KEGG ORTHOLOGY: K13375

ORTHOLOGY: K13375

Entry

K13375                      KO

Symbol

TGFB1

Name

transforming growth factor beta-1

Pathway

map04010

MAPK signaling pathway

map04060

Cytokine-cytokine receptor interaction

map04068

FoxO signaling pathway

map04110

Cell cycle

map04148

Efferocytosis

map04218

Cellular senescence

map04350

TGF-beta signaling pathway

map04380

Osteoclast differentiation

map04390

Hippo signaling pathway

map04659

Th17 cell differentiation

map04672

Intestinal immune network for IgA production

map04926

Relaxin signaling pathway

map04932

Non-alcoholic fatty liver disease

map04933

AGE-RAGE signaling pathway in diabetic complications

map05140

Leishmaniasis

map05142

Chagas disease

map05144

Malaria

map05145

Toxoplasmosis

map05146

Amoebiasis

map05152

Tuberculosis

map05161

Hepatitis B

map05166

Human T-cell leukemia virus 1 infection

map05200

Pathways in cancer

map05205

Proteoglycans in cancer

map05210

Colorectal cancer

map05211

Renal cell carcinoma

map05212

Pancreatic cancer

map05220

Chronic myeloid leukemia

map05225

Hepatocellular carcinoma

map05226

Gastric cancer

map05321

Inflammatory bowel disease

map05323

Rheumatoid arthritis

map05410

Hypertrophic cardiomyopathy

map05414

Dilated cardiomyopathy

map05415

Diabetic cardiomyopathy

Disease

H00083

Allograft rejection

H00084

Graft-versus-host disease

H00218

Cystic fibrosis

H00434

Camurati-Engelmann disease

H02669

Inflammatory bowel disease, immunodeficiency, and encephalopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K13375  TGFB1; transforming growth factor beta-1
   04350 TGF-beta signaling pathway
    K13375  TGFB1; transforming growth factor beta-1
   04390 Hippo signaling pathway
    K13375  TGFB1; transforming growth factor beta-1
   04068 FoxO signaling pathway
    K13375  TGFB1; transforming growth factor beta-1
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K13375  TGFB1; transforming growth factor beta-1
09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    K13375  TGFB1; transforming growth factor beta-1
  09143 Cell growth and death
   04110 Cell cycle
    K13375  TGFB1; transforming growth factor beta-1
   04218 Cellular senescence
    K13375  TGFB1; transforming growth factor beta-1
09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K13375  TGFB1; transforming growth factor beta-1
   04672 Intestinal immune network for IgA production
    K13375  TGFB1; transforming growth factor beta-1
  09152 Endocrine system
   04926 Relaxin signaling pathway
    K13375  TGFB1; transforming growth factor beta-1
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K13375  TGFB1; transforming growth factor beta-1
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K13375  TGFB1; transforming growth factor beta-1
   05205 Proteoglycans in cancer
    K13375  TGFB1; transforming growth factor beta-1
  09162 Cancer: specific types
   05210 Colorectal cancer
    K13375  TGFB1; transforming growth factor beta-1
   05212 Pancreatic cancer
    K13375  TGFB1; transforming growth factor beta-1
   05225 Hepatocellular carcinoma
    K13375  TGFB1; transforming growth factor beta-1
   05226 Gastric cancer
    K13375  TGFB1; transforming growth factor beta-1
   05220 Chronic myeloid leukemia
    K13375  TGFB1; transforming growth factor beta-1
   05211 Renal cell carcinoma
    K13375  TGFB1; transforming growth factor beta-1
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K13375  TGFB1; transforming growth factor beta-1
   05161 Hepatitis B
    K13375  TGFB1; transforming growth factor beta-1
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    K13375  TGFB1; transforming growth factor beta-1
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K13375  TGFB1; transforming growth factor beta-1
   05144 Malaria
    K13375  TGFB1; transforming growth factor beta-1
   05145 Toxoplasmosis
    K13375  TGFB1; transforming growth factor beta-1
   05140 Leishmaniasis
    K13375  TGFB1; transforming growth factor beta-1
   05142 Chagas disease
    K13375  TGFB1; transforming growth factor beta-1
  09163 Immune disease
   05323 Rheumatoid arthritis
    K13375  TGFB1; transforming growth factor beta-1
   05321 Inflammatory bowel disease
    K13375  TGFB1; transforming growth factor beta-1
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K13375  TGFB1; transforming growth factor beta-1
   05414 Dilated cardiomyopathy
    K13375  TGFB1; transforming growth factor beta-1
   05415 Diabetic cardiomyopathy
    K13375  TGFB1; transforming growth factor beta-1
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K13375  TGFB1; transforming growth factor beta-1
   04933 AGE-RAGE signaling pathway in diabetic complications
    K13375  TGFB1; transforming growth factor beta-1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts
    K13375  TGFB1; transforming growth factor beta-1
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K13375  TGFB1; transforming growth factor beta-1
   00536 Glycosaminoglycan binding proteins
    K13375  TGFB1; transforming growth factor beta-1
Chaperones and folding catalysts [BR:ko03110]
Intramolecular chaperones
  Others
   K13375  TGFB1; transforming growth factor beta-1
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Transforming growth factors (RSTK binding)
   K13375  TGFB1; transforming growth factor beta-1
Glycosaminoglycan binding proteins [BR:ko00536]
Heparan sulfate / Heparin
  Growth factors/receptors
   K13375  TGFB1; transforming growth factor beta-1

Genes

HSA:	7040(TGFB1)

PTR:	456060(TGFB1)

PPS:	100980947(TGFB1)

GGO:	101124474(TGFB1)

PON:	100459982(TGFB1)

PPYG:

129021011(TGFB1)

NLE:	100581386(TGFB1)

HMH:	116480647(TGFB1)

SSYN:

129466443(TGFB1)

MCC:	106992315(TGFB1)

MCF:	102129546(TGFB1)

MTHB:

126941768

MNI:	105495300(TGFB1)

CSAB:

103234729(TGFB1)

CATY:

105598017(TGFB1)

PANU:

101006627(TGFB1)

TGE:	112612158(TGFB1)

MLEU:

105542552(TGFB1)

RRO:	104676086(TGFB1)

RBB:	108536158(TGFB1)

TFN:	117075968(TGFB1)

PTEH:

111554142(TGFB1)

CANG:

105507882(TGFB1)

CJC:	100401979(TGFB1)

SBQ:	101047980(TGFB1)

CIMI:

108285710(TGFB1)

ANAN:

105723444(TGFB1)

CSYR:

103254633(TGFB1)

MMUR:

105869115(TGFB1)

LCAT:

123624079(TGFB1)

PCOQ:

105820566(TGFB1)

OGA:	100949640(TGFB1)

MMU:	21803(Tgfb1)

MCAL:

110298438(Tgfb1)

MPAH:

110336543(Tgfb1)

RNO:	59086(Tgfb1)

MCOC:

116101857(Tgfb1)

ANU:	117713589(Tgfb1)

MUN:	110561197(Tgfb1)

CGE:	100773359(Tgfb1)

MAUA:

101834601(Tgfb1)

PROB:

127238425(Tgfb1)

PLEU:

114685302(Tgfb1)

MORG:

121449432(Tgfb1)

MFOT:

126494578

AAMP:

119821456(Tgfb1)

NGI:	103751514(Tgfb1)

HGL:	101704230(Tgfb1)

CPOC:

100135628(Tgfb1)

CCAN:

109685632(Tgfb1)

DORD:

106000874(Tgfb1)

DSP:	122097410(Tgfb1)

PLOP:

125338685(Tgfb1)

NCAR:

124967085

MMMA:

107151630(Tgfb1)

OCU:	100008645(TGFB1) 100352301 103345448

OPI:	101529904 101533379(TGFB1)

TUP:	102488524(TGFB1)

GVR:	103599185 103599191

CFA:	403998(TGFB1)

CLUD:

112645426(TGFB1)

VVP:	112928349(TGFB1)

VLG:	121485274(TGFB1)

NPO:	129500810(TGFB1)

AML:	100470703(TGFB1)

UMR:	103677394(TGFB1)

UAH:	113243540(TGFB1)

UAR:	123781846(TGFB1)

ELK:

111161420

LLV:

125089683

MPUF:

101670127(TGFB1)

MNP:	132005078(TGFB1)

MLK:	131817494(TGFB1)

NVS:	122912064(TGFB1)

ORO:	101385166(TGFB1)

EJU:	114202548(TGFB1)

ZCA:	113936424(TGFB1)

MLX:	118022632(TGFB1)

NSU:	110590084(TGFB1)

LWW:	102747528(TGFB1)

FCA:	768263(TGFB1)

PYU:	121018482(TGFB1)

PCOO:

112850697(TGFB1)

PBG:	122494005(TGFB1)

PVIV:

125152868(TGFB1)

LRUF:

124511094

PTG:	102951285(TGFB1)

PPAD:

109257972 109258015

PUC:

125915432

AJU:

106987682

HHV:	120243258(TGFB1)

BTA:	282089(TGFB1)

BOM:	102283357(TGFB1)

BIU:	109572866(TGFB1)

BBUB:

102413660(TGFB1)

BBIS:

104995381(TGFB1)

CHX:	102191364(TGFB1)

OAS:	443417(TGFB1)

BTAX:

128063320(TGFB1)

CSUM:

138095833(TGFB1)

ODA:	120872413(TGFB1)

CCAD:

122420314(TGFB1)

MREE:

136161363(TGFB1)

MBEZ:

129546785(TGFB1)

SSC:	397078(TGFB1)

CFR:	102509937(TGFB1)

CBAI:

105062879(TGFB1)

CDK:	105093367(TGFB1)

VPC:	102539136(TGFB1)

BACU:

103002687(TGFB1)

BMUS:

118885169(TGFB1)

LVE:	103075846(TGFB1)

OOR:	101286197(TGFB1)

DLE:	111180824(TGFB1)

PCAD:

102975643(TGFB1)

PSIU:

116743550(TGFB1)

NASI:

112415266(TGFB1)

ECB:	100033900(TGFB1)

EPZ:	103562543(TGFB1)

EAI:	106843812(TGFB1)

MYB:	102262083(TGFB1)

MYD:	102752983(TGFB1)

MMYO:

118674276(TGFB1)

MLF:	102435068(TGFB1)

MDT:	132216839(TGFB1)

PKL:	118702316(TGFB1)

EFUS:

103284692(TGFB1)

MNA:	107534176(TGFB1)

DRO:	112320009(TGFB1)

SHON:

118982068(TGFB1)

AJM:	119058462(TGFB1)

PDIC:

114510965(TGFB1)

PHAS:

123823713(TGFB1)

MMF:	118638486(TGFB1)

PPAM:

129076675(TGFB1)

HAI:	109376590(TGFB1)

RFQ:	117035087(TGFB1)

PALE:

102884154(TGFB1)

PGIG:

120586591(TGFB1)

PVP:	105307945(TGFB1)

RAY:	107505490(TGFB1)

MJV:	108383720(TGFB1)

TOD:	119248636 119249350(TGFB1)

SARA:

101551346(TGFB1)

SETR:

126028183(TGFB1)

LAV:	100667634(TGFB1)

TMU:

101342543

ETF:	101650988(TGFB1)

DNM:	101437737(TGFB1)

MDO:	100019183(TGFB1)

GAS:	123256028(TGFB1)

SHR:	100932607(TGFB1)

AFZ:

127556228

PCW:	110202366(TGFB1)

TVP:	118838177(TGFB1)

PBRV:

138153908(TGFB1)

OAA:	114812005(TGFB1)

GGA:	100873157(TGFB1)

PCOC:

116241290

CJO:	107307103(TGFB1)

LSR:

110482796

FAB:	101818496(TGFB1)

OMA:	130266108(TGFB1)

PHI:	102112781(TGFB1)

PMAJ:

107198990(TGFB1)

CCAE:

111942551

ACOE:

138101275 138101281

ZLE:	135441732(TGFB1)

SHAB:

115603255(TGFB1)

AGEN:

126036615

HHAR:

128138108(TGFB1)

GCL:

127028058

AROW:

112965764

ASN:	102369002(TGFB1)

AMJ:	102567067(TGFB1)

CMY:	114022153(TGFB1)

CCAY:

125628071(TGFB1)

DCC:	119847152(TGFB1)

CPIC:

101937891(TGFB1)

CABI:

116833884(TGFB1)

MRV:

120388881

ACS:	100553920(tgfb1)

ASAO:

132780051(TGFB1)

PVT:	110088538(TGFB1)

SUND:

121917546 121917598

PBI:	103064413(TGFB1)

PMUR:

107295274(TGFB1)

CTIG:

120319885(TGFB1)

TSR:	106551445(TGFB1)

PGUT:

117677694(TGFB1)

APRI:

131204693(TGFB1)

PTEX:

113445961(TGFB1)

NSS:	113426022(TGFB1)

VKO:	123025913(TGFB1)

PMUA:

114603306(TGFB1)

PRAF:

128418274(TGFB1)

ZVI:	118086683(TGFB1)

HCG:	128332607(TGFB1)

GJA:	107123911(TGFB1)

STOW:

125434165(TGFB1)

EMC:	129343744(TGFB1)

XLA:	108700276(tgfb1.S) 397778(tgfb1.L)

XTR:	100498430(tgfb1)

NPR:

108800768

RTEM:

120913378(TGFB1)

BBUF:

121009227(TGFB1)

BGAR:

122946366 122946419

MUO:	115480705(TGFB1)

GSH:	117365844(TGFB1)

DRE:	359834(tgfb1a) 563884(tgfb1b)

SRX:	107706521 107744019 107745447 107754964

SANH:

107680100 107681095 107703499 107703980

SGH:	107551248 107573058 107589304 107598564

CCAR:

109047284 109055145 109103035 109103040

CAUA:

113038645 113038646 113058184 113064252 113115386

CGIB:

127942123 127973105 127985940 128028714

PTET:

122326853(tgfb1b) 122358909(tgfb1a)

LROH:

127152294(tgfb1b) 127177456(tgfb1a)

OMC:	131520886(tgfb1a) 131528700(tgfb1b)

PPRM:

120465196(tgfb1a) 120490762(tgfb1b)

RKG:	130096464(tgfb1b) 130104467(tgfb1a)

MAMB:

125249338(tgfb1a) 125252540(tgfb1b)

CIDE:

127495355 127503585

CERY:

137004117(tgfb1a) 137012525(tgfb1b)

MASI:

127422282 127428507 127429503 127430733

TROS:

130564574(tgfb1a) 130570154(tgfb1b)

TDW:	130408414(tgfb1b) 130428583(tgfb1a)

MANU:

129423621(tgfb1b) 129437532(tgfb1a)

IPU:	108279384(tgfb1b) 108280750(tgfb1a)

IFU:	128622552(tgfb1b) 128624118(tgfb1a)

PHYP:

113541584 113543081

SMEO:

124397911(tgfb1b) 124402798(tgfb1a)

TFD:	113651967(tgfb1b) 113653216(tgfb1a)

TVC:	132849264(tgfb1a) 132860460(tgfb1b)

TRN:	134302490(tgfb1a) 134330170(tgfb1b)

AMEX:

103024607(tgfb1a) 103033069(tgfb1b)

CMAO:

118796969(tgfb1a) 118819844(tgfb1b)

EEE:	113573801 113590492

CHAR:

105890611 105904460(tgfb1b)

TRU:	101074275(tgf-beta1)

TFS:	130534625(tgfb1a)

TNG:	GSTEN00035186G001

LCO:

109141681

NCC:

104950840

TBEN:

117471062(tgfb1a)

CGOB:

115017895

PGEO:

117457172(tgfb1a)

GACU:

117555603(tgfb1a)

ELY:	117259934(tgfb1a)

EFO:	125888922(tgfb1a)

PLEP:

121943219(tgfb1a)

SLUC:

116039943(tgfb1a)

ECRA:

117941999(tgfb1a)

ESP:

116682862

PFLV:

114552362

GAT:	120821525(tgfb1a)

PPUG:

119217376(tgfb1a)

AFB:	129090601(tgfb1a)

CLUM:

117741227(tgfb1a)

PSWI:

130210959(tgfb1a)

CANA:

137790230(tgfb1a)

CVE:	137874610(tgfb1a)

MSAM:

119882881(tgfb1a)

SCHU:

122879501(tgfb1a)

CUD:	121521145(tgfb1a)

ALAT:

119009263(tgfb1a)

ASTR:

137596754(tgfb1a)

MZE:

101473892

ONL:	100694653(tgfb1a)

OAU:	116320331(tgfb1a)

OLA:

101157631

OML:	112149754(tgfb1a)

CSAI:

133442009(tgfb1a)

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122832892(tgfb1a)

PPRL:

129358768(tgfb1a)

CVG:

107103699

CTUL:

119784075(tgfb1a)

GMU:	124884769(tgfb1a)

NFU:

107379821

KMR:	108228916(tgfb1a)

ALIM:

106529655

NWH:	119411428(tgfb1a)

AOCE:

111581736

EJA:	138205254(tgfb1a)

MCEP:

125013476(tgfb1a)

CSEM:

103377845

POV:

109630415

SSEN:

122773574(tgfb1a)

HHIP:

117772384(tgfb1a)

HSP:	118105944(tgfb1a)

PPLT:

128440037(tgfb1a)

SMAU:

118299716(tgfb1a)

LCF:	108876160(tgfb1a)

SDU:

111216899

SLAL:

111662255

XGL:	120791875(tgfb1a)

HCQ:

109510758

SSCV:

125972061(tgfb1a)

SBIA:

133504741(tgfb1a)

PEE:	133405086(tgfb1a)

PTAO:

133482292(tgfb1a)

BPEC:

110163549

MALB:

109963227

BSPL:

114867748(tgfb1a)

SJO:	128360542(tgfb1a)

SASA:

100136559(TGFB1) 106563563(TGF-beta) 106613337

STRU:

115154758 115204365 115206692

OTW:	112228884 112231247 112240152

OMY:	100136774 101268942(tgfb1a) 110534057 118936254(tgfb1a)

OGO:	124006497(tgfb1a) 124006978 124007511

ONE:	115101394 115135570

OKI:	109873349 109874437 109882711

OKE:	118381881(tgfb1a) 118385063 118390427

SALP:

111950026 111964258 112070992

SNH:	120021386 120028313(tgfb1a) 120056617

CCLU:

121541234 121541907 121567690 121579543

ELS:	105010856 105027026

SFM:	108924734 108933453

PKI:	111838013 111841476

AANG:

118209403 118236609(tgfb1a)

LOC:	102698936(tgfb1)

PSPA:

121304906

ARUT:

117394578

PSEX:

120538772

LCM:	102364242(TGFB1)

» show all

Reference

PMID:3470709

Authors

Derynck R, Rhee L, Chen EY, Van Tilburg A

Title

Intron-exon structure of the human transforming growth factor-beta precursor gene.

Journal

Nucleic Acids Res 15:3188-9 (1987)
DOI:10.1093/nar/15.7.3188

Sequence

[hsa:7040]

LinkDB

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