KEGG   PATHWAY: zca05417
Entry
zca05417                    Pathway                                
Name
Lipid and atherosclerosis - Zalophus californianus (California sea lion)
Description
Atherosclerosis is a chronic inflammatory disease marked by a narrowing of the arteries from lipid-rich plaques present within the walls of arterial blood vessels. It represents the root cause of the majority of cardiovascular diseases (CVDs) and their complications, including conditions such as coronary artery disease, myocardial infarction and stroke.  An elevated level of low density lipoprotein (LDL) cholesterol constitutes a major risk factor for genesis of atherosclerosis. LDL can accumulate within the blood vessel wall and undergo modification by oxidation. Oxidized LDL (oxLDL) leads to endothelial dysfunction leading to expression of adhesion molecules and recruitment of monocyte in subendothelial space. The monocytes proliferate, differentiate into macrophages, and take up the lipoproteins, forming cholesterol-engorged "foam cells." With the time, the foam cells die, leaving a 'necrotic core' of crystalline cholesterol and cell debris. Smooth muscle cells proliferate and migrate into the region, laying down a protective cap over the lesion. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), which mediates the recognition and internalization of oxLDL, is involved in all of these events critical in the pathogenesis of atherosclerosis.
Class
Human Diseases; Cardiovascular disease
Pathway map
zca05417  Lipid and atherosclerosis
zca05417

Organism
Zalophus californianus (California sea lion) [GN:zca]
Gene
113937492  APOB; apolipoprotein B-100 isoform X1 [KO:K14462]
113914552  APOA4; apolipoprotein A-IV [KO:K08760]
113915030  APOA1; apolipoprotein A-I [KO:K08757]
113917152  LDLR; low-density lipoprotein receptor [KO:K12473]
113921340  OLR1; oxidized low-density lipoprotein receptor 1 [KO:K08763]
113936356  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
113915492  MMP1; interstitial collagenase [KO:K01388] [EC:3.4.24.7]
113930801  transforming protein RhoA-like [KO:K04513]
113916294  RHOA; transforming protein RhoA [KO:K04513]
113937156  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
113911718  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
113924761  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
113917022  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
113918898  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
113928897  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
113917179  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
113911688  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
113935537  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113932035  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113910017  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113935677  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
113914539  BAD; bcl2-associated agonist of cell death [KO:K02158]
113936987  BCL2L1; bcl-2-like protein 1 [KO:K04570]
113912489  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
113928769  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
113922602  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
113925863  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
113926407  SOD2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
113939477  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
113936050  POU2F2; POU domain, class 2, transcription factor 2 isoform X2 [KO:K09364]
113932099  POU2F1; POU domain, class 2, transcription factor 1 isoform X2 [KO:K09364]
113914582  POU2F3; POU domain, class 2, transcription factor 3 isoform X1 [KO:K09364]
113938082  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
113931071  CD40LG; CD40 ligand [KO:K03161]
113910089  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
113926705  cytochrome P450 2J2 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
113926528  AGER; advanced glycosylation end product-specific receptor [KO:K19722]
113930946  NOX1; NADPH oxidase 1 isoform X1 [KO:K08008]
113930268  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
113931739  NCF1; neutrophil cytosol factor 1 [KO:K08011]
113936564  cytochrome b-245 light chain [KO:K08009]
113931998  NCF2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
113923107  NCF4; neutrophil cytosol factor 4 [KO:K08012]
113932378  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
113919987  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
113937725  SRC; proto-oncogene tyrosine-protein kinase Src isoform X2 [KO:K05704] [EC:2.7.10.2]
113934060  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
113939486  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
118356749  cell division control protein 42 homolog [KO:K04393]
113920047  cell division control protein 42 homolog [KO:K04393]
113929757  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
113908643  cell division control protein 42 homolog [KO:K04393]
113931995  cell division control protein 42 homolog [KO:K04393]
113934992  cell division control protein 42 homolog [KO:K04393]
113936412  cell division control protein 42 homolog [KO:K04393]
113936173  cell division control protein 42 homolog [KO:K04393]
113939897  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
113917379  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
113910278  FOS; proto-oncogene c-Fos [KO:K04379]
113939569  JUN; transcription factor AP-1 [KO:K04448]
113907932  C-C motif chemokine 2 [KO:K14624]
113916701  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
113925270  CXCL8; interleukin-8 [KO:K10030]
113939775  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
113908216  MAP2K6; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
113923113  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
113926549  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
113921975  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
113927499  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
113914876  HRAS; GTPase HRas isoform X1 [KO:K02833]
113921792  KRAS; GTPase KRas isoform X1 [KO:K07827]
113931879  NRAS; GTPase NRas [KO:K07828]
113933258  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
113912320  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
113914948  RELA; transcription factor p65 [KO:K04735]
113924266  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
113932874  SELE; E-selectin isoform X1 [KO:K06494]
113933162  P-selectin isoform X1 [KO:K06496]
113927174  VCAM1; vascular cell adhesion protein 1 [KO:K06527]
113914358  stromelysin-1 [KO:K01394] [EC:3.4.24.17]
113937554  MMP9; LOW QUALITY PROTEIN: matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
113921804  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
113937839  IL1B; interleukin-1 beta [KO:K04519]
113911910  IL6; interleukin-6 [KO:K05405]
113927740  TNF; tumor necrosis factor [KO:K03156]
113920960  HSPD1; 60 kDa heat shock protein, mitochondrial [KO:K04077] [EC:5.6.1.7]
113935353  60 kDa heat shock protein, mitochondrial-like [KO:K04077] [EC:5.6.1.7]
113927727  HSPA1L; heat shock 70 kDa protein 1-like isoform X1 [KO:K03283]
113925488  heat shock cognate 71 kDa protein-like [KO:K03283]
113928528  heat shock cognate 71 kDa protein-like [KO:K03283]
113930576  heat shock cognate 71 kDa protein-like [KO:K03283]
118357183  LOW QUALITY PROTEIN: heat shock 70 kDa protein 1-like [KO:K03283]
113927729  HSPA1B; heat shock 70 kDa protein 1B [KO:K03283]
113913731  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
113908528  HSPA2; heat shock-related 70 kDa protein 2 [KO:K26598]
113928876  HSPA4; heat shock 70 kDa protein 4 isoform X1 [KO:K09489]
113926602  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
113920779  heat shock protein HSP 90-alpha [KO:K04079]
113909364  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
113927654  heat shock protein HSP 90-beta-like [KO:K04079]
113938319  heat shock protein HSP 90-beta-like [KO:K04079]
113922031  HSP90B1; endoplasmin [KO:K09487]
113925471  TLR2; toll-like receptor 2 [KO:K10159]
113937054  LOW QUALITY PROTEIN: lipopolysaccharide-binding protein-like [KO:K05399]
113937934  lipopolysaccharide-binding protein isoform X1 [KO:K05399]
113929013  CD14; LOW QUALITY PROTEIN: monocyte differentiation antigen CD14 [KO:K04391]
113913314  LY96; lymphocyte antigen 96 isoform X1 [KO:K05400]
113934760  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
113914776  toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
113916493  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
113922141  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
113931272  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
113913973  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
113921522  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
113927705  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
113926671  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
113923411  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
113924180  IKBKB; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
113930597  NF-kappa-B essential modulator isoform X1 [KO:K07210]
113930605  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
118356554  NF-kappa-B essential modulator-like isoform X1 [KO:K07210]
113910226  NFKBIA; NF-kappa-B inhibitor alpha isoform X1 [KO:K04734]
113928818  TICAM2; TIR domain-containing adapter molecule 2 [KO:K05409]
113918381  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
113908816  TRAF3; LOW QUALITY PROTEIN: TNF receptor-associated factor 3 [KO:K03174]
113937213  MIB2; E3 ubiquitin-protein ligase MIB2 isoform X1 [KO:K10645] [EC:2.3.2.27]
113912914  MIB1; E3 ubiquitin-protein ligase MIB1 isoform X1 [KO:K10645] [EC:2.3.2.27]
113920122  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
113932728  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
113921986  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
113914873  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
113936398  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
113934655  interferon alpha-1-like [KO:K05414]
113934682  LOW QUALITY PROTEIN: interferon alpha-3-like [KO:K05414]
113934985  interferon alpha-14-like [KO:K05414]
113934667  LOW QUALITY PROTEIN: interferon alpha-1/2-like [KO:K05414]
113934678  LOW QUALITY PROTEIN: interferon alpha-1/2-like [KO:K05414]
113912225  LOW QUALITY PROTEIN: interferon alpha-1/2-like [KO:K05414]
113934419  IFNB1; interferon beta [KO:K05415]
113911048  CD36; platelet glycoprotein 4 isoform X1 [KO:K06259]
113918247  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
113934741  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
113926428  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
113933383  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
113913209  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
113910123  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
113934411  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
113936670  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
113917495  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
113924627  TLR6; toll-like receptor 6 [KO:K10169]
113928623  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
113921540  RAP1B; ras-related protein Rap-1b [KO:K07836]
113939093  CCL5; C-C motif chemokine 5 [KO:K12499]
113908217  CCL3L3; C-C motif chemokine 3-like 1 [KO:K05408]
113939090  LOW QUALITY PROTEIN: C-C motif chemokine 3-like [KO:K05408]
113939711  regakine-1-like [KO:K05408]
113924855  growth-regulated protein homolog gamma-like [KO:K05505]
118356741  growth-regulated protein homolog gamma-like [KO:K05505]
113924854  growth-regulated protein homolog beta-like [KO:K05505]
113916510  IL12A; interleukin-12 subunit alpha isoform X1 [KO:K05406]
113929340  IL12B; interleukin-12 subunit beta [KO:K05425]
113938902  NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
113913830  IL18; interleukin-18 [KO:K05482]
113934315  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
113932654  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
113922091  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
113910509  ERO1A; ERO1-like protein alpha isoform X1 [KO:K10950] [EC:1.8.4.-]
113918169  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
113929050  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
113925843  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
113911484  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
113921368  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
113937908  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
113909121  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
113921771  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
113939180  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
113934602  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
113927218  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
113913021  XBP1; X-box-binding protein 1 [KO:K09027]
113934154  ABCA1; phospholipid-transporting ATPase ABCA1 isoform X1 [KO:K05641]
113917166  ABCG1; ATP-binding cassette sub-family G member 1 isoform X1 [KO:K05679]
113919460  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
113932810  PYCARD; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
113934464  VLDLR; very low-density lipoprotein receptor isoform X1 [KO:K20053]
113933750  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
113918509  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
113926172  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
113938162  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
113935527  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
113937245  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
113915286  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
113909205  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
113937989  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
113938304  PLCG1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
113922995  calmodulin-like [KO:K02183]
113923011  CALML3; LOW QUALITY PROTEIN: calmodulin-like protein 3 [KO:K02183]
113936086  CALM3; calmodulin-3 [KO:K02183]
113914077  calmodulin-1-like [KO:K02183]
113929195  calmodulin-1-like [KO:K02183]
113925822  calmodulin-1-like [KO:K02183]
113929739  calmodulin-A-like [KO:K02183]
113914445  CALML6; calmodulin-like protein 6 [KO:K02183]
113908798  CALM1; calmodulin-1 [KO:K02183]
113910547  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
113920384  neo-calmodulin-like [KO:K02183]
113937538  CALM2; calmodulin-2 [KO:K02183]
113922505  calmodulin-A-like [KO:K02183]
118356210  calmodulin-A-like [KO:K02183]
113924138  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
113924414  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
113919467  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
113934908  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
113937385  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
113916957  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
113915274  tumor necrosis factor receptor superfamily member 1A-like isoform X1 [KO:K04722]
113922015  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
113931754  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
113919983  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
113922975  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
113911261  cytochrome c [KO:K08738]
113926974  cytochrome c-like [KO:K08738]
113921409  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
113909591  CASP9; LOW QUALITY PROTEIN: caspase-9 [KO:K04399] [EC:3.4.22.62]
113925298  CASP6; caspase-6 isoform X1 [KO:K04396] [EC:3.4.22.59]
113924509  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
113923463  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
113939587  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00187  Cholesterol
C00338  Lipopolysaccharide
C00422  Triacylglycerol
C00704  Superoxide
C00865  Phospholipid
C01245  D-myo-Inositol 1,4,5-trisphosphate
C02530  Cholesterol ester
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:23899566
  Authors
Hopkins PN
  Title
Molecular biology of atherosclerosis.
  Journal
Physiol Rev 93:1317-542 (2013)
DOI:10.1152/physrev.00004.2012
Reference
PMID:22064431
  Authors
Weber C, Noels H
  Title
Atherosclerosis: current pathogenesis and therapeutic options.
  Journal
Nat Med 17:1410-22 (2011)
DOI:10.1038/nm.2538
Reference
PMID:25869663
  Authors
Tabas I, Garcia-Cardena G, Owens GK
  Title
Recent insights into the cellular biology of atherosclerosis.
  Journal
J Cell Biol 209:13-22 (2015)
DOI:10.1083/jcb.201412052
Reference
PMID:25614320
  Authors
Tall AR, Yvan-Charvet L
  Title
Cholesterol, inflammation and innate immunity.
  Journal
Nat Rev Immunol 15:104-16 (2015)
DOI:10.1038/nri3793
Reference
PMID:31336709
  Authors
Kattoor AJ, Goel A, Mehta JL
  Title
LOX-1: Regulation, Signaling and Its Role in Atherosclerosis.
  Journal
Antioxidants (Basel) 8:E218 (2019)
DOI:10.3390/antiox8070218
Reference
PMID:11985903
  Authors
Mehta JL, Li D
  Title
Identification, regulation and function of a novel lectin-like oxidized low-density lipoprotein receptor.
  Journal
J Am Coll Cardiol 39:1429-35 (2002)
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Related
pathway
zca04020  Calcium signaling pathway
zca04115  p53 signaling pathway
zca04141  Protein processing in endoplasmic reticulum
zca04151  PI3K-Akt signaling pathway
zca04210  Apoptosis
zca04620  Toll-like receptor signaling pathway
zca04621  NOD-like receptor signaling pathway
zca04668  TNF signaling pathway
zca04670  Leukocyte transendothelial migration
zca04975  Fat digestion and absorption
zca04979  Cholesterol metabolism
zca05418  Fluid shear stress and atherosclerosis
KO pathway
ko05417   
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