Homo sapiens (human): 7040
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Entry
7040 CDS
T01001
Symbol
TGFB1, CED, DPD1, IBDIMDE, LAP, TGF-beta1, TGFB, TGFbeta
Name
(RefSeq) transforming growth factor beta 1
KO
K13375
transforming growth factor beta-1
Organism
hsa
Homo sapiens (human)
Pathway
hsa04010
MAPK signaling pathway
hsa04060
Cytokine-cytokine receptor interaction
hsa04068
FoxO signaling pathway
hsa04110
Cell cycle
hsa04148
Efferocytosis
hsa04218
Cellular senescence
hsa04350
TGF-beta signaling pathway
hsa04380
Osteoclast differentiation
hsa04390
Hippo signaling pathway
hsa04659
Th17 cell differentiation
hsa04672
Intestinal immune network for IgA production
hsa04926
Relaxin signaling pathway
hsa04932
Non-alcoholic fatty liver disease
hsa04933
AGE-RAGE signaling pathway in diabetic complications
hsa05140
Leishmaniasis
hsa05142
Chagas disease
hsa05144
Malaria
hsa05145
Toxoplasmosis
hsa05146
Amoebiasis
hsa05152
Tuberculosis
hsa05161
Hepatitis B
hsa05166
Human T-cell leukemia virus 1 infection
hsa05200
Pathways in cancer
hsa05205
Proteoglycans in cancer
hsa05210
Colorectal cancer
hsa05211
Renal cell carcinoma
hsa05212
Pancreatic cancer
hsa05220
Chronic myeloid leukemia
hsa05225
Hepatocellular carcinoma
hsa05226
Gastric cancer
hsa05321
Inflammatory bowel disease
hsa05323
Rheumatoid arthritis
hsa05410
Hypertrophic cardiomyopathy
hsa05414
Dilated cardiomyopathy
hsa05415
Diabetic cardiomyopathy
Network
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06162
Hepatitis B virus (HBV)
nt06218
TGFB signaling (cancer)
nt06225
HIF-1 signaling (cancer)
nt06260
Colorectal cancer
nt06261
Gastric cancer
nt06263
Hepatocellular carcinoma
nt06264
Renal cell carcinoma
nt06276
Chronic myeloid leukemia
nt06507
TGFB signaling
nt06535
Efferocytosis
Element
N00063
TGF-beta signaling pathway
N00079
HIF-1 signaling pathway
N00080
Loss of VHL to HIF-1 signaling pathway
N00081
Mutation-inactivated VHL to HIF-1 signaling pathway
N00531
HBV HBx to TGF-beta signaling pathway
N01460
Plasmin mediated activation of latent TGF-beta
N01773
PTGS2-PGE2-TGFB1 pathway
N01781
Activation of LXRs by oxysterols
Disease
H00083
Allograft rejection
H00084
Graft-versus-host disease
H00218
Cystic fibrosis
H00434
Camurati-Engelmann disease
H02669
Inflammatory bowel disease, immunodeficiency, and encephalopathy
Drug target
Fresolimumab:
D09620
Linavonkibart:
D12801
Livmoniplimab:
D12793
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
7040 (TGFB1)
04350 TGF-beta signaling pathway
7040 (TGFB1)
04390 Hippo signaling pathway
7040 (TGFB1)
04068 FoxO signaling pathway
7040 (TGFB1)
09133 Signaling molecules and interaction
04060 Cytokine-cytokine receptor interaction
7040 (TGFB1)
09140 Cellular Processes
09141 Transport and catabolism
04148 Efferocytosis
7040 (TGFB1)
09143 Cell growth and death
04110 Cell cycle
7040 (TGFB1)
04218 Cellular senescence
7040 (TGFB1)
09150 Organismal Systems
09151 Immune system
04659 Th17 cell differentiation
7040 (TGFB1)
04672 Intestinal immune network for IgA production
7040 (TGFB1)
09152 Endocrine system
04926 Relaxin signaling pathway
7040 (TGFB1)
09158 Development and regeneration
04380 Osteoclast differentiation
7040 (TGFB1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
7040 (TGFB1)
05205 Proteoglycans in cancer
7040 (TGFB1)
09162 Cancer: specific types
05210 Colorectal cancer
7040 (TGFB1)
05212 Pancreatic cancer
7040 (TGFB1)
05225 Hepatocellular carcinoma
7040 (TGFB1)
05226 Gastric cancer
7040 (TGFB1)
05220 Chronic myeloid leukemia
7040 (TGFB1)
05211 Renal cell carcinoma
7040 (TGFB1)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
7040 (TGFB1)
05161 Hepatitis B
7040 (TGFB1)
09171 Infectious disease: bacterial
05152 Tuberculosis
7040 (TGFB1)
09174 Infectious disease: parasitic
05146 Amoebiasis
7040 (TGFB1)
05144 Malaria
7040 (TGFB1)
05145 Toxoplasmosis
7040 (TGFB1)
05140 Leishmaniasis
7040 (TGFB1)
05142 Chagas disease
7040 (TGFB1)
09163 Immune disease
05323 Rheumatoid arthritis
7040 (TGFB1)
05321 Inflammatory bowel disease
7040 (TGFB1)
09166 Cardiovascular disease
05410 Hypertrophic cardiomyopathy
7040 (TGFB1)
05414 Dilated cardiomyopathy
7040 (TGFB1)
05415 Diabetic cardiomyopathy
7040 (TGFB1)
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
7040 (TGFB1)
04933 AGE-RAGE signaling pathway in diabetic complications
7040 (TGFB1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03110 Chaperones and folding catalysts [BR:
hsa03110
]
7040 (TGFB1)
09183 Protein families: signaling and cellular processes
04052 Cytokines and neuropeptides [BR:
hsa04052
]
7040 (TGFB1)
00536 Glycosaminoglycan binding proteins [BR:
hsa00536
]
7040 (TGFB1)
Chaperones and folding catalysts [BR:
hsa03110
]
Intramolecular chaperones
Others
7040 (TGFB1)
Cytokines and neuropeptides [BR:
hsa04052
]
Cytokines
Transforming growth factors (RSTK binding)
7040 (TGFB1)
Glycosaminoglycan binding proteins [BR:
hsa00536
]
Heparan sulfate / Heparin
Growth factors/receptors
7040 (TGFB1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
TGFb_propeptide
TGF_beta
Motif
Other DBs
NCBI-GeneID:
7040
NCBI-ProteinID:
NP_000651
OMIM:
190180
HGNC:
11766
Ensembl:
ENSG00000105329
UniProt:
P01137
A0A499FJK2
Structure
PDB
LinkDB
All DBs
Position
19:complement(41330323..41353922)
Genome browser
AA seq
390 aa
AA seq
DB search
MPPSGLRLLPLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLA
SPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEI
YDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWR
YLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFT
TGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYI
DFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQA
LEPLPIVYYVGRKPKVEQLSNMIVRSCKCS
NT seq
1173 nt
NT seq
+upstream
nt +downstream
nt
atgccgccctccgggctgcggctgctgccgctgctgctaccgctgctgtggctactggtg
ctgacgcctggccggccggccgcgggactatccacctgcaagactatcgacatggagctg
gtgaagcggaagcgcatcgaggccatccgcggccagatcctgtccaagctgcggctcgcc
agccccccgagccagggggaggtgccgcccggcccgctgcccgaggccgtgctcgccctg
tacaacagcacccgcgaccgggtggccggggagagtgcagaaccggagcccgagcctgag
gccgactactacgccaaggaggtcacccgcgtgctaatggtggaaacccacaacgaaatc
tatgacaagttcaagcagagtacacacagcatatatatgttcttcaacacatcagagctc
cgagaagcggtacctgaacccgtgttgctctcccgggcagagctgcgtctgctgaggctc
aagttaaaagtggagcagcacgtggagctgtaccagaaatacagcaacaattcctggcga
tacctcagcaaccggctgctggcacccagcgactcgccagagtggttatcttttgatgtc
accggagttgtgcggcagtggttgagccgtggaggggaaattgagggctttcgccttagc
gcccactgctcctgtgacagcagggataacacactgcaagtggacatcaacgggttcact
accggccgccgaggtgacctggccaccattcatggcatgaaccggcctttcctgcttctc
atggccaccccgctggagagggcccagcatctgcaaagctcccggcaccgccgagccctg
gacaccaactattgcttcagctccacggagaagaactgctgcgtgcggcagctgtacatt
gacttccgcaaggacctcggctggaagtggatccacgagcccaagggctaccatgccaac
ttctgcctcgggccctgcccctacatttggagcctggacacgcagtacagcaaggtcctg
gccctgtacaaccagcataacccgggcgcctcggcggcgccgtgctgcgtgccgcaggcg
ctggagccgctgcccatcgtgtactacgtgggccgcaagcccaaggtggagcagctgtcc
aacatgatcgtgcgctcctgcaagtgcagctga
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