KEGG   DRUG: Dexmedetomidine hydrochloride
Entry
D01205                      Drug                                   
Name
Dexmedetomidine hydrochloride (JAN/USP);
Igalmi (TN);
Precedex (TN)
Product
DEXMEDETOMIDINE HYDROCHLORIDE (WG Critical Care), IGALMI (BioXcel Therapeutics), PRECEDEX (Henry Schein), PRECEDEX (Hospira), PRECEDEX (Hospira), PRECEDEX (Hospira)
  Generic
DEXMEDETOMIDINE (Accord Healthcare), DEXMEDETOMIDINE (Accord Healthcare), DEXMEDETOMIDINE (Athenex Pharmaceutical Division), DEXMEDETOMIDINE (Avenacy), DEXMEDETOMIDINE (Eugia US LLC), DEXMEDETOMIDINE (Gland Pharma Limited), DEXMEDETOMIDINE (Medical Purchasing Solutions), DEXMEDETOMIDINE (Medical Purchasing Solutions), DEXMEDETOMIDINE (Meitheal Pharmaceuticals), DEXMEDETOMIDINE (Mylan Institutional LLC), DEXMEDETOMIDINE (Piramal Critical Care), DEXMEDETOMIDINE (Piramal Critical Care), DEXMEDETOMIDINE (Piramal Critical Care), DEXMEDETOMIDINE HCL (Hikma Pharmaceuticals USA), DEXMEDETOMIDINE HCL (Medical Purchasing Solutions), DEXMEDETOMIDINE HYDROCHLORIDE (Amneal Pharmaceuticals LLC), DEXMEDETOMIDINE HYDROCHLORIDE (Amneal Pharmaceuticals LLC), DEXMEDETOMIDINE HYDROCHLORIDE (Baxter Healthcare Company), DEXMEDETOMIDINE HYDROCHLORIDE (Baxter Healthcare Corporation), DEXMEDETOMIDINE HYDROCHLORIDE (CIVICA), DEXMEDETOMIDINE HYDROCHLORIDE (Dr.Reddy's Laboratories), DEXMEDETOMIDINE HYDROCHLORIDE (Fresenius Kabi USA), DEXMEDETOMIDINE HYDROCHLORIDE (Fresenius Kabi USA), DEXMEDETOMIDINE HYDROCHLORIDE (Gland Pharma Limited), DEXMEDETOMIDINE HYDROCHLORIDE (Hikma Pharmaceuticals USA), DEXMEDETOMIDINE HYDROCHLORIDE (Medical Purchasing Solutions), DEXMEDETOMIDINE HYDROCHLORIDE (Medical Purchasing Solutions), DEXMEDETOMIDINE HYDROCHLORIDE (Medical Purchasing Solutions), DEXMEDETOMIDINE HYDROCHLORIDE (Mylan Institutional LLC), DEXMEDETOMIDINE HYDROCHLORIDE (Par Pharmaceutical), DEXMEDETOMIDINE HYDROCHLORIDE (Piramal Critical Care), DEXMEDETOMIDINE HYDROCHLORIDE (Slayback Pharma LLC), DEXMEDETOMIDINE HYDROCHLORIDE (Slayback Pharma LLC), DEXMEDETOMIDINE HYDROCHLORIDE (Sun Pharmaceuticals Industries), DEXMEDETOMIDINE HYDROCHLORIDE (Zydus Lifesciences Limited), DEXMEDETOMIDINE HYDROCHLORIDE (Zydus Pharmaceuticals USA), DEXMEDETOMIDINE HYDROCHLORIDE IN 0.9% SODIUM CHLORIDE (Baxter Healthcare Corporation), DEXMEDETOMIDINE HYDROCHLORIDE IN 0.9% SODIUM CHLORIDE (Sagent Pharmaceuticals), DEXMEDETOMIDINE HYDROCHLORIDE IN 0.9% SODIUM CHLORIDE (Sandoz), DEXMEDETOMIDINE HYDROCHLORIDE IN SODIUM CHLORIDE (Precision Dose)
Formula
C13H16N2. HCl
Exact mass
236.108
Mol weight
236.7405
Structure
Simcomp
Class
Cardiovascular agent
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01449  alpha2-Adrenergic receptor agonist
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
 DG01638  CYP2A6 substrate
 DG01639  CYP2C19 substrate
 DG01644  CYP2D6 substrate
 DG02855  CYP2E1 substrate
Remark
Therapeutic category: 1129
ATC code: N05CM18
Chemical structure group: DG00926
Product (DG00926): D01205<JP/US>
Efficacy
Sedative-hypnotic, Tranquilizer, alpha2-Adrenergic receptor agonist
  Disease
Schizophrenia [DS:H01649]
Bipolar I or II disorder [DS:H01653]
Target
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP2A6 [HSA:1548]; CYP1A2 [HSA:1544], CYP2E1 [HSA:1571], CYP2D6 [HSA:1565], CYP2C19 [HSA:1557]
Interaction
Structure map
map07215  alpha-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CM Other hypnotics and sedatives
     N05CM18 Dexmedetomidine
      D01205  Dexmedetomidine hydrochloride (JAN/USP) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1129  Others
     D01205  Dexmedetomidine hydrochloride (JAN/USP)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01456  Adrenergic receptor agonist
   DG01450  alpha-Adrenergic receptor agonist
    DG01449  alpha2-Adrenergic receptor agonist
     DG00926  Dexmedetomidine
      D01205  Dexmedetomidine hydrochloride
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00926  Dexmedetomidine
    D01205  Dexmedetomidine hydrochloride
  DG01638  CYP2A6 substrate
   DG00926  Dexmedetomidine
    D01205  Dexmedetomidine hydrochloride
  DG01639  CYP2C19 substrate
   DG00926  Dexmedetomidine
    D01205  Dexmedetomidine hydrochloride
  DG01644  CYP2D6 substrate
   DG00926  Dexmedetomidine
    D01205  Dexmedetomidine hydrochloride
  DG02855  CYP2E1 substrate
   DG00926  Dexmedetomidine
    D01205  Dexmedetomidine hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA2
     D01205  Dexmedetomidine hydrochloride (JAN/USP) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01205
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D01205
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01205
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01205
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01205
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01456  Adrenergic receptor agonist
   DG01450  alpha-Adrenergic receptor agonist
    DG01449  alpha2-Adrenergic receptor agonist
     DG00926  Dexmedetomidine
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00926  Dexmedetomidine
  DG01638  CYP2A6 substrate
   DG00926  Dexmedetomidine
  DG01639  CYP2C19 substrate
   DG00926  Dexmedetomidine
  DG01644  CYP2D6 substrate
   DG00926  Dexmedetomidine
  DG02855  CYP2E1 substrate
   DG00926  Dexmedetomidine
Other DBs
CAS: 145108-58-3
PubChem: 7848268
ChEBI: 31472
LigandBox: D01205
LinkDB
KCF data

ATOM        16
            1   X   Cl   27.3320  -22.4150
            2   C8y C    20.8462  -21.6678
            3   C1c C    22.0574  -20.9599
            4   C8y C    19.6349  -20.9599
            5   C8x C    20.8462  -23.0602
            6   C8y C    23.2859  -21.6678
            7   C1a C    22.0574  -19.5614
            8   C8y C    18.4180  -21.6678
            9   C1a C    19.6292  -19.5614
            10  C8x C    19.6349  -23.7624
            11  C8x C    23.3213  -23.0709
            12  N5x N    24.5990  -21.1978
            13  C8x C    18.4238  -23.0719
            14  C1a C    17.2070  -20.9657
            15  N4x N    24.6642  -23.4622
            16  C8x C    25.4403  -22.3076
BOND        16
            1     2   3 1
            2     2   4 2
            3     2   5 1
            4     3   6 1
            5     3   7 1 #Down
            6     4   8 1
            7     4   9 1
            8     5  10 2
            9     6  11 2
            10    6  12 1
            11    8  13 2
            12    8  14 1
            13   11  15 1
            14   12  16 2
            15   10  13 1
            16   15  16 1

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