KEGG   PATHWAY: panu05415
Entry
panu05415                   Pathway                                
Name
Diabetic cardiomyopathy - Papio anubis (olive baboon)
Description
Diabetic cardiomyopathy has been defined as left ventricular dysfunction that occurs among patients with diabetes mellitus independent of a recognized cause such as coronary artery disease or hypertension. The pathogenesis of diabetic cardiomyopathy broadly involves hyperglycemia, increased circulating fatty acids, and insulin resistance contributing to reactive oxygen species (ROS) generation, mitochondrial dysfunction, impaired calcium metabolism, Renin-Angiotensin System (RAS) activation, and altered substrate metabolism. These effects result in cardiac fibrosis, hypertrophy, cardiomyocyte death, contractile dysfunction, endothelial cell damage and eventually heart failure. In the process of cardiac fibrosis, cardiac fibroblasts are the final effector cell.
Class
Human Diseases; Cardiovascular disease
Pathway map
panu05415  Diabetic cardiomyopathy
panu05415

Organism
Papio anubis (olive baboon) [GN:panu]
Gene
100381181  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
101021830  SLC2A4; solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
101012191  GFPT1; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 isoform X4 [KO:K00820] [EC:2.6.1.16]
101024327  GFPT2; LOW QUALITY PROTEIN: glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 [KO:K00820] [EC:2.6.1.16]
116269450  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
116269451  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
101008925  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X10 [KO:K04515] [EC:2.7.11.17]
101009984  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X37 [KO:K04515] [EC:2.7.11.17]
101011087  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101019885  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X18 [KO:K04515] [EC:2.7.11.17]
101018203  TNNI3; troponin I, cardiac muscle [KO:K12044]
101014706  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
101007188  PLN; cardiac phospholamban [KO:K05852]
101021063  ATP2A2; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
101009959  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
100999076  ATP2A1; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
116268873  SP1; transcription factor Sp1 isoform X1 [KO:K04684]
101013870  AGT; angiotensinogen isoform X2 [KO:K09821]
101018390  REN; renin [KO:K01380] [EC:3.4.23.15]
100999092  chymase [KO:K01329] [EC:3.4.21.39]
101009865  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101006760  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
101020657  NCF1; neutrophil cytosol factor 1 [KO:K08011]
101005729  cytochrome b-245 light chain isoform X2 [KO:K08009]
101007374  NCF2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
101006767  NCF4; neutrophil cytosol factor 4 isoform X2 [KO:K08012]
101003935  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
101016465  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
101003219  AGTR1; type-1 angiotensin II receptor [KO:K04166]
101026781  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X6 [KO:K02580]
101017078  RELA; transcription factor p65 isoform X1 [KO:K04735]
101001103  MAPK12; mitogen-activated protein kinase 12 isoform X2 [KO:K04441] [EC:2.7.11.24]
101002393  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101024189  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101024771  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101005010  MAPK10; mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
101022320  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101019884  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101014166  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
101003884  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
101005809  COL1A2; collagen alpha-2(I) chain [KO:K06236]
101004530  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
101025205  COL3A1; collagen alpha-1(III) chain [KO:K19720]
101006627  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
101009253  TGFB2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376]
100997116  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
101019590  CD36; platelet glycoprotein 4 [KO:K06259]
101011461  PPARA; peroxisome proliferator-activated receptor alpha isoform X2 [KO:K07294]
101008303  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform isoform X4 [KO:K19523] [EC:2.3.1.21]
101000103  PDK4; pyruvate dehydrogenase kinase, isozyme 4 [KO:K00898] [EC:2.7.11.2]
101003598  PDK2; pyruvate dehydrogenase kinase, isozyme 2 [KO:K00898] [EC:2.7.11.2]
101007312  PDK3; pyruvate dehydrogenase kinase, isozyme 3 isoform X2 [KO:K00898] [EC:2.7.11.2]
101016532  PRKCA; protein kinase C alpha type isoform X4 [KO:K02677] [EC:2.7.11.13]
101003920  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
100137590  PTPA; serine/threonine-protein phosphatase 2A activator [KO:K17605]
101025668  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
101016118  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X2 [KO:K06269] [EC:3.1.3.16]
101014342  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
100137367  CTSD; cathepsin D precursor [KO:K01379] [EC:3.4.23.5]
101020378  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
101016112  CPT2; carnitine O-palmitoyltransferase 2, mitochondrial [KO:K08766] [EC:2.3.1.21]
100997985  INS; insulin isoform X2 [KO:K04526]
101012351  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
100999369  IRS1; insulin receptor substrate 1 [KO:K16172]
101004976  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101008699  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101002278  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100510873  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X4 [KO:K02649]
101009981  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101002971  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101016586  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100997634  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101000402  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100381179  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101015041  MTOR; serine/threonine-protein kinase mTOR isoform X2 [KO:K07203] [EC:2.7.11.1]
100998800  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101007834  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
101004773  TBC1D4; TBC1 domain family member 4 isoform X1 [KO:K17902]
101019297  MPC1L; LOW QUALITY PROTEIN: mitochondrial pyruvate carrier 1-like protein [KO:K22138]
101021356  MPC1; mitochondrial pyruvate carrier 1 [KO:K22138]
100999150  MPC2; mitochondrial pyruvate carrier 2 [KO:K22139]
101007903  PDHA2; pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial [KO:K00161] [EC:1.2.4.1]
101021972  PDHA1; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial [KO:K00161] [EC:1.2.4.1]
101012318  PDHB; pyruvate dehydrogenase E1 component subunit beta, mitochondrial [KO:K00162] [EC:1.2.4.1]
14444642  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
14444630  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
14444636  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
14444638  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
14444637  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
14444639  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
116273132  LOW QUALITY PROTEIN: uncharacterized protein LOC116273132 [KO:K03884] [EC:7.1.1.2]
14444640  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
101006922  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
100998941  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1 [KO:K03943] [EC:7.1.1.2]
101009040  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
101007924  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
101013937  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
103885307  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
101025484  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
108580506  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
101014495  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
108580495  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
101026476  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
108586421  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
101021591  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
100999652  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
101013121  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
101008045  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 isoform X1 [KO:K03951]
101025936  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
101008424  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial isoform X1 [KO:K03953]
101006233  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X3 [KO:K03954]
103876537  acyl carrier protein, mitochondrial [KO:K03955]
101024176  acyl carrier protein, mitochondrial-like [KO:K03955]
116272890  acyl carrier protein, mitochondrial [KO:K03955]
101007204  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
101026186  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
101002746  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
101001064  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 isoform X1 [KO:K11353]
101019309  NDUFB1; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
101021838  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial isoform X2 [KO:K03958]
101005887  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
108587044  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
101004754  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
101026496  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
101002541  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
101015506  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6-like [KO:K03962]
100997770  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
101026190  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
101003419  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
101022237  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
101022093  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
101014764  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
101001230  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934] [EC:7.1.1.2]
101002291  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
101020754  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
101017486  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
116275293  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
101026904  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
101002763  NDUFS8; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
100998717  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
101017439  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
101025145  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
116273554  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
101000070  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
101001260  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236]
101006239  succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
101002161  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
101011036  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
110741279  LOW QUALITY PROTEIN: succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
101026782  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
14444641  CYTB; cytochrome b [KO:K00412]
101021397  cytochrome c1, heme protein, mitochondrial [KO:K00413]
101009600  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
101026315  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
101006001  cytochrome b-c1 complex subunit 6, mitochondrial isoform X2 [KO:K00416]
100997829  cytochrome b-c1 complex subunit 7 isoform X1 [KO:K00417]
101017841  cytochrome b-c1 complex subunit 8 [KO:K00418]
100997845  cytochrome b-c1 complex subunit 9 isoform X1 [KO:K00419]
116273763  cytochrome b-c1 complex subunit 10 [KO:K00420]
14444635  COX3; cytochrome c oxidase subunit III [KO:K02262]
14444631  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
14444632  COX2; cytochrome c oxidase subunit II [KO:K02261]
101006909  cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like [KO:K02263]
101019045  cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform X1 [KO:K02263]
101003461  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
101020469  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263]
101001315  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
101006649  COX5A; cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
103877721  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
101007148  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
103876119  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
101000271  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
101018921  cytochrome c oxidase subunit 6B2 [KO:K02267]
101010708  cytochrome c oxidase subunit 6B1 [KO:K02267]
108586074  cytochrome c oxidase subunit 6C-like [KO:K02268]
101013819  cytochrome c oxidase subunit 6C [KO:K02268]
101002878  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
101019499  cytochrome c oxidase subunit 7A2, mitochondrial isoform X1 [KO:K02270]
116271663  cytochrome c oxidase subunit 7A1, mitochondrial isoform X1 [KO:K02270]
116271667  cytochrome c oxidase subunit 7A1, mitochondrial isoform X1 [KO:K02270]
101021606  cytochrome c oxidase subunit 7A1, mitochondrial isoform X2 [KO:K02270]
101013709  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
116269782  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
103884346  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
108581070  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
108585455  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
101014053  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
108586679  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
108587428  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
108586288  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
116274896  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
116274898  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
108585269  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
101019295  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
101026809  cytochrome c oxidase subunit 8C, mitochondrial isoform X2 [KO:K02273]
100126727  COX8A; cytochrome c oxidase subunit 8A, mitochondrial precursor [KO:K02273]
100997548  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
101017406  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
101010257  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
100137597  ATP5C1; ATP synthase subunit gamma, mitochondrial [KO:K02136]
101005176  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
14444634  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
101000308  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial isoform X2 [KO:K02127]
101007596  ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
101021172  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
101011935  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
101017933  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial isoform X1 [KO:K02128]
101018964  ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
101024769  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
101007673  ATP synthase subunit d, mitochondrial [KO:K02138]
101016617  ATP synthase subunit O, mitochondrial [KO:K02137]
100137250  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
101005105  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
14444633  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
101020566  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
101009552  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
101019427  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X2 [KO:K15041]
100998956  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
101009750  SLC25A31; ADP/ATP translocase 4 isoform X1 [KO:K05863]
101025041  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
101000631  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
100997257  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
100137333  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101024888  NOS3; LOW QUALITY PROTEIN: nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
100126722  GAPDH; glyceraldehyde-3-phosphate dehydrogenase isoform X2 [KO:K00134] [EC:1.2.1.12]
101015786  glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
101009923  PARP1; poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
101012981  GSR; glutathione reductase, mitochondrial [KO:K00383] [EC:1.8.1.7]
101016512  TGFBR1; TGF-beta receptor type-1 isoform X2 [KO:K04674] [EC:2.7.11.30]
101023107  TGFBR2; TGF-beta receptor type-2 isoform X2 [KO:K04388] [EC:2.7.11.30]
101004882  SMAD2; mothers against decapentaplegic homolog 2 isoform X2 [KO:K04500]
101013089  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
101012903  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100998763  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100999120  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X5 [KO:K05858] [EC:3.1.4.11]
101010000  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X4 [KO:K05858] [EC:3.1.4.11]
101020307  angiotensin-converting enzyme isoform X1 [KO:K01283] [EC:3.4.15.1]
Compound
C00001  H2O
C00002  ATP
C00005  NADPH
C00006  NADP+
C00022  Pyruvate
C00024  Acetyl-CoA
C00027  Hydrogen peroxide
C00031  D-Glucose
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00051  Glutathione
C00076  Calcium cation
C00085  D-Fructose 6-phosphate
C00092  D-Glucose 6-phosphate
C00095  D-Fructose
C00118  D-Glyceraldehyde 3-phosphate
C00127  Glutathione disulfide
C00162  Fatty acid
C00165  Diacylglycerol
C00195  N-Acylsphingosine
C00236  3-Phospho-D-glyceroyl phosphate
C00318  L-Carnitine
C00352  D-Glucosamine 6-phosphate
C00369  Starch
C00533  Nitric oxide
C00546  Methylglyoxal
C00704  Superoxide
C00794  D-Sorbitol
C00873  Angiotensin I
C02135  Angiotensin II
C02843  Long-chain acyl-CoA
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06156  alpha-D-Glucosamine 1-phosphate
C16844  Hydroxyl radical
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
C22310  Fructose 3-phosphate
C22311  3-Deoxyglucosone
Reference
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  Authors
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  Title
Of mice and men: models and mechanisms of diabetic cardiomyopathy.
  Journal
Basic Res Cardiol 114:2 (2018)
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Reference
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Pharmacol Ther 142:375-415 (2014)
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Reference
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Cardiovasc Diabetol 16:28 (2017)
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Reference
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Tan Y, Zhang Z, Zheng C, Wintergerst KA, Keller BB, Cai L
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Nat Rev Cardiol 17:585-607 (2020)
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Int J Mol Sci 20:E2833 (2019)
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Trends Pharmacol Sci 39:452-467 (2018)
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Diabetic Cardiomyopathy: An Immunometabolic Perspective.
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Front Endocrinol (Lausanne) 8:72 (2017)
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Reference
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Reference
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  Title
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  Authors
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  Title
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  Authors
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  Title
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  Authors
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  Authors
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Reference
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  Authors
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  Journal
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Reference
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Reference
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Related
pathway
panu00010  Glycolysis / Gluconeogenesis
panu00020  Citrate cycle (TCA cycle)
panu00190  Oxidative phosphorylation
panu00520  Amino sugar and nucleotide sugar metabolism
panu03320  PPAR signaling pathway
panu04071  Sphingolipid signaling pathway
panu04150  mTOR signaling pathway
panu04210  Apoptosis
panu04260  Cardiac muscle contraction
panu04350  TGF-beta signaling pathway
panu04614  Renin-angiotensin system
panu04910  Insulin signaling pathway
panu04930  Type II diabetes mellitus
panu04931  Insulin resistance
panu04933  AGE-RAGE signaling pathway in diabetic complications
panu04940  Type I diabetes mellitus
KO pathway
ko05415   
LinkDB

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