KEGG   PATHWAY: psex04020
Entry
psex04020                   Pathway                                
Name
Calcium signaling pathway - Polypterus senegalus (gray bichir)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
psex04020  Calcium signaling pathway
psex04020

Other DBs
GO: 0019722
Organism
Polypterus senegalus (gray bichir) [GN:psex]
Gene
120539338  sodium/calcium exchanger 1-like [KO:K05849]
120540300  slc8a2b; sodium/calcium exchanger 2b [KO:K05849]
120516909  slc8a1b; sodium/calcium exchanger 1b isoform X1 [KO:K05849]
120518362  slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
120540309  atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
120526137  atp2b4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
120534302  atp2b1a; plasma membrane calcium-transporting ATPase 1a isoform X1 [KO:K05850] [EC:7.2.2.10]
120542125  atp2b3b; plasma membrane calcium-transporting ATPase 3b isoform X1 [KO:K05850] [EC:7.2.2.10]
120539193  muscarinic acetylcholine receptor M1-like [KO:K04129]
120516780  muscarinic acetylcholine receptor M3-like [KO:K04131]
120518456  muscarinic acetylcholine receptor M5-like [KO:K04133]
120540942  adora2aa; adenosine A2a receptor a [KO:K04266]
120531548  adora2b; adenosine receptor A2b [KO:K04267]
120543090  adrb1; beta-1 adrenergic receptor [KO:K04141]
120542083  beta-2 adrenergic receptor-like [KO:K04142]
120538910  beta-4C adrenergic receptor-like isoform X1 [KO:K04143]
120543021  D(1) dopamine receptor-like [KO:K04144]
120519044  D(1C) dopamine receptor [KO:K05840]
120539761  D(1) dopamine receptor-like [KO:K05840]
120528621  drd5a; D(1B) dopamine receptor [KO:K05840]
120543051  histamine H2 receptor-like [KO:K04150]
120527211  si:dkey-247m21.3; 5-hydroxytryptamine receptor 4 [KO:K04160]
120542914  htr4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
120528647  5-hydroxytryptamine receptor 4 [KO:K04160]
120529645  5-hydroxytryptamine receptor 5A-like [KO:K04161]
120530618  htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
120538896  5-hydroxytryptamine receptor 7-like [KO:K04163]
120540777  5-hydroxytryptamine receptor 7-like [KO:K04163]
120528657  5-hydroxytryptamine receptor 7-like [KO:K04163]
120514201  gnas; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
120530340  gnal; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
120529518  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
120515751  adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
120526110  adcy3a; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
120524043  adenylate cyclase type 2-like [KO:K08044] [EC:4.6.1.1]
120535204  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
120529809  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
120543008  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
120514851  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
120541109  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
120525396  pln; cardiac phospholamban [KO:K05852]
120523167  sarcolipin [KO:K22642]
120538111  si:dkey-28b4.8; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
120531398  atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
120540949  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
120536414  atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
120523954  stromal interaction molecule 1-like isoform X1 [KO:K16059]
120527636  stim2b; stromal interaction molecule 2 [KO:K18196]
120540818  orai1b; calcium release-activated calcium channel protein 1 [KO:K16056]
120531317  orai2; protein orai-2 [KO:K16057]
120537462  calcium release-activated calcium channel protein 1-like [KO:K16057]
120540046  voltage-dependent L-type calcium channel subunit alpha-1C-like isoform X1 [KO:K04850]
120542743  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04853]
120525930  voltage-dependent L-type calcium channel subunit alpha-1S-like isoform X1 [KO:K04857]
120540050  voltage-dependent P/Q-type calcium channel subunit alpha-1A-like [KO:K04344]
120543001  cacna1ba; calcium channel, voltage-dependent, N type, alpha 1B subunit, a [KO:K04849]
120537999  voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
120517215  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
120542474  LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1H-like [KO:K04855]
120536964  voltage-dependent T-type calcium channel subunit alpha-1I-like isoform X1 [KO:K04856]
120532329  chrna8; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
120528116  chrna11; cholinergic receptor, nicotinic, alpha 11 isoform X1 [KO:K04809]
120542371  glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
120542265  grin2aa; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2A [KO:K05209]
120537070  glutamate receptor ionotropic, NMDA 2B-like [KO:K05210]
120517590  grin2cb; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
120518718  glutamate receptor ionotropic, NMDA 2D-like [KO:K05212]
120533075  grin3a; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
120537897  grin3bb; glutamate receptor ionotropic, NMDA 3A isoform X1 [KO:K05214]
120531399  p2rx1; P2X purinoceptor 1 [KO:K05215]
120540737  p2rx2; P2X purinoceptor 2 isoform X1 [KO:K05216]
120538116  p2rx3b; P2X purinoceptor 3b isoform X1 [KO:K05217]
120540934  p2rx4b; P2X purinoceptor 4b isoform X1 [KO:K05218]
120531282  p2rx5; P2X purinoceptor 5 isoform X1 [KO:K05219]
120540933  p2rx7; P2X purinoceptor 7 [KO:K05220]
120538749  ryanodine receptor 1-like isoform X1 [KO:K04961]
120516764  ryr2a; ryanodine receptor 2 isoform X1 [KO:K04962]
120518470  ryr3; ryanodine receptor 3 isoform X1 [KO:K04963]
120526646  trdn; triadin [KO:K23449]
120518400  casq1b; calsequestrin-1b [KO:K23468]
120522965  casq2; calsequestrin-2 [KO:K23445]
120530250  unm_hu7910; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
120525076  cysltr3; cysteinyl leukotriene receptor 1 [KO:K04322]
120537182  cysltr1; cysteinyl leukotriene receptor 1 isoform X1 [KO:K04322]
120524040  LOW QUALITY PROTEIN: cysteinyl leukotriene receptor 2-like [KO:K04323]
120539637  chrm2a; muscarinic acetylcholine receptor M2a [KO:K04130]
120539529  alpha-1A adrenergic receptor-like [KO:K04135]
120514597  alpha-1A adrenergic receptor-like [KO:K04135]
120542810  alpha-1B adrenergic receptor-like [KO:K04136]
120527891  adra1d; alpha-1D adrenergic receptor [KO:K04137]
120533703  agtr1a; type-1A angiotensin II receptor [KO:K04166]
120527125  ednraa; endothelin receptor type Aa [KO:K04197]
120523771  endothelin receptor type B [KO:K04198]
120537178  endothelin receptor type B-like [KO:K04198]
120532428  proteinase-activated receptor 1-like [KO:K03914]
120525332  grm1b; metabotropic glutamate receptor 1b isoform X1 [KO:K04603]
120523150  grm5b; metabotropic glutamate receptor 5b isoform X1 [KO:K04604]
120523613  grpr; gastrin-releasing peptide receptor [KO:K04169]
120541173  hrh1; histamine H1 receptor [KO:K04149]
120542548  histamine H1 receptor-like [KO:K04149]
120537502  htr2cl1; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1 [KO:K04157]
120523692  5-hydroxytryptamine receptor 2A-like [KO:K04157]
120537461  htr2b; 5-hydroxytryptamine receptor 2B [KO:K04157]
120516786  lutropin-choriogonadotropic hormone receptor-like isoform X1 [KO:K04248]
120516972  lutropin-choriogonadotropic hormone receptor-like [KO:K04248]
120538369  ntsr1; neurotensin receptor type 1 [KO:K04211]
120542500  neurotensin receptor type 1-like [KO:K04211]
120541478  oxtr; oxytocin receptor [KO:K04229]
120533827  avpr1aa; arginine vasopressin receptor 1Aa [KO:K04226]
120526666  vasopressin V1b receptor-like [KO:K04227]
120523956  ltb4r2b; leukotriene B4 receptor 2b [KO:K04297]
120517819  ptafr; platelet-activating factor receptor [KO:K04279]
120541107  prostaglandin E2 receptor EP1 subtype-like isoform X1 [KO:K04258]
120541125  prostaglandin E2 receptor EP1 subtype-like [KO:K04258]
120515009  ptgfr; prostaglandin F2-alpha receptor [KO:K04262]
120518568  B2 bradykinin receptor-like isoform X1 [KO:K03916]
120518677  B2 bradykinin receptor-like [KO:K03916]
120538867  substance-P receptor-like [KO:K04222]
120516174  tacr2; substance-K receptor [KO:K04223]
120532729  neuromedin-K receptor-like [KO:K04224]
120542970  neuromedin-K receptor-like [KO:K04224]
120537865  tbxa2r; thromboxane A2 receptor [KO:K04264]
120514980  thyrotropin-releasing hormone receptor-like [KO:K04282]
120515879  trhra; thyrotropin-releasing hormone receptor [KO:K04282]
120534967  trhr2; thyrotropin releasing hormone receptor 2 [KO:K04282]
120523066  cholecystokinin receptor-like [KO:K04194]
120527634  cckar; cholecystokinin receptor type A isoform X1 [KO:K04194]
120531714  C-X-C chemokine receptor type 4-like [KO:K04189]
120527303  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
120537716  guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
120527302  gna14a; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
120537713  guanine nucleotide-binding protein subunit alpha-11-like isoform X1 [KO:K04637]
120533101  egf; pro-epidermal growth factor [KO:K04357]
120538847  tgfa; protransforming growth factor alpha isoform X1 [KO:K08774]
120542103  platelet-derived growth factor subunit A-like isoform X1 [KO:K04359]
120523158  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
120527165  pdgfc; platelet-derived growth factor C [KO:K05450]
120543141  fibroblast growth factor 1-like [KO:K18496]
120527622  fgf2; fibroblast growth factor 2 [KO:K18497]
120539476  fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
120523816  fibroblast growth factor 9 [KO:K04358]
120514487  fgf8a; fibroblast growth factor 8 isoform X1 [KO:K04358]
120532133  fgf5; fibroblast growth factor 5 [KO:K04358]
120541342  fgf7; fibroblast growth factor 7 isoform X1 [KO:K04358]
120525968  fgf4; fibroblast growth factor 4 isoform X1 [KO:K04358]
120533718  fgf6a; fibroblast growth factor 6a [KO:K04358]
120525976  fgf3; fibroblast growth factor 3 [KO:K04358]
120527274  fibroblast growth factor 10-like [KO:K04358]
120542903  fgf18a; fibroblast growth factor 18a isoform X1 [KO:K04358]
120527474  fgf20a; fibroblast growth factor 20a [KO:K04358]
120527912  fgf24; fibroblast growth factor 24 isoform X1 [KO:K04358]
120536266  fgf22; fibroblast growth factor 22 [KO:K04358]
120537094  fgf16; fibroblast growth factor 16 isoform X1 [KO:K04358]
120517840  fgf19; fibroblast growth factor 19 [KO:K22603]
120533587  fgf23; fibroblast growth factor 23 [KO:K22428]
120525694  vegfaa; vascular endothelial growth factor A-A isoform X1 [KO:K05448]
120533789  vascular endothelial growth factor A-like [KO:K05448]
120523608  vegfd; vascular endothelial growth factor D [KO:K05449]
120527040  vegfc; vascular endothelial growth factor C isoform X1 [KO:K05449]
120526256  ngfb; nerve growth factor [KO:K02582]
120534137  hepatocyte growth factor-like isoform X1 [KO:K05460]
120527350  glial cell line-derived neurotrophic factor-like isoform X1 [KO:K05452]
120529821  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
120518186  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
120525163  erbb3a; receptor tyrosine-protein kinase erbB-3a isoform X1 [KO:K05084] [EC:2.7.10.1]
120530767  receptor tyrosine-protein kinase erbB-4-like isoform X1 [KO:K05085] [EC:2.7.10.1]
120527608  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
120542138  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
120538938  fgfr1a; fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
120522839  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
120527855  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
120542196  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
120523848  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
120537290  kdrl; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
120542443  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
120527610  kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
120517965  ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
120527322  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a [KO:K04360] [EC:2.7.10.1]
120541406  NT-3 growth factor receptor-like [KO:K05101] [EC:2.7.10.1]
120534110  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
120540350  macrophage-stimulating protein receptor-like isoform X1 [KO:K05100] [EC:2.7.10.1]
120529236  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
120531248  plcd4b; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
120517820  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A-like [KO:K05857] [EC:3.1.4.11]
120529683  plcd1a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1a isoform X1 [KO:K05857] [EC:3.1.4.11]
120518946  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
120539203  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
120516316  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
120516513  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
120515081  plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
120529699  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1-like isoform X1 [KO:K01116] [EC:3.1.4.11]
120535553  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
120540913  plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
120540181  inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
120534185  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
120526198  itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
120541035  tpcn1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
120525941  tpcn2; two pore calcium channel protein 2 [KO:K14077]
120540002  mcoln1a; mucolipin-1a [KO:K04992]
120517074  sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
120518308  sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
120539123  mcu; calcium uniporter protein, mitochondrial [KO:K20858]
120543172  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
120515492  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
120541564  vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
120538806  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
120523443  slc25a6; ADP/ATP translocase 3 [KO:K05863]
120527513  slc25a4; ADP/ATP translocase 1 [KO:K05863]
120537285  slc25a5; ADP/ATP translocase 2 [KO:K05863]
120541382  ppifa; peptidylprolyl isomerase Fa [KO:K09565] [EC:5.2.1.8]
120541959  tnnc1b; troponin C type 1b (slow) [KO:K05865]
120514784  troponin C, skeletal muscle-like [KO:K12042]
120514846  troponin C, skeletal muscle [KO:K12042]
120530526  calglandulin-like [KO:K02183]
120521606  calmodulin-like [KO:K02183]
120538670  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
120539370  calm3b; calmodulin 3b (phosphorylase kinase, delta) [KO:K02183]
120523494  calmodulin-alpha-like [KO:K02183]
120541657  calml4a; calmodulin-like protein 4a [KO:K02183]
120516414  calmodulin-alpha-like [KO:K02183]
120516454  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
120516564  calmodulin-like [KO:K02183]
120516565  calmodulin-like [KO:K02183]
120518519  calmodulin-1 [KO:K02183]
120531507  phkg1b; phosphorylase kinase, gamma 1b (muscle) [KO:K00871] [EC:2.7.11.19]
120536637  phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
120523590  phosphorylase b kinase regulatory subunit alpha, liver isoform-like isoform X1 [KO:K07190]
120535345  phkb; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
120529801  phka1a; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
120538383  myosin light chain kinase 2, skeletal/cardiac muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
120531737  mylka; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
120517084  mylk5; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
120535353  mylk3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
120529538  myosin light chain kinase 3-like isoform X1 [KO:K00907] [EC:2.7.11.18]
120540870  camk1b; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
120525911  calcium/calmodulin-dependent protein kinase type 1D-like [KO:K08794] [EC:2.7.11.17]
120538731  camk2g2; calcium/calmodulin-dependent protein kinase type II delta chain isoform X1 [KO:K04515] [EC:2.7.11.17]
120538827  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
120533088  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
120542230  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
120532928  camk4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
120532800  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like [KO:K04348] [EC:3.1.3.16]
120515967  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
120542168  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
120516240  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
120526159  tfeb; transcription factor EB isoform X1 [KO:K15590]
120515872  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
120514215  nfatc2a; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
120535233  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
120523960  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
120540577  nos1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
120531344  nos2b; nitric oxide synthase 2b, inducible [KO:K13241] [EC:1.14.13.39]
120515929  nitric oxide synthase, endothelial-like [KO:K13242] [EC:1.14.13.39]
120531902  pde1a; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
120524929  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B-like isoform X1 [KO:K13755] [EC:3.1.4.17]
120529404  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C-like isoform X1 [KO:K13755] [EC:3.1.4.17]
120526386  ptk2ba; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
120538717  itpkcb; inositol-trisphosphate 3-kinase Cb isoform X1 [KO:K00911] [EC:2.7.1.127]
120525711  inositol-trisphosphate 3-kinase B-like [KO:K00911] [EC:2.7.1.127]
120518598  itpka; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
120517149  protein kinase C alpha type-like [KO:K02677] [EC:2.7.11.13]
120542651  prkcba; protein kinase C, beta a isoform X1 [KO:K19662] [EC:2.7.11.13]
120518916  protein kinase C alpha type-like isoform X1 [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
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Berridge MJ, Bootman MD, Roderick HL.
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Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
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Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
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FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
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Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
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Reference
PMID:11698232
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Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
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J Bioenerg Biomembr 35:577-98 (2003)
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Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
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Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
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Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
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Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
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STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
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Reference
PMID:19172794
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Baba Y, Kurosaki T
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[Regulation of store-operated calcium entry by STIM1].
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Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
psex04010  MAPK signaling pathway
psex04070  Phosphatidylinositol signaling system
psex04210  Apoptosis
KO pathway
ko04020   
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