KEGG   ORTHOLOGY: K00431
Entry
K00431                      KO                                     
Symbol
TPO
Name
thyroid peroxidase [EC:1.11.1.8]
Pathway
map00350  Tyrosine metabolism
map01100  Metabolic pathways
map04918  Thyroid hormone synthesis
map05320  Autoimmune thyroid disease
Module
M00043  Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxine
Reaction
R03208  
R03539  
R03953  
R03973  
Disease
H00251  Thyroid dyshormonogenesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K00431  TPO; thyroid peroxidase
 09150 Organismal Systems
  09152 Endocrine system
   04918 Thyroid hormone synthesis
    K00431  TPO; thyroid peroxidase
 09160 Human Diseases
  09163 Immune disease
   05320 Autoimmune thyroid disease
    K00431  TPO; thyroid peroxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.11  Acting on a peroxide as acceptor
   1.11.1  Peroxidases
    1.11.1.8  iodide peroxidase
     K00431  TPO; thyroid peroxidase
Other DBs
GO: 0004447
Genes
HSA: 7173(TPO)
PTR: 112208205(TPO)
PPS: 100996140(TPO)
GGO: 101154382(TPO)
PON: 100456793(TPO)
PPYG: 129030203(TPO)
NLE: 100600125(TPO) 115834294
HMH: 116480453(TPO)
SSYN: 129468214(TPO)
MCC: 721610(TPO)
MCF: 102125126(TPO)
MTHB: 126933457
MNI: 105497560(TPO)
CSAB: 103220948(TPO)
CATY: 105587598(TPO)
PANU: 101002980(TPO)
TGE: 112604644(TPO)
MLEU: 105546350(TPO)
RRO: 104680243(TPO)
RBB: 108520786(TPO)
TFN: 117062801(TPO)
PTEH: 111526756(TPO)
CANG: 105525386(TPO)
CJC: 100386952(TPO)
SBQ: 101037216(TPO)
CIMI: 108292902(TPO)
ANAN: 110567902(TPO)
CSYR: 103263957(TPO)
MMUR: 105870505(TPO)
LCAT: 123636559(TPO)
PCOQ: 105824646(TPO)
OGA: 100950962(TPO)
MMU: 22018(Tpo)
MCAL: 110307221(Tpo)
MPAH: 110324682(Tpo)
RNO: 54314(Tpo)
MCOC: 116080994(Tpo)
ANU: 117717370(Tpo)
ASYL: 127687959(Tpo)
MUN: 110561242(Tpo)
CGE: 100774668(Tpo)
MAUA: 101838356(Tpo)
PROB: 127234369(Tpo)
PLEU: 114683239(Tpo)
MORG: 121432305(Tpo)
MFOT: 126491107
AAMP: 119807272(Tpo)
NGI: 103747657(Tpo)
HGL: 101704548(Tpo)
CPOC: 100723704(Tpo)
CCAN: 109698840(Tpo)
DORD: 105995174(Tpo)
DSP: 122100091(Tpo)
PLOP: 125356021(Tpo)
NCAR: 124962925
MMMA: 107137072(Tpo)
ITI: 101976264(Tpo)
OPI: 101529357(TPO)
TUP: 102498362(TPO)
GVR: 103595081(TPO)
CFA: 403521(TPO)
CLUD: 112664926(TPO)
VVP: 112927779(TPO)
VLG: 121491902(TPO)
NPO: 129511138(TPO)
AML: 100482359(TPO)
UMR: 103659385(TPO)
UAH: 113269244(TPO)
UAR: 123786594(TPO)
ELK: 111154148
LLV: 125108840
MPUF: 101677724(TPO)
MNP: 132021091(TPO)
MLK: 131807442(TPO)
NVS: 122915502(TPO)
ORO: 101386003(TPO)
EJU: 114206012(TPO)
ZCA: 113937469(TPO)
NSU: 110587338(TPO)
LWW: 102736066(TPO)
FCA: 101098706(TPO)
PYU: 121044026(TPO)
PCOO: 112864369(TPO)
PBG: 122467124(TPO)
PVIV: 125158263(TPO)
LRUF: 124525761
LGF: 123581696(TPO)
AJU: 106970832
PTG: 102968585(TPO)
PPAD: 109258749(TPO)
PUC: 125937367
PLEZ: 122215282(TPO)
HHV: 120247915(TPO)
BTA: 525013(TPO)
BOM: 102270919(TPO)
BBUB: 102407971(TPO)
BBIS: 104994785(TPO)
CHX: 102182976(TPO)
OAS: 105606468(TPO)
BTAX: 128052765(TPO)
CSUM: 138080824(TPO)
ODA: 120864488(TPO)
CCAD: 122432081(TPO)
MREE: 136176341(TPO)
OVR: 110141220(TPO)
MBEZ: 129557445(TPO)
SSC: 445522(TPO)
CFR: 102509347(TPO)
CBAI: 105075311(TPO)
CDK: 105105788(TPO)
VPC: 102531846(TPO)
BACU: 103019738(TPO)
BMUS: 118905807(TPO)
LVE: 103068590(TPO)
OOR: 101277595(TPO)
LALB: 132531324(TPO)
GMF: 115846069(TPO)
DDP: 132435538(TPO)
DLE: 111167991(TPO)
PCAD: 102992243(TPO)
PSIU: 116764397(TPO)
PPHC: 136133503(TPO)
NASI: 112407583(TPO)
ECB: 100072955(TPO)
EPZ: 103558875(TPO)
EAI: 106831426(TPO)
MYB: 102261673(TPO)
MYD: 102752073(TPO)
MMYO: 118669324(TPO)
MDT: 132213679(TPO)
MYUM: 139019657(TPO)
PKL: 118714838(TPO)
EFUS: 103283185(TPO)
MNA: 107526670(TPO)
DRO: 112298003(TPO)
SHON: 118988799(TPO)
AJM: 119053969(TPO)
PDIC: 114498752(TPO)
PHAS: 123822481(TPO)
MMF: 118630987(TPO)
PPAM: 129065568(TPO)
HAI: 109384713(TPO)
RFQ: 117032670(TPO)
PALE: 102894645(TPO)
PGIG: 120596537(TPO)
PVP: 105306937(TPO)
RAY: 107516248(TPO)
MJV: 108410043(TPO)
TOD: 119258688(TPO)
SARA: 101544834(TPO)
SFUM: 130034800(TPO)
SETR: 126024250(TPO)
LAV: 100654315(TPO)
TMU: 101356790
ETF: 101650056(TPO)
DNM: 101411611(TPO)
MDO: 100032350(TPO)
GAS: 123233464(TPO)
SHR: 100914346(TPO)
AFZ: 127546516
PCW: 110193820(TPO)
TVP: 118844045(TPO)
PBRV: 138177497(TPO)
MLAO: 141521203(TPO)
OAA: 100080616(TPO)
TACU: 119949810(TPO)
GGA: 776120(TPO)
PCOC: 116240489(TPO)
MGP: 100547103(TPO)
CJO: 107312163(TPO)
TPAI: 128087649(TPO)
LMUT: 125689477(TPO)
NMEL: 110396710(TPO)
APLA: 101799650(TPO)
ACYG: 106030804(TPO)
CATA: 118246103(TPO)
AFUL: 116487946(TPO)
TGU: 100218312(TPO)
LSR: 110482186(TPO)
SCAN: 103822861(TPO)
PMOA: 120505263(TPO)
OTC: 121344293(TPO)
PRUF: 121359149(TPO)
ATRC: 139599488(TPO)
GFR: 102035753(TPO)
FAB: 101810932(TPO)
OMA: 130250535(TPO)
PHI: 102101957(TPO)
PMAJ: 107202328(TPO)
CCAE: 111926044(TPO)
CCW: 104685517(TPO)
CBRC: 103622838(TPO)
ACOE: 138108610(TPO)
ETL: 114069616(TPO)
ZAB: 102067657(TPO)
ZLE: 135446359(TPO)
ACHL: 103798919(TPO)
SVG: 106849075(TPO)
MMEA: 130576566(TPO)
HRT: 120750049(TPO)
SATI: 136358333(TPO)
CCIC: 134041644(TPO)
FPG: 101922364(TPO)
FCH: 102045733(TPO)
CCRI: 104164426(TPO)
SHAB: 115609450(TPO)
ACUN: 113477604(TPO)
TALA: 104359736(TPO)
ACHC: 115351124(TPO)
HALD: 104315049(TPO)
HLE: 104831289(TPO)
AGEN: 126046400
HHAR: 128152043(TPO)
GCL: 127014894
LDI: 104351831(TPO)
MNB: 103777585(TPO)
DPUB: 104305690(TPO)
PPUS: 135177071(TPO)
AVIT: 104270482(TPO)
BRHI: 104489655(TPO)
EGZ: 104122160(TPO)
NNI: 104013841(TPO)
PCRI: 104032438
PCAO: 104047200
PADL: 103921358(TPO)
AFOR: 103895897(TPO)
FGA: 104079472(TPO)
GSTE: 104252217(TPO)
CBOY: 140649946(TPO)
CLV: 102095211(TPO)
CNIC: 135987257(TPO)
MUI: 104533545(TPO)
PGUU: 104469372(TPO)
PLET: 104625294
EHS: 104504514(TPO)
CUCA: 104064875(TPO)
TEO: 104380949(TPO)
OHA: 104329380(TPO)
ACAR: 104529229(TPO)
CPEA: 104390153(TPO)
CVF: 104289037(TPO)
RTD: 128907817(TPO)
CRID: 134513937(TPO)
AAM: 106492987(TPO)
AROW: 112973093(TPO)
NPD: 112945458(TPO)
TGT: 104580334(TPO)
DNE: 112992818(TPO)
SCAM: 104143498(TPO)
ASN: 102375780(TPO)
AMJ: 106736998(TPO)
CPOO: 109312104(TPO)
GGN: 109300041(TPO)
PSS: 102447524(TPO)
CMY: 102940210(TPO)
CCAY: 125635012(TPO)
DCC: 119853278(TPO)
CPIC: 101932866(TPO)
TST: 117874041(TPO)
CABI: 116817604(TPO)
MRV: 120401415(TPO)
ACS: 100562991(tpo)
ASAO: 132773157(TPO)
PVT: 110073409(TPO)
SUND: 121925349(TPO)
PBI: 103055216(TPO)
PMUR: 107288276(TPO)
CTIG: 120310082(TPO)
TSR: 106551315(TPO)
PGUT: 117674498(TPO)
PCAE: 139308717(TPO)
APRI: 131195643(TPO)
PTEX: 113455290(TPO)
NSS: 113410540(TPO)
VKO: 123017669(TPO)
PMUA: 114593754(TPO) 114600521
PRAF: 128410067(TPO) 128417614
ZVI: 118078350 118082781(TPO)
HCG: 128339342 128340645(TPO)
GJA: 107108843 107120374(TPO)
STOW: 125426778 125439527(TPO)
EMC: 129323482 129324144(TPO)
XLA: 100049788(tpo.S)
XTR: 100036738(tpo)
NPR: 108789262(TPO)
RTEM: 120936386(TPO)
ACAT: 141141190(TPO)
BBUF: 120999023(TPO)
BGAR: 122935226(TPO)
DTC: 141091193(TPO)
PWL: 138297132(TPO)
MUO: 115464797(TPO)
GSH: 117357180(TPO)
DRE: 100331172(epx) 569363(tpo)
SRX: 107707791(tpo) 107732259
SGH: 107594129
CCAR: 109084952(tpo) 109099142(epx)
CAUA: 113042938 113085118(tpo)
PTET: 122330629(epx) 122334382(tpo)
LROH: 127156758(epx) 127179243(tpo)
GRF: 141296243(tpo) 141301292(epx)
OMC: 131523159(tpo) 131534985(epx)
RKG: 130075798(tpo) 130106479(epx)
MAMB: 125247940(epx) 125269309(tpo)
CERY: 137006300(tpo) 137015584(epx)
TDW: 130414644(epx) 130436790(tpo)
MANU: 129417025(tpo) 129433472(epx)
PDAB: 135737759(tpo) 135768213(epx)
IPU: 108269580 108274988(epx)
IFU: 128612578(tpo) 128617734(epx)
PHYP: 113529680 113538844(tpo)
SMEO: 124389670(tpo) 124392946(epx)
TFD: 113653966(epx) 113659460(tpo)
TVC: 132852534(tpo) 132856864(epx)
CGAR: 128517001(epx) 128535754(tpo)
NGRA: 132881726(epx) 132893672(tpo)
TRN: 134321707(epx) 134325721(tpo)
AMEX: 103026466(epx) 103032699(tpo)
CMAO: 118811861(epx) 118823206(tpo)
EEE: 113572650(tpo) 113583564
CHAR: 105892418(epx) 105909411(tpo)
SPIL: 134068056(tpo) 134093465(epx)
TFS: 130536010(epx) 130540092(tpo)
LCO: 104928854 104934649(tpo)
NCC: 104944637
TBEN: 117486655 117491490(epx)
CGOB: 115009405 115027547(tpo)
GACU: 117538992(epx) 117542389
EMAC: 134879856(epx) 134882017(tpo)
ELY: 117261785(epx) 117267275
EFO: 125886852(epx) 125901384(tpo)
PLEP: 121950093(epx) 121953636(tpo)
SLUC: 116038497(epx) 116042521(tpo)
ECRA: 117935626(tpo) 117949679(epx)
ESP: 116669921(tpo) 116694341
PFLV: 114547036(tpo) 114560272
GAT: 120808678(epx) 120832611(tpo)
PPUG: 119195992(epx) 119227498(tpo)
AFB: 129107865(epx)
CLUM: 117731997(epx) 117751548(tpo)
PSWI: 130195613(epx) 130201641
CANA: 137803730(epx)
CVE: 137877949 137881678(epx)
MSAM: 119893789(epx) 119910842(tpo)
SCHU: 122862127(tpo) 122875391(epx)
CUD: 121514495(epx) 121526598
SPUL: 138591245(tpo) 138612682(epx)
LMIX: 132972597(epx) 132993189(tpo)
ALAT: 119005006(tpo) 119024167(epx)
ASTR: 137593770(epx) 137611202(tpo)
MZE: 101470734(tpo) 101472649
ONL: 100692514 100700906(tpo)
OAU: 116326276(epx) 120434955(tpo)
OLA: 101167362 105356959(tpo)
OML: 112143527(tpo) 112152280(epx)
CSAI: 133444161(epx) 133462180
PFOR: 103141318 103154181(tpo)
PLAI: 106953134(tpo) 106964663
PMEI: 106923933(tpo) 106933097
GAF: 122835368(epx) 122845674(tpo)
PPRL: 129369558(epx) 129374765
CVG: 107100628
CTUL: 119787434(epx) 119797839(tpo)
GMU: 124858077(epx) 124884924(tpo)
NFU: 107388669 107392598(tpo)
KMR: 108230067(epx) 108241739(tpo)
ALIM: 106521174 106521219(tpo)
NWH: 119416466(epx) 119427722(tpo)
AOCE: 111562581(tpo) 111584102(epx)
EJA: 138206282(epx) 138212549(tpo)
BFRE: 138626549(epx) 138633479(tpo)
MCEP: 125014719(epx) 125023792(tpo)
CSEM: 103379991(tpo) 103380299
POV: 109624077 109627948(tpo)
SSEN: 122776537(epx) 122783162(tpo)
SSOE: 131444873(tpo) 131469675(epx)
HHIP: 117756338 117762621(epx)
HSP: 118109462(epx) 118116664(tpo)
PPLT: 128444133(epx) 128450360(tpo)
SMAU: 118286573(sntg2) 118315245(epx)
LCF: 108886978(epx) 108897943
SDU: 111226032(tpo) 111229744
XGL: 120792877(epx) 120795322(tpo)
SSCV: 125970095(epx) 125981320(tpo)
SBIA: 133501708(epx) 133513472(tpo)
PEE: 133402397(epx) 133412463(tpo)
PTAO: 133478512(epx) 133487880(tpo)
BPEC: 110155374(tpo) 110169467
ENY: 140349477(epx) 140371018(tpo)
MALB: 109965011(tpo) 109972931
BSPL: 114848308(tpo) 114857330(epx)
SJO: 128359350(epx)
SSCO: 133982501(epx) 134000449(tpo)
SASA: 106584777 106611389(tpo)
OTW: 112237628(epx) 112256946(tpo)
OMY: 110504252(tpo) 110522697(epx)
OGO: 124037374(epx) 124046982(tpo)
ONE: 115121024
OKE: 118369032(tpo) 118377954(epx)
OMM: 135526888(tpo) 135533365(epx)
SALP: 112069494(tpo) 112070266
CCLU: 121540756(epx) 121544226(tpo)
ELS: 105028745(tpo) 105029701
OEP: 134020675(epx) 134027117(tpo)
SFM: 108942507(tpo)
PKI: 111848005 111857914(tpo)
AANG: 118215539(epx) 118234749(tpo)
AROT: 135241772(epx) 135252679(tpo)
CCOG: 133111088(epx) 133122436(tpo)
LOC: 102695049(tpo)
PSPA: 121294970(epx) 121317659(tpo)
ARUT: 117411246(tpo) 117432329(epx)
PSEX: 120526592(tpo)
LCM: 102362813(TPO)
CMK: 103175078 103185975(tpo)
RTP: 109918711(tpo) 109928222
CPLA: 122548625(tpo) 122557877
HOC: 132824289 132835956(tpo)
LERI: 129696869(tpo) 129705776
HAKA: 140729849(epx) 140732814(tpo)
PMRN: 116945253(TPO)
LRJ: 133353287(TPO)
SCLV: 120346294
PMEO: 129593455
AIRR: 138314855
LJP: 135477769
HSY: 130614431
 » show all
Reference
PMID:1497352
  Authors
Rawitch AB, Pollock G, Yang SX, Taurog A
  Title
Thyroid peroxidase glycosylation: the location and nature of the N-linked oligosaccharide units in porcine thyroid peroxidase.
  Journal
Arch Biochem Biophys 297:321-7 (1992)
DOI:10.1016/0003-9861(92)90679-Q
  Sequence
[ssc:445522]
Reference
  Authors
Ruf J, Carayon P
  Title
Structural and functional aspects of thyroid peroxidase.
  Journal
Arch Biochem Biophys 445:269-77 (2006)
DOI:10.1016/j.abb.2005.06.023
LinkDB

KEGG   ENZYME: 1.11.1.8
Entry
EC 1.11.1.8                 Enzyme                                 
Name
iodide peroxidase;
thyroid peroxidase;
iodoperoxidase (heme type);
iodide peroxidase-tyrosine iodinase;
thyroperoxidase;
tyrosine iodinase;
TPO;
iodinase
Class
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases
Sysname
iodide:hydrogen-peroxide oxidoreductase
Reaction(IUBMB)
(1) 2 iodide + H2O2 + 2 H+ = diiodine + 2 H2O [RN:R02810];
(2) [thyroglobulin]-L-tyrosine + iodide + H2O2 = [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O;
(3) [thyroglobulin]-3-iodo-L-tyrosine + iodide + H2O2 = [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O;
(4) 2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-L-thyroxine + [thyroglobulin]-aminoacrylate + 2 H2O [RN:R08523];
(5) [thyroglobulin]-3-iodo-L-tyrosine + [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-3,5,3'-triiodo-L-thyronine + [thyroglobulin]-aminoacrylate + 2 H2O [RN:R08522]
Reaction(KEGG)
Substrate
iodide [CPD:C00708];
H2O2 [CPD:C00027];
H+ [CPD:C00080];
[thyroglobulin]-L-tyrosine [CPD:C16733];
[thyroglobulin]-3-iodo-L-tyrosine [CPD:C16732];
[thyroglobulin]-3,5-diiodo-L-tyrosine [CPD:C16731]
Product
diiodine [CPD:C01382];
H2O [CPD:C00001];
[thyroglobulin]-3-iodo-L-tyrosine [CPD:C16732];
[thyroglobulin]-3,5-diiodo-L-tyrosine [CPD:C16731];
[thyroglobulin]-L-thyroxine [CPD:C16729];
[thyroglobulin]-aminoacrylate [CPD:C16734];
[thyroglobulin]-3,5,3'-triiodo-L-thyronine [CPD:C16730]
Comment
Thyroid peroxidase catalyses the biosynthesis of the thyroid hormones L-thyroxine and triiodo-L-thyronine. It catalyses both the iodination of tyrosine residues in thyroglobulin (forming mono- and di-iodinated forms) and their coupling to form either L-thyroxine or triiodo-L-thyronine.
History
EC 1.11.1.8 created 1961, modified 2012
Pathway
ec00350  Tyrosine metabolism
ec01100  Metabolic pathways
Orthology
K00431  thyroid peroxidase
Genes
HSA7173(TPO)
PTR112208205(TPO)
PPS100996140(TPO)
GGO101154382(TPO)
PON100456793(TPO)
PPYG129030203(TPO)
NLE100600125(TPO) 115834294
HMH116480453(TPO)
SSYN129468214(TPO)
MCC721610(TPO)
MCF102125126(TPO)
MTHB126933457
MNI105497560(TPO)
CSAB103220948(TPO)
CATY105587598(TPO)
PANU101002980(TPO)
TGE112604644(TPO)
MLEU105546350(TPO)
RRO104680243(TPO)
RBB108520786(TPO)
TFN117062801(TPO)
PTEH111526756(TPO)
CANG105525386(TPO)
CJC100386952(TPO)
SBQ101037216(TPO)
CIMI108292902(TPO)
ANAN110567902(TPO)
CSYR103263957(TPO)
MMUR105870505(TPO)
LCAT123636559(TPO)
PCOQ105824646(TPO)
OGA100950962(TPO)
MMU22018(Tpo)
MCAL110307221(Tpo)
MPAH110324682(Tpo)
RNO54314(Tpo)
MCOC116080994(Tpo)
ANU117717370(Tpo)
ASYL127687959(Tpo)
MUN110561242(Tpo)
CGE100774668(Tpo)
MAUA101838356(Tpo)
PROB127234369(Tpo)
PLEU114683239(Tpo)
MORG121432305(Tpo)
MFOT126491107
AAMP119807272(Tpo)
NGI103747657(Tpo)
HGL101704548(Tpo)
CPOC100723704(Tpo)
CCAN109698840(Tpo)
DORD105995174(Tpo)
DSP122100091(Tpo)
PLOP125356021(Tpo)
NCAR124962925
MMMA107137072(Tpo)
ITI101976264(Tpo)
OCU100358662 127486836
OPI101529357(TPO)
TUP102498362(TPO)
GVR103595081(TPO)
CFA403521(TPO)
CLUD112664926(TPO)
VVP112927779(TPO)
VLG121491902(TPO)
NPO129511138(TPO)
AML100482359(TPO)
UMR103659385(TPO)
UAH113269244(TPO)
UAR123786594(TPO)
ELK111154148
LLV125108840
MPUF101677724(TPO)
MNP132021091(TPO)
MLK131807442(TPO)
NVS122915502(TPO)
ORO101386003(TPO)
EJU114206012(TPO)
ZCA113937469(TPO)
MLX118007270 118007322
NSU110587338(TPO)
LWW102736066(TPO)
FCA101098706(TPO)
PYU121044026(TPO)
PCOO112864369(TPO)
PBG122467124(TPO)
PVIV125158263(TPO)
LRUF124525761
LGF123581696(TPO)
AJU106970832
PTG102968585(TPO)
PPAD109258749(TPO)
PUC125937367
PLEZ122215282(TPO)
HHV120247915(TPO)
BTA525013(TPO)
BOM102270919(TPO)
BBUB102407971(TPO)
BBIS104994785(TPO)
CHX102182976(TPO)
OAS105606468(TPO)
BTAX128052765(TPO)
CSUM138080824(TPO)
ODA120864488(TPO)
CCAD122432081(TPO)
MREE136176341(TPO)
OVR110141220(TPO)
MBEZ129557445(TPO)
SSC445522(TPO)
CFR102509347(TPO)
CBAI105075311(TPO)
CDK105105788(TPO)
VPC102531846(TPO)
BACU103019738(TPO)
BMUS118905807(TPO)
LVE103068590(TPO)
OOR101277595(TPO)
LALB132531324(TPO)
GMF115846069(TPO)
DDP132435538(TPO)
DLE111167991(TPO)
PCAD102992243(TPO)
PSIU116764397(TPO)
PPHC136133503(TPO)
NASI112407583(TPO)
ECB100072955(TPO)
EPZ103558875(TPO)
EAI106831426(TPO)
MYB102261673(TPO)
MYD102752073(TPO)
MMYO118669324(TPO)
MDT132213679(TPO)
MYUM139019657(TPO)
PKL118714838(TPO)
EFUS103283185(TPO)
MNA107526670(TPO)
DRO112298003(TPO)
SHON118988799(TPO)
AJM119053969(TPO)
PDIC114498752(TPO)
PHAS123822481(TPO)
MMF118630987(TPO)
PPAM129065568(TPO)
HAI109384713(TPO)
RFQ117032670(TPO)
PALE102894645(TPO)
PGIG120596537(TPO)
PVP105306937(TPO)
RAY107516248(TPO)
MJV108410043(TPO)
TOD119258688(TPO)
SARA101544834(TPO)
SFUM130034800(TPO)
SETR126024250(TPO)
LAV100654315(TPO)
TMU101356790
ETF101650056(TPO)
DNM101411611(TPO)
MDO100032350(TPO)
GAS123233464(TPO)
SHR100914346(TPO)
AFZ127546516
PCW110193820(TPO)
TVP118844045(TPO)
PBRV138177497(TPO)
MLAO141521203(TPO)
OAA100080616(TPO)
TACU119949810(TPO)
GGA776120(TPO)
PCOC116240489(TPO)
MGP100547103(TPO)
CJO107312163(TPO)
TPAI128087649(TPO)
LMUT125689477(TPO)
NMEL110396710(TPO)
APLA101799650(TPO)
ACYG106030804(TPO)
CATA118246103(TPO)
AFUL116487946(TPO)
TGU100218312(TPO)
LSR110482186(TPO)
SCAN103822861(TPO)
PMOA120505263(TPO)
OTC121344293(TPO)
PRUF121359149(TPO)
ATRC139599488(TPO)
GFR102035753(TPO)
FAB101810932(TPO)
OMA130250535(TPO)
PHI102101957(TPO)
PMAJ107202328(TPO)
CCAE111926044(TPO)
CCW104685517(TPO)
CBRC103622838(TPO)
ACOE138108610(TPO)
ETL114069616(TPO)
ZAB102067657(TPO)
ZLE135446359(TPO)
ACHL103798919(TPO)
SVG106849075(TPO)
MMEA130576566(TPO)
HRT120750049(TPO)
SATI136358333(TPO)
CCIC134041644(TPO)
FPG101922364(TPO)
FCH102045733(TPO)
CCRI104164426(TPO)
SHAB115609450(TPO)
ACUN113477604(TPO)
TALA104359736(TPO)
ACHC115351124(TPO)
HALD104315049(TPO)
HLE104831289(TPO)
AGEN126046400
HHAR128152043(TPO)
GCL127014894
LDI104351831(TPO)
MNB103777585(TPO)
DPUB104305690(TPO)
PPUS135177071(TPO)
AVIT104270482(TPO)
BRHI104489655(TPO)
EGZ104122160(TPO)
NNI104013841(TPO)
PCRI104032438
PCAO104047200
PADL103921358(TPO)
AFOR103895897(TPO)
FGA104079472(TPO)
GSTE104252217(TPO)
CBOY140649946(TPO)
CLV102095211(TPO)
CNIC135987257(TPO)
MUI104533545(TPO)
PGUU104469372(TPO)
PLET104625294
EHS104504514(TPO)
CUCA104064875(TPO)
TEO104380949(TPO)
OHA104329380(TPO)
ACAR104529229(TPO)
CPEA104390153(TPO)
CVF104289037(TPO)
RTD128907817(TPO)
CRID134513937(TPO)
AAM106492987(TPO)
AROW112973093(TPO)
NPD112945458(TPO)
TGT104580334(TPO)
DNE112992818(TPO)
SCAM104143498(TPO)
ASN102375780(TPO)
AMJ106736998(TPO)
CPOO109312104(TPO)
GGN109300041(TPO)
PSS102447524(TPO)
CMY102940210(TPO)
CCAY125635012(TPO)
DCC119853278(TPO)
CPIC101932866(TPO)
TST117874041(TPO)
CABI116817604(TPO)
MRV120401415(TPO)
ACS100562991(tpo)
ASAO132773157(TPO)
PVT110073409(TPO)
SUND121925349(TPO)
PBI103055216(TPO)
PMUR107288276(TPO)
CTIG120310082(TPO)
TSR106551315(TPO)
PGUT117674498(TPO)
PCAE139308717(TPO)
APRI131195643(TPO)
PTEX113455290(TPO)
NSS113410540(TPO)
VKO123017669(TPO)
PMUA114593754(TPO) 114600521
PRAF128410067(TPO) 128417614
ZVI118078350 118082781(TPO)
HCG128339342 128340645(TPO)
GJA107108843 107120374(TPO)
STOW125426778 125439527(TPO)
EMC129323482 129324144(TPO)
XLA100049788(tpo.S)
XTR100036738(tpo)
NPR108789262(TPO)
RTEM120936386(TPO)
ACAT141141190(TPO)
BBUF120999023(TPO)
BGAR122935226(TPO)
DTC141091193(TPO)
PWL138297132(TPO)
MUO115464797(TPO)
GSH117357180(TPO)
DRE100331172(epx) 569363(tpo)
SRX107707791(tpo) 107732259
SANH107676453 107678715(tpo) 107701038
SGH107594129
CCAR109084952(tpo) 109099142(epx)
CAUA113042938 113085118(tpo)
CGIB128013963 128031820
PTET122330629(epx) 122334382(tpo)
LROH127156758(epx) 127179243(tpo)
GRF141296243(tpo) 141301292(epx)
OMC131523159(tpo) 131534985(epx)
PPRM120471728(epx) 120473217 120473261
RKG130075798(tpo) 130106479(epx)
MAMB125247940(epx) 125269309(tpo)
CIDE127498092 127507673
CERY137006300(tpo) 137015584(epx)
MASI127435674 127455176
TROS130550078(epx) 130559836 130560167
TDW130414644(epx) 130436790(tpo)
MANU129417025(tpo) 129433472(epx)
PDAB135737759(tpo) 135768213(epx)
IPU108269580 108274988(epx)
IFU128612578(tpo) 128617734(epx)
PHYP113529680 113538844(tpo)
SMEO124389670(tpo) 124392946(epx)
TFD113653966(epx) 113659460(tpo)
TVC132852534(tpo) 132856864(epx)
CGAR128517001(epx) 128535754(tpo)
NGRA132881726(epx) 132893672(tpo)
TRN134321707(epx) 134325721(tpo)
AMEX103026466(epx) 103032699(tpo)
CMAO118811861(epx) 118823206(tpo)
EEE113572650(tpo) 113583564
CHAR105892418(epx) 105909411(tpo)
SPIL134068056(tpo) 134093465(epx)
TRU101062981 101079869 115247027
TFS130536010(epx) 130540092(tpo)
TNGGSTEN00010284G001 GSTEN00012455G001
LCO104928854 104934649(tpo)
NCC104944637
TBEN117486655 117491490(epx)
CGOB115009405 115027547(tpo)
PGEO117448489 117468095
GACU117538992(epx) 117542389
EMAC134879856(epx) 134882017(tpo)
ELY117261785(epx) 117267275
EFO125886852(epx) 125901384(tpo)
PLEP121950093(epx) 121953636(tpo)
SLUC116038497(epx) 116042521(tpo)
ECRA117935626(tpo) 117949679(epx)
ESP116669921(tpo) 116694341
PFLV114547036(tpo) 114560272
GAT120808678(epx) 120832611(tpo)
PPUG119195992(epx) 119227498(tpo)
AFB129107865(epx)
CLUM117731997(epx) 117751548(tpo)
PSWI130195613(epx) 130201641
CANA137803730(epx)
CVE137877949 137881678(epx)
MSAM119893789(epx) 119910842(tpo)
SCHU122862127(tpo) 122875391(epx)
CUD121514495(epx) 121526598
SPUL138591245(tpo) 138612682(epx)
LMIX132972597(epx) 132993189(tpo)
ALAT119005006(tpo) 119024167(epx)
ASTR137593770(epx) 137611202(tpo)
MZE101470734(tpo) 101472649
ONL100692514 100700906(tpo)
OAU116326276(epx) 120434955(tpo)
OLA101167362 105356959(tpo)
OML112143527(tpo) 112152280(epx)
CSAI133444161(epx) 133462180
XMA102230399 102232241
XCO114134369 114151183
XHE116709035 116709593 116732146
PRET103460527 103466494
PFOR103141318 103154181(tpo)
PLAI106953134(tpo) 106964663
PMEI106923933(tpo) 106933097
GAF122835368(epx) 122845674(tpo)
PPRL129369558(epx) 129374765
CVG107100628
CTUL119787434(epx) 119797839(tpo)
GMU124858077(epx) 124884924(tpo)
NFU107388669 107392598(tpo)
KMR108230067(epx) 108241739(tpo)
ALIM106521174 106521219(tpo)
NWH119416466(epx) 119427722(tpo)
AOCE111562581(tpo) 111584102(epx)
EJA138206282(epx) 138212549(tpo)
BFRE138626549(epx) 138633479(tpo)
MCEP125014719(epx) 125023792(tpo)
CSEM103379991(tpo) 103380299
POV109624077 109627948(tpo)
SSEN122776537(epx) 122783162(tpo)
SSOE131444873(tpo) 131469675(epx)
HHIP117756338 117762621(epx)
HSP118109462(epx) 118116664(tpo)
PPLT128444133(epx) 128450360(tpo)
SMAU118286573(sntg2) 118315245(epx)
LCF108886978(epx) 108897943
SDU111226032(tpo) 111229744
SLAL111666321 111666895 111670224(tpo)
XGL120792877(epx) 120795322(tpo)
HCQ109507502 109530238
SSCV125970095(epx) 125981320(tpo)
SBIA133501708(epx) 133513472(tpo)
PEE133402397(epx) 133412463(tpo)
PTAO133478512(epx) 133487880(tpo)
BPEC110155374(tpo) 110169467
ENY140349477(epx) 140371018(tpo)
MALB109965011(tpo) 109972931
BSPL114848308(tpo) 114857330(epx)
SJO128359350(epx)
SSCO133982501(epx) 134000449(tpo)
GMH115544232 115550900
SASA106584777 106611389(tpo)
STRU115161765 115192923
OTW112237628(epx) 112256946(tpo)
OMY110504252(tpo) 110522697(epx)
OGO124037374(epx) 124046982(tpo)
ONE115121024
OKI109881152 109904614
OKE118369032(tpo) 118377954(epx)
OMM135526888(tpo) 135533365(epx)
OCLA139383708 139407472
SALP112069494(tpo) 112070266
SNH120022964 120022991 120051654(epx)
CCLU121540756(epx) 121544226(tpo)
ELS105028745(tpo) 105029701
OEP134020675(epx) 134027117(tpo)
SFM108942507(tpo)
PKI111848005 111857914(tpo)
AANG118215539(epx) 118234749(tpo)
AROT135241772(epx) 135252679(tpo)
CCOG133111088(epx) 133122436(tpo)
LOC102695049(tpo)
PSPA121294970(epx) 121317659(tpo)
ARUT117411246(tpo) 117432329(epx)
PSEX120526592(tpo)
LCM102362813(TPO)
CMK103175078 103185975(tpo)
RTP109918711(tpo) 109928222
CPLA122548625(tpo) 122557877
HOC132824289 132835956(tpo)
LERI129696869(tpo) 129705776
HAKA140729849(epx) 140732814(tpo)
PMRN116945253(TPO)
LRJ133353287(TPO)
CIN100183311 100183818 445593
SCLV120346294
TCF131881866 131882001 131882614 131891773
PMEO129593455
CVN111102674 111110753
AIRR138314855
LJP135477769
HSY130614431
PFLAPflav_004530
 » show all
Reference
1  [PMID:13718859]
  Authors
CUNNINGHAM BA, KIRKWOOD S.
  Title
Enzyme systems concerned with the synthesis of monoiodotyrosine. III. Ion requirements of the soluble system.
  Journal
J Biol Chem 236:485-9 (1961)
Reference
2  [PMID:13964156]
  Authors
HOSOYA T, KONDO Y, UI N.
  Title
Peroxidase activity in thyroid gland and partial purification of the enzyme.
  Journal
J Biochem 52:180-9 (1962)
DOI:10.1093/oxfordjournals.jbchem.a127594
Reference
3  [PMID:12325367]
  Authors
Coval ML, Taurog A.
  Title
Purification and iodinating activity of hog thyroid peroxidase.
  Journal
J Biol Chem 242:5510-23 (1967)
Reference
4  [PMID:7021557]
  Authors
Gavaret JM, Cahnmann HJ, Nunez J
  Title
Thyroid hormone synthesis in thyroglobulin. The mechanism of the coupling reaction.
  Journal
J Biol Chem 256:9167-73 (1981)
Reference
5  [PMID:7142155]
  Authors
Ohtaki S, Nakagawa H, Nakamura M, Yamazaki I
  Title
One- and two-electron oxidations of tyrosine, monoiodotyrosine, and diiodotyrosine catalyzed by hog thyroid peroxidase.
  Journal
J Biol Chem 257:13398-403 (1982)
Reference
6  [PMID:6706930]
  Authors
Magnusson RP, Taurog A, Dorris ML
  Title
Mechanism of iodide-dependent catalatic activity of thyroid peroxidase and lactoperoxidase.
  Journal
J Biol Chem 259:197-205 (1984)
Reference
7  [PMID:2996435]
  Authors
Virion A, Courtin F, Deme D, Michot JL, Kaniewski J, Pommier J
  Title
Spectral characteristics and catalytic properties of thyroid peroxidase-H2O2 compounds in the iodination and coupling reactions.
  Journal
Arch Biochem Biophys 242:41-7 (1985)
DOI:10.1016/0003-9861(85)90477-1
Reference
8  [PMID:1497352]
  Authors
Rawitch AB, Pollock G, Yang SX, Taurog A
  Title
Thyroid peroxidase glycosylation: the location and nature of the N-linked oligosaccharide units in porcine thyroid peroxidase.
  Journal
Arch Biochem Biophys 297:321-7 (1992)
DOI:10.1016/0003-9861(92)90679-Q
  Sequence
[ssc:445522]
Reference
9  [PMID:8448141]
  Authors
Sun W, Dunford HB
  Title
Kinetics and mechanism of the peroxidase-catalyzed iodination of tyrosine.
  Journal
Biochemistry 32:1324-31 (1993)
DOI:10.1021/bi00056a018
Reference
10 [PMID:8651700]
  Authors
Taurog A, Dorris ML, Doerge DR
  Title
Mechanism of simultaneous iodination and coupling catalyzed by thyroid peroxidase.
  Journal
Arch Biochem Biophys 330:24-32 (1996)
DOI:10.1006/abbi.1996.0222
Reference
11 [PMID:16098474]
  Authors
Ruf J, Carayon P
  Title
Structural and functional aspects of thyroid peroxidase.
  Journal
Arch Biochem Biophys 445:269-77 (2006)
DOI:10.1016/j.abb.2005.06.023
Other DBs
ExplorEnz - The Enzyme Database: 1.11.1.8
IUBMB Enzyme Nomenclature: 1.11.1.8
ExPASy - ENZYME nomenclature database: 1.11.1.8
BRENDA, the Enzyme Database: 1.11.1.8
CAS: 9031-28-1
LinkDB

KEGG   REACTION: R03953
Entry
R03953                      Reaction                               
Definition
3-Iodo-L-tyrosine + 3,5-Diiodo-L-tyrosine + Hydrogen peroxide <=> Triiodothyronine + Dehydroalanine + 2 H2O
Equation
Comment
thyroid peroxidase, TPO
reaction on thyroglobulin [KO:K10809] (see R08522)
Reaction class
RC00878  C01060_C02465
RC01037  C02218_C02515
Enzyme
Pathway
rn00350  Tyrosine metabolism
rn01100  Metabolic pathways
Module
M00043  Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxine
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.11  Acting on a peroxide as acceptor
   1.11.1  Peroxidases
    1.11.1.8
     R03953  3-Iodo-L-tyrosine + 3,5-Diiodo-L-tyrosine + Hydrogen peroxide <=> Triiodothyronine + Dehydroalanine + 2 H2O
Orthology
K00431  thyroid peroxidase [EC:1.11.1.8]
LinkDB

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