KEGG   DRUG: Fenfluramine hydrochloride
Entry
D04148                      Drug                                   
Name
Fenfluramine hydrochloride (JAN/USAN);
Fintepla (TN);
Pondimin (TN)
Product
Formula
C12H16F3N. HCl
Exact mass
267.1002
Mol weight
267.7183
Structure
Simcomp
Class
Gastrointestinal agent
 DG01705  Anoretic
  DG01704  Phenethylamine anorexic
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
 DG02919  CYP2B6 substrate
 DG01642  CYP2C9 substrate
 DG01639  CYP2C19 substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
 DG02925  CYP3A5 substrate
Remark
Therapeutic category: 1139
ATC code: A08AA02 N03AX26
Chemical structure group: DG00103
Product (DG00103): D04148<JP/US>
Efficacy
Antiepileptic, Appetite suppressant
  Disease
Dravet syndrome [DS:H01818]
Lennox-Gastaut syndrome [DS:H01813]
Target
SLC6A4 (HTT) [HSA:6532] [KO:K05037]
HTR1D [HSA:3352] [KO:K04153]
HTR2A [HSA:3356] [KO:K04157]
HTR2C [HSA:3358] [KO:K04157]
SIGMAR1 [HSA:10280] [KO:K20719]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
hsa05022  Pathways of neurodegeneration - multiple diseases
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP2B6 [HSA:1555], CYP2D6 [HSA:1565]; CYP2C9 [HSA:1559], CYP2C19 [HSA:1557], CYP3A4 [HSA:1576], CYP3A5 [HSA:1577]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A08 ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
   A08A ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
    A08AA Centrally acting antiobesity products
     A08AA02 Fenfluramine
      D04148  Fenfluramine hydrochloride (JAN/USAN) <US>
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AX Other antiepileptics
     N03AX26 Fenfluramine
      D04148  Fenfluramine hydrochloride (JAN/USAN) <US>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   113  Antiepileptics
    1139  Others
     D04148  Fenfluramine hydrochloride (JAN/USAN)
Drug groups [BR:br08330]
 Gastrointestinal agent
  DG01705  Anoretic
   DG01704  Phenethylamine anorexic
    DG00103  Fenfluramine
     D04148  Fenfluramine hydrochloride
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00103  Fenfluramine
    D04148  Fenfluramine hydrochloride
  DG02919  CYP2B6 substrate
   DG00103  Fenfluramine
    D04148  Fenfluramine hydrochloride
  DG01642  CYP2C9 substrate
   DG00103  Fenfluramine
    D04148  Fenfluramine hydrochloride
  DG01639  CYP2C19 substrate
   DG00103  Fenfluramine
    D04148  Fenfluramine hydrochloride
  DG01644  CYP2D6 substrate
   DG00103  Fenfluramine
    D04148  Fenfluramine hydrochloride
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00103  Fenfluramine
     D04148  Fenfluramine hydrochloride
  DG02925  CYP3A5 substrate
   DG00103  Fenfluramine
    D04148  Fenfluramine hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    HTR1D
     D04148  Fenfluramine hydrochloride (JAN/USAN) <JP/US>
    HTR2A
     D04148  Fenfluramine hydrochloride (JAN/USAN) <JP/US>
    HTR2C
     D04148  Fenfluramine hydrochloride (JAN/USAN) <JP/US>
 Transporters
  Solute carrier family
   SLC6
    SLC6A4 (HTT)
     D04148  Fenfluramine hydrochloride (JAN/USAN) <JP/US>
  Other transporters
   Auxiliary transport proteins (TC:8.A)
    SIGMAR1
     D04148  Fenfluramine hydrochloride (JAN/USAN) <JP/US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D04148
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D04148
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D04148
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D04148
Drug groups [BR:br08330]
 Gastrointestinal agent
  DG01705  Anoretic
   DG01704  Phenethylamine anorexic
    DG00103  Fenfluramine
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00103  Fenfluramine
  DG02919  CYP2B6 substrate
   DG00103  Fenfluramine
  DG01642  CYP2C9 substrate
   DG00103  Fenfluramine
  DG01639  CYP2C19 substrate
   DG00103  Fenfluramine
  DG01644  CYP2D6 substrate
   DG00103  Fenfluramine
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00103  Fenfluramine
  DG02925  CYP3A5 substrate
   DG00103  Fenfluramine
Other DBs
CAS: 404-82-0
PubChem: 47206095
ChEBI: 59729
LigandBox: D04148
NIKKAJI: J349.650C
LinkDB
KCF data

ATOM        17
            1   C8y C    16.3100  -16.0300
            2   C8x C    15.1200  -15.3300
            3   C8x C    16.3100  -17.4300
            4   C1b C    17.5000  -15.3300
            5   C8y C    13.8600  -16.0300
            6   C8x C    15.1200  -18.1300
            7   C1c C    18.7600  -16.0300
            8   C8x C    13.8600  -17.4300
            9   C1d C    12.6700  -15.3300
            10  N1b N    19.9500  -15.3300
            11  C1a C    18.7600  -17.4300
            12  X   F    11.3400  -14.5600
            13  X   F    12.0400  -16.3800
            14  X   F    13.4400  -14.2100
            15  C1b C    21.2100  -16.0300
            16  C1a C    22.4000  -15.3300
            17  X   Cl   23.3100  -17.7800
BOND        16
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 2
            6     4   7 1
            7     5   8 2
            8     5   9 1
            9     7  10 1
            10    7  11 1
            11    9  12 1
            12    9  13 1
            13    9  14 1
            14   10  15 1
            15   15  16 1
            16    6   8 1

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