PMID:1497352

Rawitch AB, Pollock G, Yang SX, Taurog A

Thyroid peroxidase glycosylation: the location and nature of the N-linked oligosaccharide units in porcine thyroid peroxidase.

Arch Biochem Biophys 297:321-7 (1992)
DOI:10.1016/0003-9861(92)90679-Q

[ssc:445522]

PMID:16098474

Ruf J, Carayon P

Structural and functional aspects of thyroid peroxidase.

Arch Biochem Biophys 445:269-77 (2006)
DOI:10.1016/j.abb.2005.06.023

Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases
BRITE hierarchy

iodide:hydrogen-peroxide oxidoreductase

(1) 2 iodide + H2O2 + 2 H+ = diiodine + 2 H2O [RN:R02810];
(2) [thyroglobulin]-L-tyrosine + iodide + H2O2 = [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O;
(3) [thyroglobulin]-3-iodo-L-tyrosine + iodide + H2O2 = [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O;
(4) 2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-L-thyroxine + [thyroglobulin]-aminoacrylate + 2 H2O [RN:R08523];
(5) [thyroglobulin]-3-iodo-L-tyrosine + [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-3,5,3'-triiodo-L-thyronine + [thyroglobulin]-aminoacrylate + 2 H2O [RN:R08522]

R02810 R08522 R08523;
(other) R03208 R03539 R03953 R03973 R08520 R08521
Reaction

iodide [CPD:C00708];
H2O2 [CPD:C00027];
H+ [CPD:C00080];
[thyroglobulin]-L-tyrosine [CPD:C16733];
[thyroglobulin]-3-iodo-L-tyrosine [CPD:C16732];
[thyroglobulin]-3,5-diiodo-L-tyrosine [CPD:C16731]

Thyroid peroxidase catalyses the biosynthesis of the thyroid hormones L-thyroxine and triiodo-L-thyronine. It catalyses both the iodination of tyrosine residues in thyroglobulin (forming mono- and di-iodinated forms) and their coupling to form either L-thyroxine or triiodo-L-thyronine.

EC 1.11.1.8 created 1961, modified 2012

1  [PMID:13718859]

CUNNINGHAM BA, KIRKWOOD S.

Enzyme systems concerned with the synthesis of monoiodotyrosine. III. Ion requirements of the soluble system.

J Biol Chem 236:485-9 (1961)

2  [PMID:13964156]

HOSOYA T, KONDO Y, UI N.

Peroxidase activity in thyroid gland and partial purification of the enzyme.

J Biochem 52:180-9 (1962)
DOI:10.1093/oxfordjournals.jbchem.a127594

3  [PMID:12325367]

Coval ML, Taurog A.

Purification and iodinating activity of hog thyroid peroxidase.

J Biol Chem 242:5510-23 (1967)

4  [PMID:7021557]

Gavaret JM, Cahnmann HJ, Nunez J

Thyroid hormone synthesis in thyroglobulin. The mechanism of the coupling reaction.

J Biol Chem 256:9167-73 (1981)

5  [PMID:7142155]

Ohtaki S, Nakagawa H, Nakamura M, Yamazaki I

One- and two-electron oxidations of tyrosine, monoiodotyrosine, and diiodotyrosine catalyzed by hog thyroid peroxidase.

J Biol Chem 257:13398-403 (1982)

6  [PMID:6706930]

Magnusson RP, Taurog A, Dorris ML

Mechanism of iodide-dependent catalatic activity of thyroid peroxidase and lactoperoxidase.

J Biol Chem 259:197-205 (1984)

7  [PMID:2996435]

Virion A, Courtin F, Deme D, Michot JL, Kaniewski J, Pommier J

Spectral characteristics and catalytic properties of thyroid peroxidase-H2O2 compounds in the iodination and coupling reactions.

Arch Biochem Biophys 242:41-7 (1985)
DOI:10.1016/0003-9861(85)90477-1

8  [PMID:1497352]

Rawitch AB, Pollock G, Yang SX, Taurog A

Thyroid peroxidase glycosylation: the location and nature of the N-linked oligosaccharide units in porcine thyroid peroxidase.

Arch Biochem Biophys 297:321-7 (1992)
DOI:10.1016/0003-9861(92)90679-Q

[ssc:445522]

9  [PMID:8448141]

Sun W, Dunford HB

Kinetics and mechanism of the peroxidase-catalyzed iodination of tyrosine.

Biochemistry 32:1324-31 (1993)
DOI:10.1021/bi00056a018

10 [PMID:8651700]

Taurog A, Dorris ML, Doerge DR

Mechanism of simultaneous iodination and coupling catalyzed by thyroid peroxidase.

Arch Biochem Biophys 330:24-32 (1996)
DOI:10.1006/abbi.1996.0222

11 [PMID:16098474]

Ruf J, Carayon P

Structural and functional aspects of thyroid peroxidase.

Arch Biochem Biophys 445:269-77 (2006)
DOI:10.1016/j.abb.2005.06.023