KEGG   PATHWAY: pps04020
Entry
pps04020                    Pathway                                
Name
Calcium signaling pathway - Pan paniscus (bonobo)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
pps04020  Calcium signaling pathway
pps04020

Other DBs
GO: 0019722
Organism
Pan paniscus (bonobo) [GN:pps]
Gene
100980273  SLC8A2; sodium/calcium exchanger 2 isoform X3 [KO:K05849]
100969645  SLC8A1; sodium/calcium exchanger 1 isoform X2 [KO:K05849]
100986811  SLC8A3; sodium/calcium exchanger 3 isoform X3 [KO:K05849]
100988724  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
100982359  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
100973331  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
100978284  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
100970743  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
100989641  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
100969893  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
100970926  ADORA2A; adenosine receptor A2a [KO:K04266]
100994290  ADORA2B; adenosine receptor A2b [KO:K04267]
100978740  ADRB1; beta-1 adrenergic receptor [KO:K04141]
100983950  ADRB2; beta-2 adrenergic receptor isoform X2 [KO:K04142]
100972927  ADRB3; beta-3 adrenergic receptor [KO:K04143]
100988335  DRD1; D(1A) dopamine receptor [KO:K04144]
100994450  DRD5; D(1B) dopamine receptor [KO:K05840]
100989107  HRH2; histamine H2 receptor isoform X1 [KO:K04150]
100983386  HTR4; 5-hydroxytryptamine receptor 4 isoform X2 [KO:K04160]
100990391  LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 5B-like [KO:K04161]
100989351  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
100978121  HTR6; 5-hydroxytryptamine receptor 6 isoform X1 [KO:K04162]
100981020  HTR7; 5-hydroxytryptamine receptor 7 isoform X4 [KO:K04163]
100990650  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X2 [KO:K04632]
117974231  neuroendocrine secretory protein 55 [KO:K04632]
100975164  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
100984585  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
100992014  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
100995134  ADCY3; adenylate cyclase type 3 isoform X4 [KO:K08043] [EC:4.6.1.1]
100978200  ADCY4; adenylate cyclase type 4 isoform X2 [KO:K08044] [EC:4.6.1.1]
100984225  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
100994715  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100972356  ADCY9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
100982589  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
100970917  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100968237  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
100973367  PLN; cardiac phospholamban [KO:K05852]
100985389  SLN; sarcolipin [KO:K22642]
100982448  MRLN; myoregulin [KO:K22643]
100991365  C3H4orf3; uncharacterized protein C4orf3 homolog [KO:K26467]
100991253  SMIM6; small integral membrane protein 6 [KO:K26468]
100979248  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
103787182  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
100968452  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein isoform X2 [KO:K23450]
100990966  STIM1; stromal interaction molecule 1 isoform X4 [KO:K16059]
100969937  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
100987781  calcium release-activated calcium channel protein 1 isoform X1 [KO:K16056]
100988709  ORAI2; protein orai-2 isoform X1 [KO:K16057]
100972631  ORAI3; protein orai-3 [KO:K16058]
100971701  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X6 [KO:K04850]
100975108  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X4 [KO:K04851]
100988624  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
100982136  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
100971898  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X4 [KO:K04344]
100979369  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X6 [KO:K04849]
100973580  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
100983419  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
100983134  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X9 [KO:K04855]
100972510  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
100977072  neuronal acetylcholine receptor subunit alpha-7 isoform X2 [KO:K04809]
100987673  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
100977852  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X2 [KO:K05209]
100974219  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
100977548  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
100973890  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
100994570  P2RX1; P2X purinoceptor 1 [KO:K05215]
100970270  P2RX3; P2X purinoceptor 3 isoform X1 [KO:K05217]
100990374  P2RX4; P2X purinoceptor 4 isoform X4 [KO:K05218]
100987979  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
100976042  P2RX6; P2X purinoceptor 6 isoform X1 [KO:K05221]
100990943  P2RX7; P2X purinoceptor 7 [KO:K05220]
100992272  RYR1; ryanodine receptor 1 isoform X1 [KO:K04961]
100974705  RYR2; ryanodine receptor 2 isoform X4 [KO:K04962]
100969544  RYR3; ryanodine receptor 3 isoform X1 [KO:K04963]
100981711  TRDN; triadin isoform X1 [KO:K23449]
100994461  CASQ1; calsequestrin-1 [KO:K23468]
100994765  CASQ2; calsequestrin-2 [KO:K23445]
100977040  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X15 [KO:K00476] [EC:1.14.11.16]
100988950  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
100976535  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
103782638  CHRM2; muscarinic acetylcholine receptor M2 isoform X2 [KO:K04130]
100986808  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
106634821  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
100978396  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
100992718  AGTR1; type-1 angiotensin II receptor isoform X3 [KO:K04166]
100986370  EDNRB; endothelin receptor type B [KO:K04198]
100968079  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
100988134  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
100983802  GRPR; gastrin-releasing peptide receptor isoform X2 [KO:K04169]
100979999  HRH1; histamine H1 receptor [KO:K04149]
100970741  HTR2A; 5-hydroxytryptamine receptor 2A isoform X1 [KO:K04157]
100986689  HTR2C; 5-hydroxytryptamine receptor 2C isoform X1 [KO:K04157]
100985583  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
100989161  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
100992141  NTSR1; neurotensin receptor type 1 [KO:K04211]
100977222  OXTR; oxytocin receptor [KO:K04229]
100993523  AVPR1A; vasopressin V1a receptor [KO:K04226]
100995333  AVPR1B; vasopressin V1b receptor [KO:K04227]
100984964  PTAFR; platelet-activating factor receptor [KO:K04279]
100975934  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
100993214  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
100977391  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
100972709  BDKRB1; B1 bradykinin receptor isoform X2 [KO:K03915]
100972150  BDKRB2; B2 bradykinin receptor [KO:K03916]
100982037  TACR1; substance-P receptor [KO:K04222]
100970551  TACR2; substance-K receptor [KO:K04223]
100983956  TACR3; neuromedin-K receptor [KO:K04224]
100988035  TBXA2R; thromboxane A2 receptor [KO:K04264]
100992440  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
100995235  CCKAR; cholecystokinin receptor type A [KO:K04194]
100992776  CCKBR; gastrin/cholecystokinin type B receptor isoform X2 [KO:K04195]
100968161  CXCR4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
100986730  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
100972605  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
100987065  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
100987012  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
100975632  EGF; pro-epidermal growth factor [KO:K04357]
100973153  TGFA; protransforming growth factor alpha isoform X3 [KO:K08774]
100991389  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100984583  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
100982459  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
100992738  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
100968351  FGF2; fibroblast growth factor 2 [KO:K18497]
100992612  FGF10; fibroblast growth factor 10 [KO:K04358]
100989491  FGF6; fibroblast growth factor 6 [KO:K04358]
100982572  FGF17; fibroblast growth factor 17 isoform X2 [KO:K04358]
100985264  FGF16; fibroblast growth factor 16 [KO:K04358]
100967980  FGF3; fibroblast growth factor 3 [KO:K04358]
100979704  FGF9; fibroblast growth factor 9 [KO:K04358]
100968963  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
100967638  FGF4; fibroblast growth factor 4 [KO:K04358]
100969230  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
117974215  FGF7; fibroblast growth factor 7 [KO:K04358]
117980428  FGF18; fibroblast growth factor 18 [KO:K04358]
100970008  FGF20; fibroblast growth factor 20 [KO:K04358]
134728514  fibroblast growth factor 7-like [KO:K04358]
100967291  FGF19; fibroblast growth factor 19 [KO:K22603]
100975521  FGF21; fibroblast growth factor 21 [KO:K22429]
100989835  FGF23; fibroblast growth factor 23 [KO:K22428]
100970217  VEGFA; vascular endothelial growth factor A, long form isoform X4 [KO:K05448]
117974938  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
100969999  VEGFD; vascular endothelial growth factor D [KO:K05449]
100990660  VEGFC; vascular endothelial growth factor C [KO:K05449]
100995667  NGF; beta-nerve growth factor [KO:K02582]
100983117  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
117979789  LOW QUALITY PROTEIN: hepatocyte growth factor-like protein [KO:K23441]
100971481  LOW QUALITY PROTEIN: hepatocyte growth factor-like protein [KO:K23441]
100996101  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
100969352  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
100974885  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100977227  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
100974494  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
100996186  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X3 [KO:K05085] [EC:2.7.10.1]
100982337  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
100975853  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
100988115  FGFR1; fibroblast growth factor receptor 1 isoform X8 [KO:K04362] [EC:2.7.10.1]
100981139  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
100976551  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100991315  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
100977352  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
100969442  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
100986594  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
100994887  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
100994282  NTRK3; NT-3 growth factor receptor isoform X5 [KO:K05101] [EC:2.7.10.1]
100991777  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
100982426  MST1R; macrophage-stimulating protein receptor isoform X2 [KO:K05100] [EC:2.7.10.1]
100994039  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
100969236  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X2 [KO:K05857] [EC:3.1.4.11]
100988032  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
100980795  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
100969660  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2 [KO:K05858] [EC:3.1.4.11]
100987524  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100969344  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X8 [KO:K05858] [EC:3.1.4.11]
100978643  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
100995010  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X3 [KO:K01116] [EC:3.1.4.11]
100984694  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
100992707  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
100988020  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X2 [KO:K05861] [EC:3.1.4.11]
100984884  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
100980378  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
100982024  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X5 [KO:K04960]
100974952  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
100990039  TPCN1; two pore channel protein 1 isoform X4 [KO:K16896]
100971084  TPCN2; two pore channel protein 2 isoform X3 [KO:K14077]
100985054  MCOLN1; mucolipin-1 [KO:K04992]
100975357  MCOLN2; mucolipin-2 isoform X1 [KO:K04993]
100975689  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
100992056  SPHK2; sphingosine kinase 2 isoform X2 [KO:K04718] [EC:2.7.1.91]
100977890  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
100990265  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
100983168  VDAC1; voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
100982601  voltage-dependent anion-selective channel protein 1 [KO:K05862]
100990596  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
100987711  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
100991246  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
100984012  SLC25A31; ADP/ATP translocase 4 isoform X1 [KO:K05863]
100981051  ADP/ATP translocase 3-like [KO:K05863]
100971042  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
129395394  ADP/ATP translocase 3 [KO:K05863]
100970528  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
100984453  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
100968994  TNNC2; troponin C, skeletal muscle isoform X1 [KO:K12042]
100990459  CALML5; calmodulin-like protein 5 [KO:K02183]
100990795  CALML3; calmodulin-like protein 3 [KO:K02183]
100996176  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
100976055  calmodulin-2-like [KO:K02183]
100979074  CALML6; calmodulin-like protein 6 [KO:K02183]
100983464  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
100986631  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
100987241  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X2 [KO:K07190]
100981775  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
100976010  PHKB; phosphorylase b kinase regulatory subunit beta isoform X2 [KO:K07190]
100978891  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
100974667  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
100979422  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
100995666  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
100995267  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X2 [KO:K08794] [EC:2.7.11.17]
100980159  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G isoform X1 [KO:K08794] [EC:2.7.11.17]
100979439  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
100973727  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X3 [KO:K04515] [EC:2.7.11.17]
100983859  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X24 [KO:K04515] [EC:2.7.11.17]
100982179  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
100986246  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
100970371  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
100976987  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
100968593  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100976831  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X5 [KO:K04348] [EC:3.1.3.16]
100995767  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
100973991  TFEB; transcription factor EB [KO:K15590]
100974281  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
100980286  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
100988212  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
100982481  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X6 [KO:K17334]
100996089  NOS1; nitric oxide synthase 1 isoform X1 [KO:K13240] [EC:1.14.13.39]
100976546  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
100974638  NOS3; nitric oxide synthase 3 isoform X1 [KO:K13242] [EC:1.14.13.39]
100995565  PDE1B; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X3 [KO:K13755] [EC:3.1.4.17]
100989825  PDE1C; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X5 [KO:K13755] [EC:3.1.4.17]
100981582  PDE1A; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X10 [KO:K13755] [EC:3.1.4.17]
100991936  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
100974308  ITPKB; inositol-trisphosphate 3-kinase B isoform X1 [KO:K00911] [EC:2.7.1.127]
100988859  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
100967981  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100970296  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
100990245  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100968473  CALM1; calmodulin-1 isoform X2 [KO:K02183]
100977014  CALM3; calmodulin-3 [KO:K02183]
100980454  CALM2; calmodulin-2 isoform X1 [KO:K02183]
100989438  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
117979174  PPP3R1; calcineurin subunit B type 1 isoform X2 [KO:K06268]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
pps04010  MAPK signaling pathway
pps04070  Phosphatidylinositol signaling system
pps04210  Apoptosis
pps04720  Long-term potentiation
pps04730  Long-term depression
KO pathway
ko04020   
LinkDB

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