| Entry |
|
|---|
| Name |
Desvenlafaxine succinate (USAN);
Desvenlafaxine succinate hydrate (JAN);
Pristiq (TN) |
|---|
| Product |
|
|---|
| Generic |
DESVENLAFAXINE (A-S Medication Solutions), DESVENLAFAXINE (A-S Medication Solutions), DESVENLAFAXINE (Actavis Pharma), DESVENLAFAXINE (American Health Packaging), DESVENLAFAXINE (Bryant Ranch Prepack), DESVENLAFAXINE (Bryant Ranch Prepack), DESVENLAFAXINE (Bryant Ranch Prepack), DESVENLAFAXINE (Golden State Medical Supply), DESVENLAFAXINE (Hikma Pharmaceuticals USA), DESVENLAFAXINE (REMEDYREPACK), DESVENLAFAXINE (Slate Run Pharmaceuticals), DESVENLAFAXINE ER (Direct_Rx), DESVENLAFAXINE SUCCINATE (A-S Medication Solutions), DESVENLAFAXINE (A-S Medication Solutions), DESVENLAFAXINE (A-S Medication Solutions), DESVENLAFAXINE (Alembic Pharmaceuticals Limited), DESVENLAFAXINE (Breckenridge Pharmaceutical), DESVENLAFAXINE SUCCINATE (Bryant Ranch Prepack), DESVENLAFAXINE (Bryant Ranch Prepack), DESVENLAFAXINE (DIRECT RX), DESVENLAFAXINE SUCCINATE (Greenstone LLC), DESVENLAFAXINE SUCCINATE (Lupin Pharmaceuticals), DESVENLAFAXINE (Preferred Pharmaceutical), DESVENLAFAXINE SUCCINATE (Preferred Pharmaceuticals), DESVENLAFAXINE (Preferred Pharmaceuticals), DESVENLAFAXINE SUCCINATE (Preferred Pharmaceuticals), DESVENLAFAXINE (Proficient Rx LP) |
|---|
| Formula |
C16H25NO2. C4H6O4. H2O
|
|---|
| Exact mass |
399.2257
|
|---|
| Mol weight |
399.4785
|
|---|
| Structure |
|
|---|
| Class |
Neuropsychiatric agent
DG01658 Serotonin and norepinephrine reuptake inhibitor (SNRI)
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG02924 UGT substrate
|
|---|
| Remark |
| Product (DG00963): | D07793<US> D02570<US> D11619<US> |
|
|---|
| Efficacy |
Antidepressant, Serotonin-noradrenaline reuptake inhibitor (SNRI) |
|---|
| Disease |
Major depressive disorder [DS: H01646] |
|---|
| Comment |
Treatment of major depressive disorder
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07234 | Neurotransmitter transporter inhibitors |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06A ANTIDEPRESSANTS
N06AX Other antidepressants
N06AX23 Desvenlafaxine
D02570 Desvenlafaxine succinate (USAN) <US>
USP drug classification [BR:br08302]
Antidepressants
SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
Desvenlafaxine
D02570 Desvenlafaxine succinate (USAN)
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC6
SLC6A2 (NAT1)
D02570 Desvenlafaxine succinate (USAN) <US>
SLC6A4 (HTT)
D02570 Desvenlafaxine succinate (USAN) <US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
D02570
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D02570
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D02570
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 28
1 O6a O 27.9300 -21.8400
2 C6a C 29.1900 -21.1400
3 C1b C 30.3800 -21.8400
4 C1b C 31.5700 -21.1400
5 C6a C 32.7600 -21.8400
6 O6a O 34.0200 -21.1400
7 O6a O 29.1900 -19.7400
8 O6a O 32.7600 -23.1700
9 O0 O 37.3800 -21.1400
10 C8x C 18.9700 -22.3300
11 C8y C 18.9700 -23.7300
12 C8x C 20.1600 -24.4300
13 C8x C 21.3500 -23.7300
14 C8y C 21.3500 -22.3300
15 C8x C 20.1600 -21.6300
16 C1x C 23.8000 -23.7300
17 C1z C 23.8000 -22.3300
18 C1c C 22.5400 -21.6300
19 C1x C 24.9900 -24.4300
20 C1x C 26.1800 -23.7300
21 C1x C 26.1800 -22.3300
22 C1x C 24.9900 -21.6300
23 O1a O 17.7800 -24.4300
24 O1a O 23.8000 -20.9300
25 C1b C 22.5228 -20.2301
26 N1c N 21.3149 -19.5524
27 C1a C 20.0958 -20.2768
28 C1a C 21.2978 -18.1301
BOND 27
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 5 6 1
6 2 7 2
7 5 8 2
8 10 11 2
9 11 12 1
10 12 13 2
11 13 14 1
12 14 15 2
13 10 15 1
14 16 17 1
15 17 18 1
16 14 18 1
17 16 19 1
18 19 20 1
19 20 21 1
20 21 22 1
21 17 22 1
22 11 23 1
23 17 24 1
24 18 25 1
25 25 26 1
26 26 27 1
27 26 28 1
|
|---|
