KEGG   PATHWAY: pdic04020
Entry
pdic04020                   Pathway                                
Name
Calcium signaling pathway - Phyllostomus discolor (pale spear-nosed bat)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
pdic04020  Calcium signaling pathway
pdic04020

Other DBs
GO: 0019722
Organism
Phyllostomus discolor (pale spear-nosed bat) [GN:pdic]
Gene
114511732  SLC8A2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
114498478  SLC8A1; sodium/calcium exchanger 1 isoform X2 [KO:K05849]
114493399  SLC8A3; sodium/calcium exchanger 3 isoform X6 [KO:K05849]
114511989  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
114512655  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
114505390  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
114501451  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
114500732  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
114512305  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
114490307  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
114509573  ADORA2A; LOW QUALITY PROTEIN: adenosine receptor A2a [KO:K04266]
114515089  ADORA2B; LOW QUALITY PROTEIN: adenosine receptor A2b [KO:K04267]
114495957  ADRB1; beta-1 adrenergic receptor [KO:K04141]
114510124  ADRB2; beta-2 adrenergic receptor [KO:K04142]
114508710  ADRB3; beta-3 adrenergic receptor [KO:K04143]
114509848  DRD1; D(1A) dopamine receptor [KO:K04144]
114493165  DRD5; D(1B) dopamine receptor [KO:K05840]
114510279  HRH2; histamine H2 receptor [KO:K04150]
114509861  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
114514343  LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 5B-like [KO:K04161]
114507989  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
114498107  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
114498037  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
114506244  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
114507035  neuroendocrine secretory protein 55-like [KO:K04632]
114506842  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
114490247  adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
114508056  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
114500049  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
114492860  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
114488191  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
114514654  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
114503776  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
114505902  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
114502442  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
114496184  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
114494305  PLN; cardiac phospholamban [KO:K05852]
114500931  SLN; sarcolipin [KO:K22642]
114498096  MRLN; myoregulin [KO:K22643]
114509974  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
114491123  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
114514989  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
114511653  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
114499697  STIM1; stromal interaction molecule 1 isoform X2 [KO:K16059]
114492320  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
114509296  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
114501599  ORAI2; protein orai-2 isoform X1 [KO:K16057]
114511815  ORAI3; protein orai-3 [KO:K16058]
114512949  CACNA1C; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
114501473  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X11 [KO:K04851]
114505705  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
114512262  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
114502598  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
114494895  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X10 [KO:K04849]
114511888  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
114504331  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X2 [KO:K04854]
114499037  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X2 [KO:K04855]
114513940  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
114488626  neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
114500715  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X2 [KO:K05208]
114503314  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
114514185  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
114503958  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
114511731  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
114512233  GRIN3A; glutamate receptor ionotropic, NMDA 3A isoform X1 [KO:K05213]
114503607  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
114515167  P2RX1; P2X purinoceptor 1 isoform X1 [KO:K05215]
114489723  P2RX2; P2X purinoceptor 2 isoform X1 [KO:K05216]
114500138  P2RX3; P2X purinoceptor 3 [KO:K05217]
114509709  P2RX4; P2X purinoceptor 4 [KO:K05218]
114515057  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
114510209  P2RX6; P2X purinoceptor 6 [KO:K05221]
114509355  P2RX7; P2X purinoceptor 7 [KO:K05220]
114510907  RYR1; ryanodine receptor 1 isoform X4 [KO:K04961]
114512445  RYR2; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
114490278  RYR3; LOW QUALITY PROTEIN: ryanodine receptor 3 [KO:K04963]
114493836  triadin-like [KO:K23449]
114495081  triadin [KO:K23449]
114512000  CASQ1; calsequestrin-1 [KO:K23468]
114489032  CASQ2; calsequestrin-2 [KO:K23445]
114514403  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X2 [KO:K00476] [EC:1.14.11.16]
114505003  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
114508418  CYSLTR2; LOW QUALITY PROTEIN: cysteinyl leukotriene receptor 2 [KO:K04323]
114507875  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
114503100  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
114509527  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
114506620  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
114490804  AGTR1; type-1 angiotensin II receptor [KO:K04166]
114502638  endothelin-1 receptor [KO:K04197]
114508546  EDNRB; endothelin receptor type B [KO:K04198]
114497723  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
114495128  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
114499828  GRM5; metabotropic glutamate receptor 5 isoform X2 [KO:K04604]
114505288  GRPR; gastrin-releasing peptide receptor [KO:K04169]
114501713  HRH1; LOW QUALITY PROTEIN: histamine H1 receptor [KO:K04149]
118498392  5-hydroxytryptamine receptor 2C-like [KO:K04157]
114493886  HTR2B; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
114508752  HTR2A; 5-hydroxytryptamine receptor 2A isoform X1 [KO:K04157]
114500728  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
114505947  NTSR1; neurotensin receptor type 1 [KO:K04211]
114501954  OXTR; oxytocin receptor [KO:K04229]
114514150  AVPR1A; vasopressin V1a receptor [KO:K04226]
114512101  AVPR1B; vasopressin V1b receptor [KO:K04227]
114492080  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
114497525  PTAFR; platelet-activating factor receptor [KO:K04279]
114497256  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
114497488  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
114493425  BDKRB1; B1 bradykinin receptor [KO:K03915]
114492951  BDKRB2; B2 bradykinin receptor isoform X1 [KO:K03916]
114499856  TACR1; substance-P receptor [KO:K04222]
114497784  TACR2; substance-K receptor [KO:K04223]
114493227  TACR3; neuromedin-K receptor [KO:K04224]
114502391  TBXA2R; thromboxane A2 receptor [KO:K04264]
114514765  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
114493131  CCKAR; cholecystokinin receptor type A [KO:K04194]
114500411  CCKBR; gastrin/cholecystokinin type B receptor isoform X1 [KO:K04195]
114494698  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
114508313  GNAQ; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
114502886  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
114511771  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
114502918  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
114492590  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
114498679  TGFA; protransforming growth factor alpha [KO:K08774]
114510403  PDGFA; platelet-derived growth factor subunit A isoform X2 [KO:K04359]
114514158  PDGFB; platelet-derived growth factor subunit B isoform X2 [KO:K17386]
114504215  PDGFC; platelet-derived growth factor C [KO:K05450]
114500653  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
114510422  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
114502553  FGF2; fibroblast growth factor 2 [KO:K18497]
114509809  FGF18; fibroblast growth factor 18 [KO:K04358]
114496691  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
114503602  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
114504014  FGF17; fibroblast growth factor 17 [KO:K04358]
114512610  FGF6; fibroblast growth factor 6 [KO:K04358]
114491712  FGF7; fibroblast growth factor 7 [KO:K04358]
114499168  FGF3; fibroblast growth factor 3 [KO:K04358]
114505270  FGF16; fibroblast growth factor 16 [KO:K04358]
114514054  FGF9; fibroblast growth factor 9 [KO:K04358]
114493120  FGF5; fibroblast growth factor 5 [KO:K04358]
114500857  FGF4; fibroblast growth factor 4 [KO:K04358]
114501717  FGF10; fibroblast growth factor 10 [KO:K04358]
114508944  FGF20; fibroblast growth factor 20 [KO:K04358]
114499167  FGF19; fibroblast growth factor 19 [KO:K22603]
114510830  FGF21; fibroblast growth factor 21 [KO:K22429]
114514005  FGF23; fibroblast growth factor 23 [KO:K22428]
114494974  VEGFA; vascular endothelial growth factor A [KO:K05448]
114499451  VEGFB; vascular endothelial growth factor B isoform X2 [KO:K16858]
114505353  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
114508695  VEGFC; vascular endothelial growth factor C isoform X2 [KO:K05449]
114488932  NGF; beta-nerve growth factor [KO:K02582]
114507737  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
114501410  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
114506691  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
114507607  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
114502459  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
114512713  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
114494770  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
114493180  PDGFRA; platelet-derived growth factor receptor alpha isoform X2 [KO:K04363] [EC:2.7.10.1]
114509632  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
114508370  FGFR1; fibroblast growth factor receptor 1 isoform X5 [KO:K04362] [EC:2.7.10.1]
114496712  FGFR2; fibroblast growth factor receptor 2 isoform X8 [KO:K05093] [EC:2.7.10.1]
114489924  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
114509287  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
114489006  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
114505286  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
114509396  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
114492293  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
114489015  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
114492084  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
114488572  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
114507559  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
114501397  MST1R; LOW QUALITY PROTEIN: macrophage-stimulating protein receptor [KO:K05100] [EC:2.7.10.1]
114497427  RET; LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
114502949  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
114495656  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
114501986  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X3 [KO:K05857] [EC:3.1.4.11]
114499423  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
114492321  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
114506463  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
114506992  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2 [KO:K05858] [EC:3.1.4.11]
114506303  PLCG1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
114488244  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X2 [KO:K05859] [EC:3.1.4.11]
114496437  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
114513682  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
114501461  ITPR1; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
114513086  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
114493819  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X2 [KO:K04960]
114491309  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
114510056  TPCN1; two pore calcium channel protein 1 [KO:K16896]
114500116  TPCN2; two pore calcium channel protein 2 isoform X1 [KO:K14077]
114509978  MCOLN1; mucolipin-1 isoform X2 [KO:K04992]
114497202  MCOLN2; mucolipin-2 isoform X2 [KO:K04993]
114497304  MCOLN3; mucolipin-3 isoform X2 [KO:K04994]
114503018  SPHK1; sphingosine kinase 1 isoform X2 [KO:K04718] [EC:2.7.1.91]
114511602  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
114496429  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
114509433  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
114496446  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
114491433  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 2-like [KO:K15040]
114508533  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
114503154  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
114489892  ADP/ATP translocase 3 [KO:K05863]
114504719  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
114508039  ADP/ATP translocase 3-like [KO:K05863]
114508763  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
114496644  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
114501979  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
114506654  TNNC2; troponin C, skeletal muscle [KO:K12042]
114513363  calmodulin-1-like [KO:K02183]
114497344  calmodulin-1-like [KO:K02183]
114511152  CALM3; calmodulin-3 [KO:K02183]
114511912  calmodulin-1-like [KO:K02183]
114496832  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
114499227  CALM2; calmodulin-2 [KO:K02183]
114501791  calmodulin-alpha-like [KO:K02183]
114492575  CALM1; calmodulin-1 isoform X2 [KO:K02183]
114492868  calmodulin-like protein 3 [KO:K02183]
114492882  CALML4; calmodulin-like protein 4 isoform X5 [KO:K02183]
114493421  calmodulin-like [KO:K02183]
114505420  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
114493851  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
114488357  PHKB; phosphorylase b kinase regulatory subunit beta [KO:K07190]
114504615  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
114504634  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
114488355  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
114490158  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
114496983  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
114506860  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
114511905  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G isoform X4 [KO:K08794] [EC:2.7.11.17]
114492449  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
114501548  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X4 [KO:K08794] [EC:2.7.11.17]
114509628  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
114502936  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X3 [KO:K04515] [EC:2.7.11.17]
114490227  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
114497712  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
114511230  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
114503003  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
114497754  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
114492341  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
114512239  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
114498589  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
114495451  TFEB; transcription factor EB [KO:K15590]
114506388  NFATC1; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
114506923  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X2 [KO:K17332]
114488255  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
114491690  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
114509381  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
114503016  NOS2; nitric oxide synthase, inducible isoform X2 [KO:K13241] [EC:1.14.13.39]
114508069  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
114513032  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
114494449  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
114508177  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X4 [KO:K13755] [EC:3.1.4.17]
114502461  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
114511542  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
114512353  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
114492636  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
114502829  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
114494685  PRKCB; LOW QUALITY PROTEIN: protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
114511158  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
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Berridge MJ, Bootman MD, Roderick HL.
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Calcium signalling: dynamics, homeostasis and remodelling.
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Nat Rev Mol Cell Biol 4:517-29 (2003)
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The versatility and universality of calcium signalling.
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Nat Rev Mol Cell Biol 1:11-21 (2000)
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Reference
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Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
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Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
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J Biol Chem 272:19125-32 (1997)
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Reference
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Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
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J Neurochem 64:953-60 (1995)
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Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
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Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
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Acta Physiol (Oxf) 204:151-7 (2012)
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Immunodeficiency due to defects in store-operated calcium entry.
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Ann N Y Acad Sci 1238:74-90 (2011)
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Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
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STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
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Seikagaku 80:1123-8 (2008)
Reference
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Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
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The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
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Pflugers Arch 458:869-76 (2009)
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Reference
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Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
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Eur Biophys J 39:27-36 (2009)
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Reference
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Marty I
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Triadin regulation of the ryanodine receptor complex.
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J Physiol 593:3261-6 (2015)
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Reference
PMID:20807542
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Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
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Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
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J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
pdic04010  MAPK signaling pathway
pdic04070  Phosphatidylinositol signaling system
pdic04210  Apoptosis
pdic04720  Long-term potentiation
pdic04730  Long-term depression
KO pathway
ko04020   
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