers in head and neck cancer in the era of genomics.
  Journal
Nat Rev Clin Oncol 12:11-26 (2015)
DOI:10.1038/nrclinonc.2014.192
Reference
PMID:29932446
  Authors
Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM
  Title
Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
  Journal
Cancers (Basel) 10:E213 (2018)
DOI:10.3390/cancers10070213
Reference
PMID:19649319
  Authors
Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
  Title
Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
  Journal
PLoS Pathog 5:e1000530 (2009)
DOI:10.1371/journal.ppat.1000530
Reference
PMID:19244339
  Authors
Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
  Journal
J Virol 83:4652-69 (2009)
DOI:10.1128/JVI.02408-08
Reference
PMID:19394062
  Authors
Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
  Journal
Virology 388:236-47 (2009)
DOI:10.1016/j.virol.2009.03.027
Reference
PMID:25635182
  Authors
Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
  Title
Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
  Journal
Future Virol 4:79-91 (2009)
DOI:10.2217/17460794.4.1.79
Reference
PMID:10818681
  Authors
Longnecker R
  Title
Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
  Journal
Adv Cancer Res 79:175-200 (2000)
DOI:10.1016/s0065-230x(00)79006-3
Reference
PMID:30116721
  Authors
El-Sharkawy A, Al Zaidan L, Malki A
  Title
Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
  Journal
Front Oncol 8:265 (2018)
DOI:10.3389/fonc.2018.00265
Reference
PMID:12811813
  Authors
Dolcetti R, Masucci MG
  Title
Epstein-Barr virus: induction and control of cell transformation.
  Journal
J Cell Physiol 196:207-18 (2003)
DOI:10.1002/jcp.10263
Reference
PMID:21347341
  Authors
Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
  Journal
PLoS Pathog 7:e1001275 (2011)
DOI:10.1371/journal.ppat.1001275
Related
pathway
oaa03050  Proteasome
oaa04010  MAPK signaling pathway
oaa04020  Calcium signaling pathway
oaa04064  NF-kappa B signaling pathway
oaa04110  Cell cycle
oaa04115  p53 signaling pathway
oaa04210  Apoptosis
oaa04612  Antigen processing and presentation
oaa04620  Toll-like receptor signaling pathway
oaa04622  RIG-I-like receptor signaling pathway
oaa04630  JAK-STAT signaling pathway
oaa04662  B cell receptor signaling pathway
KO pathway
ko05169   
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