KEGG   PATHWAY: ssc04020
Entry
ssc04020                    Pathway                                
Name
Calcium signaling pathway - Sus scrofa (pig)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
ssc04020  Calcium signaling pathway
ssc04020

Other DBs
GO: 0019722
Organism
Sus scrofa (pig) [GN:ssc]
Gene
100152101  SLC8A3; sodium/calcium exchanger 3 isoform X2 [KO:K05849]
100519030  SLC8A2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
100622020  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
397636  ATP2B1; plasma membrane calcium-transporting ATPase 1 [KO:K05850] [EC:7.2.2.10]
100520061  ATP2B3; LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 3 [KO:K05850] [EC:7.2.2.10]
100623420  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
100625418  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
397099  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
100144478  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
100155818  CHRM5; LOW QUALITY PROTEIN: muscarinic acetylcholine receptor M5 [KO:K04133]
503661  ADORA2A; adenosine receptor A2a [KO:K04266]
606745  ADORA2B; adenosine receptor A2b [KO:K04267]
397355  ADRB1; beta-1 adrenergic receptor [KO:K04141]
397357  ADRB2; beta-2 adrenergic receptor [KO:K04142]
397356  ADRB3; beta-3 adrenergic receptor [KO:K04143]
100144487  DRD1; D(1A) dopamine receptor [KO:K04144]
100524631  DRD5; D(1B) dopamine receptor [KO:K05840]
100625720  HRH2; histamine H2 receptor isoform X2 [KO:K04150]
397431  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
100154782  5-hydroxytryptamine receptor 5B [KO:K04161]
100623476  HTR6; LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 6 [KO:K04162]
397158  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
100049657  GNAS; SCG6 (secretogranin VI) isoform SCG6 [KO:K04632]
100736677  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X2 [KO:K04633]
100624934  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100517503  ADCY2; LOW QUALITY PROTEIN: adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
100514402  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
100152067  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
100620994  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
100622999  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100625423  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
397652  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
100623628  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
397421  PLN; cardiac phospholamban [KO:K05852]
733627  SLN; sarcolipin [KO:K22642]
105667210  MRLN; myoregulin [KO:K22643]
110255263  CXH4orf3; uncharacterized protein C4orf3 homolog [KO:K26467]
100516962  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
396820  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
396875  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
100525465  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
100171399  STIM1; stromal interaction molecule 1 precursor [KO:K16059]
100519497  STIM2; LOW QUALITY PROTEIN: stromal interaction molecule 2 [KO:K18196]
100154923  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
100521440  ORAI2; protein orai-2 [KO:K16057]
100736565  ORAI3; protein orai-3 [KO:K16058]
100518733  CACNA1C; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
100511102  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X14 [KO:K04851]
100514745  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
100622149  CACNA1S; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
100525387  CACNA1A; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
102164336  CACNA1B; LOW QUALITY PROTEIN: voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
100511769  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
100513431  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
110259950  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
100154640  CACNA1I; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
100415931  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
397440  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
100736832  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
100626022  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
100515684  GRIN2C; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2C [KO:K05211]
100521797  GRIN2D; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2D [KO:K05212]
100153054  GRIN3A; glutamate receptor ionotropic, NMDA 3A isoform X1 [KO:K05213]
100623799  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
106504105  P2RX1; P2X purinoceptor 1 isoform X1 [KO:K05215]
100736581  P2RX2; P2X purinoceptor 2 isoform X1 [KO:K05216]
503656  P2RX3; P2X purinoceptor 3 [KO:K05217]
100157723  P2RX4; P2X purinoceptor 4 [KO:K05218]
100519563  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
100515342  P2RX6; P2X purinoceptor 6 isoform X1 [KO:K05221]
497623  P2RX7; P2X purinoceptor 7 isoform X1 [KO:K05220]
396718  RYR1; ryanodine receptor 1 [KO:K04961]
396856  RYR2; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
396888  RYR3; LOW QUALITY PROTEIN: ryanodine receptor 3 [KO:K04963]
102166405  TRDN; triadin isoform X1 [KO:K23449]
100156448  CASQ1; calsequestrin-1 precursor [KO:K23468]
397436  CASQ2; LOW QUALITY PROTEIN: calsequestrin-2 [KO:K23445]
100526167  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X20 [KO:K00476] [EC:1.14.11.16]
397242  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
397243  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
397498  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
100144471  ADRA1A; alpha-1A adrenergic receptor [KO:K04135]
100519931  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
552898  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
100519976  AGTR1; type-1 angiotensin II receptor [KO:K04166]
397457  EDNRA; endothelin-1 receptor precursor [KO:K04197]
414911  EDNRB; endothelin B receptor precursor [KO:K04198]
100521609  F2R; proteinase-activated receptor 1 precursor [KO:K03914]
100625610  GRM1; metabotropic glutamate receptor 1 isoform X2 [KO:K04603]
102161751  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
100517439  GRPR; gastrin-releasing peptide receptor [KO:K04169]
100523996  HRH1; histamine H1 receptor isoform X1 [KO:K04149]
397432  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
396837  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
100524920  HTR2C; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled [KO:K04157]
407247  LHCGR; lutropin-choriogonadotropic hormone receptor precursor [KO:K04248]
110257490  NTSR1; neurotensin receptor type 1 [KO:K04211]
397092  OXTR; oxytocin receptor [KO:K04229]
100525342  AVPR1A; vasopressin V1a receptor [KO:K04226]
100517909  AVPR1B; vasopressin V1b receptor [KO:K04227]
100156094  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
100523973  PTAFR; platelet-activating factor receptor [KO:K04279]
100515879  PTGER1; prostaglandin E2 receptor EP1 subtype isoform X1 [KO:K04258]
396811  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
397126  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
100127469  BDKRB1; B1 bradykinin receptor [KO:K03915]
110255240  BDKRB2; B2 bradykinin receptor isoform X2 [KO:K03916]
110259991  TACR1; substance-P receptor [KO:K04222]
100151877  TACR2; LOW QUALITY PROTEIN: substance-K receptor [KO:K04223]
100521983  TACR3; LOW QUALITY PROTEIN: neuromedin-K receptor [KO:K04224]
110259364  TBXA2R; thromboxane A2 receptor [KO:K04264]
100415777  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
100738769  LOW QUALITY PROTEIN: thyrotropin-releasing hormone receptor-like [KO:K04282]
100623128  CCKAR; cholecystokinin receptor type A isoform X2 [KO:K04194]
100625698  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
396659  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
654405  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
733588  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
100048958  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
100518537  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
397083  EGF; pro-epidermal growth factor precursor [KO:K04357]
397484  TGFA; protransforming growth factor alpha precursor [KO:K08774]
100519764  PDGFA; platelet-derived growth factor subunit A isoform X5 [KO:K04359]
100515267  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
100524161  PDGFD; LOW QUALITY PROTEIN: platelet-derived growth factor D [KO:K05450]
397497  FGF1; fibroblast growth factor 1 [KO:K18496]
397643  FGF2; fibroblast growth factor 2 [KO:K18497]
396717  FGF9; fibroblast growth factor 9 [KO:K04358]
100155720  FGF17; fibroblast growth factor 17 [KO:K04358]
100152116  FGF6; fibroblast growth factor 6 [KO:K04358]
100152223  FGF16; fibroblast growth factor 16 [KO:K04358]
100156242  FGF8; LOW QUALITY PROTEIN: fibroblast growth factor 8 [KO:K04358]
100513672  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
100516301  FGF20; fibroblast growth factor 20 [KO:K04358]
100518595  FGF4; fibroblast growth factor 4 [KO:K04358]
100519127  FGF3; fibroblast growth factor 3 [KO:K04358]
100525013  FGF18; fibroblast growth factor 18 isoform X2 [KO:K04358]
100525086  FGF10; fibroblast growth factor 10 [KO:K04358]
397281  FGF7; fibroblast growth factor 7 [KO:K04358]
110259378  FGF22; fibroblast growth factor 22 [KO:K04358]
100518950  FGF19; fibroblast growth factor 19 [KO:K22603]
100302504  FGF21; fibroblast growth factor 21 precursor [KO:K22429]
100155339  FGF23; fibroblast growth factor 23 [KO:K22428]
397157  VEGFA; vascular endothelial growth factor A precursor [KO:K05448]
100521837  VEGFB; vascular endothelial growth factor B isoform X2 [KO:K16858]
100155670  VEGFD; vascular endothelial growth factor D [KO:K05449]
100738968  NGF; beta-nerve growth factor [KO:K02582]
100525120  HGF; hepatocyte growth factor isoform X3 [KO:K05460]
100512987  MST1; hepatocyte growth factor-like protein isoform X6 [KO:K23441]
100322894  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
397070  EGFR; epidermal growth factor receptor precursor [KO:K04361] [EC:2.7.10.1]
100516641  ERBB2; receptor tyrosine-protein kinase erbB-2 precursor [KO:K05083] [EC:2.7.10.1]
100525045  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
100525789  ERBB4; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
100627123  PDGFRA; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
102166564  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
100153248  FGFR1; LOW QUALITY PROTEIN: fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
396762  FGFR2; fibroblast growth factor receptor 2 precursor [KO:K05093] [EC:2.7.10.1]
100514115  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100127133  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
396763  FLT1; vascular endothelial growth factor receptor 1 isoform X2 [KO:K05096] [EC:2.7.10.1]
100518179  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
397311  KDR; vascular endothelial growth factor receptor 2 isoform X2 [KO:K05098] [EC:2.7.10.1]
100154471  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
100519209  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
397511  NTRK3; NT-3 growth factor receptor precursor [KO:K05101] [EC:2.7.10.1]
654328  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
100626292  MST1R; macrophage-stimulating protein receptor isoform X9 [KO:K05100] [EC:2.7.10.1]
100155053  RET; LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
110261595  uncharacterized protein LOC110261595 [KO:K10784]
100620407  uncharacterized protein LOC100620407 [KO:K10784]
100626606  uncharacterized protein LOC100626606 [KO:K10784]
110255290  LOW QUALITY PROTEIN: uncharacterized protein LOC110255290 [KO:K10784]
100621559  T-cell receptor beta-1 chain C region [KO:K10785]
110257615  uncharacterized protein LOC110257615 [KO:K10785]
396781  IgG heavy chain precursor [KO:K06856]
100038328  immunoglobulin heavy variable 3-23 [KO:K06856]
397119  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
100521111  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
100627099  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 [KO:K05857] [EC:3.1.4.11]
100152679  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100157641  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
100516581  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
100525148  PLCB3; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100152497  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
100518663  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
100157745  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
397632  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
397454  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
100517279  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
100155015  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
100511702  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
106504056  TPCN1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
100523421  TPCN2; two pore calcium channel protein 2 isoform X1 [KO:K14077]
100524240  MCOLN1; mucolipin-1 isoform X3 [KO:K04992]
100522324  MCOLN2; mucolipin-2 isoform X1 [KO:K04993]
100625693  MCOLN3; LOW QUALITY PROTEIN: mucolipin-3 [KO:K04994]
100519210  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
100738292  SPHK2; LOW QUALITY PROTEIN: sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
100153794  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
397010  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
397659  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
397651  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
403155  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
100158185  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
100517196  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
100518564  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
100152612  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
100156435  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
414905  TNNC2; troponin C, skeletal muscle [KO:K12042]
100154056  CALM1; calmodulin [KO:K02183]
396838  CALM3; calmodulin [KO:K02183]
100522926  CALM2; calmodulin [KO:K02183]
100738118  CALML5; calmodulin-like protein 5 [KO:K02183]
100623661  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
100519528  CALML4; calmodulin-like 4 [KO:K02183]
100310801  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
397548  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
100519810  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X8 [KO:K07190]
100525092  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
100625881  PHKB; phosphorylase b kinase regulatory subunit beta isoform X2 [KO:K07190]
396848  MYLK; myosin light chain kinase, smooth muscle isoform X7 [KO:K00907] [EC:2.7.11.18]
100524288  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
100157526  MYLK4; myosin light chain kinase family member 4 isoform X4 [KO:K00907] [EC:2.7.11.18]
110260971  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
100511150  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
100512553  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
100156272  CAMK1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
397674  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
397394  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
100626014  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X7 [KO:K04515] [EC:2.7.11.17]
100516166  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
100515364  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X3 [KO:K05869] [EC:2.7.11.17]
397241  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
100158082  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
396603  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X3 [KO:K04348] [EC:3.1.3.16]
100625117  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
100627903  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
100157940  TFEB; transcription factor EB isoform X1 [KO:K15590]
397318  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
100134969  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
100739450  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
100154469  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
100520934  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
396859  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
397557  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
100152819  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
100521662  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
102161696  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
100157507  PTK2B; protein-tyrosine kinase 2-beta isoform X7 [KO:K05871] [EC:2.7.10.2]
100516235  ITPKA; LOW QUALITY PROTEIN: inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
100524376  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
102164283  ITPKB; LOW QUALITY PROTEIN: inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
397184  PRKCA; LOW QUALITY PROTEIN: protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100522792  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100518074  PRKCG; protein kinase C gamma type isoform X3 [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
ssc04010  MAPK signaling pathway
ssc04070  Phosphatidylinositol signaling system
ssc04210  Apoptosis
ssc04720  Long-term potentiation
ssc04730  Long-term depression
KO pathway
ko04020   
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