KEGG   NETWORK: N00233Help
Entry
N00233                      Network                                

Name
IGF2-IGF1R-RAS-ERK signaling pathway
Definition
IGF2 -> IGF1R -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
  Expanded
3481 -> 3480 -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595)
Class
nt06210 ERK signaling
nt06263 Hepatocellular carcinoma
Type
Reference
Pathway
hsa04010  MAPK signaling pathway
hsa04014  Ras signaling pathway
Gene
3481  IGF2; insulin like growth factor 2
3480  IGF1R; insulin like growth factor 1 receptor
2885  GRB2; growth factor receptor bound protein 2
6654  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
6655  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
Reference
  Authors
Aaltonen KE, Rosendahl AH, Olsson H, Malmstrom P, Hartman L, Ferno M
  Title
Association between insulin-like growth factor-1 receptor (IGF1R) negativity and poor prognosis in a cohort of women with primary breast cancer.
  Journal
BMC Cancer 14:794 (2014)
DOI:10.1186/1471-2407-14-794
Reference
  Authors
Iams WT, Lovly CM
  Title
Molecular Pathways: Clinical Applications and Future Direction of Insulin-like Growth Factor-1 Receptor Pathway Blockade.
  Journal
Clin Cancer Res 21:4270-7 (2015)
DOI:10.1158/1078-0432.CCR-14-2518
LinkDB All DBs

DBGET integrated database retrieval system