KEGG   DISEASE: 糖尿病性細小血管合併症
エントリ  
H02559                                                             
名称    
糖尿病性細小血管合併症
  下位グループ
糖尿病性腎症 [DS:H01456]
糖尿病性網膜症 [DS:H01457]
糖尿病性神経障害 [DS:H01459]
概要    
Microvascular complications of diabetes (MVCD) caused by damage in the small blood vessels contribute to pathologic and functional changes in many tissues, including eye, heart, kidney, skin, and neuronal tissues. These changes are traditionally known as diabetic retinopathy, nephropathy, and neuropathy.
カテゴリ  
内分泌代謝疾患
階層分類  
ICD-11 による疾患分類 [BR:jp08403]
 08 神経系の疾患
  神経根, 神経叢または末梢神経の疾患
   多発ニューロパチー
    8C03  その他の二次性多発ニューロパチー
     H02559  糖尿病性細小血管合併症
 09 視覚系の疾患
  眼球後極部の疾患
   網膜の疾患
    9B71  網膜症
     H02559  糖尿病性細小血管合併症
 16 泌尿生殖器系の疾患
  尿路系の疾患
   腎不全
    GB61  慢性腎不全
     H02559  糖尿病性細小血管合併症
パスウェイに基づく疾患分類 [BR:jp08402]
 細胞プロセス
  nt06535  エフェロサイトーシス
   H02559  糖尿病性細小血管合併症
ネットワーク
nt06535 Efferocytosis
病因遺伝子 
(MVCD1) VEGFA [HSA:7422] [KO:K05448]
(MVCD2) EPO [HSA:2056] [KO:K05437]
(MVCD3) ACE [HSA:1636] [KO:K01283]
(MVCD4) IL1RN [HSA:3557] [KO:K05481]
(MVCD5) PON1 [HSA:5444] [KO:K01045]
(MVCD6) SOD2 [HSA:6648] [KO:K04564]
(MVCD7) HFE [HSA:3077] [KO:K26535]
リンク   
ICD-11: GB61.Z 9B71.0 8C03.0
MeSH: D003928 D003930 D003929
OMIM: 603933 612623 612624 612628 612633 612634 612635
文献    
  著者
He Z, King GL
  タイトル
Microvascular complications of diabetes.
  雑誌
Endocrinol Metab Clin North Am 33:215-38, xi-xii (2004)
DOI:10.1016/j.ecl.2003.12.003
文献    
  著者
Li J, Cao Y, Liu W, Wang Q, Qian Y, Lu P
  タイトル
Correlations among Diabetic Microvascular Complications: A Systematic Review and Meta-analysis.
  雑誌
Sci Rep 9:3137 (2019)
DOI:10.1038/s41598-019-40049-z
文献    
PMID:11978667 (MVCD1)
  著者
Awata T, Inoue K, Kurihara S, Ohkubo T, Watanabe M, Inukai K, Inoue I, Katayama S
  タイトル
A common polymorphism in the 5'-untranslated region of the VEGF gene is associated with diabetic retinopathy in type 2 diabetes.
  雑誌
Diabetes 51:1635-9 (2002)
DOI:10.2337/diabetes.51.5.1635
文献    
PMID:18458324 (MVCD2)
  著者
Tong Z, Yang Z, Patel S, Chen H, Gibbs D, Yang X, Hau VS, Kaminoh Y, Harmon J, Pearson E, Buehler J, Chen Y, Yu B, Tinkham NH, Zabriskie NA, Zeng J, Luo L, Sun JK, Prakash M, Hamam RN, Tonna S, Constantine R, Ronquillo CC, Sadda S, Avery RL, Brand JM, London N, Anduze AL, King GL, Bernstein PS, Watkins S, Jorde LB, Li DY, Aiello LP, Pollak MR, Zhang K
  タイトル
Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications.
  雑誌
Proc Natl Acad Sci U S A 105:6998-7003 (2008)
DOI:10.1073/pnas.0800454105
文献    
PMID:9120002 (MVCD3)
  著者
Marre M, Jeunemaitre X, Gallois Y, Rodier M, Chatellier G, Sert C, Dusselier L, Kahal Z, Chaillous L, Halimi S, Muller A, Sackmann H, Bauduceau B, Bled F, Passa P, Alhenc-Gelas F
  タイトル
Contribution of genetic polymorphism in the renin-angiotensin system to the development of renal complications in insulin-dependent diabetes: Genetique de la Nephropathie Diabetique (GENEDIAB) study group.
  雑誌
J Clin Invest 99:1585-95 (1997)
DOI:10.1172/JCI119321
文献    
PMID:8786086 (MVCD4)
  著者
Blakemore AI, Cox A, Gonzalez AM, Maskil JK, Hughes ME, Wilson RM, Ward JD, Duff GW
  タイトル
Interleukin-1 receptor antagonist allele (IL1RN*2) associated with nephropathy in diabetes mellitus.
  雑誌
Hum Genet 97:369-74 (1996)
DOI:10.1007/BF02185776
文献    
PMID:9661650 (MVCD5)
  著者
Kao YL, Donaghue K, Chan A, Knight J, Silink M
  タイトル
A variant of paraoxonase (PON1) gene is associated with diabetic retinopathy in IDDM.
  雑誌
J Clin Endocrinol Metab 83:2589-92 (1998)
DOI:10.1210/jcem.83.7.5096
文献    
PMID:12624725 (MVCD6)
  著者
Nomiyama T, Tanaka Y, Piao L, Nagasaka K, Sakai K, Ogihara T, Nakajima K, Watada H, Kawamori R
  タイトル
The polymorphism of manganese superoxide dismutase is associated with diabetic nephropathy in Japanese type 2 diabetic patients.
  雑誌
J Hum Genet 48:138-41 (2003)
DOI:10.1007/s100380300021
文献    
PMID:14618419 (MVCD7)
  著者
Peterlin B, Globocnik Petrovic M, Makuc J, Hawlina M, Petrovic D
  タイトル
A hemochromatosis-causing mutation C282Y is a risk factor for proliferative diabetic retinopathy in Caucasians with type 2 diabetes.
  雑誌
J Hum Genet 48:646-649 (2003)
DOI:10.1007/s10038-003-0094-3
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