KEGG   Homo sapiens (human): 50484
Entry
50484             CDS       T01001                                 

Gene name
RRM2B, MTDPS8A, MTDPS8B, P53R2
Definition
(RefSeq) ribonucleotide reductase regulatory TP53 inducible subunit M2B
  KO
K10808  ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00230  Purine metabolism
hsa00240  Pyrimidine metabolism
hsa00480  Glutathione metabolism
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa04115  p53 signaling pathway
Disease
H00469  Mitochondrial DNA depletion syndrome
H01118  Progressive external ophthalmoplegia
H01390  Mitochondrial neurogastrointestinal encephalomyopathy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    50484 (RRM2B)
   00240 Pyrimidine metabolism
    50484 (RRM2B)
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    50484 (RRM2B)
  09111 Xenobiotics biodegradation and metabolism
   00983 Drug metabolism - other enzymes
    50484 (RRM2B)
 09140 Cellular Processes
  09143 Cell growth and death
   04115 p53 signaling pathway
    50484 (RRM2B)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:hsa03400]
    50484 (RRM2B)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.17  Acting on CH or CH2 groups
   1.17.4  With a disulfide as acceptor
    1.17.4.1  ribonucleoside-diphosphate reductase
     50484 (RRM2B)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  Other factors with a suspected DNA repair function
   Modulation of nucleotide pools
    50484 (RRM2B)
SSDB
Motif
Pfam: Ribonuc_red_sm
Other DBs
NCBI-GeneID: 50484
NCBI-ProteinID: NP_056528
OMIM: 604712
HGNC: 17296
Ensembl: ENSG00000048392
Vega: OTTHUMG00000164776
Pharos: Q7LG56(Tbio)
UniProt: Q7LG56
LinkDB
Structure
PDB: 
4DJN 3HF1 2VUX

Position
8q22.3
AA seq 351 aa
MGDPERPEAAGLDQDERSSSDTNESEIKSNEEPLLRKSSRRFVIFPIQYPDIWKMYKQAQ
ASFWTAEEVDLSKDLPHWNKLKADEKYFISHILAFFAASDGIVNENLVERFSQEVQVPEA
RCFYGFQILIENVHSEMYSLLIDTYIRDPKKREFLFNAIETMPYVKKKADWALRWIADRK
STFGERVVAFAAVEGVFFSGSFAAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFQ
YLVNKPSEERVREIIVDAVKIEQEFLTEALPVGLIGMNCILMKQYIEFVADRLLVELGFS
KVFQAENPFDFMENISLEGKTNFFEKRVSEYQRFAVMAETTDNVFTLDADF
NT seq 1056 nt   +upstreamnt  +downstreamnt
atgggcgacccggaaaggccggaagcggccgggctggatcaggatgagagatcatcttca
gacaccaacgaaagtgaaataaagtcaaatgaagagccactcctaagaaagagttctcgc
cggtttgtcatctttccaatccagtaccctgatatttggaaaatgtataaacaggcacag
gcttccttctggacagcagaagaggtcgacttatcaaaggatctccctcactggaacaag
cttaaagcagatgagaagtacttcatctctcacatcttagccttttttgcagccagtgat
ggaattgtaaatgaaaatttggtggagcgctttagtcaggaggtgcaggttccagaggct
cgctgtttctatggctttcaaattctcatcgagaatgttcactcagagatgtacagtttg
ctgatagacacttacatcagagatcccaagaaaagggaatttttatttaatgcaattgaa
accatgccctatgttaagaaaaaagcagattgggccttgcgatggatagcagatagaaaa
tctacttttggggaaagagtggtggcctttgctgctgtagaaggagttttcttctcagga
tcttttgctgctatattctggctaaagaagagaggtcttatgccaggactcactttttcc
aatgaactcatcagcagagatgaaggacttcactgtgactttgcttgcctgatgttccaa
tacttagtaaataagccttcagaagaaagggtcagggagatcattgttgatgctgtcaaa
attgagcaggagtttttaacagaagccttgccagttggcctcattggaatgaattgcatt
ttgatgaaacagtacattgagtttgtagctgacagattacttgtggaacttggattctca
aaggtttttcaggcagaaaatccttttgattttatggaaaacatttctttagaaggaaaa
acaaatttctttgagaaacgagtttcagagtatcagcgttttgcagttatggcagaaacc
acagataacgtcttcaccttggatgcagatttttaa

KEGG   Homo sapiens (human): 6240
Entry
6240              CDS       T01001                                 

Gene name
RRM1, R1, RIR1, RR1
Definition
(RefSeq) ribonucleotide reductase catalytic subunit M1
  KO
K10807  ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00230  Purine metabolism
hsa00240  Pyrimidine metabolism
hsa00480  Glutathione metabolism
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
Drug target
Caracemide: D03378
Cladribine: D01370
Clofarabine: D03546
Fludarabine (DG00685): D01907 D07966
Gemcitabine (DG00688): D01155 D02368 D10222
Tezacitabine: D06100
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    6240 (RRM1)
   00240 Pyrimidine metabolism
    6240 (RRM1)
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    6240 (RRM1)
  09111 Xenobiotics biodegradation and metabolism
   00983 Drug metabolism - other enzymes
    6240 (RRM1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:hsa03400]
    6240 (RRM1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.17  Acting on CH or CH2 groups
   1.17.4  With a disulfide as acceptor
    1.17.4.1  ribonucleoside-diphosphate reductase
     6240 (RRM1)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  Other factors with a suspected DNA repair function
   Modulation of nucleotide pools
    6240 (RRM1)
SSDB
Motif
Pfam: Ribonuc_red_lgC Ribonuc_red_lgN ATP-cone
Other DBs
NCBI-GeneID: 6240
NCBI-ProteinID: NP_001024
OMIM: 180410
HGNC: 10451
Ensembl: ENSG00000167325
Vega: OTTHUMG00000133361
Pharos: P23921(Tclin)
UniProt: P23921
LinkDB
Structure
PDB: 

Position
11p15.4
AA seq 792 aa
MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLA
AETAATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGKHSPMVAKST
LDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHK
EDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCAL
ISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIY
LEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLD
EVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNL
GTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKI
IDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGAL
EASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIA
PMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQII
ACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKL
TSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKVSKEEEEKERNTAAMVCS
LENRDECLMCGS
NT seq 2379 nt   +upstreamnt  +downstreamnt
atgcatgtgatcaagcgagatggccgccaagaacgagtcatgtttgacaaaattacatct
cgaatccagaagctttgttatggactcaatatggattttgttgatcctgctcagatcacc
atgaaagtaatccaaggcttgtacagtggggtcaccacagtggaactagatactttggct
gctgaaacagctgcaaccttgactactaagcaccctgactatgctatcctggcagccagg
atcgctgtctctaacttgcacaaagaaacaaagaaagtgttcagtgatgtgatggaagac
ctctataactacataaatccacataatggcaaacactctcccatggtggccaagtcaaca
ttggatattgttctggccaataaagatcgcctgaattctgctattatctatgaccgagat
ttctcttacaattacttcggctttaagacgctagagcggtcttatttgttgaagatcaat
ggaaaagtggctgaaagaccacaacatatgttgatgagagtatctgttgggatccacaaa
gaagacattgatgcagcaattgaaacatataatcttctttctgagaggtggtttactcat
gcttcgcccactctcttcaatgctggtaccaaccgcccacaactttctagctgttttctt
ctgagtatgaaagatgacagcattgaaggcatttatgacactctaaagcaatgtgcattg
atttctaagtctgctggaggaattggtgttgctgtgagttgtattcgggctactggcagc
tacattgctgggactaatggcaattccaatggccttgtaccgatgctgagagtatataac
aacacagctcgatatgtggatcaaggtgggaacaagcgtcctggggcatttgctatttac
ctggagccttggcatttagacatctttgaattccttgatttaaagaagaacacaggaaag
gaagagcagcgtgccagagatcttttctttgctctttggattccggatctcttcatgaaa
cgagtggagactaatcaggactggtctttgatgtgtccaaatgagtgtcctggtctggat
gaggtttggggagaggaatttgagaaactatatgcaagttatgagaaacaaggtcgtgtc
cgcaaagttgtaaaagctcagcagctttggtatgccatcattgagtctcagacggaaaca
ggcaccccgtatatgctctacaaagattcctgtaatcgaaagagcaaccagcagaacctg
ggaaccatcaaatgcagcaacctgtgcacagaaatagtggagtacaccagcaaagatgag
gttgctgtttgtaatttggcttccctggccctgaatatgtatgtcacatcagaacacaca
tacgactttaagaagttggctgaagtcactaaagtcgttgtccgaaacttgaataaaatt
attgatataaactactatcctgtaccagaggcatgcctatcaaataaacgccatcgcccc
attggaattggggtacaaggtctggcagatgcttttatcctgatgagatacccttttgag
agtgcagaagcccagttactgaataagcagatctttgaaactatttattatggtgctctg
gaagccagctgtgaccttgccaaggagcagggcccatacgaaacctatgagggctctcca
gttagcaaaggaattcttcagtatgatatgtggaatgttactcctacagacctatgggac
tggaaggttctcaaggagaagattgcaaagtatggtataagaaacagtttacttattgcc
ccgatgcctacagcttccactgctcagatcctggggaataatgagtccattgaaccttac
accagcaacatctatactcgcagagtcttgtcaggagaatttcagattgtaaatcctcac
ttattgaaagatcttaccgagcggggcctatggcatgaagagatgaaaaaccagattatt
gcatgcaatggctctattcagagcataccagaaattcctgatgacctgaagcaactttat
aaaactgtgtgggaaatctctcagaaaactgttctcaagatggcagctgagagaggtgct
ttcattgatcaaagccaatctttgaacatccacattgctgagcctaactatggcaaactc
actagtatgcacttctacggctggaagcagggtttgaagactgggatgtattatttaagg
acaagaccagcggctaatccaatccagttcactctaaataaggagaagctaaaagataaa
gaaaaggtatcaaaagaggaagaagagaaggagaggaacacagcagccatggtgtgctct
ttggagaatagagatgaatgtctgatgtgtggatcctga

KEGG   Homo sapiens (human): 6241
Entry
6241              CDS       T01001                                 

Gene name
RRM2, C2orf48, R2, RR2, RR2M
Definition
(RefSeq) ribonucleotide reductase regulatory subunit M2
  KO
K10808  ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00230  Purine metabolism
hsa00240  Pyrimidine metabolism
hsa00480  Glutathione metabolism
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa04115  p53 signaling pathway
Drug target
Hydroxycarbamide: D00341
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    6241 (RRM2)
   00240 Pyrimidine metabolism
    6241 (RRM2)
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    6241 (RRM2)
  09111 Xenobiotics biodegradation and metabolism
   00983 Drug metabolism - other enzymes
    6241 (RRM2)
 09140 Cellular Processes
  09143 Cell growth and death
   04115 p53 signaling pathway
    6241 (RRM2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:hsa03400]
    6241 (RRM2)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.17  Acting on CH or CH2 groups
   1.17.4  With a disulfide as acceptor
    1.17.4.1  ribonucleoside-diphosphate reductase
     6241 (RRM2)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  Other factors with a suspected DNA repair function
   Modulation of nucleotide pools
    6241 (RRM2)
SSDB
Motif
Pfam: Ribonuc_red_sm
Other DBs
NCBI-GeneID: 6241
NCBI-ProteinID: NP_001025
OMIM: 180390
HGNC: 10452
Ensembl: ENSG00000171848
Vega: OTTHUMG00000090449
Pharos: P31350(Tclin)
UniProt: P31350
LinkDB
Structure
PDB: 
3OLJ 3VPN 3VPO 3VPM 2UW2

Position
2p25.1
AA seq 389 aa
MLSLRVPLAPITDPQQLQLSPLKGLSLVDKENTPPALSGTRVLASKTARRIFQEPTEPKT
KAAAPGVEDEPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLK
PEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLI
DTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSF
ASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIE
QEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTN
FFEKRVGEYQRMGVMSSPTENSFTLDADF
NT seq 1170 nt   +upstreamnt  +downstreamnt
atgctctccctccgtgtcccgctcgcgcccatcacggacccgcagcagctgcagctctcg
ccgctgaaggggctcagcttggtcgacaaggagaacacgccgccggccctgagcgggacc
cgcgtcctggccagcaagaccgcgaggaggatcttccaggagcccacggagccgaaaact
aaagcagctgcccccggcgtggaggatgagccgctgctgagagaaaacccccgccgcttt
gtcatcttccccatcgagtaccatgatatctggcagatgtataagaaggcagaggcttcc
ttttggaccgccgaggaggtggacctctccaaggacattcagcactgggaatccctgaaa
cccgaggagagatattttatatcccatgttctggctttctttgcagcaagcgatggcata
gtaaatgaaaacttggtggagcgatttagccaagaagttcagattacagaagcccgctgt
ttctatggcttccaaattgccatggaaaacatacattctgaaatgtatagtcttcttatt
gacacttacataaaagatcccaaagaaagggaatttctcttcaatgccattgaaacgatg
ccttgtgtcaagaagaaggcagactgggccttgcgctggattggggacaaagaggctacc
tatggtgaacgtgttgtagcctttgctgcagtggaaggcattttcttttccggttctttt
gcgtcgatattctggctcaagaaacgaggactgatgcctggcctcacattttctaatgaa
cttattagcagagatgagggtttacactgtgattttgcttgcctgatgttcaaacacctg
gtacacaaaccatcggaggagagagtaagagaaataattatcaatgctgttcggatagaa
caggagttcctcactgaggccttgcctgtgaagctcattgggatgaattgcactctaatg
aagcaatacattgagtttgtggcagacagacttatgctggaactgggttttagcaaggtt
ttcagagtagagaacccatttgactttatggagaatatttcactggaaggaaagactaac
ttctttgagaagagagtaggcgagtatcagaggatgggagtgatgtcaagtccaacagag
aattcttttaccttggatgctgacttctaa

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