KEGG ORTHOLOGY: K12568

ORTHOLOGY: K12568

Entry

K12568                      KO

Symbol

MYBPC3

Name

myosin-binding protein C, cardiac-type

Pathway

map04820

Cytoskeleton in muscle cells

map05410

Hypertrophic cardiomyopathy

map05414

Dilated cardiomyopathy

Disease

H00292

Hypertrophic cardiomyopathy

H00294

Dilated cardiomyopathy

H01216

Left ventricular noncompaction

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09142 Cell motility
   04820 Cytoskeleton in muscle cells
    K12568  MYBPC3; myosin-binding protein C, cardiac-type
09160 Human Diseases
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K12568  MYBPC3; myosin-binding protein C, cardiac-type
   05414 Dilated cardiomyopathy
    K12568  MYBPC3; myosin-binding protein C, cardiac-type

Genes

HSA:	4607(MYBPC3)

PTR:	451168(MYBPC3)

PPS:	100970200(MYBPC3)

GGO:	101135116(MYBPC3)

PON:	100452875(MYBPC3)

NLE:	100597511(MYBPC3)

HMH:	116476276(MYBPC3)

MCC:	712093(MYBPC3)

MCF:	102136226 102143947(MYBPC3)

MTHB:

126932340 126936394

MNI:	105471685(MYBPC3)

CSAB:

103242082(MYBPC3)

CATY:

105592817(MYBPC3)

PANU:

101023930(MYBPC3) 116269826 116273503

TGE:	112606348(MYBPC3)

MLEU:

105554820(MYBPC3)

RRO:	104668410(MYBPC3)

RBB:	108521947(MYBPC3)

TFN:	117080143(MYBPC3)

PTEH:

111544802(MYBPC3)

CANG:

105527132(MYBPC3)

CJC:	100397177(MYBPC3)

SBQ:	101028426(MYBPC3)

CIMI:

108304845(MYBPC3)

CSYR:

103251527(MYBPC3)

MMUR:

105884826(MYBPC3)

LCAT:

123642674(MYBPC3)

PCOQ:

105811045(MYBPC3)

OGA:	100964819(MYBPC3)

MMU:	17868(Mybpc3)

MCAL:

110284709(Mybpc3)

MPAH:

110317766(Mybpc3)

RNO:	295929(Mybpc3)

MCOC:

116090462(Mybpc3)

ANU:	117703373(Mybpc3)

MUN:	110550747(Mybpc3)

CGE:	100763069(Mybpc3)

MAUA:

101844507(Mybpc3)

PROB:

127222252(Mybpc3)

PLEU:

114699683(Mybpc3)

MORG:

121437668(Mybpc3)

MFOT:

126489774

AAMP:

119815274(Mybpc3)

NGI:	103742511(Mybpc3)

HGL:	101708550(Mybpc3)

CPOC:

100726817(Mybpc3)

CCAN:

109696197(Mybpc3)

DORD:

105996035(Mybpc3)

DSP:	122105354(Mybpc3)

PLOP:

125361428(Mybpc3)

NCAR:

124960238

MMMA:

107134600(Mybpc3)

OCU:

100346773

OPI:	101527713(MYBPC3)

TUP:	102474589(MYBPC3)

GVR:	103592090(MYBPC3)

CFA:	483624(MYBPC3)

CLUD:

112663323(MYBPC3)

VVP:	112923986(MYBPC3)

VLG:	121472215(MYBPC3)

NPO:	129503161(MYBPC3)

AML:	100476063(MYBPC3)

UMR:	103672388(MYBPC3)

UAH:	113264965(MYBPC3)

UAR:	123785131(MYBPC3)

ELK:

111149549

LLV:

125078752

MPUF:

101690976(MYBPC3)

MNP:	132008237 132008432

MLK:	131812420(MYBPC3)

NVS:	122914317(MYBPC3)

ORO:	101375851(MYBPC3)

EJU:	114215179(MYBPC3)

ZCA:	113915256(MYBPC3)

MLX:	118015832(MYBPC3)

NSU:	110575772(MYBPC3)

LWW:	102745115(MYBPC3)

FCA:	101094698(MYBPC3)

PYU:	121043452(MYBPC3)

PCOO:

112865191(MYBPC3)

PBG:	122484435(MYBPC3)

PVIV:

125147008(MYBPC3)

LRUF:

124506124

PTG:	102951375(MYBPC3)

PPAD:

109245117(MYBPC3)

PUC:

125934091

AJU:

106978063

HHV:	120228481(MYBPC3)

BTA:	767614(MYBPC3)

BOM:	102280788(MYBPC3)

BIU:	109569053(MYBPC3)

BBUB:

102397518(MYBPC3)

BBIS:

104990391(MYBPC3)

CHX:	102186137(MYBPC3)

OAS:	101119505(MYBPC3)

BTAX:

128060158(MYBPC3)

ODA:	120876955(MYBPC3)

CCAD:

122449571(MYBPC3)

MBEZ:

129554819(MYBPC3)

SSC:	100628050(MYBPC3)

CFR:	102512554(MYBPC3)

CBAI:

105076447(MYBPC3)

CDK:	105106876(MYBPC3)

VPC:	102528798(MYBPC3)

BACU:

102998160(MYBPC3)

BMUS:

118899820(MYBPC3)

LVE:	103075643(MYBPC3)

OOR:	101288961(MYBPC3)

DLE:	111184070(MYBPC3)

PCAD:

102974892 114487947

PSIU:

116758703(MYBPC3)

NASI:

112402473(MYBPC3)

ECB:	100057959(MYBPC3)

EPZ:	103561120(MYBPC3)

EAI:	106844012(MYBPC3)

MYB:	102245724(MYBPC3)

MYD:	102769548(MYBPC3)

MMYO:

118665061(MYBPC3)

MLF:	102442564(MYBPC3)

PKL:	118713060(MYBPC3)

EFUS:

103291019(MYBPC3)

MNA:	107530269(MYBPC3)

DRO:	112303174(MYBPC3)

SHON:

118974534(MYBPC3)

AJM:	119064453(MYBPC3)

PDIC:

114499001(MYBPC3)

PHAS:

123810081(MYBPC3)

MMF:	118628656(MYBPC3)

PPAM:

129081470(MYBPC3)

HAI:	109390178(MYBPC3)

RFQ:	117029987(MYBPC3)

PALE:

102880234(MYBPC3)

PGIG:

120607159(MYBPC3)

PVP:	105290034(MYBPC3)

RAY:	107511848(MYBPC3)

MJV:	108383732(MYBPC3)

TOD:	119254311(MYBPC3)

SARA:

101556114(MYBPC3)

SETR:

126018601(MYBPC3)

LAV:	100656664 100665230(MYBPC3)

TMU:

101361471

ETF:	101660162(MYBPC3)

DNM:	101434430(MYBPC3)

MDO:	100016276(MYBPC3)

GAS:	123252578(MYBPC3)

SHR:	100917019(MYBPC3)

AFZ:

127540915

PCW:	110223922(MYBPC3)

OAA:	100082389(MYBPC3)

GGA:	396013(MYBPC3)

PCOC:

116228992(MYBPC3)

MGP:

100551308

CJO:	107314740(MYBPC3)

TPAI:

128086331(MYBPC3)

LMUT:

125695466(MYBPC3)

NMEL:

110400979(MYBPC3)

APLA:

101804232(MYBPC3)

ACYG:

106043779(MYBPC3)

CATA:

118249812(MYBPC3)

AFUL:

116489603(MYBPC3)

TGU:	100220915(MYBPC3)

LSR:	110472057(MYBPC3)

SCAN:

103826696(MYBPC3)

PMOA:

120500413(MYBPC3)

OTC:	121347622(MYBPC3)

PRUF:

121349393(MYBPC3)

GFR:	102036581(MYBPC3)

FAB:	101815991(MYBPC3)

OMA:	130253740(MYBPC3)

PHI:	102111997(MYBPC3)

PMAJ:

107205761(MYBPC3)

CCAE:

111930171(MYBPC3)

CCW:	104697853(MYBPC3)

CBRC:

103620922(MYBPC3)

ETL:	114058800(MYBPC3)

ZAB:	102072106(MYBPC3)

ACHL:

103797595(MYBPC3)

SVG:	106856526(MYBPC3)

MMEA:

130572362(MYBPC3)

HRT:	120754622(MYBPC3)

FPG:	101910468(MYBPC3)

FCH:	102058773(MYBPC3)

CLV:	102086395(MYBPC3)

EGZ:	104134106(MYBPC3)

NNI:	104020386(MYBPC3)

PCRI:

104036409(MYBPC3)

PLET:

104619186(MYBPC3)

EHS:	104508425(MYBPC3)

PCAO:

104043988(MYBPC3)

ACUN:

113480597(MYBPC3)

TALA:

104362482(MYBPC3)

PADL:

103921731(MYBPC3)

AFOR:

103897538(MYBPC3)

ACHC:

115338123(MYBPC3)

HALD:

104317175(MYBPC3)

HLE:	104839702(MYBPC3)

AGEN:

126049434

GCL:

127016355

CCRI:

104159362(MYBPC3)

CSTI:

104561762(MYBPC3)

CMAC:

104483403(MYBPC3)

BREG:

104633810(MYBPC3)

FGA:	104077824(MYBPC3)

GSTE:

104254166

LDI:	104350798(MYBPC3)

MNB:	103776568(MYBPC3)

OHA:	104328143(MYBPC3)

NNT:

104412410

SHAB:

115606591(MYBPC3)

DPUB:

104297429(MYBPC3)

PGUU:

104469685(MYBPC3)

ACAR:

104530022

CPEA:

104390406(MYBPC3)

CVF:	104295850(MYBPC3)

RTD:	128909156(MYBPC3)

CUCA:

104067352(MYBPC3)

TEO:

104373402

BRHI:

104488066(MYBPC3)

AAM:	106498120(MYBPC3)

AROW:

112973937(MYBPC3)

NPD:	112943821(MYBPC3)

TGT:	104571235(MYBPC3)

DNE:	112979234(MYBPC3)

SCAM:

104149271(MYBPC3)

ASN:	102374181(MYBPC3)

AMJ:	102558720(MYBPC3)

CPOO:

109321517(MYBPC3)

GGN:	109298890(MYBPC3)

PSS:	102455683(MYBPC3)

CMY:	102939270(MYBPC3)

CCAY:

125638667(MYBPC3)

DCC:	119857316(MYBPC3)

CPIC:

101942758(MYBPC3)

TST:	117876913(MYBPC3)

CABI:

116825881(MYBPC3)

MRV:	120403673(MYBPC3)

ACS:	100554792(mybpc3)

ASAO:

132767806(MYBPC3)

PVT:	110082151(MYBPC3)

SUND:

121919751(MYBPC3)

PBI:	103059827 103067958

PMUR:

107289842(MYBPC3)

CTIG:

120314617(MYBPC3)

TSR:	106552446(MYBPC3)

PGUT:

117666169(MYBPC3)

APRI:

131187482(MYBPC3)

PTEX:

113441213(MYBPC3)

NSS:	113414343(MYBPC3)

VKO:	123026510(MYBPC3)

PMUA:

114595726(MYBPC3)

PRAF:

128413046(MYBPC3)

ZVI:	118084669(MYBPC3)

HCG:	128328504(MYBPC3)

GJA:	107123205(MYBPC3)

STOW:

125427208(MYBPC3)

EMC:	129323419(MYBPC3)

XLA:	108713456(mybpc3.L) 398261(mybpc3.S)

XTR:	100127177(mybpc3)

NPR:	108791597(MYBPC3)

RTEM:

120917158(MYBPC3)

BBUF:

120980236(MYBPC3)

BGAR:

122920210(MYBPC3)

MUO:	115469644(MYBPC3)

GSH:	117352251(MYBPC3)

DRE:	556489(mybpc3)

SRX:	107740474 107755066(mybpc3)

SANH:

107670721 107700455

SGH:	107554890 107595066(mybpc3)

CCAR:

109095236(mybpc3) 109102750

CAUA:

113051548 113105964

CGIB:

127962664 128016945

PTET:

122348837(mybpc3)

LROH:

127168316(mybpc3)

OMC:	131543529(mybpc3)

PPRM:

120475983(mybpc3)

RKG:	130083016(mybpc3)

MAMB:

125264744(mybpc3)

CIDE:

127516384

MASI:

127451329 127455763

TROS:

130560798(mybpc3)

TDW:	130429699(mybpc3)

MANU:

129443201(mybpc3)

IPU:

108259630

IFU:	128602718(mybpc3)

PHYP:

113540892(mybpc3)

SMEO:

124379659(mybpc3)

TFD:	113636698(mybpc3)

TVC:	132838625(mybpc3)

AMEX:

103036358(mybpc3)

CMAO:

118817466(mybpc3)

EEE:	113576706(mybpc3)

CHAR:

105893037(mybpc3)

TRU:	101066948(mybpc3)

TFS:	130521878(mybpc3)

TNG:	GSTEN00017866G001

LCO:	104919251(mybpc3)

NCC:	104940772(mybpc3)

TBEN:

117471848(mybpc3)

CGOB:

115004496(mybpc3)

PGEO:

117466863(mybpc3)

GACU:

117546808(mybpc3)

EMAC:

134863685(mybpc3)

ELY:	117256133(mybpc3)

EFO:	125900786(mybpc3)

PLEP:

121937581(mybpc3)

SLUC:

116067781(mybpc3)

ECRA:

117949770(mybpc3)

ESP:	116677634(mybpc3)

PFLV:

114563650(mybpc3)

GAT:	120832164(mybpc3)

PPUG:

119195717(mybpc3)

AFB:	129106046(mybpc3)

CLUM:

117749607(mybpc3)

PSWI:

130192519(mybpc3)

MSAM:

119889785(mybpc3)

SCHU:

122880952(mybpc3)

CUD:	121512242(mybpc3)

ALAT:

119017736(mybpc3)

MZE:	101484191(mybpc3)

ONL:	100690737(mybpc3)

OAU:	116327213(mybpc3)

OLA:	101167858(mybpc3)

OML:	112160511(mybpc3)

CSAI:

133461335(mybpc3)

XMA:	102233302(mybpc3)

XCO:	114143388(mybpc3)

XHE:	116718321(mybpc3)

PRET:

103462402(mybpc3)

PFOR:

103139315 103139407(mybpc3)

PLAI:

106945290 106946992(mybpc3)

PMEI:

106909674 106909989

GAF:	122822195(mybpc3)

PPRL:

129369676(mybpc3)

CVG:	107091201(mybpc3)

CTUL:

119782743(mybpc3)

GMU:	124866477(mybpc3)

NFU:	107381470(mybpc3)

KMR:	108228883(mybpc3)

ALIM:

106530463(mybpc3)

NWH:	119425115(mybpc3)

AOCE:

111567318

MCEP:

125005330(mybpc3)

CSEM:

103378697(mybpc3)

POV:	109625197(mybpc3)

SSEN:

122772595(mybpc3)

HHIP:

117754005(mybpc3)

HSP:	118108502(mybpc3)

SMAU:

118302071(mybpc3)

LCF:

108889687

SDU:	111238440(mybpc3)

SLAL:

111668337(mybpc3)

XGL:	120785289(mybpc3)

HCQ:	109514300(mybpc3)

SSCV:

125967660

SBIA:

133498530(mybpc3)

PEE:	133399194(mybpc3)

PTAO:

133470451(mybpc3)

BPEC:

110173105(mybpc3)

MALB:

109963594(mybpc3)

BSPL:

114851747(mybpc3)

SJO:	128359453(mybpc3)

SASA:

106563522 106587482

STRU:

115167118 115203214

OTW:	112249597 112263800

OMY:	110506650 110526520(mybpc3)

OGO:	124033655 124035635

ONE:	115112415 115113705

OKI:	109888417 109895336

OKE:	118360190 118393969

SALP:

111969470 111974997

SNH:	120024804 120052732

CCLU:

121556303 123481013

ELS:	105022248(mybpc3)

SFM:	108939285(mybpc3)

PKI:	111843323 111851935

AANG:

118227395(mybpc3)

LOC:	102684297(mybpc3)

PSPA:

121294572 121329842

ARUT:

117432349 117434953

PSEX:

120529954(mybpc3)

LCM:	102360344(MYBPC3)

RTP:	109930779(mybpc3)

CPLA:

122558014

HOC:

132824336

LERI:

129705931(mybpc3)

PMRN:

LRJ:

CIN:

SCLV:

MMER:

Reference

PMID:7744002

Authors

Gautel M, Zuffardi O, Freiburg A, Labeit S

Title

Phosphorylation switches specific for the cardiac isoform of myosin binding protein-C: a modulator of cardiac contraction?

Journal

EMBO J 14:1952-60 (1995)
DOI:10.1002/j.1460-2075.1995.tb07187.x

Sequence

[hsa:4607]

Reference

PMID:9048664

Authors

Carrier L, Bonne G, Bahrend E, Yu B, Richard P, Niel F, Hainque B, Cruaud C, Gary F, Labeit S, Bouhour JB, Dubourg O, Desnos M, Hagege AA, Trent RJ, Komajda M, Fiszman M, Schwartz K

Title

Organization and sequence of human cardiac myosin binding protein C gene (MYBPC3) and identification of mutations predicted to produce truncated proteins in familial hypertrophic cardiomyopathy.

Journal

Circ Res 80:427-34 (1997)
DOI:10.1161/01.res.0000435859.24609.b3

Sequence

[hsa:4607]

LinkDB

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