| Entry |
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| Name |
Clomipramine hydrochloride (JP18/USP);
Anafranil (TN) |
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| Product |
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| Generic |
CLOMIPRAMINE HCL (Amneal Pharmaceuticals NY LLC), CLOMIPRAMINE HYDROCHLORIDE (Ajanta Pharma USA), CLOMIPRAMINE HYDROCHLORIDE (Alembic Pharmaceuticals Limited), CLOMIPRAMINE HYDROCHLORIDE (Alembic Pharmaceuticals), CLOMIPRAMINE HYDROCHLORIDE (American Health Packaging), CLOMIPRAMINE HYDROCHLORIDE (Aurobindo Pharma Limited), CLOMIPRAMINE HYDROCHLORIDE (Bryant Ranch Prepack), CLOMIPRAMINE HYDROCHLORIDE (Bryant Ranch Prepack), CLOMIPRAMINE HYDROCHLORIDE (Golden State Medical Supply), CLOMIPRAMINE HYDROCHLORIDE (JUBILANT CADISTA PHARMACEUTICALS), CLOMIPRAMINE HYDROCHLORIDE (Leading Pharma), CLOMIPRAMINE HYDROCHLORIDE (Lifestar Pharma LLC), CLOMIPRAMINE HYDROCHLORIDE (Lupin Pharmaceuticals), CLOMIPRAMINE HYDROCHLORIDE (Major Pharmaceuticals), CLOMIPRAMINE HYDROCHLORIDE (Micro Labs Limited), CLOMIPRAMINE HYDROCHLORIDE (Northstar Rx LLC.), CLOMIPRAMINE HYDROCHLORIDE (Proficient Rx LP), CLOMIPRAMINE HYDROCHLORIDE (Rising Pharma Holdings), CLOMIPRAMINE HYDROCHLORIDE (Taro Pharmaceuticals U.S.A.), CLOMIPRAMINE HYDROCHLORIDE (TruPharma LLC), CLOMIPRAMINE HYDROCHLORIDE (Upsher-Smith Laboratories), CLOMIPRAMINE HYDROCHLORIDE (VGYAAN Pharmaceuticals LLC), CLOMIPRAMINE HYDROCHLORIDE (Zydus Lifesciences Limited), CLOMIPRAMINE HYDROCHLORIDE (Zydus Pharmaceuticals USA) |
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| Formula |
C19H23ClN2. HCl
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| Exact mass |
350.1317
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| Mol weight |
351.31
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| Structure |
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| Simcomp |
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| Class |
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG01728 Tricyclic antidepressant
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG01639 CYP2C19 substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
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| Remark |
| Product (DG00929): | D00811<JP/US> |
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| Efficacy |
Antidepressant, Serotonin-noradrenaline reuptake inhibitor (SNRI) |
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| Disease |
Obsessive-compulsive disorder [DS: H01450] |
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| Target |
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| Pathway |
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| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]; CYP1A2 [HSA: 1544], CYP3A4 [HSA: 1576], CYP2C19 [HSA: 1557]
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| Interaction |
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| Structure map |
| map07234 | Neurotransmitter transporter inhibitors |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06A ANTIDEPRESSANTS
N06AA Non-selective monoamine reuptake inhibitors
N06AA04 Clomipramine
D00811 Clomipramine hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Antidepressants
Tricyclics
Clomipramine
D00811 Clomipramine hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
117 Psychotropics
1174 Imipramines
D00811 Clomipramine hydrochloride (JP18/USP)
1179 Others
D00811 Clomipramine hydrochloride (JP18/USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG00929 Clomipramine
D00811 Clomipramine hydrochloride
DG01728 Tricyclic antidepressant
DG00929 Clomipramine
D00811 Clomipramine hydrochloride
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00929 Clomipramine
D00811 Clomipramine hydrochloride
DG01639 CYP2C19 substrate
DG00929 Clomipramine
D00811 Clomipramine hydrochloride
DG01644 CYP2D6 substrate
DG00929 Clomipramine
D00811 Clomipramine hydrochloride
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00929 Clomipramine
D00811 Clomipramine hydrochloride
Drug classes [BR:br08332]
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
D00811 Clomipramine hydrochloride
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC6
SLC6A2 (NAT1)
D00811 Clomipramine hydrochloride (JP18/USP) <JP/US>
SLC6A4 (HTT)
D00811 Clomipramine hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00811 Clomipramine hydrochloride
D00811 Clomipramine hydrochloride tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00811
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
D00811
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG00929 Clomipramine
DG01728 Tricyclic antidepressant
DG00929 Clomipramine
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00929 Clomipramine
DG01639 CYP2C19 substrate
DG00929 Clomipramine
DG01644 CYP2D6 substrate
DG00929 Clomipramine
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00929 Clomipramine
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 23
1 C1x C 18.7534 -14.2894
2 C8y C 17.9113 -13.1798
3 C8y C 18.2465 -11.8230
4 N1y N 19.5075 -11.2449
5 C1x C 20.1592 -14.3146
6 C8y C 20.7611 -11.8672
7 C8y C 21.0476 -13.2359
8 C8x C 17.2394 -10.8546
9 C8y C 15.8974 -11.2427
10 C8x C 15.5622 -12.5995
11 C8x C 16.5693 -13.5676
12 C8x C 22.3788 -13.6730
13 C8x C 23.4230 -12.7386
14 C8x C 23.1366 -11.3699
15 C8x C 21.8052 -10.9328
16 X Cl 14.8980 -10.2821
17 C1b C 19.5292 -9.8700
18 C1b C 20.7532 -9.1889
19 C1b C 21.9216 -9.8884
20 N1c N 23.1437 -9.2083
21 C1a C 24.3784 -9.9469
22 C1a C 23.1657 -7.8400
23 X Cl 26.3900 -12.4600
BOND 24
1 3 4 1
2 1 5 1
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 3 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 2 11 2
13 7 12 2
14 12 13 1
15 13 14 2
16 14 15 1
17 6 15 2
18 9 16 1
19 4 17 1
20 17 18 1
21 18 19 1
22 19 20 1
23 20 21 1
24 20 22 1
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