Homo sapiens (human): 355
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Entry
355 CDS
T01001
Symbol
FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6
Name
(RefSeq) Fas cell surface death receptor
KO
K04390
tumor necrosis factor receptor superfamily member 6
Organism
hsa
Homo sapiens (human)
Pathway
hsa01524
Platinum drug resistance
hsa04010
MAPK signaling pathway
hsa04060
Cytokine-cytokine receptor interaction
hsa04115
p53 signaling pathway
hsa04210
Apoptosis
hsa04217
Necroptosis
hsa04650
Natural killer cell mediated cytotoxicity
hsa04668
TNF signaling pathway
hsa04932
Non-alcoholic fatty liver disease
hsa04936
Alcoholic liver disease
hsa04940
Type I diabetes mellitus
hsa05010
Alzheimer disease
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05130
Pathogenic Escherichia coli infection
hsa05142
Chagas disease
hsa05143
African trypanosomiasis
hsa05160
Hepatitis C
hsa05161
Hepatitis B
hsa05162
Measles
hsa05163
Human cytomegalovirus infection
hsa05164
Influenza A
hsa05165
Human papillomavirus infection
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05168
Herpes simplex virus 1 infection
hsa05169
Epstein-Barr virus infection
hsa05170
Human immunodeficiency virus 1 infection
hsa05200
Pathways in cancer
hsa05205
Proteoglycans in cancer
hsa05320
Autoimmune thyroid disease
hsa05330
Allograft rejection
hsa05332
Graft-versus-host disease
hsa05417
Lipid and atherosclerosis
Network
nt06161
Human immunodeficiency virus 1 (HIV-1)
nt06162
Hepatitis B virus (HBV)
nt06163
Hepatitis C virus (HCV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165
Epstein-Barr virus (EBV)
nt06167
Human cytomegalovirus (HCMV)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06231
Apoptosis (cancer)
nt06263
Hepatocellular carcinoma
nt06460
Alzheimer disease
nt06463
Parkinson disease
nt06466
Pathways of neurodegeneration
nt06524
Apoptosis
nt06527
Necroptosis
Element
N00146
Crosstalk between extrinsic and intrinsic apoptotic pathways
N00527
HCV Core to crosstalk between extrinsic and intrinsic apoptotic pathways
N00535
HBV HBx to p53-mediated transcription
N01005
Mutation-caused aberrant Abeta to crosstalk between extrinsic and intrinsic apoptotic pathways
N01056
FAS-JNK signaling pathway
N01632
FASLG-RIPK1/3 signaling pathway
Disease
H00005
Chronic lymphocytic leukemia
H00007
Hodgkin lymphoma
H00009
Adult T-cell leukemia
H00017
Esophageal cancer
H00108
Autoimmune lymphoproliferative syndromes
H01463
Mycosis fungoides
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
355 (FAS)
04668 TNF signaling pathway
355 (FAS)
09133 Signaling molecules and interaction
04060 Cytokine-cytokine receptor interaction
355 (FAS)
09140 Cellular Processes
09143 Cell growth and death
04210 Apoptosis
355 (FAS)
04217 Necroptosis
355 (FAS)
04115 p53 signaling pathway
355 (FAS)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
355 (FAS)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
355 (FAS)
05205 Proteoglycans in cancer
355 (FAS)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
355 (FAS)
05161 Hepatitis B
355 (FAS)
05160 Hepatitis C
355 (FAS)
05164 Influenza A
355 (FAS)
05162 Measles
355 (FAS)
05168 Herpes simplex virus 1 infection
355 (FAS)
05163 Human cytomegalovirus infection
355 (FAS)
05167 Kaposi sarcoma-associated herpesvirus infection
355 (FAS)
05169 Epstein-Barr virus infection
355 (FAS)
05165 Human papillomavirus infection
355 (FAS)
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
355 (FAS)
09174 Infectious disease: parasitic
05142 Chagas disease
355 (FAS)
05143 African trypanosomiasis
355 (FAS)
09163 Immune disease
05320 Autoimmune thyroid disease
355 (FAS)
05330 Allograft rejection
355 (FAS)
05332 Graft-versus-host disease
355 (FAS)
09164 Neurodegenerative disease
05010 Alzheimer disease
355 (FAS)
05022 Pathways of neurodegeneration - multiple diseases
355 (FAS)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
355 (FAS)
09167 Endocrine and metabolic disease
04940 Type I diabetes mellitus
355 (FAS)
04936 Alcoholic liver disease
355 (FAS)
04932 Non-alcoholic fatty liver disease
355 (FAS)
09176 Drug resistance: antineoplastic
01524 Platinum drug resistance
355 (FAS)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04050 Cytokine receptors [BR:
hsa04050
]
355 (FAS)
04090 CD molecules [BR:
hsa04090
]
355 (FAS)
Cytokine receptors [BR:
hsa04050
]
Tumor necrosis factor receptors
TNF receptor superfamily
355 (FAS)
CD molecules [BR:
hsa04090
]
Proteins
355 (FAS)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Death
TNFR_c6
Peptidase_C8
Death_3
Motif
Other DBs
NCBI-GeneID:
355
NCBI-ProteinID:
NP_000034
OMIM:
134637
HGNC:
11920
Ensembl:
ENSG00000026103
UniProt:
P25445
Structure
PDB
LinkDB
All DBs
Position
10:88964050..89017059
Genome browser
AA seq
335 aa
AA seq
DB search
MLGIWTLLPLVLTSVARLSSKSVNAQVTDINSKGLELRKTVTTVETQNLEGLHHDGQFCH
KPCPPGERKARDCTVNGDEPDCVPCQEGKEYTDKAHFSSKCRRCRLCDEGHGLEVEINCT
RTQNTKCRCKPNFFCNSTVCEHCDPCTKCEHGIIKECTLTSNTKCKEEGSRSNLGWLCLL
LLPIPLIVWVKRKEVQKTCRKHRKENQGSHESPTLNPETVAINLSDVDLSKYITTIAGVM
TLSQVKGFVRKNGVNEAKIDEIKNDNVQDTAEQKVQLLRNWHQLHGKKEAYDTLIKDLKK
ANLCTLAEKIQTIILKDITSDSENSNFRNEIQSLV
NT seq
1008 nt
NT seq
+upstream
nt +downstream
nt
atgctgggcatctggaccctcctacctctggttcttacgtctgttgctagattatcgtcc
aaaagtgttaatgcccaagtgactgacatcaactccaagggattggaattgaggaagact
gttactacagttgagactcagaacttggaaggcctgcatcatgatggccaattctgccat
aagccctgtcctccaggtgaaaggaaagctagggactgcacagtcaatggggatgaacca
gactgcgtgccctgccaagaagggaaggagtacacagacaaagcccatttttcttccaaa
tgcagaagatgtagattgtgtgatgaaggacatggcttagaagtggaaataaactgcacc
cggacccagaataccaagtgcagatgtaaaccaaactttttttgtaactctactgtatgt
gaacactgtgacccttgcaccaaatgtgaacatggaatcatcaaggaatgcacactcacc
agcaacaccaagtgcaaagaggaaggatccagatctaacttggggtggctttgtcttctt
cttttgccaattccactaattgtttgggtgaagagaaaggaagtacagaaaacatgcaga
aagcacagaaaggaaaaccaaggttctcatgaatctccaactttaaatcctgaaacagtg
gcaataaatttatctgatgttgacttgagtaaatatatcaccactattgctggagtcatg
acactaagtcaagttaaaggctttgttcgaaagaatggtgtcaatgaagccaaaatagat
gagatcaagaatgacaatgtccaagacacagcagaacagaaagttcaactgcttcgtaat
tggcatcaacttcatggaaagaaagaagcgtatgacacattgattaaagatctcaaaaaa
gccaatctttgtactcttgcagagaaaattcagactatcatcctcaaggacattactagt
gactcagaaaattcaaacttcagaaatgaaatccaaagcttggtctag
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