Entry
Name
Salmonella infection - Sarcophilus harrisii (Tasmanian devil)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
BRITE hierarchy
Pathway map
Ortholog table
Organism
Sarcophilus harrisii (Tasmanian devil) [GN:
shr ]
Gene
100918641 PLEKHM1; pleckstrin homology domain-containing family M member 1 isoform X1 [KO:K23282 ]
100916193 VPS11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179 ]
100925909 VPS16; vacuolar protein sorting-associated protein 16 homolog isoform X2 [KO:K20180 ]
100933441 VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181 ]
100925671 VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182 ]
100922541 VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184 ]
100931447 DYNC1H1; cytoplasmic dynein 1 heavy chain 1 isoform X1 [KO:K10413 ]
100915845 DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414 ]
100931475 DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X2 [KO:K10415 ]
100915957 DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 isoform X2 [KO:K10416 ]
100925661 DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416 ]
100922428 DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417 ]
100924224 ARL8A; ADP-ribosylation factor-like protein 8A isoform X1 [KO:K07955 ]
100929917 PLEKHM2; pleckstrin homology domain-containing family M member 2 isoform X1 [KO:K15348 ]
100933994 GCC2; GRIP and coiled-coil domain-containing protein 2 isoform X1 [KO:K20282 ]
100915023 AHNAK; neuroblast differentiation-associated protein AHNAK isoform X1 [KO:K23934 ]
100924967 ELMO2; engulfment and cell motility protein 2 isoform X1 [KO:K18985 ]
100917142 MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351 ]
100917903 MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754 ]
100927147 MYLPF; myosin regulatory light chain 2, skeletal muscle isoform isoform X1 [KO:K12758 ]
100933194 FHOD1; LOW QUALITY PROTEIN: FH1/FH2 domain-containing protein 1 [KO:K23938 ]
100918370 CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393 ]
100919657 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
100924737 WASF3; wiskott-Aldrich syndrome protein family member 3 isoform X2 [KO:K06083 ]
100934823 LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein family member 3-like [KO:K06083 ]
100922101 ARPC1A; actin-related protein 2/3 complex subunit 1A isoform X1 [KO:K05757 ]
100921689 ARPC2; actin-related protein 2/3 complex subunit 2 isoform X2 [KO:K05758 ]
100921388 ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754 ]
100929811 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
100932099 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
105749979 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
100925455 PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289 ] [EC:2.7.1.153 ]
100930379 PIK3C2A; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1 [KO:K00923 ] [EC:2.7.1.154 ]
100913785 PIK3C2B; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta [KO:K00923 ] [EC:2.7.1.154 ]
100913329 TIRAP; toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403 ]
100927751 MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
100917609 TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403 ]
100930713 TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404 ]
100920451 TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793 ]
100919027 NFKBIA; LOW QUALITY PROTEIN: NF-kappa-B inhibitor alpha [KO:K04734 ]
100917619 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
100920057 NOD1; LOW QUALITY PROTEIN: nucleotide-binding oligomerization domain-containing protein 1 [KO:K08727 ]
100919788 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
116421331 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171 ]
100914028 baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060 ]
100933131 baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060 ]
105750042 TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
105749071 tumor necrosis factor receptor superfamily member 10A isoform X1 [KO:K04722 ]
100925851 PYCARD; apoptosis-associated speck-like protein containing a CARD [KO:K12799 ]
Compound
C01194 1-Phosphatidyl-D-myo-inositol
C04549 1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C11554 1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
Authors
Bernal-Bayard J, Ramos-Morales F
Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
Journal
Reference
Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
Journal
Reference
Authors
Wemyss MA, Pearson JS
Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
Journal
Reference
Authors
Bierschenk D, Boucher D, Schroder K
Title
Salmonella-induced inflammasome activation in humans.
Journal
Reference
Authors
Pinaud L, Sansonetti PJ, Phalipon A
Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
Journal
Reference
Authors
LaRock DL, Chaudhary A, Miller SI
Title
Salmonellae interactions with host processes.
Journal
Reference
Authors
Ramsden AE, Holden DW, Mota LJ
Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
Journal
Reference
Authors
van der Heijden J, Finlay BB
Title
Type III effector-mediated processes in Salmonella infection.
Journal
Reference
Authors
Galan JE
Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
Journal
Reference
Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
Title
Salmonella takes control: effector-driven manipulation of the host.
Journal
Reference
Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
Journal
Reference
Authors
Patel JC, Galan JE
Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
Journal
Reference
Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
Journal
Reference
Authors
Fu Y, Galan JE
Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
Journal
Related pathway
shr04621 NOD-like receptor signaling pathway
KO pathway
LinkDB
All DBs