Entry
Name
Axon guidance - Pteropus alecto (black flying fox)
Description
Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.
Class
Organismal Systems; Development and regeneration
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Pteropus alecto (black flying fox) [GN:
pale ]
Gene
102896228 PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116 ] [EC:3.1.4.11 ]
102890005 TRPC1; short transient receptor potential channel 1 isoform X2 [KO:K04964 ]
102894586 TRPC3; short transient receptor potential channel 3 isoform X1 [KO:K04966 ]
102884419 TRPC4; short transient receptor potential channel 4 isoform X1 [KO:K04967 ]
102883120 TRPC6; short transient receptor potential channel 6 isoform X1 [KO:K04969 ]
102880029 PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
102883156 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
102898473 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
102886274 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
102884312 NFATC3; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333 ]
102888827 NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334 ]
102897644 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
102882497 LRIG2; leucine-rich repeats and immunoglobulin-like domains protein 2 isoform X1 [KO:K24609 ]
102892785 GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630 ]
102885642 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
102898665 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
102889024 SRGAP2; SLIT-ROBO Rho GTPase-activating protein 2 isoform X2 [KO:K07526 ]
102878117 SRGAP1; SLIT-ROBO Rho GTPase-activating protein 1 isoform X1 [KO:K07526 ]
102890092 SRGAP3; LOW QUALITY PROTEIN: SLIT-ROBO Rho GTPase-activating protein 3 [KO:K07526 ]
102883742 DPYSL2; dihydropyrimidinase-related protein 2 isoform X2 [KO:K07528 ]
102884350 PTCH1; LOW QUALITY PROTEIN: protein patched homolog 1 [KO:K06225 ]
102888385 CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
102889227 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
102880320 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
102889576 PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
102879163 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
102891637 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X3 [KO:K02649 ]
102879453 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
102878224 PARD6A; partitioning defective 6 homolog alpha isoform X3 [KO:K06093 ]
Compound
Reference
Authors
Guan KL, Rao Y.
Title
Signalling mechanisms mediating neuronal responses to guidance cues.
Journal
Reference
Authors
Govek EE, Newey SE, Van Aelst L.
Title
The role of the Rho GTPases in neuronal development.
Journal
Reference
Authors
Huber AB, Kolodkin AL, Ginty DD, Cloutier JF.
Title
Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance.
Journal
Reference
Authors
Negishi M, Oinuma I, Katoh H.
Title
Plexins: axon guidance and signal transduction.
Journal
Reference
Authors
Huot J.
Title
Ephrin signaling in axon guidance.
Journal
Reference
Authors
Patel BN, Van Vactor DL.
Title
Axon guidance: the cytoplasmic tail.
Journal
Reference
Authors
Yu TW, Bargmann CI.
Title
Dynamic regulation of axon guidance.
Journal
Reference
Authors
Dickson BJ.
Title
Molecular mechanisms of axon guidance.
Journal
Reference
Authors
Barallobre MJ, Pascual M, Del Rio JA, Soriano E.
Title
The Netrin family of guidance factors: emphasis on Netrin-1 signalling.
Journal
Reference
Authors
Sabatier C, Plump AS, Le Ma, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M.
Title
The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.
Journal
Reference
Authors
Fujita Y, Yamashita T
Title
Axon growth inhibition by RhoA/ROCK in the central nervous system.
Journal
Reference
Authors
Yamashita T, Mueller BK, Hata K
Title
Neogenin and repulsive guidance molecule signaling in the central nervous system.
Journal
Reference
Authors
van Erp S, van den Heuvel DMA, Fujita Y, Robinson RA, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers JAA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ
Title
Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.
Journal
Related pathway
pale04060 Cytokine-cytokine receptor interaction
KO pathway
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