KEGG   PATHWAY: tod04151
Entry
tod04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Talpa occidentalis (Iberian mole)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
tod04151  PI3K-Akt signaling pathway
tod04151

Other DBs
GO: 0043491
Organism
Talpa occidentalis (Iberian mole) [GN:tod]
Gene
119243624  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
119258571  TGFA; protransforming growth factor alpha [KO:K08774]
119260331  EREG; proepiregulin [KO:K09784]
119260866  AREG; amphiregulin [KO:K09782]
119243330  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
119233727  FGF8; fibroblast growth factor 8 [KO:K04358]
119233989  FGF17; fibroblast growth factor 17 isoform X2 [KO:K04358]
119250505  FGF4; fibroblast growth factor 4 [KO:K04358]
119258917  FGF9; fibroblast growth factor 9 [KO:K04358]
119236494  FGF18; fibroblast growth factor 18 [KO:K04358]
119260547  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
119260669  FGF10; fibroblast growth factor 10 [KO:K04358]
119238608  FGF7; fibroblast growth factor 7 [KO:K04358]
119246660  FGF16; fibroblast growth factor 16 [KO:K04358]
119239834  FGF22; fibroblast growth factor 22 [KO:K04358]
119248385  FGF6; fibroblast growth factor 6 [KO:K04358]
119248799  FGF3; fibroblast growth factor 3 [KO:K04358]
119256992  FGF20; fibroblast growth factor 20 [KO:K04358]
119248800  FGF19; fibroblast growth factor 19 [KO:K22603]
119249534  FGF21; fibroblast growth factor 21 [KO:K22429]
119248386  FGF23; fibroblast growth factor 23 [KO:K22428]
119236301  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
119255407  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
119247804  NTF3; neurotrophin-3 [KO:K04356]
119249562  NTF4; neurotrophin-4 [KO:K12457]
119249861  INS; LOW QUALITY PROTEIN: insulin [KO:K04526]
119247369  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
119249859  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
119241452  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
119247250  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
119234253  PDGFC; platelet-derived growth factor C [KO:K05450]
119242140  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
119235789  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
119247448  KITLG; kit ligand isoform X1 [KO:K05461]
119249581  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
119252508  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
119250028  VEGFB; vascular endothelial growth factor B isoform X2 [KO:K16858]
119239359  PGF; placenta growth factor isoform X1 [KO:K16859]
119257997  VEGFC; vascular endothelial growth factor C [KO:K05449]
119246321  VEGFD; vascular endothelial growth factor D [KO:K05449]
119244822  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
119238770  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
119258279  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
119234549  ANGPT4; angiopoietin-4 [KO:K05467]
119235283  EFNA4; ephrin-A4 [KO:K05462]
119236395  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
119236452  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
119260387  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
119240495  EFNA2; LOW QUALITY PROTEIN: ephrin-A2 [KO:K05462]
119260558  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
119240616  NRTN; neurturin [KO:K25414]
119236744  ARTN; artemin [KO:K25415]
119239853  PSPN; persephin [KO:K25416]
119231744  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
119230565  ERBB2; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
119248041  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
119255187  receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
119257820  FGFR1; fibroblast growth factor receptor 1 isoform X4 [KO:K04362] [EC:2.7.10.1]
119234070  FGFR2; fibroblast growth factor receptor 2 isoform X2 [KO:K05093] [EC:2.7.10.1]
119260900  FGFR3; LOW QUALITY PROTEIN: fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
119236003  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
119230893  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
119236305  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
119232387  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
119240421  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
119245137  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
119261223  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
119243270  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
119243273  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
119261155  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
119258796  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
119258799  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
119235094  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
119261390  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
119245963  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
119231355  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
119235251  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
119233871  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X2 [KO:K05126] [EC:2.7.10.1]
119232938  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
119259378  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
119239071  SOS2; son of sevenless homolog 2 [KO:K03099]
119249824  HRAS; GTPase HRas isoform X1 [KO:K02833]
119247626  KRAS; GTPase KRas isoform X1 [KO:K07827]
119236713  NRAS; GTPase NRas [KO:K07828]
119255730  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
119238768  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
119240577  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
119234388  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
119241775  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
119256266  IRS1; insulin receptor substrate 1 [KO:K16172]
119233466  TLR2; toll-like receptor 2 [KO:K10159]
119232116  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
119241672  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
119232025  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
119241794  CD19; B-lymphocyte antigen CD19 [KO:K06465]
119233957  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
119231053  somatotropin [KO:K05438]
119253510  PRL; prolactin [KO:K05439]
119245295  OSM; oncostatin-M [KO:K05418]
119233628  IL2; interleukin-2 [KO:K05429]
119243289  IL6; interleukin-6 [KO:K05405]
119243728  IL4; interleukin-4 [KO:K05430]
119240528  IL7; interleukin-7 isoform X2 [KO:K05431]
119232539  interferon alpha-6-like [KO:K05414]
119231101  IFNB1; interferon beta [KO:K05415]
119242332  EPO; erythropoietin [KO:K05437]
119231567  CSF3; granulocyte colony-stimulating factor isoform X2 [KO:K05423]
119261160  GHR; growth hormone receptor isoform X2 [KO:K05080]
119261215  PRLR; prolactin receptor [KO:K05081]
119260852  OSMR; oncostatin-M-specific receptor subunit beta [KO:K05057]
119244171  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
119247294  IL2RB; interleukin-2 receptor subunit beta isoform X2 [KO:K05069]
119246676  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
119236842  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
119241806  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
119261071  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
119257231  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
119257233  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
119240974  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
119236146  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
119235485  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
119232810  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
119241109  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
119230660  COL1A1; collagen alpha-1(I) chain [KO:K06236]
119242305  COL1A2; collagen alpha-2(I) chain [KO:K06236]
119247593  COL2A1; collagen alpha-1(II) chain [KO:K19719]
119259652  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
119259724  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
119245557  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
119245974  COL4A6; LOW QUALITY PROTEIN: collagen alpha-6(IV) chain [KO:K06237]
119255204  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
119256269  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
119237553  collagen alpha-4(VI) chain-like [KO:K06238]
119256334  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
119256709  COL6A6; collagen alpha-6(VI) chain isoform X1 [KO:K06238]
119256742  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
119257143  COL6A2; LOW QUALITY PROTEIN: collagen alpha-2(VI) chain [KO:K06238]
119257144  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
119236736  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
119252606  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
119237139  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
119243181  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
119251530  LAMA2; laminin subunit alpha-2 [KO:K05637]
119243134  LAMA3; LOW QUALITY PROTEIN: laminin subunit alpha-3 [KO:K06240]
119237708  LAMA5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
119252798  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
119245555  LAMB1; laminin subunit beta-1 [KO:K05636]
119259980  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
119233987  LAMB3; laminin subunit beta-3 [KO:K06244]
119251271  LAMB4; laminin subunit beta-4 [KO:K06245]
119241165  LAMC1; laminin subunit gamma-1 isoform X1 [KO:K05635]
119241167  LAMC2; laminin subunit gamma-2 [KO:K06246]
119230378  LAMC3; LOW QUALITY PROTEIN: laminin subunit gamma-3 [KO:K06247]
119230969  CHAD; chondroadherin [KO:K06248]
119245048  RELN; reelin [KO:K06249] [EC:3.4.21.-]
119238471  THBS1; thrombospondin-1 [KO:K16857]
119242237  COMP; cartilage oligomeric matrix protein [KO:K04659]
119237187  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
119253047  THBS2; thrombospondin-2 [KO:K04659]
119260835  THBS4; thrombospondin-4 isoform X1 [KO:K04659]
119256180  FN1; fibronectin isoform X1 [KO:K05717]
119261066  SPP1; osteopontin [KO:K06250]
119231814  VTN; vitronectin [KO:K06251]
119230765  TNC; tenascin isoform X1 [KO:K06252]
119252238  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
119241260  TNR; tenascin-R [KO:K06252]
119241263  TNN; tenascin-N [KO:K06252]
119247802  VWF; von Willebrand factor isoform X1 [KO:K03900]
119261154  IBSP; bone sialoprotein 2 [KO:K06253]
119261356  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
119261366  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
119231095  ITGA2B; integrin alpha-IIb [KO:K06476]
119232129  ITGA3; integrin alpha-3 [KO:K06482]
119255992  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
119248012  ITGA5; integrin alpha-5 [KO:K06484]
119255931  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
119248024  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
119244715  ITGA8; integrin alpha-8 [KO:K06584]
119257958  ITGA9; LOW QUALITY PROTEIN: integrin alpha-9 [KO:K06585]
119236364  ITGA10; integrin alpha-10 [KO:K06586]
119238788  ITGA11; integrin alpha-11 [KO:K06587]
119256010  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
119244619  ITGB1; integrin beta-1 [KO:K05719]
119230608  ITGB3; integrin beta-3 [KO:K06493]
119231693  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
119257448  ITGB5; integrin beta-5 [KO:K06588]
119254765  ITGB6; integrin beta-6 [KO:K06589]
119247980  ITGB7; integrin beta-7 [KO:K06590]
119243189  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
119235583  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
119257726  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119236721  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
119257304  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
119237093  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
119260810  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
119241117  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
119260779  F2R; proteinase-activated receptor 1 [KO:K03914]
119250070  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
119247518  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
119232591  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
119240051  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
119235378  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
119246051  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
119248381  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
119258907  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
119235240  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
119241578  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
119247771  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
119257308  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
119238634  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
119239088  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
119250114  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
119245241  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
119236993  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
119240544  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
119250456  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1 [KO:K04544]
119230380  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
119238256  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
119242272  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
119236596  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
119240995  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
119242246  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X2 [KO:K04548]
119231337  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
119245286  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
119232047  uncharacterized protein LOC119232047 isoform X1 [KO:K21290]
119242012  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
119240488  STK11; serine/threonine-protein kinase STK11 isoform X2 [KO:K07298] [EC:2.7.11.1]
119235081  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
119260486  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
119233476  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
119231219  TSC1; hamartin [KO:K07206]
119242027  TSC2; tuberin isoform X1 [KO:K07207]
119249007  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
119242023  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
119235686  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
119232762  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
119257810  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
119236050  EIF4E1B; eukaryotic translation initiation factor 4E type 1B isoform X1 [KO:K03259]
119243700  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
119256311  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X3 [KO:K03259]
119232527  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
119249909  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
119247974  EIF4B; eukaryotic translation initiation factor 4B isoform X2 [KO:K03258]
119231954  RPS6; 40S ribosomal protein S6 [KO:K02991]
119240406  40S ribosomal protein S6-like [KO:K02991]
119231758  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
119233319  LOW QUALITY PROTEIN: serine/threonine-protein kinase N1-like [KO:K06071] [EC:2.7.11.13]
119241039  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
119236710  PKN2; serine/threonine-protein kinase N2 [KO:K23691] [EC:2.7.11.13]
119233040  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692] [EC:2.7.11.13]
119252895  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
119235558  SGK2; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
119240947  SGK3; serine/threonine-protein kinase Sgk3 [KO:K13304] [EC:2.7.11.1]
119244519  AKT3; RAC-gamma serine/threonine-protein kinase isoform X3 [KO:K04456] [EC:2.7.11.1]
119239481  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119249321  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119230814  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
119244861  MAGI2; LOW QUALITY PROTEIN: membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
119234402  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
119236868  THEM4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
119257786  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
119243468  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
119249625  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
119240660  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
119234435  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
119242887  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X4 [KO:K04354]
119260982  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
119257744  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
119239016  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
119246800  PPP2R3B; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
119234468  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
119250005  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
119252478  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
119239170  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
119239382  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
119252516  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
119239380  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
119239419  heat shock protein HSP 90-alpha [KO:K04079]
119247362  HSP90B1; endoplasmin [KO:K09487]
119240944  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
119236119  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
119243743  PHLPP1; LOW QUALITY PROTEIN: PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
119249035  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
119238348  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
119245774  MTCP1; protein p13 MTCP-1 [KO:K16837]
119251590  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
119230413  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
119257489  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
119248315  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
119249557  GYS1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
119238940  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
119254664  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X1 [KO:K01596] [EC:4.1.1.32]
119230428  G6PC1; glucose-6-phosphatase catalytic subunit 1 isoform X1 [KO:K01084] [EC:3.1.3.9]
119230539  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
119254775  G6PC2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
119238040  MYC; LOW QUALITY PROTEIN: myc proto-oncogene protein [KO:K04377]
119249876  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
119246910  LOW QUALITY PROTEIN: G1/S-specific cyclin-D1-like [KO:K04503]
119252397  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
119247697  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
119248037  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
119248102  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
119242143  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
119247816  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
119252455  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
119239439  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
119249194  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
119252757  FOXO3; forkhead box protein O3 isoform X1 [KO:K09408]
119248895  RBL2; retinoblastoma-like protein 2 [KO:K16332]
119240071  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
119259202  BCL2L11; bcl-2-like protein 11 isoform X2 [KO:K16341]
119234735  LOW QUALITY PROTEIN: 14-3-3 protein theta-like [KO:K16197]
119235730  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
119259564  YWHAQ; 14-3-3 protein theta [KO:K16197]
119238993  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
119232973  YWHAE; 14-3-3 protein epsilon [KO:K06630]
119244870  YWHAH; 14-3-3 protein eta [KO:K16198]
119241537  YWHAG; 14-3-3 protein gamma [KO:K16198]
119250022  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
119234413  BCL2L1; bcl-2-like protein 1 [KO:K04570]
119243742  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
119235667  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
119256146  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
119255950  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
119247241  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
119232783  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
119235594  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
119246923  cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
119239846  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
119247555  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
119255317  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
119243789  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X3 [KO:K09047]
119252241  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
119236308  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
119243747  induced myeloid leukemia cell differentiation protein Mcl-1 homolog [KO:K02539]
119231234  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
119247943  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
119245781  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
119233588  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X2 [KO:K04467] [EC:2.7.11.10]
119257853  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
119248814  RELA; transcription factor p65 isoform X1 [KO:K04735]
119243680  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
119252897  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
119247528  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
119230677  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
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PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
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PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
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Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
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West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
tod00010  Glycolysis / Gluconeogenesis
tod04010  MAPK signaling pathway
tod04012  ErbB signaling pathway
tod04062  Chemokine signaling pathway
tod04064  NF-kappa B signaling pathway
tod04068  FoxO signaling pathway
tod04110  Cell cycle
tod04115  p53 signaling pathway
tod04150  mTOR signaling pathway
tod04210  Apoptosis
tod04370  VEGF signaling pathway
tod04510  Focal adhesion
tod04620  Toll-like receptor signaling pathway
tod04630  JAK-STAT signaling pathway
tod04662  B cell receptor signaling pathway
tod04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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