KEGG   PATHWAY: slal04340
Entry
slal04340                   Pathway                                
Name
Hedgehog signaling pathway - Seriola lalandi dorsalis (Yellowtail amberjack)
Description
The Hedgehog (Hh) signaling pathway has numerous roles in the control of cell proliferation, tissue patterning, stem cell maintenance and development. The primary cilium is an important center for transduction of the Hedgehog signal in vertebrates. In Hh's absence, the Ptch receptor localizes to the cilium, where it inhibits Smo activation. Gli proteins are phosphorylated by PKA, CKI and GSK3B and partially degraded into truncated Gli repressor form (GliR) that suppresses Hh target gene transcription in the nucleus. In Hh's presence, Ptch disappears from the cilium, and activated Smo contributes to the translocation of the protein complex Gli, Sufu, Kif7 to ciliary tip, where Gli dissociates from the negative regulator Sufu. The production of Gli activator form (GliA) occurs and the increased nuclear accumulation of GliA results in activation transcription of Hh target genes.
Class
Environmental Information Processing; Signal transduction
Pathway map
slal04340  Hedgehog signaling pathway
slal04340

Organism
Seriola lalandi dorsalis (Yellowtail amberjack) [GN:slal]
Gene
111644627  ptch1; protein patched homolog 1 isoform X1 [KO:K06225]
111654484  ptch2; protein patched homolog 2 [KO:K11101]
111668893  smo; smoothened homolog [KO:K06226]
111662146  gpr161; G-protein coupled receptor 161 [KO:K08439]
111653688  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
111665555  prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
111658500  cAMP-dependent protein kinase catalytic subunit beta-like isoform X1 [KO:K04345] [EC:2.7.11.11]
111663566  csnk1a1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
111648383  casein kinase I-like isoform X1 [KO:K08958] [EC:2.7.11.1]
111654873  casein kinase I isoform X1 [KO:K08958] [EC:2.7.11.1]
111670111  csnk1g1; casein kinase I isoform X1 [KO:K08958] [EC:2.7.11.1]
111664378  csnk1d; casein kinase I isoform X1 [KO:K08959] [EC:2.7.11.1]
111669752  casein kinase I-like [KO:K08959] [EC:2.7.11.1]
111646153  casein kinase I-like [KO:K08960] [EC:2.7.11.1]
111673768  csnk1e; casein kinase I [KO:K08960] [EC:2.7.11.1]
111662131  gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
111659810  gli1; zinc finger protein GLI1 [KO:K16797]
111663022  zinc finger protein GLI2-like isoform X1 [KO:K16798]
111646880  zinc finger protein GLI2-like [KO:K16798]
111645780  gli3; transcriptional activator GLI3 isoform X1 [KO:K06230]
111657305  sufu; suppressor of fused homolog isoform X1 [KO:K06229]
111646280  kif7; kinesin-like protein KIF7 [KO:K18806]
111653610  hhip; hedgehog-interacting protein isoform X1 [KO:K06231]
111647809  G1/S-specific cyclin-D1-like [KO:K04503]
111670038  G1/S-specific cyclin-D1-like [KO:K04503]
111669291  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
111660519  G1/S-specific cyclin-D2-like [KO:K10151]
111660040  G1/S-specific cyclin-D2-like [KO:K10151]
111666072  G1/S-specific cyclin-D2-like [KO:K10151]
111649666  apoptosis regulator Bcl-2-like [KO:K02161]
111666676  apoptosis regulator Bcl-2-like [KO:K02161]
111670485  bcl2; apoptosis regulator Bcl-2 [KO:K02161]
111647272  cul1; cullin-1 isoform X1 [KO:K03347]
111646646  fbxw11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
111645274  hhat; protein-cysteine N-palmitoyltransferase HHAT isoform X1 [KO:K24678] [EC:2.3.1.-]
111666538  protein-cysteine N-palmitoyltransferase HHAT-like protein isoform X1 [KO:K24679]
111656268  hhatl; protein-cysteine N-palmitoyltransferase HHAT-like protein [KO:K24679]
111650879  tiggy-winkle hedgehog protein-like [KO:K11988]
111665139  shh; sonic hedgehog protein [KO:K11988]
111671496  indian hedgehog B protein-like [KO:K11989]
111672455  indian hedgehog B protein-like [KO:K11989]
111668972  desert hedgehog protein A-like isoform X1 [KO:K11990]
111661440  disp1; protein dispatched homolog 1 [KO:K24680]
111650037  scube2; signal peptide, CUB and EGF-like domain-containing protein 2 isoform X1 [KO:K24706]
111662908  boc; brother of CDO [KO:K20020]
111662262  cdon; cell adhesion molecule-related/down-regulated by oncogenes [KO:K20033]
111666760  growth arrest-specific protein 1-like [KO:K06232]
111672236  growth arrest-specific protein 1-like [KO:K06232]
111644615  gas1; growth arrest-specific protein 1 [KO:K06232]
111653055  lrp2; low-density lipoprotein receptor-related protein 2 [KO:K06233]
111648849  low-density lipoprotein receptor-related protein 2-like isoform X1 [KO:K06233]
111652868  low-density lipoprotein receptor-related protein 2-like [KO:K06233]
111667552  uncharacterized protein C16orf52 homolog B [KO:K23663]
111672007  uncharacterized protein C16orf52 homolog A-like isoform X1 [KO:K23663]
111657260  megf8; multiple epidermal growth factor-like domains protein 8 [KO:K23664]
111660553  mgrn1; E3 ubiquitin-protein ligase MGRN1 [KO:K10604] [EC:2.3.2.27]
111659714  E3 ubiquitin-protein ligase SMURF2-like [KO:K04678] [EC:2.3.2.26]
111646327  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
111673792  E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
111664712  grk3; beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
111648821  nucleoprotein TPR-like [KO:K19605]
111670932  evc; ellis-van Creveld syndrome protein [KO:K19605]
111670959  evc2; limbin [KO:K19608]
111645341  efcab7; EF-hand calcium-binding domain-containing protein 7 isoform X1 [KO:K23852]
111672932  iqce; IQ domain-containing protein E [KO:K24677]
111669797  arrestin red cell [KO:K04439]
111667942  arrb2; beta-arrestin-2 [KO:K04439]
111663363  beta-arrestin-1 [KO:K04439]
111652682  kif3a; kinesin-like protein KIF3A [KO:K10394]
111654442  cullin-3-like isoform X1 [KO:K03869]
111655296  cullin-3 isoform X1 [KO:K03869]
111663094  cullin-3-like [KO:K03869]
111652278  speckle-type POZ protein [KO:K10523]
111668769  spopl; speckle-type POZ protein-like [KO:K10523]
111660580  speckle-type POZ protein-like [KO:K10523]
Compound
C00575  3',5'-Cyclic AMP
Reference
PMID:26875496
  Authors
Xavier GM, Seppala M, Barrell W, Birjandi AA, Geoghegan F, Cobourne MT
  Title
Hedgehog receptor function during craniofacial development.
  Journal
Dev Biol 415:198-215 (2016)
DOI:10.1016/j.ydbio.2016.02.009
Reference
PMID:23719536
  Authors
Briscoe J, Therond PP
  Title
The mechanisms of Hedgehog signalling and its roles in development and disease.
  Journal
Nat Rev Mol Cell Biol 14:416-29 (2013)
DOI:10.1038/nrm3598
Reference
PMID:26077918
  Authors
Alman BA
  Title
The role of hedgehog signalling in skeletal health and disease.
  Journal
Nat Rev Rheumatol 11:552-60 (2015)
DOI:10.1038/nrrheum.2015.84
Reference
PMID:26064136
  Authors
Mooney CJ, Hakimjavadi R, Fitzpatrick E, Kennedy E, Walls D, Morrow D, Redmond EM, Cahill PA
  Title
Hedgehog and Resident Vascular Stem Cell Fate.
  Journal
Stem Cells Int 2015:468428 (2015)
DOI:10.1155/2015/468428
Reference
PMID:23799571
  Authors
Sasai N, Briscoe J
  Title
Primary cilia and graded Sonic Hedgehog signaling.
  Journal
Wiley Interdiscip Rev Dev Biol 1:753-72 (2012)
DOI:10.1002/wdev.43
Reference
PMID:20708941
  Authors
Heretsch P, Tzagkaroulaki L, Giannis A
  Title
Modulators of the hedgehog signaling pathway.
  Journal
Bioorg Med Chem 18:6613-24 (2010)
DOI:10.1016/j.bmc.2010.07.038
Reference
PMID:22534646
  Authors
Anderson E, Peluso S, Lettice LA, Hill RE
  Title
Human limb abnormalities caused by disruption of hedgehog signaling.
  Journal
Trends Genet 28:364-73 (2012)
DOI:10.1016/j.tig.2012.03.012
Reference
PMID:18583599
  Authors
Rohatgi R, Scott MP
  Title
Cell biology. Arrestin' movement in cilia.
  Journal
Science 320:1726-7 (2008)
DOI:10.1126/science.1160448
Reference
PMID:24925320
  Authors
Yue S, Tang LY, Tang Y, Tang Y, Shen QH, Ding J, Chen Y, Zhang Z, Yu TT, Zhang YE, Cheng SY
  Title
Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception.
  Journal
Elife 3:e02555 (2014)
DOI:10.7554/eLife.02555
Reference
PMID:22056910
  Authors
Ok CY, Singh RR, Vega F
  Title
Aberrant activation of the hedgehog signaling pathway in malignant hematological neoplasms.
  Journal
Am J Pathol 180:2-11 (2012)
DOI:10.1016/j.ajpath.2011.09.009
Reference
PMID:26366162
  Authors
Hsia EY, Gui Y, Zheng X
  Title
Regulation of Hedgehog signaling by ubiquitination.
  Journal
Front Biol (Beijing) 10:203-220 (2015)
DOI:10.1007/s11515-015-1343-5
Reference
PMID:29290584
  Authors
Pusapati GV, Kong JH, Patel BB, Krishnan A, Sagner A, Kinnebrew M, Briscoe J, Aravind L, Rohatgi R
  Title
CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog.
  Journal
Dev Cell 44:113-129.e8 (2018)
DOI:10.1016/j.devcel.2017.12.003
Reference
PMID:24582806
  Authors
Pusapati GV, Hughes CE, Dorn KV, Zhang D, Sugianto P, Aravind L, Rohatgi R
  Title
EFCAB7 and IQCE regulate hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia.
  Journal
Dev Cell 28:483-96 (2014)
DOI:10.1016/j.devcel.2014.01.021
Reference
PMID:27779865
  Authors
Rodgers UR, Lanyon-Hogg T, Masumoto N, Ritzefeld M, Burke R, Blagg J, Magee AI, Tate EW
  Title
Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells.
  Journal
ACS Chem Biol 11:3256-3262 (2016)
DOI:10.1021/acschembio.6b00896
Related
pathway
slal04120  Ubiquitin mediated proteolysis
KO pathway
ko04340   
LinkDB

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