Entry
Name
Endocytosis - Peromyscus leucopus (white-footed mouse)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Peromyscus leucopus (white-footed mouse) [GN:
pleu ]
Gene
114688360 Pip5k1c; LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889 ] [EC:2.7.1.68 ]
114682164 Zfyve16; zinc finger FYVE domain-containing protein 16 isoform X1 [KO:K04679 ]
114706315 Zfyve9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679 ]
114685390 Tfrc; LOW QUALITY PROTEIN: transferrin receptor protein 1 [KO:K06503 ]
114695792 Sh3kbp1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470 ]
114691639 Bin1; myc box-dependent-interacting protein 1 isoform X2 [KO:K12562 ]
114706483 Eps15; epidermal growth factor receptor substrate 15 isoform X2 [KO:K12472 ]
114709608 Eps15l1; epidermal growth factor receptor substrate 15-like 1 isoform X2 [KO:K12472 ]
114697251 Ldlrap1; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474 ]
114695594 Wasl; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612 ]
114682779 Arpc5l; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754 ]
114689719 Wipf3; WAS/WASL-interacting protein family member 3 isoform X1 [KO:K19475 ]
114690029 Hspa6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283 ]
114693729 Dnajc6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526 ]
114697177 Capzb; F-actin-capping protein subunit beta isoform X5 [KO:K10365 ]
114704565 Vps29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467 ]
114704762 Vps26a; vacuolar protein sorting-associated protein 26A isoform X2 [KO:K18466 ]
114702588 Vps26b; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 26B [KO:K18466 ]
114709420 LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 26A-like [KO:K18466 ]
114709955 Vps35; vacuolar protein sorting-associated protein 35 [KO:K18468 ]
114680599 Hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X2 [KO:K12182 ]
114693935 Stam; signal transducing adapter molecule 1 isoform X1 [KO:K04705 ]
114685634 Tsg101; tumor susceptibility gene 101 protein isoform X1 [KO:K12183 ]
114702920 LOW QUALITY PROTEIN: tumor susceptibility gene 101 protein-like [KO:K12183 ]
114694185 Vps28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184 ]
114686018 Vps37d; vacuolar protein sorting-associated protein 37D [KO:K12185 ]
114704529 Vps37b; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 37B [KO:K12185 ]
114695144 Vps37a; vacuolar protein sorting-associated protein 37A isoform X1 [KO:K12185 ]
114703416 Vps37c; vacuolar protein sorting-associated protein 37C [KO:K12185 ]
114686261 Vps36; vacuolar protein-sorting-associated protein 36 [KO:K12190 ]
114681830 LOW QUALITY PROTEIN: vacuolar protein-sorting-associated protein 36-like [KO:K12190 ]
114682822 Vps25; vacuolar protein-sorting-associated protein 25 isoform X1 [KO:K12189 ]
114708729 Chmp4a; LOW QUALITY PROTEIN: charged multivesicular body protein 4a [KO:K12194 ]
114685586 Chmp3; charged multivesicular body protein 3 isoform X1 [KO:K12193 ]
114710709 LOW QUALITY PROTEIN: charged multivesicular body protein 3-like [KO:K12193 ]
114683424 Vps4a; vacuolar protein sorting-associated protein 4A [KO:K12196 ]
114702807 Vps4b; vacuolar protein sorting-associated protein 4B isoform X1 [KO:K12196 ]
114686840 Vta1; vacuolar protein sorting-associated protein VTA1 homolog isoform X1 [KO:K12199 ]
114709262 LOW QUALITY PROTEIN: programmed cell death 6-interacting protein [KO:K12200 ]
114691369 Igf2r; LOW QUALITY PROTEIN: cation-independent mannose-6-phosphate receptor [KO:K06564 ]
114694353 Il2rb; interleukin-2 receptor subunit beta isoform X2 [KO:K05069 ]
114686366 H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X10 [KO:K06751 ]
114687018 H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751 ]
114687019 H-2 class I histocompatibility antigen, D-37 alpha chain-like [KO:K06751 ]
114687020 H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751 ]
114687933 H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751 ]
114687935 RT1 class I histocompatibility antigen, AA alpha chain-like isoform X1 [KO:K06751 ]
114688482 H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751 ]
114688490 class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751 ]
114688492 patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751 ]
114688790 H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751 ]
114688816 LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, K-B alpha chain-like [KO:K06751 ]
114688817 H-2 class I histocompatibility antigen, alpha chain-like isoform X1 [KO:K06751 ]
114682640 class I histocompatibility antigen, Gogo-A*0501 alpha chain-like [KO:K06751 ]
114682644 H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751 ]
114682645 H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751 ]
114682649 HLA class I histocompatibility antigen, alpha chain F-like isoform X3 [KO:K06751 ]
114682653 class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751 ]
114682654 HLA class I histocompatibility antigen, alpha chain F-like [KO:K06751 ]
114682655 HLA class I histocompatibility antigen, alpha chain G [KO:K06751 ]
114682656 popy Class I histocompatibility antigen, A-1 alpha chain-like isoform X1 [KO:K06751 ]
114682666 class I histocompatibility antigen, Non-RT1.A alpha-1 chain-like isoform X1 [KO:K06751 ]
114682671 class I histocompatibility antigen, Gogo-A*0201 alpha chain-like [KO:K06751 ]
114682672 patr class I histocompatibility antigen, CH28 alpha chain-like [KO:K06751 ]
114682673 H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751 ]
114682677 class I histocompatibility antigen, Non-RT1.A alpha-1 chain-like [KO:K06751 ]
114682685 patr class I histocompatibility antigen, A-126 alpha chain isoform X1 [KO:K06751 ]
114682688 saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751 ]
114705846 RT1 class I histocompatibility antigen, AA alpha chain-like isoform X1 [KO:K06751 ]
114686335 Rabep1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480 ]
114681488 Rufy1; RUN and FYVE domain-containing protein 1 isoform X1 [KO:K12482 ]
114701131 Rufy2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482 ]
114682379 Vps45; vacuolar protein sorting-associated protein 45 isoform X1 [KO:K12479 ]
114685555 Rab11fip5; rab11 family-interacting protein 5 isoform X1 [KO:K12484 ]
114686806 Rab11fip1; LOW QUALITY PROTEIN: rab11 family-interacting protein 1 [KO:K12484 ]
114701067 Rab11fip2; rab11 family-interacting protein 2 isoform X1 [KO:K12484 ]
114691530 Rab11fip4; rab11 family-interacting protein 4 isoform X1 [KO:K12485 ]
114681253 Rab11fip3; rab11 family-interacting protein 3 isoform X1 [KO:K12485 ]
114681065 Pard6a; partitioning defective 6 homolog alpha isoform X1 [KO:K06093 ]
114697206 Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393 ]
114704921 Smap2; stromal membrane-associated protein 2 isoform X1 [KO:K12486 ]
114692321 Smap1; stromal membrane-associated protein 1 isoform X1 [KO:K12486 ]
114697222 Asap3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12488 ]
114697727 Asap1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488 ]
114698861 Asap2; LOW QUALITY PROTEIN: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 [KO:K12488 ]
114693194 Acap1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 [KO:K12489 ]
114708291 Acap3; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X3 [KO:K12489 ]
114710035 Acap2; LOW QUALITY PROTEIN: arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 [KO:K12489 ]
114698740 Arap1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439 ]
114692417 Arap2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K18440 ]
114700079 Agap3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X3 [KO:K12491 ]
114700698 Agap1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12491 ]
114704813 Agap2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X2 [KO:K17848 ]
114704187 Arfgap1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492 ]
114705715 ADP-ribosylation factor GTPase-activating protein 1-like [KO:K12492 ]
114682752 Arfgap3; LOW QUALITY PROTEIN: ADP-ribosylation factor GTPase-activating protein 3 [KO:K12493 ]
114699690 Arfgap2; ADP-ribosylation factor GTPase-activating protein 2 isoform X1 [KO:K12493 ]
114705093 Psd2; LOW QUALITY PROTEIN: PH and SEC7 domain-containing protein 2 [KO:K12494 ]
114703123 Psd3; LOW QUALITY PROTEIN: PH and SEC7 domain-containing protein 3 [KO:K12494 ]
114683401 Iqsec2; LOW QUALITY PROTEIN: IQ motif and SEC7 domain-containing protein 2 [KO:K12495 ]
114681242 Iqsec1; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495 ]
114700727 Iqsec3; LOW QUALITY PROTEIN: IQ motif and SEC7 domain-containing protein 3 [KO:K12495 ]
114690100 Arfgef1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 [KO:K18442 ]
114692654 Arfgef2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1 [KO:K18442 ]
114696759 Gbf1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443 ]
Compound
C04549 1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C11556 1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
Authors
Acconcia F, Sigismund S, Polo S
Title
Ubiquitin in trafficking: the network at work.
Journal
Reference
Authors
Donaldson JG, Porat-Shliom N, Cohen LA
Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
Journal
Reference
Authors
Sorkin A
Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
Journal
Reference
Authors
Raiborg C, Stenmark H
Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
Journal
Reference
Authors
Scita G, Di Fiore PP
Title
The endocytic matrix.
Journal
Reference
Authors
Le Roy C, Wrana JL
Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
Journal
Reference
Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
Title
The early endosome: a busy sorting station for proteins at the crossroads.
Journal
Reference
Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
Title
Viral entry, lipid rafts and caveosomes.
Journal
Reference
Authors
Grant BD, Donaldson JG
Title
Pathways and mechanisms of endocytic recycling.
Journal
Reference
Authors
Cullen PJ, Korswagen HC
Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
Journal
Related pathway
pleu04060 Cytokine-cytokine receptor interaction
pleu04070 Phosphatidylinositol signaling system
pleu04130 SNARE interactions in vesicular transport
KO pathway
LinkDB
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