Homo sapiens (human): 3156
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Entry
3156 CDS
T01001
Gene name
HMGCR, LDLCQ3
Definition
(RefSeq) 3-hydroxy-3-methylglutaryl-CoA reductase
KO
K00021
hydroxymethylglutaryl-CoA reductase (NADPH) [EC:
1.1.1.34
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00900
Terpenoid backbone biosynthesis
hsa01100
Metabolic pathways
hsa04152
AMPK signaling pathway
hsa04976
Bile secretion
Module
hsa_M00095
C5 isoprenoid biosynthesis, mevalonate pathway
Drug target
Atorvastatin (
DG00355
):
D00887
D02258
<JP/US>
D07474
D11095
<US>
Cerivastatin (
DG00356
):
D00889
D07661
Crilvastatin:
D03601
Dalvastatin:
D03643
Fluvastatin (
DG00354
):
D00892
<JP/US>
D07983
Lovastatin:
D00359
<US>
Pitavastatin (
DG01838
):
D01862
<JP/US>
D10568
<JP>
D11092
<US>
Pravastatin (
DG00353
):
D00893
<JP/US>
D08410
Rosuvastatin (
DG00357
):
D01915
<JP/US>
D08492
Simvastatin:
D00434
<JP/US>
Tenivastatin calcium:
D03816
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09109 Metabolism of terpenoids and polyketides
00900 Terpenoid backbone biosynthesis
3156 (HMGCR)
09130 Environmental Information Processing
09132 Signal transduction
04152 AMPK signaling pathway
3156 (HMGCR)
09150 Organismal Systems
09154 Digestive system
04976 Bile secretion
3156 (HMGCR)
Enzymes [BR:
hsa01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH)
3156 (HMGCR)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
HMG-CoA_red
Sterol-sensing
Patched
Motif
Other DBs
NCBI-GeneID:
3156
NCBI-ProteinID:
NP_000850
OMIM:
142910
HGNC:
5006
Ensembl:
ENSG00000113161
Vega:
OTTHUMG00000102069
Pharos:
P04035
(Tclin)
UniProt:
P04035
A0A024RAP2
LinkDB
All DBs
Structure
PDB:
3CCZ
2R4F
2Q6B
2Q6C
1DQA
3CD7
2Q1L
3CDA
3CCW
1HW8
1HWL
1DQ8
3CCT
1HWK
3BGL
1HWJ
3CDB
1HWI
1HW9
3CD5
3CD0
1DQ9
Thumbnails
Position
5q13.3
AA seq
888 aa
AA seq
DB search
MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS
DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG
LNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG
VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR
VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKR
IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSLKNPITSPVVT
QKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGNS
SLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYK
LETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGV
AGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRAC
DSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMI
SKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREV
LKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITL
MEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLAR
IVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA
NT seq
2667 nt
NT seq
+upstream
nt +downstream
nt
atgttgtcaagactttttcgaatgcatggcctctttgtggcctcccatccctgggaagtc
atagtggggacagtgacactgaccatctgcatgatgtccatgaacatgtttactggtaac
aataagatctgtggttggaattatgaatgtccaaagtttgaagaggatgttttgagcagt
gacattataattctgacaataacacgatgcatagccatcctgtatatttacttccagttc
cagaatttacgtcaacttggatcaaaatatattttgggtattgctggccttttcacaatt
ttctcaagttttgtattcagtacagttgtcattcacttcttagacaaagaattgacaggc
ttgaatgaagctttgccctttttcctacttttgattgacctttccagagcaagcacatta
gcaaagtttgccctcagttccaactcacaggatgaagtaagggaaaatattgctcgtgga
atggcaattttaggtcctacgtttaccctcgatgctcttgttgaatgtcttgtgattgga
gttggtaccatgtcaggggtacgtcagcttgaaattatgtgctgctttggctgcatgtca
gttcttgccaactacttcgtgttcatgactttcttcccagcttgtgtgtccttggtatta
gagctttctcgggaaagccgcgagggtcgtccaatttggcagctcagccattttgcccga
gttttagaagaagaagaaaataagccgaatcctgtaactcagagggtcaagatgattatg
tctctaggcttggttcttgttcatgctcacagtcgctggatagctgatccttctcctcaa
aacagtacagcagatacttctaaggtttcattaggactggatgaaaatgtgtccaagaga
attgaaccaagtgtttccctctggcagttttatctctctaaaatgatcagcatggatatt
gaacaagttattaccctaagtttagctctccttctggctgtcaagtacatcttctttgaa
caaacagagacagaatctacactctcattaaaaaaccctatcacatctcctgtagtgaca
caaaagaaagtcccagacaattgttgtagacgtgaacctatgctggtcagaaataaccag
aaatgtgattcagtagaggaagagacagggataaaccgagaaagaaaagttgaggttata
aaacccttagtggctgaaacagataccccaaacagagctacatttgtggttggtaactcc
tccttactcgatacttcatcagtactggtgacacaggaacctgaaattgaacttcccagg
gaacctcggcctaatgaagaatgtctacagatacttgggaatgcagagaaaggtgcaaaa
ttccttagtgatgctgagatcatccagttagtcaatgctaagcatatcccagcctacaag
ttggaaactctgatggaaactcatgagcgtggtgtatctattcgccgacagttactttcc
aagaagctttcagaaccttcttctctccagtacctaccttacagggattataattactcc
ttggtgatgggagcttgttgtgagaatgttattggatatatgcccatccctgttggagtg
gcaggacccctttgcttagatgaaaaagaatttcaggttccaatggcaacaacagaaggt
tgtcttgtggccagcaccaatagaggctgcagagcaataggtcttggtggaggtgccagc
agccgagtccttgcagatgggatgactcgtggcccagttgtgcgtcttccacgtgcttgt
gactctgcagaagtgaaagcctggctcgaaacatctgaagggttcgcagtgataaaggag
gcatttgacagcactagcagatttgcacgtctacagaaacttcatacaagtatagctgga
cgcaacctttatatccgtttccagtccaggtcaggggatgccatggggatgaacatgatt
tcaaagggtacagagaaagcactttcaaaacttcacgagtatttccctgaaatgcagatt
ctagccgttagtggtaactattgtactgacaagaaacctgctgctataaattggatagag
ggaagaggaaaatctgttgtttgtgaagctgtcattccagccaaggttgtcagagaagta
ttaaagactaccacagaggctatgattgaggtcaacattaacaagaatttagtgggctct
gccatggctgggagcataggaggctacaacgcccatgcagcaaacattgtcaccgccatc
tacattgcctgtggacaggatgcagcacagaatgttggtagttcaaactgtattacttta
atggaagcaagtggtcccacaaatgaagatttatatatcagctgcaccatgccatctata
gagataggaacggtgggtggtgggaccaacctactacctcagcaagcctgtttgcagatg
ctaggtgttcaaggagcatgcaaagataatcctggggaaaatgcccggcagcttgcccga
attgtgtgtgggaccgtaatggctggggaattgtcacttatggcagcattggcagcagga
catcttgtcaaaagtcacatgattcacaacaggtcgaagatcaatttacaagacctccaa
ggagcttgcaccaagaagacagcctga
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