KEGG   DRUG: Fenfluramine hydrochloride
Entry
D04148                      Drug                                   

Name
Fenfluramine hydrochloride (JAN/USAN);
Fintepla (TN);
Pondimin (TN)
Formula
C12H16F3N. HCl
Exact mass
267.1002
Mol weight
267.7183
Structure
Simcomp
Class
Other
 DG01705  Anoretic
  DG01704  Phenethylamine anorexic
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
 DG02919  CYP2B6 substrate
 DG01644  CYP2D6 substrate
Remark
ATC code: A08AA02 N03AX26
Chemical structure group: DG00103
Product (DG00103): D07945<US>
Efficacy
Appetite suppressant
  Disease
Dravet syndrome [DS:H01818]
Target
SLC6A4 (HTT) [HSA:6532] [KO:K05037]
HTR2 [HSA:3356 3357 3358] [KO:K04157]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP2B6 [HSA:1555], CYP2D6 [HSA:1565]; CYP2C9 [HSA:1559], CYP2C19 [HSA:1557], CYP3A4 [HSA:1576], CYP3A5 [HSA:1577]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A08 ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
   A08A ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
    A08AA Centrally acting antiobesity products
     A08AA02 Fenfluramine
      D04148  Fenfluramine hydrochloride (JAN/USAN)
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AX Other antiepileptics
     N03AX26 Fenfluramine
      D04148  Fenfluramine hydrochloride (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    HTR2
     D04148  Fenfluramine hydrochloride (JAN/USAN)
 Transporters
  Solute carrier family
   SLC6
    SLC6A4 (HTT)
     D04148  Fenfluramine hydrochloride (JAN/USAN)
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D04148
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D04148
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D04148
Other DBs
CAS: 404-82-0
PubChem: 47206095
ChEBI: 59729
ChEMBL: CHEMBL2106217
LigandBox: D04148
NIKKAJI: J349.650C
LinkDB
KCF data

ATOM        17
            1   C8y C    16.3100  -16.0300
            2   C8x C    15.1200  -15.3300
            3   C8x C    16.3100  -17.4300
            4   C1b C    17.5000  -15.3300
            5   C8y C    13.8600  -16.0300
            6   C8x C    15.1200  -18.1300
            7   C1c C    18.7600  -16.0300
            8   C8x C    13.8600  -17.4300
            9   C1d C    12.6700  -15.3300
            10  N1b N    19.9500  -15.3300
            11  C1a C    18.7600  -17.4300
            12  X   F    11.3400  -14.5600
            13  X   F    12.0400  -16.3800
            14  X   F    13.4400  -14.2100
            15  C1b C    21.2100  -16.0300
            16  C1a C    22.4000  -15.3300
            17  X   Cl   23.3100  -17.7800
BOND        16
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 2
            6     4   7 1
            7     5   8 2
            8     5   9 1
            9     7  10 1
            10    7  11 1
            11    9  12 1
            12    9  13 1
            13    9  14 1
            14   10  15 1
            15   15  16 1
            16    6   8 1

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