| Entry |
|
|---|
| Name |
Clozapine (JAN/USP/INN);
Clozaril (TN) |
|---|
| Product |
|
|---|
| Generic |
CLOZAPINE (Accord Healthcare), CLOZAPINE (American Health Packaging), CLOZAPINE (Aurobindo Pharma Limited), CLOZAPINE (Bryant Ranch Prepack), CLOZAPINE (Bryant Ranch Prepack), CLOZAPINE (Bryant Ranch Prepack), CLOZAPINE (Bryant Ranch Prepack), CLOZAPINE (Cardinal Health 107), CLOZAPINE (Major Pharmaceuticals), CLOZAPINE (Mylan Institutional), CLOZAPINE (Mylan Institutional), CLOZAPINE (Mylan Pharmaceuticals), CLOZAPINE (Mylan Pharmaceuticals), CLOZAPINE (Sun Pharmaceutical Industries), CLOZAPINE (Teva Pharmaceuticals USA), CLOZAPINE (Teva Pharmaceuticals USA) |
|---|
| Formula |
C18H19ClN4
|
|---|
| Exact mass |
326.1298
|
|---|
| Mol weight |
326.82
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01476 Dopamine D4-receptor antagonist
DG03200 Antipsychotic agent
DG03064 Atypical antipsychotic
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Therapeutic category: | 1179 |
|
|---|
| Efficacy |
Antipsychotic |
|---|
| Disease |
Treatment-resistant schizophrenia [DS: H01649] |
|---|
| Comment |
Multi-acting receptor targeted antipsychotic (MARTA)
Tricyclic compound
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP1A2 [HSA: 1544], CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07211 | Serotonin receptor agonists/antagonists |
| map07213 | Dopamine receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05A ANTIPSYCHOTICS
N05AH Diazepines, oxazepines, thiazepines and oxepines
N05AH02 Clozapine
D00283 Clozapine (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Antipsychotics
Treatment-Resistant
Clozapine
D00283 Clozapine (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
117 Psychotropics
1179 Others
D00283 Clozapine (JAN/USP/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01476 Dopamine D4-receptor antagonist
D00283 Clozapine
DG03200 Antipsychotic agent
DG03064 Atypical antipsychotic
D00283 Clozapine
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
D00283 Clozapine
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
D00283 Clozapine
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA2
D00283 Clozapine (JAN/USP/INN) <JP/US>
Dopamine
DRD4
D00283 Clozapine (JAN/USP/INN) <JP/US>
Serotonin
HTR2A
D00283 Clozapine (JAN/USP/INN) <JP/US>
HTR2C
D00283 Clozapine (JAN/USP/INN) <JP/US>
Ion channels
Ligand-gated ion channels
Serotonin
HTR3
D00283 Clozapine (JAN/USP/INN) <JP/US>
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D00283
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00283
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
D00283
|
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| Other DBs |
|
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| LinkDB |
|
|---|
| KCF data |
ATOM 23
1 C2y C 17.6334 -14.2894
2 C8y C 16.7913 -13.1798
3 C8y C 17.1265 -11.8230
4 N1x N 18.3875 -11.2449
5 N2x N 19.0392 -14.3146
6 C8y C 19.6411 -11.8672
7 C8y C 19.9276 -13.2359
8 C8x C 16.1194 -10.8546
9 C8x C 14.7774 -11.2427
10 C8x C 14.4422 -12.5995
11 C8x C 15.4493 -13.5676
12 C8x C 21.2588 -13.6730
13 C8y C 22.3030 -12.7386
14 C8x C 22.0166 -11.3699
15 C8x C 20.6852 -10.9328
16 N1y N 16.9989 -15.5391
17 C1x C 15.5973 -15.5391
18 C1x C 14.8965 -16.7529
19 N1y N 15.5973 -17.9669
20 C1x C 16.9989 -17.9669
21 C1x C 17.6997 -16.7529
22 X Cl 23.6578 -13.1837
23 C1a C 14.8903 -19.1909
BOND 26
1 3 4 1
2 1 5 2
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 3 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 2 11 2
13 7 12 2
14 12 13 1
15 13 14 2
16 14 15 1
17 6 15 2
18 1 16 1
19 16 17 1
20 17 18 1
21 18 19 1
22 19 20 1
23 20 21 1
24 16 21 1
25 13 22 1
26 19 23 1
|
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