KEGG ORTHOLOGY: K16798

ORTHOLOGY: K16798

Entry

K16798                      KO

Symbol

GLI2

Name

zinc finger protein GLI2

Pathway

map04340

Hedgehog signaling pathway

map04390

Hippo signaling pathway

map05200

Pathways in cancer

map05217

Basal cell carcinoma

Disease

H00267

Holoprosencephaly

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04340 Hedgehog signaling pathway
    K16798  GLI2; zinc finger protein GLI2
   04390 Hippo signaling pathway
    K16798  GLI2; zinc finger protein GLI2
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K16798  GLI2; zinc finger protein GLI2
  09162 Cancer: specific types
   05217 Basal cell carcinoma
    K16798  GLI2; zinc finger protein GLI2
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K16798  GLI2; zinc finger protein GLI2
Transcription factors [BR:ko03000]
Eukaryotic type
  Zinc finger
   Cys2His2 GLI-like
    K16798  GLI2; zinc finger protein GLI2

Genes

HSA:	2736(GLI2)

PTR:	459582(GLI2)

PPS:	100973775(GLI2)

GGO:	101133942(GLI2)

PON:	100461064(GLI2)

PPYG:

129031979(GLI2)

NLE:	100593982(GLI2)

HMH:	116462943(GLI2)

SSYN:

129472419(GLI2)

MCC:	705877(GLI2)

MCF:	102125979(GLI2)

MTHB:

126932004

MNI:	105492465(GLI2)

CSAB:

103216907(GLI2)

CATY:

105588108(GLI2)

PANU:

101020631(GLI2)

TGE:	112617135 112617179

MLEU:

105542064(GLI2)

RRO:	104672610(GLI2)

RBB:	108542113(GLI2)

TFN:	117095137(GLI2)

PTEH:

111521658(GLI2)

CANG:

105511509(GLI2)

CJC:	100413916(GLI2) 118149682

SBQ:	101053117(GLI2)

CIMI:

108294274(GLI2)

ANAN:

105728115(GLI2) 105734257

CSYR:

103268188

MMUR:

105863026(GLI2)

LCAT:

123643586(GLI2)

PCOQ:

105810638(GLI2)

OGA:	100950930(GLI2)

MMU:	14633(Gli2)

MCAL:

110297010(Gli2)

MPAH:

110321463(Gli2)

RNO:	304729(Gli2)

MCOC:

116097764(Gli2)

ANU:	117716542(Gli2)

MUN:	110546429(Gli2)

CGE:	100757572(Gli2)

MAUA:

101822742(Gli2)

PROB:

127236410(Gli2)

PLEU:

114700236(Gli2)

MORG:

121446159(Gli2)

MFOT:

126489894

AAMP:

119827879(Gli2)

NGI:	103732312(Gli2)

HGL:	101697659(Gli2)

CPOC:

100715371(Gli2)

CCAN:

109693799(Gli2)

DORD:

105988922(Gli2)

DSP:	122112408(Gli2)

PLOP:

125368077(Gli2)

NCAR:

124981379

MMMA:

107136590(Gli2)

OCU:

100359289

OPI:	101524491(GLI2)

TUP:	102500191(GLI2)

GVR:	103592188(GLI2)

CFA:	100682984(GLI2)

CLUD:

112647793(GLI2)

VVP:	112934344(GLI2)

VLG:	121482121(GLI2)

NPO:	129503780(GLI2)

AML:	100484506(GLI2)

UMR:	103658624(GLI2)

UAH:	113263366(GLI2)

UAR:	123796602(GLI2)

ELK:

111144403

LLV:

125096011

MPUF:

101674831(GLI2)

MNP:	132013967(GLI2)

MLK:	131826912(GLI2)

NVS:	122902743(GLI2)

ORO:	101378177(GLI2)

EJU:	114207330(GLI2)

ZCA:	113920980(GLI2)

MLX:	118012554(GLI2)

NSU:	110585718(GLI2)

FCA:	101101401(GLI2)

PYU:	121030313(GLI2)

PCOO:

112865618(GLI2)

PBG:	122481243(GLI2)

PVIV:

125173678(GLI2)

LRUF:

124516485

PTG:	102950503(GLI2)

PPAD:

109278776(GLI2)

PUC:

125911931

AJU:

106966424

HHV:	120233573(GLI2)

BTA:	510255(GLI2)

BOM:	102284811(GLI2)

BIU:	109568632(GLI2)

BBUB:

102410518(GLI2)

BBIS:

105003820(GLI2)

CHX:	102178402(GLI2)

OAS:	101114169(GLI2)

BTAX:

128043224(GLI2)

ODA:	120854710(GLI2)

CCAD:

122453941(GLI2)

MBEZ:

129537671(GLI2)

SSC:	100520334(GLI2)

CFR:	102510411(GLI2)

CBAI:

105068795(GLI2)

CDK:	105088521(GLI2)

VPC:	102528648(GLI2)

BACU:

103007078(GLI2)

BMUS:

118897681(GLI2)

LVE:	103078067(GLI2)

OOR:	101279232(GLI2)

DLE:	111170393(GLI2)

PCAD:

102979873(GLI2)

PSIU:

116757046(GLI2)

NASI:

112409207(GLI2)

ECB:	100067420(GLI2)

EPZ:	103558688(GLI2)

EAI:	106841821(GLI2)

MYB:	106727846(GLI2)

MYD:	102767516(GLI2)

MMYO:

118662026(GLI2)

MDT:	132238718(GLI2)

PKL:	118709125(GLI2)

EFUS:

103287730(GLI2)

MNA:	107543207(GLI2)

DRO:	112313141(GLI2)

SHON:

118989532(GLI2)

AJM:	119049366(GLI2)

PDIC:

114514362(GLI2)

PHAS:

123810269(GLI2)

MMF:	118625542(GLI2)

PPAM:

129071738(GLI2)

HAI:	109395871(GLI2)

RFQ:	117026266(GLI2)

PALE:

102880962(GLI2)

PGIG:

120606282(GLI2)

PVP:	105294458(GLI2)

RAY:	107501918(GLI2)

MJV:	108387174(GLI2)

TOD:	119255745(GLI2)

SARA:

101541171(GLI2)

SETR:

126008857(GLI2)

LAV:	100662027(GLI2)

TMU:

101342888

ETF:	101651805(GLI2)

DNM:	101411525(GLI2)

MDO:	100011403(GLI2)

GAS:	123242298(GLI2)

SHR:	100922034(GLI2)

AFZ:

127554314

PCW:	110192114(GLI2)

TVP:	118838436(GLI2)

OAA:	100081663(GLI2)

GGA:	395956(GLI2)

PCOC:

116227360(GLI2)

MGP:	100544758(GLI2)

CJO:	107316842(GLI2)

TPAI:

128077066(GLI2)

LMUT:

125696933(GLI2)

NMEL:

110399760(GLI2)

APLA:

101790468(GLI2)

ACYG:

106029881(GLI2)

CATA:

118259909(GLI2)

AFUL:

116490773(GLI2)

TGU:	100221648(GLI2)

LSR:	110468308(GLI2)

SCAN:

103814324(GLI2)

PMOA:

120498845(GLI2)

OTC:	121336848(GLI2)

PRUF:

121356740(GLI2)

GFR:	102033086(GLI2)

FAB:	101821070(GLI2)

OMA:	130255744(GLI2)

PHI:	102109885(GLI2)

PMAJ:

107207804(GLI2)

CCAE:

111932230(GLI2)

CCW:	104694004(GLI2)

CBRC:

103619738(GLI2)

ETL:	114055514(GLI2)

ZAB:	102074946(GLI2)

ZLE:	135450319(GLI2)

ACHL:

103812020

SVG:	106850436(GLI2)

MMEA:

130574972(GLI2)

HRT:	120755249(GLI2)

SATI:

136363647(GLI2)

FPG:	101920502(GLI2)

FCH:	102047999(GLI2)

CCRI:

104161192(GLI2)

NNT:	104413489(GLI2)

SHAB:

115608516(GLI2)

ACUN:

113482345(GLI2)

TALA:

104368119(GLI2)

ACHC:

115343204(GLI2)

HALD:

104317394(GLI2)

HLE:	104832457(GLI2)

AGEN:

126040248

GCL:

127018573

CSTI:

104556861(GLI2)

LDI:	104353266(GLI2)

MNB:

103772007

DPUB:

104309767(GLI2)

AVIT:

104274330(GLI2)

BRHI:

104498081(GLI2)

EGZ:	104128116(GLI2)

NNI:	104018911(GLI2)

PCRI:

104034681

PCAO:

104052365(GLI2)

PADL:

103919611(GLI2)

AFOR:

103895399(GLI2)

FGA:	104075530(GLI2)

GSTE:

104259437(GLI2)

CLV:	102091100(GLI2)

MUI:	104546917(GLI2)

PGUU:

104469894

PLET:

104619494(GLI2)

EHS:

104513552

CMAC:

104478280(GLI2)

CUCA:

104067695(GLI2)

TEO:	104375930(GLI2)

BREG:

104638269(GLI2)

OHA:	104337279(GLI2)

ACAR:

104526868(GLI2)

CPEA:

104387311(GLI2)

CVF:	104288467(GLI2)

RTD:	128912948(GLI2)

AAM:	106499223(GLI2)

AROW:

112973839(GLI2)

NPD:	112944362(GLI2)

TGT:	104574700(GLI2)

DNE:	112994247(GLI2)

SCAM:

104139624(GLI2)

ASN:	102383712(GLI2)

AMJ:	106736843(GLI2)

CPOO:

109322842(GLI2)

GGN:	109301431(GLI2)

PSS:	102447306(GLI2)

CMY:	102942969(GLI2)

CCAY:

125645011(GLI2)

DCC:	119863800(GLI2)

CPIC:

101941506(GLI2)

TST:	117885079(GLI2)

CABI:

116834029(GLI2)

MRV:	120374651(GLI2)

ACS:	100560696(gli2)

ASAO:

132774311(GLI2)

PVT:	110085459(GLI2)

SUND:

121919026(GLI2)

PBI:	103048216(GLI2)

PMUR:

107288958(GLI2)

CTIG:

120297112(GLI2)

TSR:	106541431(GLI2)

PGUT:

117668461(GLI2)

APRI:

131204340(GLI2)

PTEX:

113441115(GLI2)

NSS:	113410767(GLI2)

VKO:	123027500(GLI2)

PMUA:

114603747(GLI2)

PRAF:

128421015(GLI2)

ZVI:	118091636(GLI2)

HCG:	128338775(GLI2)

GJA:	107115973(GLI2)

STOW:

125426488(GLI2)

EMC:	129324958(GLI2)

XLA:	397838(gli2.L) 398107(gli2.S)

XTR:	100498653(gli2)

NPR:	108788339(GLI2)

RTEM:

120944261(GLI2)

BBUF:

121008030(GLI2)

BGAR:

122945278(GLI2)

MUO:	115474572(GLI2)

GSH:	117361153(GLI2)

DRE:	30154(gli2a) 548610(gli2b)

SRX:	107714335 107722873 107741990 107755624

SANH:

107660646 107661135 107701691

SGH:	107552403 107558373 107596061 107597558

CCAR:

109050433 109060593 109096381

CAUA:

113053064 113055401 113077240 113078270 113108178

CGIB:

127965409 127968345 128020002 128021966

PTET:

122351957(gli2a) 122353843(gli2b)

LROH:

127171251(gli2a) 127173370(gli2b)

OMC:	131546840(gli2a) 131549595(gli2b)

PPRM:

120480812(gli2b) 120490027(gli2a)

RKG:	130071459(gli2b) 130078724(gli2a)

MAMB:

125256618(gli2b) 125270191(gli2a)

CIDE:

127518946 127522907

CERY:

137020916(gli2b) 137035432(gli2a)

MASI:

127426536 127427725 127447085 127448479

TROS:

130556054(gli2a) 130571689(gli2b)

TDW:	130410698(gli2b) 130427893(gli2a)

MANU:

129427966(gli2b) 129451942(gli2a)

IPU:	108266950(gli2a) 108271154(gli2b)

IFU:	128608737(gli2a) 128613430(gli2b)

PHYP:

113525883(gli2) 113536614

SMEO:

124382988(gli2a) 124391133(gli2b)

TFD:	113653873(gli2b) 113654462(gli2a)

TVC:	132850118(gli2a) 132856124(gli2b)

TRN:	134323964(gli2a) 134331703(gli2b)

AMEX:

103028990(gli2b) 103029390(gli2a)

CMAO:

118819424(gli2b) 118822221(gli2a)

EEE:	113579210 113592287(gli2)

CHAR:

105901924(gli2a) 105905650

TRU:	101065958(gli2) 101077858

TFS:	130522992 130530104(gli2a)

TNG:	GSTEN00019415G001 GSTEN00033101G001

LCO:	104931307 104940382(gli2)

NCC:

104953998

TBEN:

117485821(gli2a) 117486814

CGOB:

115005695 115018486 115026727(gli2)

PGEO:

117466857(gli2a)

GACU:

117547585

EMAC:

134861170 134867881(gli2a)

ELY:	117250112 117251473(gli2a)

EFO:	125884805 125900069(gli2a)

PLEP:

121948980(gli2a)

SLUC:

116035745(gli2a) 116044855

ECRA:

117939650 117952940(gli2a)

ESP:	116678848 116684804 116697834(gli2)

PFLV:

114551254 114564487(gli2)

GAT:	120834159(gli2a)

PPUG:

119229244(gli2a)

AFB:	129104321(gli2a) 129112000

CLUM:

117741607 117750938(gli2a)

PSWI:

130205443(gli2a)

MSAM:

119903466(gli2a) 119904475

SCHU:

122872035 122885492(gli2a)

CUD:	121506035 121522978(gli2a)

ALAT:

119015197 119026351(gli2a)

MZE:	101471215 101476769

ONL:	100704788(gli2) 100709465

OAU:	116314856(gli2a) 116320508

OLA:	101164961(gli2)

OML:	112154876 112156737

CSAI:

133425090 133446164(gli2a)

XMA:	102234915(gli2) 102236609

XCO:	114140508 114147937(gli2)

XHE:	116715627 116722892(gli2)

PRET:

103457154 103460614(gli2)

PFOR:

103150931 103155370

PLAI:

106950373 106954091

PMEI:

106908601 106924468

GAF:	122826970 122839962(gli2a)

PPRL:

129354868 129356881 129374587

CVG:	107096018 107098726(gli2)

CTUL:

119771615 119793713(gli2a)

GMU:	124861393 124871561(gli2a)

NFU:	107382740(gli2) 107384568

KMR:	108228619 108249764(gli2a)

ALIM:

106517622 106531237(gli2)

NWH:	119419490(gli2a) 119428810

AOCE:

111580119 111588181(gli2)

MCEP:

125000635 125017939(gli2a)

CSEM:

103392349(gli2)

POV:	109637405(gli2) 109643926

SSEN:

122764934(gli2a) 122765313

HHIP:

117755097(gli2a) 117777991

HSP:	118103160 118120371(gli2a)

PPLT:

128431315 128456458

SMAU:

118282940(gli2a) 118316726

LCF:	108873211 108887629(gli2a)

SDU:	111228096 111235546

SLAL:

111646880 111663022

XGL:	120798130 120801980(gli2a)

HCQ:	109528960(gli2)

SSCV:

125974174

SBIA:

133511980(gli2a)

PEE:	133410885(gli2a)

PTAO:

133486896(gli2a)

BPEC:

110163922(gli2)

MALB:

109955784 109963787(gli2)

BSPL:

114845644 114847236(gli2a)

SJO:	128354604 128367579(gli2a)

SASA:

106574262 106575189 106582360 106586430

STRU:

115155624 115160961 115179192 115196014

OTW:	112224857 112238730(gli2a) 112253874 112266529

OMY:	110497104 110502095 110520285 110527499

OGO:	124008454 124011435 124044002 124047576

ONE:	115111122 115129690 115129810 115133617

OKI:	109868181 109871276(gli2) 109890624 109906701

OKE:	118363159 118366899(gli2a) 118369984 118386335

SALP:

111953355 111959648 111970933 111977296(gli2)

SNH:	120033190 120050733 120058320(gli2a) 120063931

CCLU:

121537008(gli2a) 121555139

ELS:	105019975 105024675(gli2)

SFM:	108928330(gli2) 108930821

PKI:	111851737(gli2)

AANG:

118222278(gli2a)

LOC:	102688666(gli2)

PSPA:

121322491(gli2a) 121323134

ARUT:

117412408 117426943(gli2a)

PSEX:

120530736(gli2a)

LCM:	102362197(GLI2)

CMK:	103180484(gli2a)

RTP:

109927471

CPLA:

122551762(gli2a)

HOC:	132817030(gli2a)

LERI:

129699092(gli2a)

PMRN:

116940982 116946583

LRJ:	133344871(GLI2) 133345064

BBEL:

109462330

CIN:	778919(gli)

SKO:

100377291

HHAL:

106685377(ci)

DFR:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CANU:

CVN:	111126487 111127446

OED:

MYI:

PMAX:

OBI:

LJP:

ATEN:

AQU:

Reference

PMID:21801010

Authors

Hui CC, Angers S

Title

Gli proteins in development and disease.

Journal

Annu Rev Cell Dev Biol 27:513-37 (2011)
DOI:10.1146/annurev-cellbio-092910-154048

Reference

PMID:18455992

Authors

Varjosalo M, Bjorklund M, Cheng F, Syvanen H, Kivioja T, Kilpinen S, Sun Z, Kallioniemi O, Stunnenberg HG, He WW, Ojala P, Taipale J

Title

Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling.

Journal

Cell 133:537-48 (2008)
DOI:10.1016/j.cell.2008.02.047

Sequence

[hsa:2736]

LinkDB

DBGET integrated database retrieval system